Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	2356
Gene name Gene Name - the full gene name approved by the HGNC.	Folylpolyglutamate synthase
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	FPGS
Synonyms (NCBI Gene) Gene synonyms aliases	-
Chromosome Chromosome number	9
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	9q34.11
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survi

Show/Hide all(140)

miRTarBase ID	miRNA	Experiments	Reference
MIRT023124	hsa-miR-124-3p	Microarray	18668037
MIRT046816	hsa-miR-222-3p	CLASH	23622248
MIRT045414	hsa-miR-149-5p	CLASH	23622248
MIRT715552	hsa-miR-140-3p	HITS-CLIP	19536157
MIRT715551	hsa-miR-449b-3p	HITS-CLIP	19536157
MIRT715550	hsa-miR-4286	HITS-CLIP	19536157
MIRT715549	hsa-miR-4677-3p	HITS-CLIP	19536157
MIRT715548	hsa-miR-4758-3p	HITS-CLIP	19536157
MIRT715547	hsa-miR-874-5p	HITS-CLIP	19536157
MIRT715546	hsa-miR-6807-5p	HITS-CLIP	19536157
MIRT715552	hsa-miR-140-3p	HITS-CLIP	19536157
MIRT715551	hsa-miR-449b-3p	HITS-CLIP	19536157
MIRT715550	hsa-miR-4286	HITS-CLIP	19536157
MIRT715549	hsa-miR-4677-3p	HITS-CLIP	19536157
MIRT715548	hsa-miR-4758-3p	HITS-CLIP	19536157
MIRT715547	hsa-miR-874-5p	HITS-CLIP	19536157
MIRT715546	hsa-miR-6807-5p	HITS-CLIP	19536157
MIRT706741	hsa-miR-4438	HITS-CLIP	21572407
MIRT706740	hsa-miR-4740-3p	HITS-CLIP	21572407
MIRT706738	hsa-miR-6778-3p	HITS-CLIP	21572407
MIRT706739	hsa-miR-3199	HITS-CLIP	21572407
MIRT706737	hsa-miR-8052	HITS-CLIP	21572407
MIRT706736	hsa-miR-365a-5p	HITS-CLIP	21572407
MIRT706735	hsa-miR-365b-5p	HITS-CLIP	21572407
MIRT706734	hsa-miR-5095	HITS-CLIP	21572407
MIRT706733	hsa-miR-7151-3p	HITS-CLIP	21572407
MIRT706739	hsa-miR-3199	PAR-CLIP	27292025
MIRT706736	hsa-miR-365a-5p	PAR-CLIP	27292025
MIRT706735	hsa-miR-365b-5p	PAR-CLIP	27292025
MIRT706741	hsa-miR-4438	PAR-CLIP	27292025
MIRT706740	hsa-miR-4740-3p	PAR-CLIP	27292025
MIRT706734	hsa-miR-5095	PAR-CLIP	27292025
MIRT706738	hsa-miR-6778-3p	PAR-CLIP	27292025
MIRT706733	hsa-miR-7151-3p	PAR-CLIP	27292025
MIRT706737	hsa-miR-8052	PAR-CLIP	27292025
MIRT715552	hsa-miR-140-3p	HITS-CLIP	19536157
MIRT715551	hsa-miR-449b-3p	HITS-CLIP	19536157
MIRT715550	hsa-miR-4286	HITS-CLIP	19536157
MIRT715549	hsa-miR-4677-3p	HITS-CLIP	19536157
MIRT715548	hsa-miR-4758-3p	HITS-CLIP	19536157
MIRT715547	hsa-miR-874-5p	HITS-CLIP	19536157
MIRT715546	hsa-miR-6807-5p	HITS-CLIP	19536157
MIRT715552	hsa-miR-140-3p	HITS-CLIP	19536157
MIRT715551	hsa-miR-449b-3p	HITS-CLIP	19536157
MIRT715550	hsa-miR-4286	HITS-CLIP	19536157
MIRT715549	hsa-miR-4677-3p	HITS-CLIP	19536157
MIRT715548	hsa-miR-4758-3p	HITS-CLIP	19536157
MIRT715547	hsa-miR-874-5p	HITS-CLIP	19536157
MIRT715546	hsa-miR-6807-5p	HITS-CLIP	19536157
MIRT706741	hsa-miR-4438	HITS-CLIP	21572407
MIRT706740	hsa-miR-4740-3p	HITS-CLIP	21572407
MIRT706738	hsa-miR-6778-3p	HITS-CLIP	21572407
MIRT706739	hsa-miR-3199	HITS-CLIP	21572407
MIRT706737	hsa-miR-8052	HITS-CLIP	21572407
MIRT706736	hsa-miR-365a-5p	HITS-CLIP	21572407
MIRT706735	hsa-miR-365b-5p	HITS-CLIP	21572407
MIRT706734	hsa-miR-5095	HITS-CLIP	21572407
MIRT706733	hsa-miR-7151-3p	HITS-CLIP	21572407
MIRT1003869	hsa-miR-1206	CLIP-seq
MIRT1003870	hsa-miR-124	CLIP-seq
MIRT1003871	hsa-miR-1254	CLIP-seq
MIRT1003872	hsa-miR-3116	CLIP-seq
MIRT1003873	hsa-miR-3150a-3p	CLIP-seq
MIRT1003874	hsa-miR-3175	CLIP-seq
MIRT1003875	hsa-miR-3665	CLIP-seq
MIRT1003876	hsa-miR-380	CLIP-seq
MIRT1003877	hsa-miR-3934	CLIP-seq
MIRT1003878	hsa-miR-4495	CLIP-seq
MIRT1003879	hsa-miR-4514	CLIP-seq
MIRT1003880	hsa-miR-4692	CLIP-seq
MIRT1003881	hsa-miR-4720-5p	CLIP-seq
MIRT1003882	hsa-miR-4736	CLIP-seq
MIRT1003883	hsa-miR-4799-3p	CLIP-seq
MIRT1003884	hsa-miR-506	CLIP-seq
MIRT1003885	hsa-miR-548an	CLIP-seq
MIRT1003886	hsa-miR-661	CLIP-seq
MIRT1003887	hsa-miR-939	CLIP-seq
MIRT1003888	hsa-miR-940	CLIP-seq
MIRT1003889	hsa-miR-1226	CLIP-seq
MIRT1003890	hsa-miR-125a-5p	CLIP-seq
MIRT1003891	hsa-miR-125b	CLIP-seq
MIRT1003892	hsa-miR-128	CLIP-seq
MIRT1003893	hsa-miR-148a	CLIP-seq
MIRT1003894	hsa-miR-148b	CLIP-seq
MIRT1003895	hsa-miR-152	CLIP-seq
MIRT1003875	hsa-miR-3665	CLIP-seq
MIRT1003896	hsa-miR-4319	CLIP-seq
MIRT1003897	hsa-miR-4732-3p	CLIP-seq
MIRT1003898	hsa-miR-657	CLIP-seq
MIRT1003899	hsa-miR-670	CLIP-seq
MIRT1997568	hsa-miR-2861	CLIP-seq
MIRT1997569	hsa-miR-31	CLIP-seq
MIRT1997570	hsa-miR-3667-5p	CLIP-seq
MIRT1003879	hsa-miR-4514	CLIP-seq
MIRT1003880	hsa-miR-4692	CLIP-seq
MIRT1997571	hsa-miR-4696	CLIP-seq
MIRT1997572	hsa-miR-4717-3p	CLIP-seq
MIRT1997573	hsa-miR-4749-3p	CLIP-seq
MIRT2231234	hsa-miR-4755-3p	CLIP-seq
MIRT1003879	hsa-miR-4514	CLIP-seq
MIRT1003880	hsa-miR-4692	CLIP-seq
MIRT2449884	hsa-miR-3183	CLIP-seq
MIRT2449885	hsa-miR-3617	CLIP-seq
MIRT2449886	hsa-miR-4723-3p	CLIP-seq
MIRT2449887	hsa-miR-641	CLIP-seq
MIRT2449884	hsa-miR-3183	CLIP-seq
MIRT2449885	hsa-miR-3617	CLIP-seq
MIRT2449886	hsa-miR-4723-3p	CLIP-seq
MIRT2449887	hsa-miR-641	CLIP-seq
MIRT2535161	hsa-miR-1225-3p	CLIP-seq
MIRT2535162	hsa-miR-3157-5p	CLIP-seq
MIRT2449884	hsa-miR-3183	CLIP-seq
MIRT2449885	hsa-miR-3617	CLIP-seq
MIRT2535163	hsa-miR-4532	CLIP-seq
MIRT2535164	hsa-miR-4691-3p	CLIP-seq
MIRT2449886	hsa-miR-4723-3p	CLIP-seq
MIRT1997573	hsa-miR-4749-3p	CLIP-seq
MIRT2449887	hsa-miR-641	CLIP-seq
MIRT1003887	hsa-miR-939	CLIP-seq
MIRT2535161	hsa-miR-1225-3p	CLIP-seq
MIRT1003870	hsa-miR-124	CLIP-seq
MIRT2681161	hsa-miR-185	CLIP-seq
MIRT2681162	hsa-miR-3125	CLIP-seq
MIRT2535162	hsa-miR-3157-5p	CLIP-seq
MIRT2449884	hsa-miR-3183	CLIP-seq
MIRT2449885	hsa-miR-3617	CLIP-seq
MIRT2681163	hsa-miR-3916	CLIP-seq
MIRT2681164	hsa-miR-4306	CLIP-seq
MIRT2681165	hsa-miR-4428	CLIP-seq
MIRT2681166	hsa-miR-4476	CLIP-seq
MIRT2535163	hsa-miR-4532	CLIP-seq
MIRT2681167	hsa-miR-4533	CLIP-seq
MIRT2681168	hsa-miR-4644	CLIP-seq
MIRT2535164	hsa-miR-4691-3p	CLIP-seq
MIRT2449886	hsa-miR-4723-3p	CLIP-seq
MIRT1997573	hsa-miR-4749-3p	CLIP-seq
MIRT2681169	hsa-miR-4786-5p	CLIP-seq
MIRT1003884	hsa-miR-506	CLIP-seq
MIRT2449887	hsa-miR-641	CLIP-seq
MIRT1003887	hsa-miR-939	CLIP-seq

Transcription factors

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Transcription factor	Regulation	Reference
SP1	Unknown	20072153

Show/Hide all(23)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001889	Process	Liver development	IEA
GO:0004326	Function	Tetrahydrofolylpolyglutamate synthase activity	IBA	21873635
GO:0004326	Function	Tetrahydrofolylpolyglutamate synthase activity	IDA	3619447
GO:0004326	Function	Tetrahydrofolylpolyglutamate synthase activity	TAS
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA	21873635
GO:0005739	Component	Mitochondrion	IBA	21873635
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0005759	Component	Mitochondrial matrix	TAS
GO:0005829	Component	Cytosol	IBA	21873635
GO:0005829	Component	Cytosol	TAS
GO:0006139	Process	Nucleobase-containing compound metabolic process	TAS	7721888
GO:0006536	Process	Glutamate metabolic process	IDA	3619447
GO:0006730	Process	One-carbon metabolic process	IEA
GO:0006760	Process	Folic acid-containing compound metabolic process	IDA	3619447
GO:0007420	Process	Brain development	IEA
GO:0009396	Process	Folic acid-containing compound biosynthetic process	IBA	21873635
GO:0031100	Process	Animal organ regeneration	IEA
GO:0046655	Process	Folic acid metabolic process	TAS
GO:0046872	Function	Metal ion binding	IEA
GO:0046901	Process	Tetrahydrofolylpolyglutamate biosynthetic process	IBA	21873635
GO:0046901	Process	Tetrahydrofolylpolyglutamate biosynthetic process	IDA	3619447
GO:0046901	Process	Tetrahydrofolylpolyglutamate biosynthetic process	IEA

MIM	HGNC	e!Ensembl
136510	3824	ENSG00000136877

Protein

UniProt ID

Q05932

Protein name

Folylpolyglutamate synthase, mitochondrial (EC 6.3.2.17) (Folylpoly-gamma-glutamate synthetase) (FPGS) (Tetrahydrofolylpolyglutamate synthase) (Tetrahydrofolate synthase)

Protein function

Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that

Family and domains

Sequence

MSRARSHLRAALFLAAASARGITTQVAARRGLSAWPVPQEPSMEYQDAVRMLNTLQTNAG
YLEQVKRQRGDPQTQLEAMELYLARSGLQVEDLDRLNIIHVTGTKGKGSTCAFTECILRS
YGLKTGFFSSPHLVQVRERIRINGQPISPELFTKYFWRLYHRLEETKDGSCVSMPPYFRF
LTLMAFHVFLQEKVDLAVVEVGIGGAYDCTNIIRKPVVCGVSSLGIDHTSLLGDTVEKIA
WQKGGIFKQGVPAFTVLQPEGPLAVLRDRAQQISCPLYLCPMLEALEEGGPPLTLGLEGE
HQRSNAALALQLAHCWLQRQDRHGAGEPKASRPGLLWQLPLAPVFQPTSHMRLGLRNTEW
PGRTQVLRRGPLTWYLDGAHTASSAQACVRWFRQALQGRERPSGGPEVRVLLFNATGDRD
PAALLKLLQPCQFDYAVFCPNLTEVSSTGNADQQNFTVTLDQVLLRCLEHQQHWNHLDEE
QASPDLWSAPSPEPGGSASLLLAPHPPHTCSASSLVFSCISHALQWISQGRDPIFQPPSP
PKGLLTHPVAHSGASILREAAAIHVLVTGSLHLVGGVLKLLEPALSQ

Sequence length

587

Interactions

View interactions

	KEGG		Reactome
	Folate biosynthesis Metabolic pathways Biosynthesis of cofactors Antifolate resistance Folate transport and metabolism		Metabolism of folate and pterines

Show/Hide Causal Diseases (7)

Disease term	Disease name	dbSNP ID	References
Causal
Colorectal cancer	Colorectal Carcinoma	rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800 View all (467 more)	15814641
Colorectal neoplasms	Colorectal Neoplasms	rs28929483, rs63751108, rs28929484, rs63749831, rs63750047, rs63751207, rs63749811, rs1553350126, rs63750875, rs63750955, rs587776706, rs63750871, rs587776715, rs63751466, rs63750049 View all (1682 more)	15814641
Diffuse lymphoma	Diffuse Mixed-Cell Lymphoma	rs121912651, rs121913289, rs121913293, rs878854402, rs869025340, rs1349928568, rs1569115687, rs121913291	17119116
Lymphoblastic leukemia	Childhood Acute Lymphoblastic Leukemia, L2 Acute Lymphoblastic Leukemia, Precursor Cell Lymphoblastic Leukemia Lymphoma	rs387906351, rs104894562, rs398122513, rs398122840, rs1057524466, rs1064796115, rs1064795660, rs1064793129, rs1064796227, rs1567887558, rs1161194345, rs1597558200, rs1406320425, rs1597566470, rs1597566699 View all (13 more)	25013492
Lymphoma	Lymphoma, Mixed-Cell, Lymphoma, Undifferentiated, Lymphoma, Small Noncleaved-Cell, Lymphoma, Diffuse, Lymphoma, Non-Hodgkin, Familial	rs11540652, rs1592119138, rs1592123162, rs1599367044	17119116
Non-hodgkin lymphoma	Lymphoma, Non-Hodgkin	rs121908689, rs28936699, rs121909775, rs398122800, rs121913357, rs121913355, rs398122820	17119116
Rheumatoid arthritis	Rheumatoid Arthritis	rs587776843	23897011

Show/Hide Text Mining Associations (27)

Disease Name	Relationship Type	References
Associations from Text Mining
Acute Kidney Injury	Associate	37452621
Arthritis Rheumatoid	Associate	27752107, 32940699
Ataxia Telangiectasia	Inhibit	15630450
Breast Neoplasms	Associate	26895662
Carcinoma Large Cell	Associate	27064343
Cognitive Dysfunction	Associate	37452621
Colorectal Neoplasms	Associate	15542523, 18418463, 26676887
Drug Related Side Effects and Adverse Reactions	Associate	36952646
Folate Malabsorption Hereditary	Associate	15047700
Hematologic Diseases	Associate	32481505
Hemorrhage	Associate	36952646
Kidney Diseases	Associate	37452621
Leukemia	Associate	16707018, 19131550, 25229333
Leukemia Myeloid Acute	Associate	25229333
Lymphoma Non Hodgkin	Stimulate	17119116
Lymphoma Non Hodgkin	Associate	17119116
Mesothelioma Malignant	Associate	23449276
Neoplasm Metastasis	Associate	36721160
Neoplasms	Associate	22895141, 27064343, 27387303, 36721160, 9591043
Precursor B Cell Lymphoblastic Leukemia Lymphoma	Associate	16707018
Precursor Cell Lymphoblastic Leukemia Lymphoma	Associate	16707018, 19131550, 25229333, 26107232, 27987364, 32694622, 36952646
Precursor T Cell Lymphoblastic Leukemia Lymphoma	Associate	16707018, 32940699
Recurrence	Associate	32694622
Retroperitoneal liposarcoma	Associate	25765001
Small Cell Lung Carcinoma	Associate	27064343
Stomach Neoplasms	Associate	31754833
Thymoma	Associate	27387303

FPGS (folylpolyglutamate synthase)