Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	23492
Gene name	Chromobox 7
Gene symbol	CBX7
Synonyms (NCBI Gene)	-
Chromosome	22
Chromosome location	22q13.1
Summary	This gene encodes a protein that contains the CHROMO (CHRomatin Organization MOdifier) domain. The encoded protein is a component of the Polycomb repressive complex 1 (PRC1), and is thought to control the lifespan of several normal human cells. [provided

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miRTarBase ID	miRNA	Experiments	Reference
MIRT001104	hsa-miR-421	qRT-PCRWestern blot	19802518
MIRT006371	hsa-miR-181b-5p	Luciferase reporter assay	21779448
MIRT006371	hsa-miR-181b-5p	Luciferase reporter assay	21779448
MIRT006371	hsa-miR-181b-5p	Luciferase reporter assay	21779448
MIRT006371	hsa-miR-181b-5p	Luciferase reporter assay	21779448
MIRT006371	hsa-miR-181b-5p	Luciferase reporter assay	21779448
MIRT006371	hsa-miR-181b-5p	Luciferase reporter assay	21779448
MIRT039038	hsa-miR-766-3p	CLASH	23622248
MIRT532660	hsa-miR-548aa	PAR-CLIP	22012620
MIRT532659	hsa-miR-548ap-3p	PAR-CLIP	22012620
MIRT532658	hsa-miR-548t-3p	PAR-CLIP	22012620
MIRT532657	hsa-miR-548as-3p	PAR-CLIP	22012620
MIRT532656	hsa-miR-548at-3p	PAR-CLIP	22012620
MIRT532655	hsa-miR-548ay-3p	PAR-CLIP	22012620
MIRT485708	hsa-miR-4700-3p	PAR-CLIP	23592263
MIRT485707	hsa-miR-3169	PAR-CLIP	23592263
MIRT485704	hsa-miR-4515	PAR-CLIP	23592263
MIRT485703	hsa-miR-6818-3p	PAR-CLIP	23592263
MIRT485708	hsa-miR-4700-3p	PAR-CLIP	23592263
MIRT485707	hsa-miR-3169	PAR-CLIP	23592263
MIRT485706	hsa-miR-7-5p	PAR-CLIP	23592263
MIRT485705	hsa-miR-6077	PAR-CLIP	23592263
MIRT485704	hsa-miR-4515	PAR-CLIP	23592263
MIRT485703	hsa-miR-6818-3p	PAR-CLIP	23592263
MIRT728042	hsa-miR-19a-3p	HITS-CLIP	22473208
MIRT728040	hsa-miR-19b-3p	HITS-CLIP	22473208
MIRT731983	hsa-miR-18a-3p	Luciferase reporter assayWestern blot	28123848
MIRT731983	hsa-miR-18a-3p	Luciferase reporter assayWestern blot	28123848
MIRT532660	hsa-miR-548aa	PAR-CLIP	22012620
MIRT532659	hsa-miR-548ap-3p	PAR-CLIP	22012620
MIRT532658	hsa-miR-548t-3p	PAR-CLIP	22012620
MIRT532657	hsa-miR-548as-3p	PAR-CLIP	22012620
MIRT532656	hsa-miR-548at-3p	PAR-CLIP	22012620
MIRT532655	hsa-miR-548ay-3p	PAR-CLIP	22012620
MIRT485708	hsa-miR-4700-3p	PAR-CLIP	23592263
MIRT485707	hsa-miR-3169	PAR-CLIP	23592263
MIRT485704	hsa-miR-4515	PAR-CLIP	23592263
MIRT485703	hsa-miR-6818-3p	PAR-CLIP	23592263
MIRT485708	hsa-miR-4700-3p	PAR-CLIP	23592263
MIRT485707	hsa-miR-3169	PAR-CLIP	23592263
MIRT485706	hsa-miR-7-5p	PAR-CLIP	23592263
MIRT485705	hsa-miR-6077	PAR-CLIP	23592263
MIRT485704	hsa-miR-4515	PAR-CLIP	23592263
MIRT485703	hsa-miR-6818-3p	PAR-CLIP	23592263
MIRT866903	hsa-miR-1197	CLIP-seq
MIRT866904	hsa-miR-1207-5p	CLIP-seq
MIRT866905	hsa-miR-150	CLIP-seq
MIRT866906	hsa-miR-224	CLIP-seq
MIRT866907	hsa-miR-2861	CLIP-seq
MIRT866908	hsa-miR-296-5p	CLIP-seq
MIRT866909	hsa-miR-342-5p	CLIP-seq
MIRT866910	hsa-miR-345	CLIP-seq
MIRT866911	hsa-miR-361-3p	CLIP-seq
MIRT866912	hsa-miR-4268	CLIP-seq
MIRT866913	hsa-miR-4297	CLIP-seq
MIRT866914	hsa-miR-4419a	CLIP-seq
MIRT866915	hsa-miR-4434	CLIP-seq
MIRT866916	hsa-miR-4436a	CLIP-seq
MIRT866917	hsa-miR-4448	CLIP-seq
MIRT866918	hsa-miR-4505	CLIP-seq
MIRT866919	hsa-miR-4510	CLIP-seq
MIRT866920	hsa-miR-4516	CLIP-seq
MIRT866921	hsa-miR-4522	CLIP-seq
MIRT866922	hsa-miR-4651	CLIP-seq
MIRT866923	hsa-miR-4664-5p	CLIP-seq
MIRT866924	hsa-miR-4701-5p	CLIP-seq
MIRT866925	hsa-miR-4713-5p	CLIP-seq
MIRT866926	hsa-miR-4714-5p	CLIP-seq
MIRT866927	hsa-miR-4731-5p	CLIP-seq
MIRT866928	hsa-miR-4736	CLIP-seq
MIRT866929	hsa-miR-4763-3p	CLIP-seq
MIRT866930	hsa-miR-4764-3p	CLIP-seq
MIRT866931	hsa-miR-4786-3p	CLIP-seq
MIRT866932	hsa-miR-483-3p	CLIP-seq
MIRT866933	hsa-miR-532-3p	CLIP-seq
MIRT866934	hsa-miR-570	CLIP-seq
MIRT866935	hsa-miR-588	CLIP-seq
MIRT866936	hsa-miR-608	CLIP-seq
MIRT866937	hsa-miR-668	CLIP-seq
MIRT866938	hsa-miR-671-5p	CLIP-seq
MIRT866908	hsa-miR-296-5p	CLIP-seq
MIRT1546224	hsa-miR-3127-3p	CLIP-seq
MIRT1546225	hsa-miR-3189-3p	CLIP-seq
MIRT1546226	hsa-miR-635	CLIP-seq
MIRT866904	hsa-miR-1207-5p	CLIP-seq
MIRT1957242	hsa-miR-1227	CLIP-seq
MIRT1957243	hsa-miR-125a-5p	CLIP-seq
MIRT1957244	hsa-miR-125b	CLIP-seq
MIRT1957245	hsa-miR-1285	CLIP-seq
MIRT1957246	hsa-miR-146b-3p	CLIP-seq
MIRT1957247	hsa-miR-1587	CLIP-seq
MIRT866908	hsa-miR-296-5p	CLIP-seq
MIRT1546224	hsa-miR-3127-3p	CLIP-seq
MIRT1957248	hsa-miR-3173-3p	CLIP-seq
MIRT1957249	hsa-miR-3173-5p	CLIP-seq
MIRT1957250	hsa-miR-3177-3p	CLIP-seq
MIRT1957251	hsa-miR-3187-5p	CLIP-seq
MIRT1546225	hsa-miR-3189-3p	CLIP-seq
MIRT1957252	hsa-miR-3202	CLIP-seq
MIRT1957253	hsa-miR-326	CLIP-seq
MIRT1957254	hsa-miR-330-5p	CLIP-seq
MIRT866911	hsa-miR-361-3p	CLIP-seq
MIRT1957255	hsa-miR-3650	CLIP-seq
MIRT1957256	hsa-miR-3652	CLIP-seq
MIRT1957257	hsa-miR-378g	CLIP-seq
MIRT1957258	hsa-miR-3934	CLIP-seq
MIRT1957259	hsa-miR-3937	CLIP-seq
MIRT1957260	hsa-miR-4319	CLIP-seq
MIRT1957261	hsa-miR-4324	CLIP-seq
MIRT1957262	hsa-miR-4430	CLIP-seq
MIRT1957263	hsa-miR-4446-3p	CLIP-seq
MIRT1957264	hsa-miR-4486	CLIP-seq
MIRT1957265	hsa-miR-4487	CLIP-seq
MIRT1957266	hsa-miR-4492	CLIP-seq
MIRT1957267	hsa-miR-4498	CLIP-seq
MIRT1957268	hsa-miR-4533	CLIP-seq
MIRT1957269	hsa-miR-4641	CLIP-seq
MIRT1957270	hsa-miR-4645-5p	CLIP-seq
MIRT1957271	hsa-miR-4656	CLIP-seq
MIRT1957272	hsa-miR-4673	CLIP-seq
MIRT1957273	hsa-miR-4675	CLIP-seq
MIRT1957274	hsa-miR-4695-5p	CLIP-seq
MIRT1957275	hsa-miR-4729	CLIP-seq
MIRT866928	hsa-miR-4736	CLIP-seq
MIRT1957276	hsa-miR-4741	CLIP-seq
MIRT1957277	hsa-miR-4755-3p	CLIP-seq
MIRT866929	hsa-miR-4763-3p	CLIP-seq
MIRT1957278	hsa-miR-4763-5p	CLIP-seq
MIRT866931	hsa-miR-4786-3p	CLIP-seq
MIRT1957279	hsa-miR-558	CLIP-seq
MIRT1957280	hsa-miR-612	CLIP-seq
MIRT1957281	hsa-miR-617	CLIP-seq
MIRT1546226	hsa-miR-635	CLIP-seq
MIRT866938	hsa-miR-671-5p	CLIP-seq
MIRT1957282	hsa-miR-762	CLIP-seq
MIRT1957283	hsa-miR-874	CLIP-seq
MIRT2194208	hsa-miR-1193	CLIP-seq
MIRT2194209	hsa-miR-1202	CLIP-seq
MIRT1957242	hsa-miR-1227	CLIP-seq
MIRT1957245	hsa-miR-1285	CLIP-seq
MIRT2194210	hsa-miR-1293	CLIP-seq
MIRT1957247	hsa-miR-1587	CLIP-seq
MIRT2194211	hsa-miR-218	CLIP-seq
MIRT2194212	hsa-miR-219-2-3p	CLIP-seq
MIRT2194213	hsa-miR-2277-3p	CLIP-seq
MIRT2194214	hsa-miR-2964a-3p	CLIP-seq
MIRT2194215	hsa-miR-298	CLIP-seq
MIRT2194216	hsa-miR-3125	CLIP-seq
MIRT1546224	hsa-miR-3127-3p	CLIP-seq
MIRT2194217	hsa-miR-3135b	CLIP-seq
MIRT2194218	hsa-miR-3150b-3p	CLIP-seq
MIRT1957251	hsa-miR-3187-5p	CLIP-seq
MIRT2194219	hsa-miR-3192	CLIP-seq
MIRT2194220	hsa-miR-3200-3p	CLIP-seq
MIRT866910	hsa-miR-345	CLIP-seq
MIRT866911	hsa-miR-361-3p	CLIP-seq
MIRT2194221	hsa-miR-3616-3p	CLIP-seq
MIRT2194222	hsa-miR-3658	CLIP-seq
MIRT2194223	hsa-miR-3660	CLIP-seq
MIRT2194224	hsa-miR-3663-3p	CLIP-seq
MIRT2194225	hsa-miR-3689d	CLIP-seq
MIRT2194226	hsa-miR-3916	CLIP-seq
MIRT1957259	hsa-miR-3937	CLIP-seq
MIRT2194227	hsa-miR-3972	CLIP-seq
MIRT2194228	hsa-miR-4254	CLIP-seq
MIRT2194229	hsa-miR-4314	CLIP-seq
MIRT2194230	hsa-miR-4417	CLIP-seq
MIRT2194231	hsa-miR-4436b-3p	CLIP-seq
MIRT2194232	hsa-miR-4447	CLIP-seq
MIRT2194233	hsa-miR-4472	CLIP-seq
MIRT2194234	hsa-miR-4483	CLIP-seq
MIRT1957266	hsa-miR-4492	CLIP-seq
MIRT1957267	hsa-miR-4498	CLIP-seq
MIRT866918	hsa-miR-4505	CLIP-seq
MIRT866921	hsa-miR-4522	CLIP-seq
MIRT2194235	hsa-miR-4526	CLIP-seq
MIRT1957270	hsa-miR-4645-5p	CLIP-seq
MIRT2194236	hsa-miR-4646-5p	CLIP-seq
MIRT866922	hsa-miR-4651	CLIP-seq
MIRT1957271	hsa-miR-4656	CLIP-seq
MIRT1957272	hsa-miR-4673	CLIP-seq
MIRT1957273	hsa-miR-4675	CLIP-seq
MIRT2194237	hsa-miR-4680-3p	CLIP-seq
MIRT2194238	hsa-miR-4709-5p	CLIP-seq
MIRT866926	hsa-miR-4714-5p	CLIP-seq
MIRT2194239	hsa-miR-4722-3p	CLIP-seq
MIRT2194240	hsa-miR-4728-5p	CLIP-seq
MIRT1957275	hsa-miR-4729	CLIP-seq
MIRT866927	hsa-miR-4731-5p	CLIP-seq
MIRT1957276	hsa-miR-4741	CLIP-seq
MIRT2194241	hsa-miR-4747-5p	CLIP-seq
MIRT1957277	hsa-miR-4755-3p	CLIP-seq
MIRT866930	hsa-miR-4764-3p	CLIP-seq
MIRT2194242	hsa-miR-4784	CLIP-seq
MIRT2194243	hsa-miR-4799-5p	CLIP-seq
MIRT2194244	hsa-miR-486-3p	CLIP-seq
MIRT2194245	hsa-miR-505	CLIP-seq
MIRT2194246	hsa-miR-541	CLIP-seq
MIRT2194247	hsa-miR-548an	CLIP-seq
MIRT866936	hsa-miR-608	CLIP-seq
MIRT1957280	hsa-miR-612	CLIP-seq
MIRT2194248	hsa-miR-637	CLIP-seq
MIRT2194249	hsa-miR-654-5p	CLIP-seq
MIRT866938	hsa-miR-671-5p	CLIP-seq
MIRT1957282	hsa-miR-762	CLIP-seq
MIRT2194250	hsa-miR-877	CLIP-seq
MIRT1957242	hsa-miR-1227	CLIP-seq
MIRT1957258	hsa-miR-3934	CLIP-seq
MIRT2194232	hsa-miR-4447	CLIP-seq
MIRT2194233	hsa-miR-4472	CLIP-seq
MIRT866922	hsa-miR-4651	CLIP-seq
MIRT1957277	hsa-miR-4755-3p	CLIP-seq
MIRT2385594	hsa-miR-544	CLIP-seq
MIRT866936	hsa-miR-608	CLIP-seq
MIRT2194208	hsa-miR-1193	CLIP-seq
MIRT2194215	hsa-miR-298	CLIP-seq
MIRT2446270	hsa-miR-3150a-3p	CLIP-seq
MIRT2446271	hsa-miR-3175	CLIP-seq
MIRT2194240	hsa-miR-4728-5p	CLIP-seq
MIRT2446272	hsa-miR-939	CLIP-seq
MIRT2497656	hsa-miR-1207-3p	CLIP-seq
MIRT2497657	hsa-miR-3661	CLIP-seq
MIRT2497658	hsa-miR-4456	CLIP-seq
MIRT866924	hsa-miR-4701-5p	CLIP-seq
MIRT2497659	hsa-miR-4786-5p	CLIP-seq
MIRT866935	hsa-miR-588	CLIP-seq
MIRT2497660	hsa-miR-631	CLIP-seq
MIRT2497661	hsa-miR-769-5p	CLIP-seq

Show/Hide all (15)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IBA
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IMP	19636380, 21282530
GO:0000785	Component	Chromatin	IDA	19636380
GO:0005515	Function	Protein binding	IPI	10369680, 17332741, 18927235, 19636380, 20543829, 20601937, 20696397, 21282530, 23523425, 24981860, 27705803, 28514442, 32296183, 33961781
GO:0005634	Component	Nucleus	IDA	21282530
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005829	Component	Cytosol	IDA
GO:0006325	Process	Chromatin organization	IEA
GO:0031519	Component	PcG protein complex	IBA
GO:0031519	Component	PcG protein complex	IDA	21282530
GO:0031519	Component	PcG protein complex	IEA
GO:0035102	Component	PRC1 complex	IEA
GO:0035102	Component	PRC1 complex	ISS

MIM	HGNC	e!Ensembl
608457	1557	ENSG00000100307

O95931

Protein name

Chromobox protein homolog 7

Protein function

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remod

PDB

2K1B , 2L12 , 2L1B , 3GS2 , 4MN3 , 5EPJ , 6V2R , 8SII

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00385	Chromo	11 → 60	Chromo (CHRromatin Organisation MOdifier) domain	Domain
PF17218	CBX7_C	209 → 240	CBX family C-terminal motif	Motif

Sequence

MELSAIGEQVFAVESIRKKRVRKGKVEYLVKWKGWPPKYSTWEPEEHILDPRLVMAYEEK
EERDRASGYRKRGPKPKRLLLQRLYSMDLRSSHKAKGKEKLCFSLTCPLGSGSPEGVVKA
GAPELVDKGPLVPTLPFPLRKPRKAHKYLRLSRKKFPPRGPNLESHSHRRELFLQEPPAP
DVLQAAGEWEPAAQPPEEEADADLAEGPPPWTPALPSSEVTVTDITANSITVTFREAQAA
EGFFRDRSGKF

Sequence length

251

Interactions

View interactions

	KEGG
	Polycomb repressive complex

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Prostate cancer	Uncertain significance	rs193920857	RCV000149370

Show/Hide Text Mining Associations (39)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma	Associate	36221371
Adenocarcinoma of Lung	Inhibit	36183965
Astrocytoma	Associate	24260522
Brain Neoplasms	Associate	34008756
Breast Neoplasms	Associate	27102007, 33400401
Breast Neoplasms	Inhibit	33082469
Carcinoma Embryonal	Associate	19602592
Carcinoma Hepatocellular	Associate	30481161, 31211140
Carcinoma Hepatocellular	Inhibit	31211140
Carcinoma Intraductal Noninfiltrating	Associate	21375733
Carcinoma Squamous Cell	Inhibit	36183965
Carcinoma Transitional Cell	Associate	25596753
Colonic Neoplasms	Inhibit	36183965
Colorectal Neoplasms	Associate	32953885
Ependymoma	Associate	15701279
Esophageal Neoplasms	Associate	36221371
Gastritis Atrophic	Associate	30249557
Glioblastoma	Associate	24260522, 35210369
Glioblastoma	Inhibit	27291091
Glioma	Inhibit	27291091
Hematologic Neoplasms	Associate	23955597
Leukemia	Associate	39613290
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	26343356
Leukemia Myeloid Acute	Associate	36081495
Lymphatic Metastasis	Stimulate	20723236
Lymphoma	Stimulate	20723236
Melanoma Cutaneous Malignant	Associate	32860274
Monoclonal Gammopathy of Undetermined Significance	Associate	24449210
Multiple Myeloma	Associate	23955597, 24449210
Neoplasm Metastasis	Inhibit	33344640
Neoplasms	Associate	18984978, 19602592, 29422082, 32205869, 34008756, 36361869
Neoplasms	Inhibit	20723236, 25595895, 32860274, 33082469, 33344640
Ovarian Neoplasms	Associate	32205869, 32495862
Prostatic Neoplasms	Associate	33245100
Stomach Neoplasms	Associate	20723236, 21060834, 29422082, 34117289, 35969177
Stomach Neoplasms	Inhibit	30249557
Urethral Neoplasms	Inhibit	18984978
Urinary Bladder Neoplasms	Associate	18984978
Urinary Bladder Neoplasms	Stimulate	25596753

CBX7 (chromobox 7)