Gene Gene information from NCBI Gene database.
Entrez ID 23413
Gene name Neuronal calcium sensor 1
Gene symbol NCS1
Synonyms (NCBI Gene)
FLUPFREQ
Chromosome 9
Chromosome location 9q34.11
Summary This gene is a member of the neuronal calcium sensor gene family, which encode calcium-binding proteins expressed predominantly in neurons. The protein encoded by this gene regulates G protein-coupled receptor phosphorylation in a calcium-dependent manner
miRNA miRNA information provided by mirtarbase database.
523
miRTarBase ID miRNA Experiments Reference
MIRT019373 hsa-miR-148b-3p Microarray 17612493
MIRT021815 hsa-miR-132-3p Microarray 17612493
MIRT023761 hsa-miR-1-3p Proteomics 18668040
MIRT043837 hsa-miR-330-3p CLASH 23622248
MIRT043430 hsa-miR-331-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
22
GO ID Ontology Definition Evidence Reference
GO:0005245 Function Voltage-gated calcium channel activity ISS
GO:0005509 Function Calcium ion binding IBA
GO:0005509 Function Calcium ion binding IEA
GO:0005509 Function Calcium ion binding TAS 11092894
GO:0005515 Function Protein binding IPI 12783849, 16189514, 21516116, 25074811, 25416956, 28119500, 28514442, 29966094, 32296183, 33961781
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
603315 3953 ENSG00000107130
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P62166
Protein name Neuronal calcium sensor 1 (NCS-1) (Frequenin homolog) (Frequenin-like protein) (Frequenin-like ubiquitous protein)
Protein function Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity). Stimulates PI4KB kinase activity
PDB 1G8I , 2LCP , 4GUK , 5O9S , 6QI4 , 8AHY , 8ALH , 8ALM
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00036 EF-hand_1 65 92 EF hand Domain
PF13499 EF-hand_7 98 174 EF-hand domain pair Domain
PF00036 EF-hand_1 148 175 EF hand Domain
Sequence
MGKSNSKLKPEVVEELTRKTYFTEKEVQQWYKGFIKDCPSGQLDAAGFQKIYKQFFPFGD
PTKFATFVFNVFDENKDGRIEFSEFIQALSVTSRGTLDEKLRWAFKLYDLDNDGYITRNE
MLDIVDAIYQMVGNTVELPEEENTPEK
RVDRIFAMMDKNADGKLTLQEFQEGSKADPSIV
QALSLYDGLV
Sequence length 190
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
1
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Clear cell carcinoma of kidney Uncertain significance rs146218396 RCV005929002
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Breast Neoplasms Associate 28275088, 29789326, 31659121, 32239615, 38564162
Breast Neoplasms Stimulate 31647602
Carcinoma Hepatocellular Associate 29789326
Heredodegenerative Disorders Nervous System Associate 27575489
Inflammation Stimulate 32239615
Mental Disorders Associate 37984032
Necrosis Associate 31647602
Neoplasm Metastasis Associate 29789326, 32239615
Neoplasms Associate 28275088, 29789326, 38564162
Neoplasms Stimulate 32239615