DDAH2 (DDAH family member 2, ADMA-independent)

Gene

• Entrez ID: 23564
• Gene name: DDAH family member 2, ADMA-independent
• Gene symbol: DDAH2
• Synonyms (NCBI Gene): DDAH, DDAHII, G6a, HEL-S-277, NG30
• Chromosome: 6
• Chromosome location: 6p21.33
• Summary: This gene encodes a dimethylarginine dimethylaminohydrolase. The encoded enzyme functions in nitric oxide generation by regulating the cellular concentrations of methylarginines, which in turn inhibit nitric oxide synthase activity. The protein may be loc

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT025565	hsa-miR-34a-5p	Proteomics	21566225
MIRT928703	hsa-miR-1321	CLIP-seq
MIRT928704	hsa-miR-3130-5p	CLIP-seq
MIRT928705	hsa-miR-331-3p	CLIP-seq
MIRT928706	hsa-miR-3681	CLIP-seq
MIRT928707	hsa-miR-3922-5p	CLIP-seq
MIRT928708	hsa-miR-3974	CLIP-seq
MIRT928709	hsa-miR-4251	CLIP-seq
MIRT928710	hsa-miR-4303	CLIP-seq
MIRT928711	hsa-miR-4329	CLIP-seq
MIRT928712	hsa-miR-4419a	CLIP-seq
MIRT928713	hsa-miR-4435	CLIP-seq
MIRT928714	hsa-miR-4446-5p	CLIP-seq
MIRT928715	hsa-miR-4482	CLIP-seq
MIRT928716	hsa-miR-4510	CLIP-seq
MIRT928717	hsa-miR-4530	CLIP-seq
MIRT928718	hsa-miR-4739	CLIP-seq
MIRT928719	hsa-miR-4753-5p	CLIP-seq
MIRT928720	hsa-miR-4755-3p	CLIP-seq
MIRT928721	hsa-miR-4755-5p	CLIP-seq
MIRT928722	hsa-miR-4756-5p	CLIP-seq
MIRT928723	hsa-miR-501-5p	CLIP-seq
MIRT928724	hsa-miR-659	CLIP-seq
MIRT1975048	hsa-miR-1179	CLIP-seq
MIRT1975049	hsa-miR-150	CLIP-seq
MIRT1975050	hsa-miR-4291	CLIP-seq
MIRT1975051	hsa-miR-4310	CLIP-seq
MIRT1975052	hsa-miR-4461	CLIP-seq
MIRT1975053	hsa-miR-4684-5p	CLIP-seq
MIRT1975054	hsa-miR-4713-5p	CLIP-seq
MIRT1975055	hsa-miR-532-3p	CLIP-seq
MIRT1975056	hsa-miR-606	CLIP-seq
MIRT928703	hsa-miR-1321	CLIP-seq
MIRT928704	hsa-miR-3130-5p	CLIP-seq
MIRT2210454	hsa-miR-3162-3p	CLIP-seq
MIRT2210455	hsa-miR-361-3p	CLIP-seq
MIRT928706	hsa-miR-3681	CLIP-seq
MIRT928709	hsa-miR-4251	CLIP-seq
MIRT928710	hsa-miR-4303	CLIP-seq
MIRT928711	hsa-miR-4329	CLIP-seq
MIRT928712	hsa-miR-4419a	CLIP-seq
MIRT928714	hsa-miR-4446-5p	CLIP-seq
MIRT928715	hsa-miR-4482	CLIP-seq
MIRT928716	hsa-miR-4510	CLIP-seq
MIRT2210456	hsa-miR-4639-3p	CLIP-seq
MIRT928718	hsa-miR-4739	CLIP-seq
MIRT928721	hsa-miR-4755-5p	CLIP-seq
MIRT928722	hsa-miR-4756-5p	CLIP-seq
MIRT928723	hsa-miR-501-5p	CLIP-seq
MIRT928724	hsa-miR-659	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000052	Process	Citrulline metabolic process	IDA	21493890, 37296100
GO:0005515	Function	Protein binding	IPI	16189514, 19060904, 22046132, 32296183, 33961781
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	IDA
GO:0005739	Component	Mitochondrion	IEA
GO:0016403	Function	Dimethylargininase activity	IDA	21493890, 37296100
GO:0016403	Function	Dimethylargininase activity	IGI	37296100
GO:0016403	Function	Dimethylargininase activity	IKR	37296100
GO:0016403	Function	Dimethylargininase activity	IMP	37296100
GO:0016787	Function	Hydrolase activity	IEA
GO:0043066	Process	Negative regulation of apoptotic process	TAS	16130169
GO:0045429	Process	Positive regulation of nitric oxide biosynthetic process	ISS
GO:0070062	Component	Extracellular exosome	HDA	19056867, 23533145

Other IDs

• MIM: 604744
• HGNC: 2716
• e!Ensembl: ENSG00000213722

Protein

• UniProt ID: O95865
• Protein name: Putative hydrolase DDAH2 (EC 3.-.-.-) (DDAHII) (Inactive N(G),N(G)-dimethylarginine dimethylaminohydrolase 2) (DDAH-2) (Inactive dimethylarginine dimethylaminohydrolase 2) (Protein G6a) (S-phase protein)
• Protein function: Putative hydrolase with unknown substrate (Probable). Does not hydrolyze N(G),N(G)-dimethyl-L-arginine (ADMA) which acts as an inhibitor of NOS (PubMed:21493890, PubMed:37296100). In endothelial cells, induces expression of vascular endothelial
• Tissue specificity: TISSUE SPECIFICITY: Detected in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas, and at very low levels in brain. {ECO:0000269|PubMed:10493931}.
• Sequence:

  MGTPGEGLGRCSHALIRGVPESLASGEGAGAGLPALDLAKAQREHGVLGGKLRQRLGLQL
  LELPPEESLPLGPLLGDTAVIQGDTALITRPWSPARRPEVDGVRKALQDLGLRIVEIGDE
  NATLDGTDVLFTGREFFVGLSKWTNHRGAEIVADTFRDFAVSTVPVSGPSHLRGLCGMGG
  PRTVVAGSSDAAQKAVRAMAVLTDHPYASLTLPDDAAADCLFLRPGLPGVPPFLLHRGGG
  DLPNSQEALQKLSDVTLVPVSCSELEKAGAGLSSLCLVLSTRPHS

• Sequence length: 285

Pathways

Reactome:

eNOS activation