Gene Gene information from NCBI Gene database.
Entrez ID 23603
Gene name Coronin 1C
Gene symbol CORO1C
Synonyms (NCBI Gene)
HCRNN4
Chromosome 12
Chromosome location 12q24.11
Summary This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein com
miRNA miRNA information provided by mirtarbase database.
570
miRTarBase ID miRNA Experiments Reference
MIRT001375 hsa-miR-1-3p pSILAC 18668040
MIRT019935 hsa-miR-375 Microarray 20215506
MIRT021303 hsa-miR-125a-5p Sequencing 20371350
MIRT001375 hsa-miR-1-3p Proteomics;Other 18668040
MIRT028565 hsa-miR-30a-5p Proteomics 18668040
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Transcription factor Regulation Reference
NR1I2 Activation 21072196
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
59
GO ID Ontology Definition Evidence Reference
GO:0001755 Process Neural crest cell migration IBA
GO:0001755 Process Neural crest cell migration IMP 25074804
GO:0001932 Process Regulation of protein phosphorylation IGI 19913511
GO:0001933 Process Negative regulation of protein phosphorylation IMP 19913511
GO:0003779 Function Actin binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
605269 2254 ENSG00000110880
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9ULV4
Protein name Coronin-1C (Coronin-3) (hCRNN4)
Protein function Plays a role in directed cell migration by regulating the activation and subcellular location of RAC1 (PubMed:25074804, PubMed:25925950). Increases the presence of activated RAC1 at the leading edge of migrating cells (PubMed:25074804, PubMed:25
PDB 7STY
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF08953 DUF1899 3 68 Domain of unknown function (DUF1899) Domain
PF00400 WD40 69 109 WD domain, G-beta repeat Repeat
PF00400 WD40 120 159 WD domain, G-beta repeat Repeat
PF00400 WD40 167 202 WD domain, G-beta repeat Repeat
PF16300 WD40_4 343 385 Repeat
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:10828594}.
Sequence
MRRVVRQSKFRHVFGQAVKNDQCYDDIRVSRVTWDSSFCAVNPRFVAIIIEASGGGAFLV
LPLHKTGR
IDKSYPTVCGHTGPVLDIDWCPHNDQVIASGSEDCTVMVWQIPENGLTLSLT
EPVVILEGHSKRVGIVAWHPTARNVLLSAGCDNAIIIWN
VGTGEALINLDDMHSDMIYNV
SWNRNGSLICTASKDKKVRVID
PRKQEIVAEKEKAHEGARPMRAIFLADGNVFTTGFSRM
SERQLALWNPKNMQEPIALHEMDTSNGVLLPFYDPDTSIIYLCGKGDSSIRYFEITDESP
YVHYLNTFSSKEPQRGMGYMPKRGLDVNKCEIARFFKLHERKCEPIIMTVPRKSDLFQDD
LYPDTAGPEAALEAEEWFEGKNADP
ILISLKHGYIPGKNRDLKVVKKNILDSKPTANKKC
DLISIPKKTTDTASVQNEAKLDEILKEIKSIKDTICNQDERISKLEQQMAKIAA
Sequence length 474
Interactions View interactions