Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
|
23413
|
Gene name
Gene Name - the full gene name approved by the HGNC.
|
Neuronal calcium sensor 1 |
Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
|
NCS1 |
Synonyms (NCBI Gene)
Gene synonyms aliases
|
FLUP, FREQ |
Chromosome
Chromosome number
|
9 |
Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
|
9q34.11 |
Summary
Summary of gene provided in NCBI Entrez Gene.
|
This gene is a member of the neuronal calcium sensor gene family, which encode calcium-binding proteins expressed predominantly in neurons. The protein encoded by this gene regulates G protein-coupled receptor phosphorylation in a calcium-dependent manner |
UniProt ID |
P62166
|
Protein name |
Neuronal calcium sensor 1 (NCS-1) (Frequenin homolog) (Frequenin-like protein) (Frequenin-like ubiquitous protein) |
Protein function |
Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity). Stimulates PI4KB kinase activity |
PDB |
1G8I
,
2LCP
,
4GUK
,
5O9S
,
6QI4
,
8AHY
,
8ALH
,
8ALM
|
Family and domains |
Pfam
Accession |
ID |
Position in sequence |
Description |
Type |
PF00036
|
EF-hand_1 |
65 → 92 |
EF hand |
Domain |
PF13499
|
EF-hand_7 |
98 → 174 |
EF-hand domain pair |
Domain |
PF00036
|
EF-hand_1 |
148 → 175 |
EF hand |
Domain |
|
Sequence |
|
Sequence length |
190 |
Interactions |
View interactions
|
Causal |
Disease term |
Disease name |
dbSNP ID |
References |
Alzheimer disease |
Alzheimer`s Disease |
rs63750215, rs28936379, rs63749851, rs63749884, rs28936380, rs63750048, rs63750579, rs63750264, rs63749964, rs63750671, rs281865161, rs63750066, rs63750399, rs63750734, rs63751039, rs63750973, rs63749810, rs63750643, rs193922916, rs63750306, rs63750590, rs63750526, rs63751235, rs661, rs63751037, rs63749885, rs63750231, rs63751229, rs63751272, rs63751223, rs63750391, rs63751163, rs281875357, rs63751141, rs63750082, rs121917807, rs63751399, rs63750265, rs63751144, rs63750886, rs63751068, rs121917808, rs63749891, rs63750083, rs63749824, rs63750577, rs267606983, rs63750218, rs63751287, rs63750900, rs63751475, rs63750450, rs63749805, rs63751278, rs63751106, rs63750004, rs63749806, rs63751024, rs63750248, rs63750779, rs63751139, rs63750219, rs63750298, rs63750687, rs63750851, rs1553268799, rs1561901881, rs1561905293, rs866101707, rs1566638673, rs63750009, rs1566656702, rs1566657804, rs1567885728, rs1568339995, rs1566630791, rs1555358260, rs63750964, rs1594998354, rs63751316 View all (65 more) |
23535033 |
Schizophrenia |
Schizophrenia |
rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346, rs863223347, rs863223351, rs863223352, rs61734270, rs797045205, rs869312829, rs869312830, rs770913157, rs869312832, rs869312831, rs781720548, rs1262969313 View all (12 more) |
15364041, 24631552 |
|
Unknown |
Disease term |
Disease name |
Evidence |
References |
Source |
Insomnia |
Insomnia |
|
|
GWAS |
|
|