Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	23555
Gene name Gene Name - the full gene name approved by the HGNC.	Tetraspanin 15
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	TSPAN15
Synonyms (NCBI Gene) Gene synonyms aliases	2700063A19Rik, NET-7, NET7, TM4SF15
Chromosome Chromosome number	10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	10q22.1
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate

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miRTarBase ID	miRNA	Experiments	Reference
MIRT017890	hsa-miR-335-5p	Microarray	18185580
MIRT610442	hsa-miR-4307	HITS-CLIP	23824327
MIRT610442	hsa-miR-4307	HITS-CLIP	23824327
MIRT443282	hsa-miR-490-3p	PAR-CLIP	22100165
MIRT443281	hsa-miR-5197-3p	PAR-CLIP	22100165
MIRT443280	hsa-miR-3929	PAR-CLIP	22100165
MIRT443279	hsa-miR-4419b	PAR-CLIP	22100165
MIRT443278	hsa-miR-4478	PAR-CLIP	22100165
MIRT443277	hsa-miR-4251	PAR-CLIP	22100165
MIRT443276	hsa-miR-1253	PAR-CLIP	22100165
MIRT443275	hsa-miR-6770-5p	PAR-CLIP	22100165
MIRT443274	hsa-miR-485-5p	PAR-CLIP	22100165
MIRT443273	hsa-miR-6884-5p	PAR-CLIP	22100165
MIRT443271	hsa-miR-5189-3p	PAR-CLIP	22100165
MIRT610442	hsa-miR-4307	HITS-CLIP	23824327
MIRT610442	hsa-miR-4307	HITS-CLIP	23824327
MIRT443282	hsa-miR-490-3p	PAR-CLIP	22100165
MIRT443281	hsa-miR-5197-3p	PAR-CLIP	22100165
MIRT443280	hsa-miR-3929	PAR-CLIP	22100165
MIRT443279	hsa-miR-4419b	PAR-CLIP	22100165
MIRT443278	hsa-miR-4478	PAR-CLIP	22100165
MIRT443277	hsa-miR-4251	PAR-CLIP	22100165
MIRT443276	hsa-miR-1253	PAR-CLIP	22100165
MIRT443275	hsa-miR-6770-5p	PAR-CLIP	22100165
MIRT443274	hsa-miR-485-5p	PAR-CLIP	22100165
MIRT443273	hsa-miR-6884-5p	PAR-CLIP	22100165
MIRT443271	hsa-miR-5189-3p	PAR-CLIP	22100165
MIRT1459556	hsa-miR-1275	CLIP-seq
MIRT1459557	hsa-miR-146b-3p	CLIP-seq
MIRT1459558	hsa-miR-198	CLIP-seq
MIRT1459559	hsa-miR-2355-5p	CLIP-seq
MIRT1459560	hsa-miR-2467-3p	CLIP-seq
MIRT1459561	hsa-miR-31	CLIP-seq
MIRT1459562	hsa-miR-3136-5p	CLIP-seq
MIRT1459563	hsa-miR-3184	CLIP-seq
MIRT1459564	hsa-miR-3202	CLIP-seq
MIRT1459565	hsa-miR-339-5p	CLIP-seq
MIRT1459566	hsa-miR-3613-3p	CLIP-seq
MIRT1459567	hsa-miR-3617	CLIP-seq
MIRT1459568	hsa-miR-3659	CLIP-seq
MIRT1459569	hsa-miR-3662	CLIP-seq
MIRT1459570	hsa-miR-423-5p	CLIP-seq
MIRT1459571	hsa-miR-4265	CLIP-seq
MIRT1459572	hsa-miR-4271	CLIP-seq
MIRT1459573	hsa-miR-4296	CLIP-seq
MIRT1459574	hsa-miR-4322	CLIP-seq
MIRT1459575	hsa-miR-4323	CLIP-seq
MIRT1459576	hsa-miR-4417	CLIP-seq
MIRT1459577	hsa-miR-4439	CLIP-seq
MIRT1459578	hsa-miR-4513	CLIP-seq
MIRT1459579	hsa-miR-4525	CLIP-seq
MIRT1459580	hsa-miR-4633-3p	CLIP-seq
MIRT1459581	hsa-miR-4658	CLIP-seq
MIRT1459582	hsa-miR-4665-5p	CLIP-seq
MIRT1459583	hsa-miR-4706	CLIP-seq
MIRT1459584	hsa-miR-4723-5p	CLIP-seq
MIRT1459585	hsa-miR-4725-3p	CLIP-seq
MIRT1459586	hsa-miR-4733-5p	CLIP-seq
MIRT1459587	hsa-miR-4747-5p	CLIP-seq
MIRT1459588	hsa-miR-4749-5p	CLIP-seq
MIRT1459589	hsa-miR-4758-3p	CLIP-seq
MIRT1459590	hsa-miR-495	CLIP-seq
MIRT1459591	hsa-miR-574-5p	CLIP-seq
MIRT1459592	hsa-miR-582-3p	CLIP-seq
MIRT1459593	hsa-miR-625	CLIP-seq
MIRT1459594	hsa-miR-634	CLIP-seq
MIRT1459595	hsa-miR-641	CLIP-seq
MIRT1459596	hsa-miR-642a	CLIP-seq
MIRT1459597	hsa-miR-744	CLIP-seq
MIRT1459598	hsa-miR-938	CLIP-seq
MIRT1459599	hsa-miR-943	CLIP-seq
MIRT2137937	hsa-miR-1827	CLIP-seq
MIRT1459560	hsa-miR-2467-3p	CLIP-seq
MIRT2137938	hsa-miR-3150a-3p	CLIP-seq
MIRT2137939	hsa-miR-3175	CLIP-seq
MIRT2137940	hsa-miR-3194-3p	CLIP-seq
MIRT2137941	hsa-miR-3612	CLIP-seq
MIRT1459566	hsa-miR-3613-3p	CLIP-seq
MIRT2137942	hsa-miR-3646	CLIP-seq
MIRT1459569	hsa-miR-3662	CLIP-seq
MIRT2137943	hsa-miR-4275	CLIP-seq
MIRT2137944	hsa-miR-4292	CLIP-seq
MIRT2137945	hsa-miR-4308	CLIP-seq
MIRT2137946	hsa-miR-4667-5p	CLIP-seq
MIRT2137947	hsa-miR-4700-5p	CLIP-seq
MIRT1459594	hsa-miR-634	CLIP-seq
MIRT2137948	hsa-miR-650	CLIP-seq
MIRT2137949	hsa-miR-760	CLIP-seq
MIRT2137950	hsa-miR-767-3p	CLIP-seq
MIRT2137951	hsa-miR-939	CLIP-seq
MIRT1459556	hsa-miR-1275	CLIP-seq
MIRT2358846	hsa-miR-22	CLIP-seq
MIRT1459561	hsa-miR-31	CLIP-seq
MIRT2358847	hsa-miR-3153	CLIP-seq
MIRT2358848	hsa-miR-3180-5p	CLIP-seq
MIRT2358849	hsa-miR-3192	CLIP-seq
MIRT1459564	hsa-miR-3202	CLIP-seq
MIRT1459566	hsa-miR-3613-3p	CLIP-seq
MIRT1459567	hsa-miR-3617	CLIP-seq
MIRT1459569	hsa-miR-3662	CLIP-seq
MIRT2358850	hsa-miR-3689a-3p	CLIP-seq
MIRT2358851	hsa-miR-3689c	CLIP-seq
MIRT1459572	hsa-miR-4271	CLIP-seq
MIRT2358852	hsa-miR-4278	CLIP-seq
MIRT1459579	hsa-miR-4525	CLIP-seq
MIRT1459582	hsa-miR-4665-5p	CLIP-seq
MIRT1459584	hsa-miR-4723-5p	CLIP-seq
MIRT1459585	hsa-miR-4725-3p	CLIP-seq
MIRT2358853	hsa-miR-4728-5p	CLIP-seq
MIRT1459587	hsa-miR-4747-5p	CLIP-seq
MIRT2358854	hsa-miR-520a-5p	CLIP-seq
MIRT2358855	hsa-miR-525-5p	CLIP-seq
MIRT2358856	hsa-miR-542-5p	CLIP-seq
MIRT2358857	hsa-miR-558	CLIP-seq
MIRT1459592	hsa-miR-582-3p	CLIP-seq
MIRT1459593	hsa-miR-625	CLIP-seq
MIRT1459595	hsa-miR-641	CLIP-seq
MIRT2462497	hsa-miR-1470	CLIP-seq
MIRT2462498	hsa-miR-1976	CLIP-seq
MIRT1459559	hsa-miR-2355-5p	CLIP-seq
MIRT2462499	hsa-miR-4667-3p	CLIP-seq
MIRT2462500	hsa-miR-4722-3p	CLIP-seq
MIRT1459596	hsa-miR-642a	CLIP-seq
MIRT1459598	hsa-miR-938	CLIP-seq
MIRT1459567	hsa-miR-3617	CLIP-seq
MIRT1459583	hsa-miR-4706	CLIP-seq
MIRT1459588	hsa-miR-4749-5p	CLIP-seq
MIRT1459594	hsa-miR-634	CLIP-seq
MIRT1459595	hsa-miR-641	CLIP-seq
MIRT1459597	hsa-miR-744	CLIP-seq
MIRT1459567	hsa-miR-3617	CLIP-seq
MIRT1459583	hsa-miR-4706	CLIP-seq
MIRT1459588	hsa-miR-4749-5p	CLIP-seq
MIRT1459594	hsa-miR-634	CLIP-seq
MIRT1459595	hsa-miR-641	CLIP-seq
MIRT1459597	hsa-miR-744	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	23091066, 25416956, 26686862, 32296183
GO:0005788	Component	Endoplasmic reticulum lumen	TAS
GO:0005829	Component	Cytosol	IDA
GO:0005886	Component	Plasma membrane	IDA	23091066, 30463011
GO:0005886	Component	Plasma membrane	TAS
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0008593	Process	Regulation of Notch signaling pathway	IMP	23091066
GO:0009986	Component	Cell surface	IEA
GO:0016604	Component	Nuclear body	IDA
GO:0019899	Function	Enzyme binding	IPI	23091066
GO:0030054	Component	Cell junction	IDA
GO:0031902	Component	Late endosome membrane	IEA
GO:0043231	Component	Intracellular membrane-bounded organelle	IDA
GO:0044267	Process	Cellular protein metabolic process	TAS
GO:0045746	Process	Negative regulation of Notch signaling pathway	IDA	30463011
GO:0051604	Process	Protein maturation	IBA	21873635
GO:0051604	Process	Protein maturation	IMP	23091066
GO:0072659	Process	Protein localization to plasma membrane	IBA	21873635
GO:0072659	Process	Protein localization to plasma membrane	IMP	23091066
GO:0097197	Component	Tetraspanin-enriched microdomain	IEA

MIM	HGNC	e!Ensembl
613140	23298	ENSG00000099282

Protein

UniProt ID

O95858

Protein name

Tetraspanin-15 (Tspan-15) (Tetraspan NET-7) (Transmembrane 4 superfamily member 15)

Protein function

Part of TspanC8 subgroup, composed of 6 members that interact with the transmembrane metalloprotease ADAM10. This interaction is required for ADAM10 exit from the endoplasmic reticulum and for enzymatic maturation and trafficking to the cell sur

PDB

7RD5 , 7RDB , 8ESV

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00335	Tetraspanin	20 → 258	Tetraspanin family	Family

Sequence

MPRGDSEQVRYCARFSYLWLKFSLIIYSTVFWLIGALVLSVGIYAEVERQKYKTLESAFL
APAIILILLGVVMFMVSFIGVLASLRDNLYLLQAFMYILGICLIMELIGGVVALTFRNQT
IDFLNDNIRRGIENYYDDLDFKNIMDFVQKKFKCCGGEDYRDWSKNQYHDCSAPGPLACG
VPYTCCIRNTTEVVNTMCGYKTIDKERFSVQDVIYVRGCTNAVIIWFMDNYTIMAGILLG
ILLPQFLGVLLTLLYITRVEDIIMEHSVTDGLLGPGAKPSVEAAGTGCCLCYPN

Sequence length

294

Interactions

View interactions

	Reactome
			Amyloid fiber formation

Show/Hide Unknown Diseases (2)

Disease term	Disease name	References	Source
Unknown
Ischemic stroke	Ischemic stroke	26908601	ClinVar
Diabetes	Diabetes		GWAS

Show/Hide Text Mining Associations (1)

Disease Name	Relationship Type	References
Associations from Text Mining
Squamous Cell Carcinoma of Head and Neck	Associate	37371537

TSPAN15 (tetraspanin 15)