Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	23505
Gene name Gene Name - the full gene name approved by the HGNC.	Transmembrane protein 131
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	TMEM131
Synonyms (NCBI Gene) Gene synonyms aliases	CC28, PRO1048, RW1, YR-23
Chromosome Chromosome number	2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	2q11.2

Show/Hide all(117)

miRTarBase ID	miRNA	Experiments	Reference
MIRT041822	hsa-miR-484	CLASH	23622248
MIRT1430682	hsa-miR-1245b-3p	CLIP-seq
MIRT1430683	hsa-miR-2110	CLIP-seq
MIRT1430684	hsa-miR-216a	CLIP-seq
MIRT1430685	hsa-miR-302f	CLIP-seq
MIRT1430686	hsa-miR-3120-3p	CLIP-seq
MIRT1430687	hsa-miR-3153	CLIP-seq
MIRT1430688	hsa-miR-4271	CLIP-seq
MIRT1430689	hsa-miR-4301	CLIP-seq
MIRT1430690	hsa-miR-4305	CLIP-seq
MIRT1430691	hsa-miR-4307	CLIP-seq
MIRT1430692	hsa-miR-433	CLIP-seq
MIRT1430693	hsa-miR-4330	CLIP-seq
MIRT1430694	hsa-miR-4681	CLIP-seq
MIRT1430695	hsa-miR-4725-3p	CLIP-seq
MIRT1430696	hsa-miR-4762-5p	CLIP-seq
MIRT1430697	hsa-miR-487a	CLIP-seq
MIRT1430698	hsa-miR-545	CLIP-seq
MIRT1430699	hsa-miR-552	CLIP-seq
MIRT1430700	hsa-miR-570	CLIP-seq
MIRT1430701	hsa-miR-7	CLIP-seq
MIRT1430686	hsa-miR-3120-3p	CLIP-seq
MIRT1554888	hsa-miR-4277	CLIP-seq
MIRT1430696	hsa-miR-4762-5p	CLIP-seq
MIRT1430698	hsa-miR-545	CLIP-seq
MIRT2129142	hsa-miR-129-5p	CLIP-seq
MIRT2129143	hsa-miR-198	CLIP-seq
MIRT1430684	hsa-miR-216a	CLIP-seq
MIRT1430686	hsa-miR-3120-3p	CLIP-seq
MIRT2129144	hsa-miR-3167	CLIP-seq
MIRT1430689	hsa-miR-4301	CLIP-seq
MIRT1430690	hsa-miR-4305	CLIP-seq
MIRT1430691	hsa-miR-4307	CLIP-seq
MIRT1430692	hsa-miR-433	CLIP-seq
MIRT2129145	hsa-miR-4427	CLIP-seq
MIRT2129146	hsa-miR-4474-3p	CLIP-seq
MIRT2129147	hsa-miR-4680-3p	CLIP-seq
MIRT2129148	hsa-miR-4684-5p	CLIP-seq
MIRT2129149	hsa-miR-4717-3p	CLIP-seq
MIRT2129150	hsa-miR-4755-3p	CLIP-seq
MIRT2129151	hsa-miR-4762-3p	CLIP-seq
MIRT1430696	hsa-miR-4762-5p	CLIP-seq
MIRT2129152	hsa-miR-4768-5p	CLIP-seq
MIRT2129153	hsa-miR-499a-5p	CLIP-seq
MIRT1430698	hsa-miR-545	CLIP-seq
MIRT2129154	hsa-miR-876-5p	CLIP-seq
MIRT2129155	hsa-miR-888	CLIP-seq
MIRT2129156	hsa-miR-944	CLIP-seq
MIRT2129144	hsa-miR-3167	CLIP-seq
MIRT1430689	hsa-miR-4301	CLIP-seq
MIRT1430690	hsa-miR-4305	CLIP-seq
MIRT1430691	hsa-miR-4307	CLIP-seq
MIRT1430692	hsa-miR-433	CLIP-seq
MIRT2129149	hsa-miR-4717-3p	CLIP-seq
MIRT2129150	hsa-miR-4755-3p	CLIP-seq
MIRT1430696	hsa-miR-4762-5p	CLIP-seq
MIRT2129154	hsa-miR-876-5p	CLIP-seq
MIRT1430689	hsa-miR-4301	CLIP-seq
MIRT1430690	hsa-miR-4305	CLIP-seq
MIRT1430691	hsa-miR-4307	CLIP-seq
MIRT1430692	hsa-miR-433	CLIP-seq
MIRT2644228	hsa-miR-1206	CLIP-seq
MIRT1430683	hsa-miR-2110	CLIP-seq
MIRT2644229	hsa-miR-3065-3p	CLIP-seq
MIRT2644230	hsa-miR-3140-3p	CLIP-seq
MIRT2129144	hsa-miR-3167	CLIP-seq
MIRT2644231	hsa-miR-3607-3p	CLIP-seq
MIRT2644232	hsa-miR-3686	CLIP-seq
MIRT1430688	hsa-miR-4271	CLIP-seq
MIRT2644233	hsa-miR-4282	CLIP-seq
MIRT2644234	hsa-miR-4291	CLIP-seq
MIRT1430689	hsa-miR-4301	CLIP-seq
MIRT1430690	hsa-miR-4305	CLIP-seq
MIRT1430691	hsa-miR-4307	CLIP-seq
MIRT2644235	hsa-miR-4328	CLIP-seq
MIRT1430692	hsa-miR-433	CLIP-seq
MIRT2644236	hsa-miR-4422	CLIP-seq
MIRT2129145	hsa-miR-4427	CLIP-seq
MIRT2644237	hsa-miR-4652-3p	CLIP-seq
MIRT2129147	hsa-miR-4680-3p	CLIP-seq
MIRT1430694	hsa-miR-4681	CLIP-seq
MIRT2644238	hsa-miR-4686	CLIP-seq
MIRT2129149	hsa-miR-4717-3p	CLIP-seq
MIRT1430695	hsa-miR-4725-3p	CLIP-seq
MIRT2129150	hsa-miR-4755-3p	CLIP-seq
MIRT2129151	hsa-miR-4762-3p	CLIP-seq
MIRT1430696	hsa-miR-4762-5p	CLIP-seq
MIRT2644239	hsa-miR-485-3p	CLIP-seq
MIRT1430699	hsa-miR-552	CLIP-seq
MIRT1430700	hsa-miR-570	CLIP-seq
MIRT2644240	hsa-miR-577	CLIP-seq
MIRT2644241	hsa-miR-582-5p	CLIP-seq
MIRT1430701	hsa-miR-7	CLIP-seq
MIRT2129154	hsa-miR-876-5p	CLIP-seq
MIRT2129155	hsa-miR-888	CLIP-seq
MIRT2129156	hsa-miR-944	CLIP-seq
MIRT2644228	hsa-miR-1206	CLIP-seq
MIRT2644229	hsa-miR-3065-3p	CLIP-seq
MIRT2644230	hsa-miR-3140-3p	CLIP-seq
MIRT2129144	hsa-miR-3167	CLIP-seq
MIRT2644231	hsa-miR-3607-3p	CLIP-seq
MIRT2644232	hsa-miR-3686	CLIP-seq
MIRT2644234	hsa-miR-4291	CLIP-seq
MIRT1430690	hsa-miR-4305	CLIP-seq
MIRT1430692	hsa-miR-433	CLIP-seq
MIRT2129145	hsa-miR-4427	CLIP-seq
MIRT2644237	hsa-miR-4652-3p	CLIP-seq
MIRT2129147	hsa-miR-4680-3p	CLIP-seq
MIRT2644238	hsa-miR-4686	CLIP-seq
MIRT2129149	hsa-miR-4717-3p	CLIP-seq
MIRT2129150	hsa-miR-4755-3p	CLIP-seq
MIRT2129151	hsa-miR-4762-3p	CLIP-seq
MIRT1430696	hsa-miR-4762-5p	CLIP-seq
MIRT2644239	hsa-miR-485-3p	CLIP-seq
MIRT2129154	hsa-miR-876-5p	CLIP-seq
MIRT2129155	hsa-miR-888	CLIP-seq
MIRT2129156	hsa-miR-944	CLIP-seq

Show/Hide all(5)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003674	Function	Molecular_function	ND
GO:0005575	Component	Cellular_component	ND
GO:0008150	Process	Biological_process	ND
GO:0016020	Component	Membrane	IBA	21873635
GO:0016021	Component	Integral component of membrane	IEA

MIM	HGNC	e!Ensembl
615659	30366	ENSG00000075568

Protein

UniProt ID

Q92545

Protein name

Transmembrane protein 131 (Protein RW1)

Protein function

Collagen binding transmembrane protein involved in collagen secretion by recruiting the ER-to-Golgi transport complex TRAPPIII (PubMed:32095531). May play a role in the immune response to viral infection. {ECO:0000250, ECO:0000269|PubMed:3209553

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF12371	TMEM131_like	108 → 191	Transmembrane protein 131-like	Family

Sequence

MGKRAGGGATGATTAAVSTSAGAGLEPAAARSGGPRSAAAGLLGALHLVMTLVVAAARAE
KEAFVQSESIIEVLRFDDGGLLQTETTLGLSSYQQKSISLYRGNCRPIRFEPPMLDFHEQ
PVGMPKMEKVYLHNPSSEETITLVSISATTSHFHASFFQNRKILPGGNTSFDVVFLARVV
GNVENTLFINTSNHGVFTYQVFGVGVPNPYRLRPFLGARVPVNSSFSPIINIHNPHSEPL
QVVEMYSSGGDLHLELPTGQQGGTRKLWEIPPYETKGVMRASFSSREADNHTAFIRIKTN
ASDSTEFIILPVEVEVTTAPGIYSSTEMLDFGTLRTQDLPKVLNLHLLNSGTKDVPITSV
RPTPQNDAITVHFKPITLKASESKYTKVASISFDASKAKKPSQFSGKITVKAKEKSYSKL
EIPYQAEVLDGYLGFDHAATLFHIRDSPADPVERPIYLTNTFSFAILIHDVLLPEEAKTM
FKVHNFSKPVLILPNESGYIFTLLFMPSTSSMHIDNNILLITNASKFHLPVRVYTGFLDY
FVLPPKIEERFIDFGVLSATEASNILFAIINSNPIELAIKSWHIIGDGLSIELVAVERGN
RTTIISSLPEFEKSSLSDQSSVTLASGYFAVFRVKLTAKKLEGIHDGAIQITTDYEILTI
PVKAVIAVGSLTCFPKHVVLPPSFPGKIVHQSLNIMNSFSQKVKIQQIRSLSEDVRFYYK
RLRGNKEDLEPGKKSKIANIYFDPGLQCGDHCYVGLPFLSKSEPKVQPGVAMQEDMWDAD
WDLHQSLFKGWTGIKENSGHRLSAIFEVNTDLQKNIISKITAELSWPSILSSPRHLKFPL
TNTNCSSEEEITLENPADVPVYVQFIPLALYSNPSVFVDKLVSRFNLSKVAKIDLRTLEF
QVFRNSAHPLQSSTGFMEGLSRHLILNLILKPGEKKSVKVKFTPVHNRTVSSLIIVRNNL
TVMDAVMVQGQGTTENLRVAGKLPGPGSSLRFKITEALLKDCTDSLKLREPNFTLKRTFK
VENTGQLQIHIETIEISGYSCEGYGFKVVNCQEFTLSANASRDIIILFTPDFTASRVIRE
LKFITTSGSEFVFILNASLPYHMLATCAEALPRPNWELALYIIISGIMSALFLLVIGTAY
LEAQGIWEPFRRRLSFEASNPPFDVGRPFDLRRIVGISSEGNLNTLSCDPGHSRGFCGAG
GSSSRPSAGSHKQCGPSVHPHSSHSNRNSADVENVRAKNSSSTSSRTSAQAASSQSANKT
SPLVLDSNTVTQGHTAGRKSKGAKQSQHGSQHHAHSPLEQHPQPPLPPPVPQPQEPQPER
LSPAPLAHPSHPERASSARHSSEDSDITSLIEAMDKDFDHHDSPALEVFTEQPPSPLPKS
KGKGKPLQRKVKPPKKQEEKEKKGKGKPQEDELKDSLADDDSSSTTTETSNPDTEPLLKE
DTEKQKGKQAMPEKHESEMSQVKQKSKKLLNIKKEIPTDVKPSSLELPYTPPLESKQRRN
LPSKIPLPTAMTSGSKSRNAQKTKGTSKLVDNRPPALAKFLPNSQELGNTSSSEGEKDSP
PPEWDSVPVHKPGSSTDSLYKLSLQTLNADIFLKQRQTSPTPASPSPPAAPCPFVARGSY
SSIVNSSSSSDPKIKQPNGSKHKLTKAASLPGKNGNPTFAAVTAGYDKSPGGNGFAKVSS
NKTGFSSSLGISHAPVDSDGSDSSGLWSPVSNPSSPDFTPLNSFSAFGNSFNLTGEVFSK
LGLSRSCNQASQRSWNEFNSGPSYLWESPATDPSPSWPASSGSPTHTATSVLGNTSGLWS
TTPFSSSIWSSNLSSALPFTTPANTLASIGLMGTENSPAPHAPSTSSPADDLGQTYNPWR
IWSPTIGRRSSDPWSNSHFPHEN

Sequence length

1883

Interactions

View interactions

Show/Hide Causal Diseases (2)

Disease term	Disease name	dbSNP ID	References
Causal
Autoimmune diseases	Autoimmune Diseases, AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 1, AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 2	rs869025224	30595370
Hypothyroidism	Hypothyroidism	rs869320723, rs121908862, rs121908863, rs121908865, rs121908866, rs121908867, rs121908870, rs121908871, rs121908872, rs2140110277, rs121908881, rs121908884, rs121908885, rs786205080, rs1586182912 View all (22 more)	30595370

Show/Hide Unknown Diseases (4)

Disease term	Disease name	Evidence	Source
Unknown
Bipolar Disorder	Bipolar Disorder		GWAS
Colorectal Cancer	Colorectal Cancer	In summary, our data strongly demonstrated that upregulation of GRB7 conferred MEKi resistance in CRC cells with KRAS mutations by mediating RTK signaling through the recruitment of PLK1.	GWAS, CBGDA
Insomnia	Insomnia		GWAS
Dyslexia	Dyslexia		GWAS

Show/Hide Text Mining Associations (1)

Disease Name	Relationship Type	References
Associations from Text Mining
Down Syndrome	Associate	21124956

TMEM131 (transmembrane protein 131)