DDAH1 (dimethylarginine dimethylaminohydrolase 1)
| Gene | |
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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23576 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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Dimethylarginine dimethylaminohydrolase 1 |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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DDAH1 |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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DDAH, DDAH-1, DDAHI, HEL-S-16 |
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Chromosome
Chromosome number
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1 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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1p22.3 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene belongs to the dimethylarginine dimethylaminohydrolase (DDAH) gene family. The encoded enzyme plays a role in nitric oxide generation by regulating cellular concentrations of methylarginines, which in turn inhibit nitric oxide synthase activity. |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | |||||||||||
| UniProt ID | O94760 | ||||||||||
| Protein name | N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 (DDAH-1) (Dimethylarginine dimethylaminohydrolase 1) (EC 3.5.3.18) (DDAHI) (Dimethylargininase-1) | ||||||||||
| Protein function | Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation. {ECO:0000269|PubMed:18171027, ECO:0000269|PubMed:19663506, EC | ||||||||||
| PDB | 2JAI , 2JAJ , 3I2E , 3I4A , 3P8E , 3P8P , 6DGE , 6SZP , 6SZQ , 7ULU , 7ULV , 7ULX , 7USZ , 7UT0 | ||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Detected in brain, liver, kidney and pancreas, and at low levels in skeletal muscle. {ECO:0000269|PubMed:10493931}. | ||||||||||
| Sequence |
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| Sequence length | 285 | ||||||||||
| Interactions | View interactions | ||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
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