Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	23560
Gene name	GTP binding protein 4
Gene symbol	GTPBP4
Synonyms (NCBI Gene)	CRFGNGBNOG1
Chromosome	10
Chromosome location	10p15.3
Summary	GTP-binding proteins are GTPases and function as molecular switches that can flip between two states: active, when GTP is bound, and inactive, when GDP is bound. `Active` in this context usually means that the molecule acts as a signal to trigger other ev

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miRTarBase ID	miRNA	Experiments	Reference
MIRT019721	hsa-miR-375	Microarray	20215506
MIRT028964	hsa-miR-26b-5p	Microarray	19088304
MIRT051261	hsa-miR-16-5p	CLASH	23622248
MIRT038918	hsa-miR-92a-1-5p	CLASH	23622248
MIRT718970	hsa-miR-6729-3p	HITS-CLIP	19536157
MIRT718969	hsa-miR-1224-3p	HITS-CLIP	19536157
MIRT718968	hsa-miR-6870-3p	HITS-CLIP	19536157
MIRT718967	hsa-miR-4769-3p	HITS-CLIP	19536157
MIRT718966	hsa-miR-6817-5p	HITS-CLIP	19536157
MIRT718965	hsa-miR-1260a	HITS-CLIP	19536157
MIRT718964	hsa-miR-1260b	HITS-CLIP	19536157
MIRT718963	hsa-miR-4727-5p	HITS-CLIP	19536157
MIRT718962	hsa-miR-4715-3p	HITS-CLIP	19536157
MIRT446206	hsa-miR-1264	PAR-CLIP	22100165
MIRT446205	hsa-miR-7161-3p	PAR-CLIP	22100165
MIRT446204	hsa-miR-635	PAR-CLIP	22100165
MIRT446203	hsa-miR-6774-5p	PAR-CLIP	22100165
MIRT446202	hsa-miR-4693-3p	PAR-CLIP	22100165
MIRT446201	hsa-miR-4683	PAR-CLIP	22100165
MIRT446200	hsa-miR-3175	PAR-CLIP	22100165
MIRT446199	hsa-miR-1343-5p	PAR-CLIP	22100165
MIRT446198	hsa-miR-939-5p	PAR-CLIP	22100165
MIRT446196	hsa-miR-6825-5p	PAR-CLIP	22100165
MIRT446197	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT446195	hsa-miR-2110	PAR-CLIP	22100165
MIRT446193	hsa-miR-6810-5p	PAR-CLIP	22100165
MIRT446194	hsa-miR-3150a-3p	PAR-CLIP	22100165
MIRT446191	hsa-miR-6763-5p	PAR-CLIP	22100165
MIRT446192	hsa-miR-6857-5p	PAR-CLIP	22100165
MIRT446190	hsa-miR-450a-2-3p	PAR-CLIP	22100165
MIRT446206	hsa-miR-1264	PAR-CLIP	22100165
MIRT446205	hsa-miR-7161-3p	PAR-CLIP	22100165
MIRT446204	hsa-miR-635	PAR-CLIP	22100165
MIRT446203	hsa-miR-6774-5p	PAR-CLIP	22100165
MIRT446202	hsa-miR-4693-3p	PAR-CLIP	22100165
MIRT446201	hsa-miR-4683	PAR-CLIP	22100165
MIRT446200	hsa-miR-3175	PAR-CLIP	22100165
MIRT446199	hsa-miR-1343-5p	PAR-CLIP	22100165
MIRT446198	hsa-miR-939-5p	PAR-CLIP	22100165
MIRT446196	hsa-miR-6825-5p	PAR-CLIP	22100165
MIRT446197	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT446195	hsa-miR-2110	PAR-CLIP	22100165
MIRT446193	hsa-miR-6810-5p	PAR-CLIP	22100165
MIRT446194	hsa-miR-3150a-3p	PAR-CLIP	22100165
MIRT446191	hsa-miR-6763-5p	PAR-CLIP	22100165
MIRT446192	hsa-miR-6857-5p	PAR-CLIP	22100165
MIRT446190	hsa-miR-450a-2-3p	PAR-CLIP	22100165
MIRT718970	hsa-miR-6729-3p	HITS-CLIP	19536157
MIRT718969	hsa-miR-1224-3p	HITS-CLIP	19536157
MIRT718968	hsa-miR-6870-3p	HITS-CLIP	19536157
MIRT718967	hsa-miR-4769-3p	HITS-CLIP	19536157
MIRT718966	hsa-miR-6817-5p	HITS-CLIP	19536157
MIRT718965	hsa-miR-1260a	HITS-CLIP	19536157
MIRT718964	hsa-miR-1260b	HITS-CLIP	19536157
MIRT718963	hsa-miR-4727-5p	HITS-CLIP	19536157
MIRT718962	hsa-miR-4715-3p	HITS-CLIP	19536157
MIRT446206	hsa-miR-1264	PAR-CLIP	22100165
MIRT446205	hsa-miR-7161-3p	PAR-CLIP	22100165
MIRT446204	hsa-miR-635	PAR-CLIP	22100165
MIRT446203	hsa-miR-6774-5p	PAR-CLIP	22100165
MIRT446202	hsa-miR-4693-3p	PAR-CLIP	22100165
MIRT446201	hsa-miR-4683	PAR-CLIP	22100165
MIRT446200	hsa-miR-3175	PAR-CLIP	22100165
MIRT446199	hsa-miR-1343-5p	PAR-CLIP	22100165
MIRT446198	hsa-miR-939-5p	PAR-CLIP	22100165
MIRT446196	hsa-miR-6825-5p	PAR-CLIP	22100165
MIRT446197	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT446195	hsa-miR-2110	PAR-CLIP	22100165
MIRT446193	hsa-miR-6810-5p	PAR-CLIP	22100165
MIRT446194	hsa-miR-3150a-3p	PAR-CLIP	22100165
MIRT446191	hsa-miR-6763-5p	PAR-CLIP	22100165
MIRT446192	hsa-miR-6857-5p	PAR-CLIP	22100165
MIRT446190	hsa-miR-450a-2-3p	PAR-CLIP	22100165
MIRT446206	hsa-miR-1264	PAR-CLIP	22100165
MIRT446205	hsa-miR-7161-3p	PAR-CLIP	22100165
MIRT446204	hsa-miR-635	PAR-CLIP	22100165
MIRT446203	hsa-miR-6774-5p	PAR-CLIP	22100165
MIRT446202	hsa-miR-4693-3p	PAR-CLIP	22100165
MIRT446201	hsa-miR-4683	PAR-CLIP	22100165
MIRT446200	hsa-miR-3175	PAR-CLIP	22100165
MIRT446199	hsa-miR-1343-5p	PAR-CLIP	22100165
MIRT446198	hsa-miR-939-5p	PAR-CLIP	22100165
MIRT446196	hsa-miR-6825-5p	PAR-CLIP	22100165
MIRT446197	hsa-miR-526b-5p	PAR-CLIP	22100165
MIRT446195	hsa-miR-2110	PAR-CLIP	22100165
MIRT446193	hsa-miR-6810-5p	PAR-CLIP	22100165
MIRT446194	hsa-miR-3150a-3p	PAR-CLIP	22100165
MIRT446191	hsa-miR-6763-5p	PAR-CLIP	22100165
MIRT446192	hsa-miR-6857-5p	PAR-CLIP	22100165
MIRT446190	hsa-miR-450a-2-3p	PAR-CLIP	22100165
MIRT1038147	hsa-miR-1261	CLIP-seq
MIRT1038148	hsa-miR-1299	CLIP-seq
MIRT1038149	hsa-miR-136	CLIP-seq
MIRT1038150	hsa-miR-141	CLIP-seq
MIRT1038151	hsa-miR-200a	CLIP-seq
MIRT1038152	hsa-miR-2054	CLIP-seq
MIRT1038153	hsa-miR-302a	CLIP-seq
MIRT1038154	hsa-miR-302b	CLIP-seq
MIRT1038155	hsa-miR-302c	CLIP-seq
MIRT1038156	hsa-miR-302d	CLIP-seq
MIRT1038157	hsa-miR-302e	CLIP-seq
MIRT1038158	hsa-miR-3129-3p	CLIP-seq
MIRT1038159	hsa-miR-3145-5p	CLIP-seq
MIRT1038160	hsa-miR-3163	CLIP-seq
MIRT1038161	hsa-miR-3182	CLIP-seq
MIRT1038162	hsa-miR-3187-3p	CLIP-seq
MIRT1038163	hsa-miR-3190	CLIP-seq
MIRT1038164	hsa-miR-3618	CLIP-seq
MIRT1038165	hsa-miR-3646	CLIP-seq
MIRT1038166	hsa-miR-3647-3p	CLIP-seq
MIRT1038167	hsa-miR-3676	CLIP-seq
MIRT1038168	hsa-miR-3689d	CLIP-seq
MIRT1038169	hsa-miR-371b-5p	CLIP-seq
MIRT1038170	hsa-miR-372	CLIP-seq
MIRT1038171	hsa-miR-373	CLIP-seq
MIRT1038172	hsa-miR-3926	CLIP-seq
MIRT1038173	hsa-miR-4261	CLIP-seq
MIRT1038174	hsa-miR-4267	CLIP-seq
MIRT1038175	hsa-miR-4277	CLIP-seq
MIRT1038176	hsa-miR-4328	CLIP-seq
MIRT1038177	hsa-miR-4435	CLIP-seq
MIRT1038178	hsa-miR-4491	CLIP-seq
MIRT1038179	hsa-miR-4503	CLIP-seq
MIRT1038180	hsa-miR-4504	CLIP-seq
MIRT1038181	hsa-miR-4657	CLIP-seq
MIRT1038182	hsa-miR-4659a-3p	CLIP-seq
MIRT1038183	hsa-miR-4659b-3p	CLIP-seq
MIRT1038184	hsa-miR-4670-5p	CLIP-seq
MIRT1038185	hsa-miR-4698	CLIP-seq
MIRT1038186	hsa-miR-4701-5p	CLIP-seq
MIRT1038187	hsa-miR-4709-3p	CLIP-seq
MIRT1038188	hsa-miR-4714-3p	CLIP-seq
MIRT1038189	hsa-miR-4766-5p	CLIP-seq
MIRT1038190	hsa-miR-4782-5p	CLIP-seq
MIRT1038191	hsa-miR-4789-5p	CLIP-seq
MIRT1038192	hsa-miR-4797-5p	CLIP-seq
MIRT1038193	hsa-miR-491-3p	CLIP-seq
MIRT1038194	hsa-miR-508-5p	CLIP-seq
MIRT1038195	hsa-miR-511	CLIP-seq
MIRT1038196	hsa-miR-516b	CLIP-seq
MIRT1038197	hsa-miR-520a-3p	CLIP-seq
MIRT1038198	hsa-miR-520b	CLIP-seq
MIRT1038199	hsa-miR-520c-3p	CLIP-seq
MIRT1038200	hsa-miR-520d-3p	CLIP-seq
MIRT1038201	hsa-miR-520e	CLIP-seq
MIRT1038202	hsa-miR-520f	CLIP-seq
MIRT1038203	hsa-miR-548s	CLIP-seq
MIRT1038204	hsa-miR-556-5p	CLIP-seq
MIRT1038205	hsa-miR-570	CLIP-seq
MIRT1038206	hsa-miR-588	CLIP-seq
MIRT1038207	hsa-miR-603	CLIP-seq
MIRT1038208	hsa-miR-606	CLIP-seq
MIRT1038209	hsa-miR-610	CLIP-seq
MIRT1038210	hsa-miR-656	CLIP-seq
MIRT1038211	hsa-miR-885-5p	CLIP-seq
MIRT1038212	hsa-miR-888	CLIP-seq
MIRT1038213	hsa-miR-934	CLIP-seq
MIRT2007758	hsa-miR-1227	CLIP-seq
MIRT2007759	hsa-miR-1251	CLIP-seq
MIRT1038149	hsa-miR-136	CLIP-seq
MIRT2007760	hsa-miR-3120-3p	CLIP-seq
MIRT1038159	hsa-miR-3145-5p	CLIP-seq
MIRT2007761	hsa-miR-4318	CLIP-seq
MIRT1038176	hsa-miR-4328	CLIP-seq
MIRT2007762	hsa-miR-433	CLIP-seq
MIRT2007763	hsa-miR-4693-5p	CLIP-seq
MIRT1038191	hsa-miR-4789-5p	CLIP-seq
MIRT1038192	hsa-miR-4797-5p	CLIP-seq
MIRT1038194	hsa-miR-508-5p	CLIP-seq
MIRT1038195	hsa-miR-511	CLIP-seq
MIRT1038211	hsa-miR-885-5p	CLIP-seq
MIRT2007764	hsa-miR-892a	CLIP-seq
MIRT2007759	hsa-miR-1251	CLIP-seq
MIRT2007760	hsa-miR-3120-3p	CLIP-seq
MIRT2240467	hsa-miR-330-3p	CLIP-seq
MIRT2240468	hsa-miR-4291	CLIP-seq
MIRT2240469	hsa-miR-4786-3p	CLIP-seq
MIRT2240470	hsa-miR-545	CLIP-seq
MIRT2543982	hsa-miR-1228	CLIP-seq
MIRT2543983	hsa-miR-1260	CLIP-seq
MIRT1038149	hsa-miR-136	CLIP-seq
MIRT1038150	hsa-miR-141	CLIP-seq
MIRT2543984	hsa-miR-188-3p	CLIP-seq
MIRT1038151	hsa-miR-200a	CLIP-seq
MIRT1038152	hsa-miR-2054	CLIP-seq
MIRT2543985	hsa-miR-296-3p	CLIP-seq
MIRT1038153	hsa-miR-302a	CLIP-seq
MIRT1038154	hsa-miR-302b	CLIP-seq
MIRT1038155	hsa-miR-302c	CLIP-seq
MIRT1038156	hsa-miR-302d	CLIP-seq
MIRT1038157	hsa-miR-302e	CLIP-seq
MIRT1038159	hsa-miR-3145-5p	CLIP-seq
MIRT2543986	hsa-miR-3156-3p	CLIP-seq
MIRT1038163	hsa-miR-3190	CLIP-seq
MIRT2240467	hsa-miR-330-3p	CLIP-seq
MIRT1038164	hsa-miR-3618	CLIP-seq
MIRT1038169	hsa-miR-371b-5p	CLIP-seq
MIRT1038170	hsa-miR-372	CLIP-seq
MIRT1038171	hsa-miR-373	CLIP-seq
MIRT1038173	hsa-miR-4261	CLIP-seq
MIRT2543987	hsa-miR-4282	CLIP-seq
MIRT2240468	hsa-miR-4291	CLIP-seq
MIRT1038178	hsa-miR-4491	CLIP-seq
MIRT1038180	hsa-miR-4504	CLIP-seq
MIRT1038181	hsa-miR-4657	CLIP-seq
MIRT1038185	hsa-miR-4698	CLIP-seq
MIRT1038193	hsa-miR-491-3p	CLIP-seq
MIRT1038194	hsa-miR-508-5p	CLIP-seq
MIRT2543988	hsa-miR-513a-3p	CLIP-seq
MIRT1038197	hsa-miR-520a-3p	CLIP-seq
MIRT1038198	hsa-miR-520b	CLIP-seq
MIRT1038199	hsa-miR-520c-3p	CLIP-seq
MIRT1038200	hsa-miR-520d-3p	CLIP-seq
MIRT1038201	hsa-miR-520e	CLIP-seq
MIRT1038202	hsa-miR-520f	CLIP-seq
MIRT2240470	hsa-miR-545	CLIP-seq
MIRT1038210	hsa-miR-656	CLIP-seq
MIRT1038211	hsa-miR-885-5p	CLIP-seq
MIRT1038212	hsa-miR-888	CLIP-seq
MIRT1038213	hsa-miR-934	CLIP-seq
MIRT2543982	hsa-miR-1228	CLIP-seq
MIRT2543983	hsa-miR-1260	CLIP-seq
MIRT1038149	hsa-miR-136	CLIP-seq
MIRT1038150	hsa-miR-141	CLIP-seq
MIRT2543984	hsa-miR-188-3p	CLIP-seq
MIRT1038151	hsa-miR-200a	CLIP-seq
MIRT1038152	hsa-miR-2054	CLIP-seq
MIRT2543985	hsa-miR-296-3p	CLIP-seq
MIRT1038153	hsa-miR-302a	CLIP-seq
MIRT1038154	hsa-miR-302b	CLIP-seq
MIRT1038155	hsa-miR-302c	CLIP-seq
MIRT1038156	hsa-miR-302d	CLIP-seq
MIRT1038157	hsa-miR-302e	CLIP-seq
MIRT1038159	hsa-miR-3145-5p	CLIP-seq
MIRT2543986	hsa-miR-3156-3p	CLIP-seq
MIRT1038163	hsa-miR-3190	CLIP-seq
MIRT2240467	hsa-miR-330-3p	CLIP-seq
MIRT1038164	hsa-miR-3618	CLIP-seq
MIRT1038169	hsa-miR-371b-5p	CLIP-seq
MIRT1038170	hsa-miR-372	CLIP-seq
MIRT1038171	hsa-miR-373	CLIP-seq
MIRT1038173	hsa-miR-4261	CLIP-seq
MIRT2543987	hsa-miR-4282	CLIP-seq
MIRT2240468	hsa-miR-4291	CLIP-seq
MIRT1038176	hsa-miR-4328	CLIP-seq
MIRT1038178	hsa-miR-4491	CLIP-seq
MIRT1038180	hsa-miR-4504	CLIP-seq
MIRT1038181	hsa-miR-4657	CLIP-seq
MIRT1038185	hsa-miR-4698	CLIP-seq
MIRT1038193	hsa-miR-491-3p	CLIP-seq
MIRT1038194	hsa-miR-508-5p	CLIP-seq
MIRT1038195	hsa-miR-511	CLIP-seq
MIRT2543988	hsa-miR-513a-3p	CLIP-seq
MIRT1038197	hsa-miR-520a-3p	CLIP-seq
MIRT1038198	hsa-miR-520b	CLIP-seq
MIRT1038199	hsa-miR-520c-3p	CLIP-seq
MIRT1038200	hsa-miR-520d-3p	CLIP-seq
MIRT1038201	hsa-miR-520e	CLIP-seq
MIRT1038202	hsa-miR-520f	CLIP-seq
MIRT2240470	hsa-miR-545	CLIP-seq
MIRT1038210	hsa-miR-656	CLIP-seq
MIRT1038211	hsa-miR-885-5p	CLIP-seq
MIRT1038212	hsa-miR-888	CLIP-seq
MIRT1038213	hsa-miR-934	CLIP-seq

Show/Hide all (33)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000463	Process	Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IEA
GO:0001649	Process	Osteoblast differentiation	HDA	16210410
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0003723	Function	RNA binding	IBA
GO:0003924	Function	GTPase activity	IBA
GO:0003924	Function	GTPase activity	IDA	17210637
GO:0005515	Function	Protein binding	IPI	17210637, 32296183, 32814053, 35393574
GO:0005525	Function	GTP binding	IDA	17210637
GO:0005525	Function	GTP binding	IEA
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005634	Component	Nucleus	IDA	17210637
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005730	Component	Nucleolus	IBA
GO:0005730	Component	Nucleolus	IDA
GO:0005730	Component	Nucleolus	IEA
GO:0005737	Component	Cytoplasm	IDA	17210637
GO:0005829	Component	Cytosol	IDA
GO:0008156	Process	Negative regulation of DNA replication	IMP	17210637
GO:0008285	Process	Negative regulation of cell population proliferation	IMP	17210637
GO:0010972	Process	Negative regulation of G2/M transition of mitotic cell cycle	IDA	17210637
GO:0016020	Component	Membrane	HDA	16210410, 19946888
GO:0022408	Process	Negative regulation of cell-cell adhesion	IDA	17210637
GO:0030336	Process	Negative regulation of cell migration	IDA	17210637
GO:0031397	Process	Negative regulation of protein ubiquitination	IDA	17210637
GO:0031965	Component	Nuclear membrane	IDA
GO:0042254	Process	Ribosome biogenesis	IEA
GO:0042273	Process	Ribosomal large subunit biogenesis	IBA
GO:0042273	Process	Ribosomal large subunit biogenesis	IDA	32669547
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	17210637
GO:0050821	Process	Protein stabilization	IDA	17210637
GO:1990275	Function	Preribosome binding	IDA	32669547

MIM	HGNC	e!Ensembl
619169	21535	ENSG00000107937

Q9BZE4

Protein name

GTP-binding protein 4 (Chronic renal failure gene protein) (GTP-binding protein NGB) (Nucleolar GTP-binding protein 1)

Protein function

Involved in the biogenesis of the 60S ribosomal subunit (PubMed:32669547). Acts as a TP53 repressor, preventing TP53 stabilization and cell cycle arrest (PubMed:20308539).

PDB

6LSS , 6LU8 , 8FKP , 8FKQ , 8FKR , 8FKS , 8FKT , 8FKU , 8FKV , 8FKW , 8FKX , 8FKY , 8FKZ , 8FL0 , 8FL2 , 8FL3 , 8FL4 , 8FL6 , 8FL7 , 8FL9 , 8FLA , 8FLB , 8FLC , 8FLD , 8FLE , 8FLF , 8IDT , 8IDY , 8IE3 , 8INE , 8INF , 8INK , 8IPD , 8IPX , 8IPY , 8IR1 , 8IR3 , 8RL2

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF17835	NOG1_N	6 → 165	NOG1 N-terminal helical domain	Domain
PF06858	NOG1	235 → 292	Nucleolar GTP-binding protein 1 (NOG1)	Family
PF08155	NOGCT	395 → 446	NOGCT (NUC087) domain	Domain

Sequence

MAHYNFKKITVVPSAKDFIDLTLSKTQRKTPTVIHKHYQIHRIRHFYMRKVKFTQQNYHD
RLSQILTDFPKLDDIHPFYADLMNILYDKDHYKLALGQINIAKNLVDNVAKDYVRLMKYG
DSLYRCKQLKRAALGRMCTVIKRQKQSLEYLEQVRQHLSRLPTIDPNTRTLLLCGYPNVG
KSSFINKVTRADVDVQPYAFTTKSLFVGHMDYKYLRWQVVDTPGILDHPLEDRNTIEMQA
ITALAHLRAAVLYVMDLSEQCGHGLREQLELFQNIRPLFINKPLIVVANKCDVKRIAELS
EDDQKIFTDLQSEGFPVIETSTLTEEGVIKVKTEACDRLLAHRVETKMKGNKVNEVLNRL
HLAIPTRRDDKERPPFIPEGVVARRKRMETEESRKKRERDLELEMGDDYILDLQKYWDLM
NLSEKHDKIPEIWEGHNIADYIDPAIMKKLEELEKEEELRTAAGEYDSVSESEDEEMLEI
RQLAKQIREKKKLKILESKEKNTQGPRMPRTAKKVQRTVLEKEMRSLGVDMDDKDDAHYA
VQARRSRSITRKRKREDSAPPSSVARSGSCSRTPRDVSGLRDVKMVKKAKTMMKNAQKKM
NRLGKKGEADRHVFDMKPKHLLSGKRKAGKKDRR

Sequence length

634

Interactions

View interactions

	KEGG
	Ribosome biogenesis in eukaryotes

GTPBP4 (GTP binding protein 4)