Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
23413
Gene name Gene Name - the full gene name approved by the HGNC.
Neuronal calcium sensor 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
NCS1
Synonyms (NCBI Gene) Gene synonyms aliases
FLUP, FREQ
Chromosome Chromosome number
9
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
9q34.11
Summary Summary of gene provided in NCBI Entrez Gene.
This gene is a member of the neuronal calcium sensor gene family, which encode calcium-binding proteins expressed predominantly in neurons. The protein encoded by this gene regulates G protein-coupled receptor phosphorylation in a calcium-dependent manner
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT019373 hsa-miR-148b-3p Microarray 17612493
MIRT021815 hsa-miR-132-3p Microarray 17612493
MIRT023761 hsa-miR-1-3p Proteomics 18668040
MIRT043837 hsa-miR-330-3p CLASH 23622248
MIRT043430 hsa-miR-331-3p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000287 Function Magnesium ion binding IEA
GO:0005245 Function Voltage-gated calcium channel activity ISS
GO:0005509 Function Calcium ion binding TAS 11092894
GO:0005515 Function Protein binding IPI 12783849, 16189514, 21516116, 25416956, 32296183
GO:0005737 Component Cytoplasm IDA 12783849
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
603315 3953 ENSG00000107130
Protein
UniProt ID P62166
Protein name Neuronal calcium sensor 1 (NCS-1) (Frequenin homolog) (Frequenin-like protein) (Frequenin-like ubiquitous protein)
Protein function Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity). Stimulates PI4KB kinase activity
PDB 1G8I , 2LCP , 4GUK , 5O9S , 6QI4 , 8AHY , 8ALH , 8ALM
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00036 EF-hand_1 65 92 EF hand Domain
PF13499 EF-hand_7 98 174 EF-hand domain pair Domain
PF00036 EF-hand_1 148 175 EF hand Domain
Sequence
MGKSNSKLKPEVVEELTRKTYFTEKEVQQWYKGFIKDCPSGQLDAAGFQKIYKQFFPFGD
PTKFATFVFNVFDENKDGRIEFSEFIQALSVTSRGTLDEKLRWAFKLYDLDNDGYITRNE
MLDIVDAIYQMVGNTVELPEEENTPEK
RVDRIFAMMDKNADGKLTLQEFQEGSKADPSIV
QALSLYDGLV
Sequence length 190
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Alzheimer disease Alzheimer`s Disease rs63750215, rs28936379, rs63749851, rs63749884, rs28936380, rs63750048, rs63750579, rs63750264, rs63749964, rs63750671, rs281865161, rs63750066, rs63750399, rs63750734, rs63751039
View all (65 more)
23535033
Schizophrenia Schizophrenia rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346
View all (12 more)
15364041, 24631552
Unknown
Disease term Disease name Evidence References Source
Insomnia Insomnia GWAS
Associations from Text Mining
Disease Name Relationship Type References
Breast Neoplasms Associate 28275088, 29789326, 31659121, 32239615, 38564162
Breast Neoplasms Stimulate 31647602
Carcinoma Hepatocellular Associate 29789326
Heredodegenerative Disorders Nervous System Associate 27575489
Inflammation Stimulate 32239615
Mental Disorders Associate 37984032
Necrosis Associate 31647602
Neoplasm Metastasis Associate 29789326, 32239615
Neoplasms Associate 28275088, 29789326, 38564162
Neoplasms Stimulate 32239615