Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	23406
Gene name	Coactosin like F-actin binding protein 1
Gene symbol	COTL1
Synonyms (NCBI Gene)	CLP
Chromosome	16
Chromosome location	16q24.1
Summary	This gene encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis. Although this gene has

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miRTarBase ID	miRNA	Experiments	Reference
MIRT016551	hsa-miR-193b-3p	Proteomics	21512034
MIRT024011	hsa-miR-1-3p	Microarray	18668037
MIRT044527	hsa-miR-320a	CLASH	23622248
MIRT043571	hsa-miR-331-3p	CLASH	23622248
MIRT037467	hsa-miR-744-5p	CLASH	23622248
MIRT904787	hsa-miR-1200	CLIP-seq
MIRT904788	hsa-miR-1207-5p	CLIP-seq
MIRT904789	hsa-miR-1225-3p	CLIP-seq
MIRT904790	hsa-miR-1233	CLIP-seq
MIRT904791	hsa-miR-1236	CLIP-seq
MIRT904792	hsa-miR-1285	CLIP-seq
MIRT904793	hsa-miR-2116	CLIP-seq
MIRT904794	hsa-miR-22	CLIP-seq
MIRT904795	hsa-miR-24	CLIP-seq
MIRT904796	hsa-miR-2467-3p	CLIP-seq
MIRT904797	hsa-miR-3119	CLIP-seq
MIRT904798	hsa-miR-3121-5p	CLIP-seq
MIRT904799	hsa-miR-3136-3p	CLIP-seq
MIRT904800	hsa-miR-3140-3p	CLIP-seq
MIRT904801	hsa-miR-3140-5p	CLIP-seq
MIRT904802	hsa-miR-3157-3p	CLIP-seq
MIRT904803	hsa-miR-3170	CLIP-seq
MIRT904804	hsa-miR-3187-5p	CLIP-seq
MIRT904805	hsa-miR-3200-3p	CLIP-seq
MIRT904806	hsa-miR-323b-3p	CLIP-seq
MIRT904807	hsa-miR-326	CLIP-seq
MIRT904808	hsa-miR-330-5p	CLIP-seq
MIRT904809	hsa-miR-342-5p	CLIP-seq
MIRT904810	hsa-miR-3613-3p	CLIP-seq
MIRT904811	hsa-miR-3616-5p	CLIP-seq
MIRT904812	hsa-miR-3620	CLIP-seq
MIRT904813	hsa-miR-3647-5p	CLIP-seq
MIRT904814	hsa-miR-3662	CLIP-seq
MIRT904815	hsa-miR-3678-3p	CLIP-seq
MIRT904816	hsa-miR-378g	CLIP-seq
MIRT904817	hsa-miR-3941	CLIP-seq
MIRT904818	hsa-miR-4260	CLIP-seq
MIRT904819	hsa-miR-4267	CLIP-seq
MIRT904820	hsa-miR-4286	CLIP-seq
MIRT904821	hsa-miR-4292	CLIP-seq
MIRT904822	hsa-miR-4300	CLIP-seq
MIRT904823	hsa-miR-4303	CLIP-seq
MIRT904824	hsa-miR-4437	CLIP-seq
MIRT904825	hsa-miR-4438	CLIP-seq
MIRT904826	hsa-miR-4475	CLIP-seq
MIRT904827	hsa-miR-4486	CLIP-seq
MIRT904828	hsa-miR-4502	CLIP-seq
MIRT904829	hsa-miR-4514	CLIP-seq
MIRT904830	hsa-miR-4537	CLIP-seq
MIRT904831	hsa-miR-4651	CLIP-seq
MIRT904832	hsa-miR-466	CLIP-seq
MIRT904833	hsa-miR-4664-5p	CLIP-seq
MIRT904834	hsa-miR-4672	CLIP-seq
MIRT904835	hsa-miR-4674	CLIP-seq
MIRT904836	hsa-miR-4677-3p	CLIP-seq
MIRT904837	hsa-miR-4677-5p	CLIP-seq
MIRT904838	hsa-miR-4692	CLIP-seq
MIRT904839	hsa-miR-4698	CLIP-seq
MIRT904840	hsa-miR-4711-5p	CLIP-seq
MIRT904841	hsa-miR-4713-3p	CLIP-seq
MIRT904842	hsa-miR-4733-5p	CLIP-seq
MIRT904843	hsa-miR-4736	CLIP-seq
MIRT904844	hsa-miR-4756-3p	CLIP-seq
MIRT904845	hsa-miR-4763-3p	CLIP-seq
MIRT904846	hsa-miR-4773	CLIP-seq
MIRT904847	hsa-miR-4778-3p	CLIP-seq
MIRT904848	hsa-miR-4795-5p	CLIP-seq
MIRT904849	hsa-miR-516a-3p	CLIP-seq
MIRT904850	hsa-miR-573	CLIP-seq
MIRT904851	hsa-miR-608	CLIP-seq
MIRT904852	hsa-miR-612	CLIP-seq
MIRT904853	hsa-miR-622	CLIP-seq
MIRT904854	hsa-miR-874	CLIP-seq
MIRT904855	hsa-miR-920	CLIP-seq
MIRT904856	hsa-miR-938	CLIP-seq
MIRT904857	hsa-miR-940	CLIP-seq
MIRT1547442	hsa-miR-147	CLIP-seq
MIRT1547443	hsa-miR-644	CLIP-seq
MIRT1920098	hsa-miR-1273f	CLIP-seq
MIRT1920099	hsa-miR-1294	CLIP-seq
MIRT1920100	hsa-miR-1299	CLIP-seq
MIRT1920101	hsa-miR-143	CLIP-seq
MIRT1920102	hsa-miR-1538	CLIP-seq
MIRT1920103	hsa-miR-3978	CLIP-seq
MIRT1920104	hsa-miR-4470	CLIP-seq
MIRT1920105	hsa-miR-4708-5p	CLIP-seq
MIRT1920106	hsa-miR-4745-3p	CLIP-seq
MIRT1920107	hsa-miR-4747-3p	CLIP-seq
MIRT1920108	hsa-miR-4770	CLIP-seq
MIRT1920109	hsa-miR-760	CLIP-seq
MIRT1920110	hsa-miR-875-3p	CLIP-seq
MIRT1968330	hsa-miR-135a	CLIP-seq
MIRT1968331	hsa-miR-135b	CLIP-seq
MIRT1968332	hsa-miR-1908	CLIP-seq
MIRT1968333	hsa-miR-325	CLIP-seq
MIRT1968334	hsa-miR-4287	CLIP-seq
MIRT904821	hsa-miR-4292	CLIP-seq
MIRT1968335	hsa-miR-4417	CLIP-seq
MIRT1968336	hsa-miR-4469	CLIP-seq
MIRT1968337	hsa-miR-4649-3p	CLIP-seq
MIRT904831	hsa-miR-4651	CLIP-seq
MIRT1968338	hsa-miR-4675	CLIP-seq
MIRT1968339	hsa-miR-4685-3p	CLIP-seq
MIRT1968340	hsa-miR-4741	CLIP-seq
MIRT1968341	hsa-miR-4767	CLIP-seq
MIRT904851	hsa-miR-608	CLIP-seq
MIRT1968342	hsa-miR-663	CLIP-seq
MIRT1547442	hsa-miR-147	CLIP-seq
MIRT1547443	hsa-miR-644	CLIP-seq
MIRT1547442	hsa-miR-147	CLIP-seq
MIRT1547443	hsa-miR-644	CLIP-seq
MIRT2507633	hsa-miR-1178	CLIP-seq
MIRT904787	hsa-miR-1200	CLIP-seq
MIRT904789	hsa-miR-1225-3p	CLIP-seq
MIRT904790	hsa-miR-1233	CLIP-seq
MIRT2507634	hsa-miR-1915	CLIP-seq
MIRT904797	hsa-miR-3119	CLIP-seq
MIRT904800	hsa-miR-3140-3p	CLIP-seq
MIRT904801	hsa-miR-3140-5p	CLIP-seq
MIRT2507635	hsa-miR-3158-3p	CLIP-seq
MIRT904803	hsa-miR-3170	CLIP-seq
MIRT904809	hsa-miR-342-5p	CLIP-seq
MIRT904817	hsa-miR-3941	CLIP-seq
MIRT904818	hsa-miR-4260	CLIP-seq
MIRT904819	hsa-miR-4267	CLIP-seq
MIRT904825	hsa-miR-4438	CLIP-seq
MIRT904826	hsa-miR-4475	CLIP-seq
MIRT904831	hsa-miR-4651	CLIP-seq
MIRT904832	hsa-miR-466	CLIP-seq
MIRT904833	hsa-miR-4664-5p	CLIP-seq
MIRT904834	hsa-miR-4672	CLIP-seq
MIRT904836	hsa-miR-4677-3p	CLIP-seq
MIRT2507636	hsa-miR-4685-5p	CLIP-seq
MIRT904841	hsa-miR-4713-3p	CLIP-seq
MIRT904849	hsa-miR-516a-3p	CLIP-seq
MIRT904851	hsa-miR-608	CLIP-seq
MIRT2507633	hsa-miR-1178	CLIP-seq
MIRT904789	hsa-miR-1225-3p	CLIP-seq
MIRT904790	hsa-miR-1233	CLIP-seq
MIRT2507634	hsa-miR-1915	CLIP-seq
MIRT904797	hsa-miR-3119	CLIP-seq
MIRT904799	hsa-miR-3136-3p	CLIP-seq
MIRT904800	hsa-miR-3140-3p	CLIP-seq
MIRT2507635	hsa-miR-3158-3p	CLIP-seq
MIRT904803	hsa-miR-3170	CLIP-seq
MIRT904809	hsa-miR-342-5p	CLIP-seq
MIRT2678499	hsa-miR-3960	CLIP-seq
MIRT904818	hsa-miR-4260	CLIP-seq
MIRT904825	hsa-miR-4438	CLIP-seq
MIRT2678500	hsa-miR-4479	CLIP-seq
MIRT904831	hsa-miR-4651	CLIP-seq
MIRT904833	hsa-miR-4664-5p	CLIP-seq
MIRT2678501	hsa-miR-4665-3p	CLIP-seq
MIRT904836	hsa-miR-4677-3p	CLIP-seq
MIRT2507636	hsa-miR-4685-5p	CLIP-seq
MIRT904851	hsa-miR-608	CLIP-seq

Show/Hide all (19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003779	Function	Actin binding	IDA	11583571
GO:0003779	Function	Actin binding	IEA
GO:0005515	Function	Protein binding	IPI	11297527, 16924104, 21044950, 25416956
GO:0005576	Component	Extracellular region	TAS
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005884	Component	Actin filament	IBA
GO:0019899	Function	Enzyme binding	IEA
GO:0019899	Function	Enzyme binding	IPI	11297527
GO:0030427	Component	Site of polarized growth	IBA
GO:0030833	Process	Regulation of actin filament polymerization	IBA
GO:0030864	Component	Cortical actin cytoskeleton	IBA
GO:0034774	Component	Secretory granule lumen	TAS
GO:0050832	Process	Defense response to fungus	IEA
GO:0051015	Function	Actin filament binding	IBA
GO:0070062	Component	Extracellular exosome	HDA	19056867, 20458337, 23533145
GO:1904813	Component	Ficolin-1-rich granule lumen	TAS

MIM	HGNC	e!Ensembl
606748	18304	ENSG00000103187

Q14019

Protein name

Coactosin-like protein

Protein function

Binds to F-actin in a calcium-independent manner. Has no direct effect on actin depolymerization. Acts as a chaperone for ALOX5 (5LO), influencing both its stability and activity in leukotrienes synthesis. {ECO:0000269|PubMed:11583571, ECO:00002

PDB

1T2L , 1T3X , 1T3Y , 1TMW , 1VFQ , 1WNJ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00241	Cofilin_ADF	10 → 128	Cofilin/tropomyosin-type actin-binding protein	Domain

Tissue specificity

TISSUE SPECIFICITY: Widely expressed with highest levels in placenta, lung, kidney and peripheral blood leukocytes and lower levels in brain, liver and pancreas. {ECO:0000269|PubMed:11583571}.

Sequence

MATKIDKEACRAAYNLVRDDGSAVIWVTFKYDGSTIVPGEQGAEYQHFIQQCTDDVRLFA
FVRFTTGDAMSKRSKFALITWIGENVSGLQRAKTGTDKTLVKEVVQNFAKEFVISDRKEL
EEDFIKSELKKAGGANYDAQTE

Sequence length

142

Interactions

View interactions

	Reactome
			Neutrophil degranulation

COTL1 (coactosin like F-actin binding protein 1)