KLHDC2 (kelch domain containing 2)

Gene

• Entrez ID: 23588
• Gene name: Kelch domain containing 2
• Gene symbol: KLHDC2
• Synonyms (NCBI Gene): HCLP-1, HCLP1, LCP
• Chromosome: 14
• Chromosome location: 14q21.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT048884	hsa-miR-93-5p	CLASH	23622248
MIRT042902	hsa-miR-324-3p	CLASH	23622248
MIRT138187	hsa-miR-19a-3p	HITS-CLIP	22473208
MIRT138188	hsa-miR-19b-3p	HITS-CLIP	22473208
MIRT1097134	hsa-miR-1322	CLIP-seq
MIRT1097135	hsa-miR-3664-5p	CLIP-seq
MIRT1097136	hsa-miR-4252	CLIP-seq
MIRT1097137	hsa-miR-4677-3p	CLIP-seq
MIRT1097138	hsa-miR-4679	CLIP-seq
MIRT1097139	hsa-miR-4700-3p	CLIP-seq
MIRT1097140	hsa-miR-5095	CLIP-seq
MIRT1097135	hsa-miR-3664-5p	CLIP-seq
MIRT1097136	hsa-miR-4252	CLIP-seq
MIRT1097137	hsa-miR-4677-3p	CLIP-seq
MIRT1097138	hsa-miR-4679	CLIP-seq
MIRT1097139	hsa-miR-4700-3p	CLIP-seq
MIRT2026291	hsa-miR-4708-3p	CLIP-seq
MIRT2026292	hsa-miR-4761-5p	CLIP-seq
MIRT1097140	hsa-miR-5095	CLIP-seq
MIRT2026293	hsa-miR-626	CLIP-seq
MIRT2257413	hsa-miR-1251	CLIP-seq
MIRT1097134	hsa-miR-1322	CLIP-seq
MIRT2257414	hsa-miR-19a	CLIP-seq
MIRT2257415	hsa-miR-19b	CLIP-seq
MIRT2257416	hsa-miR-2117	CLIP-seq
MIRT2257417	hsa-miR-23a	CLIP-seq
MIRT2257418	hsa-miR-23b	CLIP-seq
MIRT2257419	hsa-miR-23c	CLIP-seq
MIRT1097135	hsa-miR-3664-5p	CLIP-seq
MIRT1097136	hsa-miR-4252	CLIP-seq
MIRT2257420	hsa-miR-448	CLIP-seq
MIRT1097137	hsa-miR-4677-3p	CLIP-seq
MIRT1097138	hsa-miR-4679	CLIP-seq
MIRT2257421	hsa-miR-4684-5p	CLIP-seq
MIRT1097139	hsa-miR-4700-3p	CLIP-seq
MIRT2026291	hsa-miR-4708-3p	CLIP-seq
MIRT2257422	hsa-miR-4717-3p	CLIP-seq
MIRT2257423	hsa-miR-4717-5p	CLIP-seq
MIRT2026292	hsa-miR-4761-5p	CLIP-seq
MIRT1097140	hsa-miR-5095	CLIP-seq
MIRT2257424	hsa-miR-548aa	CLIP-seq
MIRT2257425	hsa-miR-552	CLIP-seq
MIRT2026293	hsa-miR-626	CLIP-seq
MIRT2257426	hsa-miR-645	CLIP-seq
MIRT2257427	hsa-miR-764	CLIP-seq
MIRT2257428	hsa-miR-944	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25036637, 28514442, 33961781
GO:0005634	Component	Nucleus	IDA	16964437
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016604	Component	Nuclear body	IDA
GO:0031461	Component	Cullin-RING ubiquitin ligase complex	IEA
GO:0031462	Component	Cul2-RING ubiquitin ligase complex	IDA	26138980, 29775578, 29779948, 30526872
GO:0031965	Component	Nuclear membrane	IDA
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IDA	26138980
GO:0140627	Process	Ubiquitin-dependent protein catabolic process via the C-end degron rule pathway	IDA	29775578, 29779948, 30526872
GO:0140627	Process	Ubiquitin-dependent protein catabolic process via the C-end degron rule pathway	IEA
GO:1990756	Function	Ubiquitin-like ligase-substrate adaptor activity	IDA	26138980, 29775578, 29779948, 30526872
GO:1990756	Function	Ubiquitin-like ligase-substrate adaptor activity	IEA

Other IDs

• MIM: 611280
• HGNC: 20231
• e!Ensembl: ENSG00000165516

Protein

• UniProt ID: Q9Y2U9
• Protein name: Kelch domain-containing protein 2 (Hepatocellular carcinoma-associated antigen 33) (Host cell factor homolog LCP) (Host cell factor-like protein 1) (HCLP-1)
• Protein function: Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their
• PDB: 6DO3, 6DO4, 6DO5, 8EBL, 8EBM, 8EBN, 8PIF, 8SGE, 8SGF, 8SH2, 8UXS, 9BC9, 9BCA, 9BCC
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13418	Kelch_4	217 → 266		Repeat
  PF13418	Kelch_4	267 → 312		Repeat

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed, with high levels in skeletal muscle, heart, pancreas and liver (PubMed:11384994, PubMed:16964437). Undetectable in peripheral blood leukocytes (PubMed:16964437). {ECO:0000269|PubMed:11384994, ECO:0000269|PubMed:169644
• Sequence:

  MADGNEDLRADDLPGPAFESYESMELACPAERSGHVAVSDGRHMFVWGGYKSNQVRGLYD
  FYLPREELWIYNMETGRWKKINTEGDVPPSMSGSCAVCVDRVLYLFGGHHSRGNTNKFYM
  LDSRSTDRVLQWERIDCQGIPPSSKDKLGVWVYKNKLIFFGGYGYLPEDKVLGTFEFDET
  SFWNSSHPRGWNDHVHILDTETFTWSQPITTGKAPSPRAAHACATVGNRGFVFGGRYRDA
  RMNDLHYLNLDTWEWNELIPQGICPVGRSWHSLTPVSSDHLFLFGGFTTDKQPLSDAWTY
  CISKNEWIQFNHPYTEKPRLWHTACASDEGEVIVFGGCANNLLVHHRAAHSNEILIFSVQ
  PKSLVRLSLEAVICFKEMLANSWNCLPKHLLHSVNQRFGSNNTSGS

• Sequence length: 406