Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
23560
Gene name Gene Name - the full gene name approved by the HGNC.
GTP binding protein 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
GTPBP4
Synonyms (NCBI Gene) Gene synonyms aliases
CRFG, NGB, NOG1
Chromosome Chromosome number
10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
10p15.3
Summary Summary of gene provided in NCBI Entrez Gene.
GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. `Active` in this context usually means that the molecule acts as a signal to trigger other ev
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT019721 hsa-miR-375 Microarray 20215506
MIRT028964 hsa-miR-26b-5p Microarray 19088304
MIRT051261 hsa-miR-16-5p CLASH 23622248
MIRT038918 hsa-miR-92a-1-5p CLASH 23622248
MIRT718970 hsa-miR-6729-3p HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000079 Process Regulation of cyclin-dependent protein serine/threonine kinase activity IDA 17210637
GO:0000463 Process Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IEA
GO:0001649 Process Osteoblast differentiation HDA 16210410
GO:0003723 Function RNA binding HDA 22658674, 22681889
GO:0003924 Function GTPase activity IDA 17210637
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
619169 21535 ENSG00000107937
Protein
UniProt ID Q9BZE4
Protein name GTP-binding protein 4 (Chronic renal failure gene protein) (GTP-binding protein NGB) (Nucleolar GTP-binding protein 1)
Protein function Involved in the biogenesis of the 60S ribosomal subunit (PubMed:32669547). Acts as a TP53 repressor, preventing TP53 stabilization and cell cycle arrest (PubMed:20308539).
PDB 6LSS , 6LU8 , 8FKP , 8FKQ , 8FKR , 8FKS , 8FKT , 8FKU , 8FKV , 8FKW , 8FKX , 8FKY , 8FKZ , 8FL0 , 8FL2 , 8FL3 , 8FL4 , 8FL6 , 8FL7 , 8FL9 , 8FLA , 8FLB , 8FLC , 8FLD , 8FLE , 8FLF , 8IDT , 8IDY , 8IE3 , 8INE , 8INF , 8INK , 8IPD , 8IPX , 8IPY , 8IR1 , 8IR3 , 8RL2
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF17835 NOG1_N 6 165 NOG1 N-terminal helical domain Domain
PF06858 NOG1 235 292 Nucleolar GTP-binding protein 1 (NOG1) Family
PF08155 NOGCT 395 446 NOGCT (NUC087) domain Domain
Sequence
MAHYNFKKITVVPSAKDFIDLTLSKTQRKTPTVIHKHYQIHRIRHFYMRKVKFTQQNYHD
RLSQILTDFPKLDDIHPFYADLMNILYDKDHYKLALGQINIAKNLVDNVAKDYVRLMKYG
DSLYRCKQLKRAALGRMCTVIKRQKQSLEYLEQVRQHLSRLPTID
PNTRTLLLCGYPNVG
KSSFINKVTRADVDVQPYAFTTKSLFVGHMDYKYLRWQVVDTPGILDHPLEDRNTIEMQA
ITALAHLRAAVLYVMDLSEQCGHGLREQLELFQNIRPLFINKPLIVVANKCD
VKRIAELS
EDDQKIFTDLQSEGFPVIETSTLTEEGVIKVKTEACDRLLAHRVETKMKGNKVNEVLNRL
HLAIPTRRDDKERPPFIPEGVVARRKRMETEESRKKRERDLELEMGDDYILDLQKYWDLM
NLSEKHDKIPEIWEGHNIADYIDPAI
MKKLEELEKEEELRTAAGEYDSVSESEDEEMLEI
RQLAKQIREKKKLKILESKEKNTQGPRMPRTAKKVQRTVLEKEMRSLGVDMDDKDDAHYA
VQARRSRSITRKRKREDSAPPSSVARSGSCSRTPRDVSGLRDVKMVKKAKTMMKNAQKKM
NRLGKKGEADRHVFDMKPKHLLSGKRKAGKKDRR
Sequence length 634
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  
  Ribosome biogenesis in eukaryotes  
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Kidney Disease Kidney Disease GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Stimulate 33134380
Carcinogenesis Associate 33134380
Carcinoma Hepatocellular Associate 33204302, 33411682, 34783233, 36116159
Cleft Lip Associate 28662356
Cleft Palate Associate 27369588, 28662356
Deafness Associate 35248088
Hearing Loss Associate 35248088
Neoplasm Metastasis Associate 33134380
Neoplasm Metastasis Stimulate 36116159
Neoplasms Stimulate 33134380