Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
23500
Gene name Gene Name - the full gene name approved by the HGNC.
Dishevelled associated activator of morphogenesis 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
DAAM2
Synonyms (NCBI Gene) Gene synonyms aliases
NPHS24, dJ90A20A.1
Disease Acronyms (UniProt) Disease acronyms from UniProt database
NPHS24
Chromosome Chromosome number
6
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
6p21.2
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT031230 hsa-miR-19b-3p Sequencing 20371350
MIRT031355 hsa-miR-18a-5p Sequencing 20371350
MIRT609347 hsa-miR-8485 HITS-CLIP 23824327
MIRT609346 hsa-miR-329-3p HITS-CLIP 23824327
MIRT609345 hsa-miR-362-3p HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003779 Function Actin binding IEA
GO:0016055 Process Wnt signaling pathway IEA
GO:0021516 Process Dorsal spinal cord development ISS
GO:0030036 Process Actin cytoskeleton organization IEA
GO:0048715 Process Negative regulation of oligodendrocyte differentiation IBA 21873635
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
606627 18143 ENSG00000146122
Protein
UniProt ID Q86T65
Protein name Disheveled-associated activator of morphogenesis 2
Protein function Key regulator of the Wnt signaling pathway, which is required for various processes during development, such as dorsal patterning, determination of left/right symmetry or myelination in the central nervous system. Acts downstream of Wnt ligands
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF06371 Drf_GBD 40 228 Diaphanous GTPase-binding Domain Family
PF06367 Drf_FH3 231 435 Diaphanous FH3 Domain Family
PF02181 FH2 595 969 Formin Homology 2 Domain Family
Tissue specificity TISSUE SPECIFICITY: Expressed in most tissues examined. Expressed in kidney glomeruli (PubMed:33232676). {ECO:0000269|PubMed:33232676, ECO:0000269|PubMed:9205841}.
Sequence
MAPRKRSHHGLGFLCCFGGSDIPEINLRDNHPLQFMEFSSPIPNAEELNIRFAELVDELD
LTDKNREAMFALPPEKKWQIYCSKKKEQEDPNKLATSWPDYYIDRINSMAAMQSLYAFDE
EETEMRNQVVEDLKTALRTQPMRFVTRFIELEGLTCLLNFLRSMDHATCESRIHTSLIGC
IKALMNNSQGRAHVLAQPEAISTIAQSLRTENSKTKVAVLEILGAVCL
VPGGHKKVLQAM
LHYQVYAAERTRFQTLLNELDRSLGRYRDEVNLKTAIMSFINAVLNAGAGEDNLEFRLHL
RYEFLMLGIQPVIDKLRQHENAILDKHLDFFEMVRNEDDLELARRFDMVHIDTKSASQMF
ELIHKKLKYTEAYPCLLSVLHHCLQMPYKRNGGYFQQWQLLDRILQQIVLQDERGVDPDL
APLENFNVKNIVNML
INENEVKQWRDQAEKFRKEHMELVSRLERKERECETKTLEKEEMM
RTLNKMKDKLARESQELRQARGQVAELVAQLSELSTGPVSSPPPPGGPLTLSSSMTTNDL
PPPPPPLPFACCPPPPPPPLPPGGPPTPPGAPPCLGMGLPLPQDPYPSSDVPLRKKRVPQ
PSHPLKSFNWVKLNEERVPGTVWNEIDDMQVFRILDLEDFEKMFSAYQRHQKELGSTEDI
YLASRKVKELSVIDGRRAQNCIILLSKLKLSNEEIRQAILKMDEQEDLAKDMLEQLLKFI
PEKSDIDLLEEHKHEIERMARADRFLYEMSRIDHYQQRLQALFFKKKFQERLAEAKPKVE
AILLASRELVRSKRLRQMLEVILAIGNFMNKGQRGGAYGFRVASLNKIADTKSSIDRNIS
LLHYLIMILEKHFPDILNMPSELQHLPEAAKVNLAELEKEVGNLRRGLRAVEVELEYQRR
QVREPSDKFVPVMSDFITVSSFSFSELEDQLNEARDKFAKALMHFGEHDSKMQPDEFFGI
FDTFLQAFS
EARQDLEAMRRRKEEEERRARMEAMLKEQRERERWQRQRKVLAAGSSLEEG
GEFDDLVSALRSGEVFDKDLCKLKRSRKRSGSQALEVTRERAINRLNY
Sequence length 1068
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  
  Wnt signaling pathway
Cytoskeleton in muscle cells
 
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Osteoporosis Osteoporosis, Age-Related, Osteoporosis, Osteoporosis, Senile, Post-Traumatic Osteoporosis rs72658152, rs72667023, rs587776916, rs72656370, rs768615287 30598549
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)
19358997
Unknown
Disease term Disease name Evidence References Source
Nephrotic Syndrome nephrotic syndrome, type 24 GenCC
Hypospadias Hypospadias GWAS
Oligodendroglioma Oligodendroglioma GWAS
Diabetes Diabetes GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 40179422
Adenoma Associate 27245242
Ataxia Telangiectasia Stimulate 32772041
Bone Diseases Associate 36720443
Carcinogenesis Associate 29053101
Carcinoma Hepatocellular Associate 32772041
Carcinoma Squamous Cell Associate 40179422
Colonic Neoplasms Associate 27245242
Demyelinating Diseases Associate 26293489
Femoral Fractures Associate 35052486