GPR161 (G protein-coupled receptor 161)

Gene

• Entrez ID: 23432
• Gene name: G protein-coupled receptor 161
• Gene symbol: GPR161
• Synonyms (NCBI Gene): RE2
• Chromosome: 1
• Chromosome location: 1q24.2
• Summary: The protein encoded by this gene is an orphan G protein-coupled receptor whose ligand is unknown. This gene is overexpressed in triple-negative breast cancer, and disruption of this gene slows the proliferation of basal breast cancer cells. Therefore, thi

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs200635937	A>T	Uncertain-significance, likely-pathogenic	Missense variant, intron variant, coding sequence variant, 5 prime UTR variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT022199	hsa-miR-124-3p	Microarray	18668037
MIRT1030851	hsa-miR-101	CLIP-seq
MIRT1030852	hsa-miR-1183	CLIP-seq
MIRT1030853	hsa-miR-1269	CLIP-seq
MIRT1030854	hsa-miR-1269b	CLIP-seq
MIRT1030855	hsa-miR-127-5p	CLIP-seq
MIRT1030856	hsa-miR-128	CLIP-seq
MIRT1030857	hsa-miR-1288	CLIP-seq
MIRT1030858	hsa-miR-1910	CLIP-seq
MIRT1030859	hsa-miR-203	CLIP-seq
MIRT1030860	hsa-miR-205	CLIP-seq
MIRT1030861	hsa-miR-2355-3p	CLIP-seq
MIRT1030862	hsa-miR-27a	CLIP-seq
MIRT1030863	hsa-miR-27b	CLIP-seq
MIRT1030864	hsa-miR-3133	CLIP-seq
MIRT1030865	hsa-miR-3138	CLIP-seq
MIRT1030866	hsa-miR-4456	CLIP-seq
MIRT1030867	hsa-miR-4511	CLIP-seq
MIRT1030868	hsa-miR-4515	CLIP-seq
MIRT1030869	hsa-miR-455-3p	CLIP-seq
MIRT1030870	hsa-miR-4728-3p	CLIP-seq
MIRT1030871	hsa-miR-4740-5p	CLIP-seq
MIRT1030872	hsa-miR-4793-5p	CLIP-seq
MIRT1030873	hsa-miR-4800-5p	CLIP-seq
MIRT1030874	hsa-miR-513a-5p	CLIP-seq
MIRT1030875	hsa-miR-592	CLIP-seq
MIRT1030876	hsa-miR-597	CLIP-seq
MIRT1030877	hsa-miR-604	CLIP-seq
MIRT1030878	hsa-miR-647	CLIP-seq
MIRT1030879	hsa-miR-676	CLIP-seq
MIRT1030872	hsa-miR-4793-5p	CLIP-seq
MIRT2542430	hsa-miR-1184	CLIP-seq
MIRT2542431	hsa-miR-1266	CLIP-seq
MIRT2542432	hsa-miR-3155	CLIP-seq
MIRT2542433	hsa-miR-3155b	CLIP-seq
MIRT2542434	hsa-miR-3194-5p	CLIP-seq
MIRT2542435	hsa-miR-3664-3p	CLIP-seq
MIRT2542436	hsa-miR-4518	CLIP-seq
MIRT2542437	hsa-miR-4640-5p	CLIP-seq
MIRT2542438	hsa-miR-4726-5p	CLIP-seq
MIRT2542439	hsa-miR-484	CLIP-seq
MIRT2542430	hsa-miR-1184	CLIP-seq
MIRT2542431	hsa-miR-1266	CLIP-seq
MIRT2542432	hsa-miR-3155	CLIP-seq
MIRT2542433	hsa-miR-3155b	CLIP-seq
MIRT2542434	hsa-miR-3194-5p	CLIP-seq
MIRT2542435	hsa-miR-3664-3p	CLIP-seq
MIRT2542436	hsa-miR-4518	CLIP-seq
MIRT2542437	hsa-miR-4640-5p	CLIP-seq
MIRT2542438	hsa-miR-4726-5p	CLIP-seq
MIRT2542439	hsa-miR-484	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004930	Function	G protein-coupled receptor activity	IBA
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004930	Function	G protein-coupled receptor activity	ISS
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005886	Component	Plasma membrane	IEA
GO:0005929	Component	Cilium	IEA
GO:0005929	Component	Cilium	ISS
GO:0007165	Process	Signal transduction	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IBA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISS
GO:0016020	Component	Membrane	IEA
GO:0030666	Component	Endocytic vesicle membrane	TAS
GO:0042995	Component	Cell projection	IEA
GO:0055037	Component	Recycling endosome	IBA
GO:0055037	Component	Recycling endosome	ISS
GO:0060170	Component	Ciliary membrane	IEA
GO:0060170	Component	Ciliary membrane	TAS
GO:1901621	Process	Negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning	ISS

Other IDs

• MIM: 612250
• HGNC: 23694
• e!Ensembl: ENSG00000143147

Protein

• UniProt ID: Q8N6U8
• Protein name: G-protein coupled receptor 161 (G-protein coupled receptor RE2)
• Protein function: Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression mac
• PDB: 8KH4, 8SMV
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00001	7tm_1	44 → 324	7 transmembrane receptor (rhodopsin family)	Family

• Sequence:

  MSLNSSLSCRKELSNLTEEEGGEGGVIITQFIAIIVITIFVCLGNLVIVVTLYKKSYLLT
  LSNKFVFSLTLSNFLLSVLVLPFVVTSSIRREWIFGVVWCNFSALLYLLISSASMLTLGV
  IAIDRYYAVLYPMVYPMKITGNRAVMALVYIWLHSLIGCLPPLFGWSSVEFDEFKWMCVA
  AWHREPGYTAFWQIWCALFPFLVMLVCYGFIFRVARVKARKVHCGTVVIVEEDAQRTGRK
  NSSTSTSSSGSRRNAFQGVVYSANQCKALITILVVLGAFMVTWGPYMVVIASEALWGKSS
  VSPSLETWATWLSFASAVCHPLIYGLWNKTVRKELLGMCFGDRYYREPFVQRQRTSRLFS
  ISNRITDLGLSPHLTALMAGGQPLGHSSSTGDTGFSCSQDSGTDMMLLEDYTSDDNPPSH
  CTCPPKRRSSVTFEDEVEQIKEAAKNSILHVKAEVHKSLDSYAASLAKAIEAEAKINLFG
  EEALPGVLVTARTVPGGGFGGRRGSRTLVSQRLQLQSIEEGDVLAAEQR

• Sequence length: 529

Pathways

KEGG:

Hedgehog signaling pathway

Reactome:

Hedgehog 'off' state
Hedgehog 'on' state

Associated diseases

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Medulloblastoma	Pathogenic	rs147891461	RCV002291250

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Familial pancreatic carcinoma	Benign	rs73030230	RCV005920604
GPR161-related disorder	Likely benign	rs147976800	RCV003972300
Nonpapillary renal cell carcinoma	Benign	rs73030230	RCV005920602
Ovarian cancer	Benign	rs73030230	RCV005920603
Pituitary stalk interruption syndrome	Conflicting classifications of pathogenicity	rs200635937	RCV000202520
Predisposition to medulloblastoma	Uncertain significance	rs767007902	RCV002292261
Thymoma	Benign	rs73030230, rs34499666	RCV005920605 RCV005911690

Associations from Text Mining
Disease Name	Relationship Type	References
Basal Cell Nevus Syndrome	Associate	36961676
Breast Neoplasms	Associate	24599592, 8662988
Huntington Disease	Associate	32898862
Medulloblastoma	Associate	31609649, 32056145, 36961676
Neoplasms	Associate	31609649
Pneumonia	Associate	37327587
Triple Negative Breast Neoplasms	Stimulate	24599592