Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
23484
Gene name Gene Name - the full gene name approved by the HGNC.
Leptin receptor overlapping transcript like 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
LEPROTL1
Synonyms (NCBI Gene) Gene synonyms aliases
HSPC112, Vps55, my047
Chromosome Chromosome number
8
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
8p12
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT019497 hsa-miR-148b-3p Microarray 17612493
MIRT020070 hsa-miR-375 qRT-PCR;Microarray 20584986
MIRT026914 hsa-miR-192-5p Microarray 19074876
MIRT027842 hsa-miR-98-5p Microarray 19088304
MIRT045520 hsa-miR-149-5p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 16189514, 31515488, 32296183
GO:0005768 Component Endosome IBA 21873635
GO:0016021 Component Integral component of membrane IEA
GO:0032511 Process Late endosome to vacuole transport via multivesicular body sorting pathway IBA 21873635
GO:0042802 Function Identical protein binding IPI 32296183
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
607338 6555 ENSG00000104660
Protein
UniProt ID O95214
Protein name Leptin receptor overlapping transcript-like 1 (Endospanin-2)
Protein function Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF04133 Vps55 7 124 Vacuolar protein sorting 55 Family
Tissue specificity TISSUE SPECIFICITY: Widely expressed, with highest expression in heart, testis, adrenal gland, thymus, and spleen, and lowest expression in lung and skeletal muscle.
Sequence
Sequence length 131
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Migraine Migraine Disorders rs794727411 23793025
Unknown
Disease term Disease name Evidence References Source
Psoriasis Psoriasis GWAS
Associations from Text Mining
Disease Name Relationship Type References
Breast Neoplasms Associate 35115550
Urinary Bladder Neoplasms Associate 36658180, 40043910