Gene Gene information from NCBI Gene database.
Entrez ID 2353
Gene name Fos proto-oncogene, AP-1 transcription factor subunit
Gene symbol FOS
Synonyms (NCBI Gene)
AP-1C-FOSp55
Chromosome 14
Chromosome location 14q24.3
Summary The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have b
miRNA miRNA information provided by mirtarbase database.
366
miRTarBase ID miRNA Experiments Reference
MIRT001219 hsa-miR-101-3p qRT-PCRLuciferase reporter assayWestern blot 19133651
MIRT001219 hsa-miR-101-3p qRT-PCRLuciferase reporter assayWestern blot 19133651
MIRT004484 hsa-miR-221-3p qRT-PCRLuciferase reporter assayWestern blotNorthern blot 20299489
MIRT004485 hsa-miR-222-3p qRT-PCRLuciferase reporter assayWestern blotNorthern blot 20299489
MIRT001219 hsa-miR-101-3p Luciferase reporter assay 19133651
Transcription factors Transcription factors information provided by TRRUST V2 database.
36
Transcription factor Regulation Reference
AHR Unknown 10478842
ARNT Repression 21544813
BRCA1 Unknown 11313879
CREB1 Unknown 12432566
CREM Repression 21757709
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
110
GO ID Ontology Definition Evidence Reference
GO:0000785 Component Chromatin ISA
GO:0000976 Function Transcription cis-regulatory region binding IDA 9732876
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA 30670568
GO:0000978 Function RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
164810 3796 ENSG00000170345
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P01100
Protein name Protein c-Fos (Cellular oncogene fos) (Fos proto-oncogene, AP-1 transcription factor subunit) (G0/G1 switch regulatory protein 7) (Proto-oncogene c-Fos) (Transcription factor AP-1 subunit c-Fos)
Protein function Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activatio
PDB 1A02 , 1FOS , 1S9K
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00170 bZIP_1 135 197 bZIP transcription factor Coiled-coil
Sequence
MMFSGFNADYEASSSRCSSASPAGDSLSYYHSPADSFSSMGSPVNAQDFCTDLAVSSANF
IPTVTAISTSPDLQWLVQPALVSSVAPSQTRAPHPFGVPAPSAGAYSRAGVVKTMTGGRA
QSIGRRGKVEQLSPEEEEKRRIRRERNKMAAAKCRNRRRELTDTLQAETDQLEDEKSALQ
TEIANLLKEKEKLEFIL
AAHRPACKIPDDLGFPEEMSVASLDLTGGLPEVATPESEEAFT
LPLLNDPEPKPSVEPVKSISSMELKTEPFDDFLFPASSRPSGSETARSVPDMDLSGSFYA
ADWEPLHSGSLGMGPMATELEPLCTPVVTCTPSCTAYTSSFVFTYPEADSFPSCAAAHRK
GSSSNEPSSDSLSSPTLLAL
Sequence length 380
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Endocrine resistance
MAPK signaling pathway
cAMP signaling pathway
Apoptosis
Osteoclast differentiation
Toll-like receptor signaling pathway
IL-17 signaling pathway
Th1 and Th2 cell differentiation
Th17 cell differentiation
T cell receptor signaling pathway
B cell receptor signaling pathway
TNF signaling pathway
Circadian entrainment
Cholinergic synapse
Dopaminergic synapse
Estrogen signaling pathway
Prolactin signaling pathway
Oxytocin signaling pathway
Relaxin signaling pathway
Parathyroid hormone synthesis, secretion and action
Non-alcoholic fatty liver disease
Growth hormone synthesis, secretion and action
Amphetamine addiction
Pathogenic Escherichia coli infection
Salmonella infection
Pertussis
Yersinia infection
Leishmaniasis
Chagas disease
Hepatitis B
Measles
Human T-cell leukemia virus 1 infection
Kaposi sarcoma-associated herpesvirus infection
Human immunodeficiency virus 1 infection
Coronavirus disease - COVID-19
Pathways in cancer
Chemical carcinogenesis - receptor activation
Chemical carcinogenesis - reactive oxygen species
Colorectal cancer
Breast cancer
Choline metabolism in cancer
PD-L1 expression and PD-1 checkpoint pathway in cancer
Rheumatoid arthritis
Lipid and atherosclerosis
Fluid shear stress and atherosclerosis
  Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
FCERI mediated MAPK activation
Activation of the AP-1 family of transcription factors
Interleukin-4 and Interleukin-13 signaling
TP53 Regulates Transcription of DNA Repair Genes
Estrogen-dependent gene expression
NGF-stimulated transcription
Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
8
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Acute myeloid leukemia Benign rs76195634 RCV005906227
Cervical cancer Benign rs76195634 RCV005906229
Clear cell carcinoma of kidney Benign rs76195634 RCV005906230
Gastric cancer Benign rs76195634 RCV005906231
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Acidosis Stimulate 40217316
Acro Osteolysis Associate 35145077
Adenocarcinoma Associate 26786102
Adenocarcinoma Follicular Inhibit 2803926
Adenocarcinoma of Lung Associate 23591077, 31698633, 35029906
Adenoma Associate 3348948
Adenomyosis Associate 32933042
Altitude Sickness Inhibit 33393628
Alzheimer Disease Stimulate 17712163
Alzheimer Disease Associate 9880041