FOLR2 (folate receptor beta)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
2350
Gene name Gene Name - the full gene name approved by the HGNC.
Folate receptor beta
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
FOLR2
Synonyms (NCBI Gene) Gene synonyms aliases
BETA-HFR, FBP, FBP/PL-1, FOLR1, FR-BETA, FR-P3, FRbeta
Chromosome Chromosome number
11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
11q13.4
Summary Summary of gene provided in NCBI Entrez Gene.
The protein encoded by this gene is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and the
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(17)
miRTarBase ID miRNA Experiments Reference
MIRT017234 hsa-miR-335-5p Microarray 18185580
MIRT029090 hsa-miR-26b-5p Microarray 19088304
MIRT2388070 hsa-miR-1225-3p CLIP-seq
MIRT2388071 hsa-miR-1233 CLIP-seq
MIRT2388072 hsa-miR-3160-3p CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(20)
GO ID Ontology Definition Evidence Reference
GO:0002548 Process Monocyte chemotaxis IDA 25015955
GO:0005542 Function Folic acid binding IDA 4066659, 19116913, 25015955
GO:0005576 Component Extracellular region TAS
GO:0005886 Component Plasma membrane TAS
GO:0006954 Process Inflammatory response NAS 25015955
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
136425 3793 ENSG00000165457
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P14207
Protein name Folate receptor beta (FR-beta) (Folate receptor 2) (Folate receptor, fetal/placental) (Placental folate-binding protein) (FBP)
Protein function Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH
PDB 4KMY , 4KMZ , 4KN0 , 4KN1 , 4KN2
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03024 Folate_rec 30 → 205 Folate receptor family Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in placenta and hematopoietic cells. Expression is increased in malignant tissues. {ECO:0000269|PubMed:2605182, ECO:0000269|PubMed:8445646}.
Sequence
Sequence length 255
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Antifolate resistance
Endocytosis
Folate transport and metabolism 		  Post-translational modification: synthesis of GPI-anchored proteins
Metabolism of folate and pterines
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (3)
Causal
Disease term Disease name dbSNP ID References
Anencephaly Iniencephaly, Exencephaly rs773607884 11749123
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
Neural tube defect Neural Tube Defects rs121434297, rs137853061, rs137853062, rs768434408, rs777661576, rs747846362, rs200137991, rs780014899, rs574132670, rs786204013, rs147257424, rs763539350, rs776483190, rs781461462, rs1114167354
View all (26 more)		 11749123
Show/Hide Text Mining Associations (34)
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma Associate 25971554
Adenocarcinoma of Lung Associate 34721732, 37532692
Arthritis Associate 35255727
Arthritis Rheumatoid Associate 10446858, 21477314, 25015955, 35255727
Arthritis Rheumatoid Inhibit 29096690
Autoimmune Diseases Associate 21477314, 25015955
Breast Neoplasms Associate 26248049, 26573433
Carcinoma Non Small Cell Lung Associate 30415267, 33321157
Carcinoma Ovarian Epithelial Associate 25971554
Carotid Stenosis Associate 22855837