ITGB3BP (integrin subunit beta 3 binding protein)

Gene Gene information from NCBI Gene database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
Entrez ID 23421
Gene name Integrin subunit beta 3 binding protein
Gene symbol ITGB3BP
Synonyms (NCBI Gene)
CENP-RCENPRHSU37139NRIF3TAP20
Chromosome 1
Chromosome location 1p31.3
Summary This gene encodes a transcriptional coregulator that binds to and enhances the activity of members of the nuclear receptor families, thyroid hormone receptors and retinoid X receptors. This protein also acts as a corepressor of NF-kappaB-dependent signali
miRNA miRNA information provided by mirtarbase database.
17
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
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miRTarBase ID miRNA Experiments Reference
MIRT045781 hsa-miR-9-5p CLASH 23622248
MIRT528580 hsa-miR-3156-5p PAR-CLIP 22012620
MIRT528579 hsa-miR-224-5p PAR-CLIP 22012620
MIRT528578 hsa-miR-7161-3p PAR-CLIP 22012620
MIRT528577 hsa-miR-4491 PAR-CLIP 22012620
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
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Transcription factor Regulation Reference
MTA1 Unknown 15254226
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
25
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
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GO ID Ontology Definition Evidence Reference
GO:0000775 Component Chromosome, centromeric region IEA
GO:0000776 Component Kinetochore IEA
GO:0000939 Component Inner kinetochore IPI 36085283
GO:0005515 Function Protein binding IPI 16189514, 25416956, 26496610, 31515488, 32296183, 32814053, 33961781
GO:0005515 Function Protein binding TAS 10490654
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
MIM HGNC e!Ensembl
605494 6157 ENSG00000142856
Protein Protein information from UniProt database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q13352
Protein name Centromere protein R (CENP-R) (Beta-3-endonexin) (Integrin beta-3-binding protein) (Nuclear receptor-interacting factor 3)
Protein function Transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fas
PDB 7PB8 , 7PKN , 7QOO , 7R5S , 7R5V , 7XHN , 7XHO , 7YWX , 7YYH
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF06729 CENP-R 25 → 162 Kinetochore component, CENP-R Family
Tissue specificity TISSUE SPECIFICITY: Widely expressed. Expressed in spleen, thymus, prostate, ovary, small intestine and white blood cells. Highly expressed in testis and colon. Isoform 4 is expressed in platelets, lymphocytes and granulocytes. {ECO:0000269|PubMed:1186470
Sequence
Sequence length 177
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways
  Reactome
    Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
NRIF signals cell death from the nucleus
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Deposition of new CENPA-containing nucleosomes at the centromere
Mitotic Prometaphase
EML4 and NUDC in mitotic spindle formation