Gene Gene information from NCBI Gene database.
Entrez ID 23576
Gene name Dimethylarginine dimethylaminohydrolase 1
Gene symbol DDAH1
Synonyms (NCBI Gene)
DDAHDDAH-1DDAHIHEL-S-16
Chromosome 1
Chromosome location 1p22.3
Summary This gene belongs to the dimethylarginine dimethylaminohydrolase (DDAH) gene family. The encoded enzyme plays a role in nitric oxide generation by regulating cellular concentrations of methylarginines, which in turn inhibit nitric oxide synthase activity.
miRNA miRNA information provided by mirtarbase database.
1388
miRTarBase ID miRNA Experiments Reference
MIRT003179 hsa-miR-210-3p immunoprecipitaionLuciferase reporter assayMicroarrayqRT-PCR 19826008
MIRT023452 hsa-miR-30b-5p Sequencing 20371350
MIRT025359 hsa-miR-34a-5p Proteomics 21566225
MIRT030838 hsa-miR-21-5p Microarray 18591254
MIRT050653 hsa-miR-18a-5p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
29
GO ID Ontology Definition Evidence Reference
GO:0000052 Process Citrulline metabolic process IBA
GO:0000052 Process Citrulline metabolic process IDA 19663506
GO:0003073 Process Regulation of systemic arterial blood pressure IEA
GO:0003073 Process Regulation of systemic arterial blood pressure ISS
GO:0003824 Function Catalytic activity TAS 9874257
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
604743 2715 ENSG00000153904
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O94760
Protein name N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 (DDAH-1) (Dimethylarginine dimethylaminohydrolase 1) (EC 3.5.3.18) (DDAHI) (Dimethylargininase-1)
Protein function Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation. {ECO:0000269|PubMed:18171027, ECO:0000269|PubMed:19663506, EC
PDB 2JAI , 2JAJ , 3I2E , 3I4A , 3P8E , 3P8P , 6DGE , 6SZP , 6SZQ , 7ULU , 7ULV , 7ULX , 7USZ , 7UT0
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02274 Amidinotransf 19 279 Family
Tissue specificity TISSUE SPECIFICITY: Detected in brain, liver, kidney and pancreas, and at low levels in skeletal muscle. {ECO:0000269|PubMed:10493931}.
Sequence
Sequence length 285
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    eNOS activation