Gene Gene information from NCBI Gene database.
Entrez ID 23452
Gene name Angiopoietin like 2
Gene symbol ANGPTL2
Synonyms (NCBI Gene)
ARP2HARP
Chromosome 9
Chromosome location 9q33.3
Summary Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. Angiopoietin-1, angiopoietin-2, and angiopoietin-4 participate in the formation of blood vessels. ANGPT
miRNA miRNA information provided by mirtarbase database.
443
miRTarBase ID miRNA Experiments Reference
MIRT624758 hsa-miR-211-5p HITS-CLIP 23824327
MIRT624757 hsa-miR-204-5p HITS-CLIP 23824327
MIRT624756 hsa-miR-548ac HITS-CLIP 23824327
MIRT624755 hsa-miR-548bb-3p HITS-CLIP 23824327
MIRT624754 hsa-miR-548d-3p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
11
GO ID Ontology Definition Evidence Reference
GO:0005102 Function Signaling receptor binding IBA
GO:0005102 Function Signaling receptor binding TAS 10473614
GO:0005515 Function Protein binding IPI 22660330, 24899623
GO:0005576 Component Extracellular region IEA
GO:0005615 Component Extracellular space IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
605001 490 ENSG00000136859
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9UKU9
Protein name Angiopoietin-related protein 2 (Angiopoietin-like protein 2)
Protein function Induces sprouting in endothelial cells through an autocrine and paracrine action.
PDB 6Y41
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00147 Fibrinogen_C 274 488 Fibrinogen beta and gamma chains, C-terminal globular domain Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed in heart, small intestine, spleen and stomach. Also found in lower levels in colon, ovary, adrenal gland, skeletal muscle and in prostate.
Sequence
MRPLCVTCWWLGLLAAMGAVAGQEDGFEGTEEGSPREFIYLNRYKRAGESQDKCTYTFIV
PQQRVTGAICVNSKEPEVLLENRVHKQELELLNNELLKQKRQIETLQQLVEVDGGIVSEV
KLLRKESRNMNSRVTQLYMQLLHEIIRKRDNALELSQLENRILNQTADMLQLASKYKDLE
HKYQHLATLAHNQSEIIAQLEEHCQRVPSARPVPQPPPAAPPRVYQPPTYNRIINQISTN
EIQSDQNLKVLPPPLPTMPTLTSLPSSTDKPSGPWRDCLQALEDGHDTSSIYLVKPENTN
RLMQVWCDQRHDPGGWTVIQRRLDGSVNFFRNWETYKQGFGNIDGEYWLGLENIYWLTNQ
GNYKLLVTMEDWSGRKVFAEYASFRLEPESEYYKLRLGRYHGNAGDSFTWHNGKQFTTLD
RDHDVYTGNCAHYQKGGWWYNACAHSNLNGVWYRGGHYRSRYQDGVYWAEFRGGSYSLKK
VVMMIRPN
PNTFH
Sequence length 493
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
4
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
BENIGN NEOPLASM GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
MOUTH NEOPLASM GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
OPEN-ANGLE GLAUCOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma Uncertain significance ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Acute Coronary Syndrome Associate 27101308, 30461060, 39702007
★☆☆☆☆
Found in Text Mining only
Atherosclerosis Stimulate 39702007
★☆☆☆☆
Found in Text Mining only
Atrial Fibrillation Associate 34737791
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Associate 34228231, 34685578
★☆☆☆☆
Found in Text Mining only
Carcinogenesis Associate 25287946
★☆☆☆☆
Found in Text Mining only
Carcinoma Basal Cell Associate 17273163
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Associate 35692877
★☆☆☆☆
Found in Text Mining only
Carcinoma Non Small Cell Lung Associate 26056041
★☆☆☆☆
Found in Text Mining only
Carcinoma Pancreatic Ductal Associate 25360865
★☆☆☆☆
Found in Text Mining only
Carcinoma Renal Cell Associate 11720477
★☆☆☆☆
Found in Text Mining only