PADI4 (peptidyl arginine deiminase 4)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
23569
Gene name Gene Name - the full gene name approved by the HGNC.
Peptidyl arginine deiminase 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
PADI4
Synonyms (NCBI Gene) Gene synonyms aliases
PAD, PAD4, PADI5, PDI4, PDI5
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p36.13
Summary Summary of gene provided in NCBI Entrez Gene.
This gene is a member of a gene family which encodes enzymes responsible for the conversion of arginine residues to citrulline residues. This gene may play a role in granulocyte and macrophage development leading to inflammation and immune response. [prov
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(5)
miRTarBase ID miRNA Experiments Reference
MIRT017912 hsa-miR-335-5p Microarray 18185580
MIRT2060295 hsa-miR-1915 CLIP-seq
MIRT2060296 hsa-miR-338-5p CLIP-seq
MIRT2060297 hsa-miR-4270 CLIP-seq
MIRT2060298 hsa-miR-4441 CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(39)
GO ID Ontology Definition Evidence Reference
GO:0002376 Process Immune system process IEA
GO:0004668 Function Protein-arginine deiminase activity IDA 21584310
GO:0004668 Function Protein-arginine deiminase activity IEA
GO:0004668 Function Protein-arginine deiminase activity IMP 15247907
GO:0004668 Function Protein-arginine deiminase activity TAS 10488123
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
605347 18368 ENSG00000159339
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q9UM07
Protein name Protein-arginine deiminase type-4 (EC 3.5.3.15) (HL-60 PAD) (Peptidylarginine deiminase IV) (Protein-arginine deiminase type IV)
Protein function Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance (PubMed:15339660, PubMed:15345777, PubMed:16567635, PubMed:21245532).
PDB 1WD8 , 1WD9 , 1WDA , 2DEW , 2DEX , 2DEY , 2DW5 , 3APM , 3APN , 3B1T , 3B1U , 4DKT , 4X8C , 4X8G , 5N0M , 5N0Y , 5N0Z , 5N1B , 8GOD , 8R8U , 8R8V , 8SMK , 8SML
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF08526 PAD_N 1 → 111 Protein-arginine deiminase (PAD) N-terminal domain Domain
PF08527 PAD_M 113 → 273 Protein-arginine deiminase (PAD) middle domain Domain
PF03068 PAD 283 → 660 Protein-arginine deiminase (PAD) Family
Tissue specificity TISSUE SPECIFICITY: Expressed in eosinophils and neutrophils, not expressed in peripheral monocytes or lymphocytes. {ECO:0000269|PubMed:11435484}.
Sequence
Sequence length 663
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Neutrophil extracellular trap formation   Chromatin modifying enzymes
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (1)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Rheumatoid arthritis rheumatoid arthritis, Rheumatoid arthritis N/A N/A ClinVar, GWAS
Show/Hide Text Mining Associations (102)
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Acute Kidney Injury Associate 33295402
Adenocarcinoma Stimulate 21698003, 32629995
Adenocarcinoma of Lung Stimulate 19183436
Alzheimer Disease Associate 3053167
Angioedemas Hereditary Inhibit 35886575
Arthritis Associate 15731287, 17968929, 31242568
Arthritis Infectious Associate 34868018
Arthritis Juvenile Associate 28182665, 36793709
Arthritis Rheumatoid Associate 15020330, 15077293, 15731287, 15760928, 16380915, 16385500, 16469113, 17002273, 17179172, 17469103, 17497940, 17968929, 17980669, 18462498, 18576335
View all (51 more)
Arthritis Rheumatoid Stimulate 21882827, 37108746, 37193992