Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene SNPs miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	23432
Gene name Gene Name - the full gene name approved by the HGNC.	G protein-coupled receptor 161
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	GPR161
Synonyms (NCBI Gene) Gene synonyms aliases	RE2
Chromosome Chromosome number	1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	1q24.2
Summary Summary of gene provided in NCBI Entrez Gene.	The protein encoded by this gene is an orphan G protein-coupled receptor whose ligand is unknown. This gene is overexpressed in triple-negative breast cancer, and disruption of this gene slows the proliferation of basal breast cancer cells. Therefore, thi

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SNP ID	Visualize variation	Clinical significance	Consequence
rs200635937	A>T	Uncertain-significance, likely-pathogenic	Missense variant, intron variant, coding sequence variant, 5 prime UTR variant

Show/Hide all(51)

miRTarBase ID	miRNA	Experiments	Reference
MIRT022199	hsa-miR-124-3p	Microarray	18668037
MIRT1030851	hsa-miR-101	CLIP-seq
MIRT1030852	hsa-miR-1183	CLIP-seq
MIRT1030853	hsa-miR-1269	CLIP-seq
MIRT1030854	hsa-miR-1269b	CLIP-seq
MIRT1030855	hsa-miR-127-5p	CLIP-seq
MIRT1030856	hsa-miR-128	CLIP-seq
MIRT1030857	hsa-miR-1288	CLIP-seq
MIRT1030858	hsa-miR-1910	CLIP-seq
MIRT1030859	hsa-miR-203	CLIP-seq
MIRT1030860	hsa-miR-205	CLIP-seq
MIRT1030861	hsa-miR-2355-3p	CLIP-seq
MIRT1030862	hsa-miR-27a	CLIP-seq
MIRT1030863	hsa-miR-27b	CLIP-seq
MIRT1030864	hsa-miR-3133	CLIP-seq
MIRT1030865	hsa-miR-3138	CLIP-seq
MIRT1030866	hsa-miR-4456	CLIP-seq
MIRT1030867	hsa-miR-4511	CLIP-seq
MIRT1030868	hsa-miR-4515	CLIP-seq
MIRT1030869	hsa-miR-455-3p	CLIP-seq
MIRT1030870	hsa-miR-4728-3p	CLIP-seq
MIRT1030871	hsa-miR-4740-5p	CLIP-seq
MIRT1030872	hsa-miR-4793-5p	CLIP-seq
MIRT1030873	hsa-miR-4800-5p	CLIP-seq
MIRT1030874	hsa-miR-513a-5p	CLIP-seq
MIRT1030875	hsa-miR-592	CLIP-seq
MIRT1030876	hsa-miR-597	CLIP-seq
MIRT1030877	hsa-miR-604	CLIP-seq
MIRT1030878	hsa-miR-647	CLIP-seq
MIRT1030879	hsa-miR-676	CLIP-seq
MIRT1030872	hsa-miR-4793-5p	CLIP-seq
MIRT2542430	hsa-miR-1184	CLIP-seq
MIRT2542431	hsa-miR-1266	CLIP-seq
MIRT2542432	hsa-miR-3155	CLIP-seq
MIRT2542433	hsa-miR-3155b	CLIP-seq
MIRT2542434	hsa-miR-3194-5p	CLIP-seq
MIRT2542435	hsa-miR-3664-3p	CLIP-seq
MIRT2542436	hsa-miR-4518	CLIP-seq
MIRT2542437	hsa-miR-4640-5p	CLIP-seq
MIRT2542438	hsa-miR-4726-5p	CLIP-seq
MIRT2542439	hsa-miR-484	CLIP-seq
MIRT2542430	hsa-miR-1184	CLIP-seq
MIRT2542431	hsa-miR-1266	CLIP-seq
MIRT2542432	hsa-miR-3155	CLIP-seq
MIRT2542433	hsa-miR-3155b	CLIP-seq
MIRT2542434	hsa-miR-3194-5p	CLIP-seq
MIRT2542435	hsa-miR-3664-3p	CLIP-seq
MIRT2542436	hsa-miR-4518	CLIP-seq
MIRT2542437	hsa-miR-4640-5p	CLIP-seq
MIRT2542438	hsa-miR-4726-5p	CLIP-seq
MIRT2542439	hsa-miR-484	CLIP-seq

Show/Hide all(19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004930	Function	G protein-coupled receptor activity	IBA
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004930	Function	G protein-coupled receptor activity	ISS
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005886	Component	Plasma membrane	IEA
GO:0005929	Component	Cilium	IEA
GO:0005929	Component	Cilium	ISS
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IBA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISS
GO:0016020	Component	Membrane	IEA
GO:0030666	Component	Endocytic vesicle membrane	TAS
GO:0042995	Component	Cell projection	IEA
GO:0055037	Component	Recycling endosome	IBA
GO:0055037	Component	Recycling endosome	ISS
GO:0060170	Component	Ciliary membrane	IEA
GO:0060170	Component	Ciliary membrane	TAS
GO:1901621	Process	Negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning	ISS

MIM	HGNC	e!Ensembl
612250	23694	ENSG00000143147

Protein

UniProt ID

Q8N6U8

Protein name

G-protein coupled receptor 161 (G-protein coupled receptor RE2)

Protein function

Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression mac

PDB

8KH4 , 8SMV

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00001	7tm_1	44 → 324	7 transmembrane receptor (rhodopsin family)	Family

Sequence

MSLNSSLSCRKELSNLTEEEGGEGGVIITQFIAIIVITIFVCLGNLVIVVTLYKKSYLLT
LSNKFVFSLTLSNFLLSVLVLPFVVTSSIRREWIFGVVWCNFSALLYLLISSASMLTLGV
IAIDRYYAVLYPMVYPMKITGNRAVMALVYIWLHSLIGCLPPLFGWSSVEFDEFKWMCVA
AWHREPGYTAFWQIWCALFPFLVMLVCYGFIFRVARVKARKVHCGTVVIVEEDAQRTGRK
NSSTSTSSSGSRRNAFQGVVYSANQCKALITILVVLGAFMVTWGPYMVVIASEALWGKSS
VSPSLETWATWLSFASAVCHPLIYGLWNKTVRKELLGMCFGDRYYREPFVQRQRTSRLFS
ISNRITDLGLSPHLTALMAGGQPLGHSSSTGDTGFSCSQDSGTDMMLLEDYTSDDNPPSH
CTCPPKRRSSVTFEDEVEQIKEAAKNSILHVKAEVHKSLDSYAASLAKAIEAEAKINLFG
EEALPGVLVTARTVPGGGFGGRRGSRTLVSQRLQLQSIEEGDVLAAEQR

Sequence length

529

Interactions

View interactions

	KEGG		Reactome
	Hedgehog signaling pathway		Hedgehog 'off' state Hedgehog 'on' state

Show/Hide Unknown Diseases (3)

Disease merge term	Disease name	Evidence	References	Source
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Breast Cancer	Breast cancer	N/A	N/A	GWAS
Medulloblastoma	medulloblastoma	N/A	N/A	ClinVar
Pituitary Stalk Interruption Syndrome	pituitary stalk interruption syndrome	N/A	N/A	ClinVar, GenCC

Show/Hide Text Mining Associations (7)

Disease Name	Relationship Type	References
Associations from Text Mining Disease associations identified through Pubtator
Basal Cell Nevus Syndrome	Associate	36961676
Breast Neoplasms	Associate	24599592, 8662988
Huntington Disease	Associate	32898862
Medulloblastoma	Associate	31609649, 32056145, 36961676
Neoplasms	Associate	31609649
Pneumonia	Associate	37327587
Triple Negative Breast Neoplasms	Stimulate	24599592

GPR161 (G protein-coupled receptor 161)