CELA3B (chymotrypsin like elastase 3B)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
23436
Gene name Gene Name - the full gene name approved by the HGNC.
Chymotrypsin like elastase 3B
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CELA3B
Synonyms (NCBI Gene) Gene synonyms aliases
CBPP, ELA3B
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1p36.12
Summary Summary of gene provided in NCBI Entrez Gene.
Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3B has li
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(2)
miRTarBase ID miRNA Experiments Reference
MIRT019053 hsa-miR-335-5p Microarray 18185580
MIRT030228 hsa-miR-26b-5p Microarray 19088304
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(5)
GO ID Ontology Definition Evidence Reference
GO:0004252 Function Serine-type endopeptidase activity IBA 21873635
GO:0004252 Function Serine-type endopeptidase activity NAS 2737288
GO:0005615 Component Extracellular space IBA 21873635
GO:0006508 Process Proteolysis IBA 21873635
GO:0008233 Function Peptidase activity TAS 2460440
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
618694 15945 ENSG00000219073
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P08861
Protein name Chymotrypsin-like elastase family member 3B (EC 3.4.21.70) (Elastase IIIB) (Elastase-3B) (Protease E)
Protein function Efficient protease with alanine specificity but only little elastolytic activity.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00089 Trypsin 29 → 263 Trypsin Domain
Tissue specificity TISSUE SPECIFICITY: Pancreas. Not detectable in keratinocytes. {ECO:0000269|PubMed:10620133}.
Sequence
Sequence length 270
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  
  Pancreatic secretion
Protein digestion and absorption 		 
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (3)
Unknown
Disease term Disease name Evidence References Source
Atrial Fibrillation Atrial Fibrillation GWAS
Inflammatory Bowel Disease Inflammatory Bowel Disease GWAS
Uterine Fibroids Uterine Fibroids GWAS
Show/Hide Text Mining Associations (3)
Associations from Text Mining
Disease Name Relationship Type References
Carcinoma Acinar Cell Associate 37379306
Pancreatic Neoplasms Associate 31917448, 37379306
Pancreatitis Chronic Associate 27999401, 35773178