ENTREP2 (endosomal transmembrane epsin interactor 2)

Gene

• Entrez ID: 23359
• Gene name: Endosomal transmembrane epsin interactor 2
• Gene symbol: ENTREP2
• Synonyms (NCBI Gene): FAM189A1, TMEM228
• Chromosome: 15
• Chromosome location: 15q13.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT019119	hsa-miR-335-5p	Microarray	18185580
MIRT982479	hsa-let-7a	CLIP-seq
MIRT982480	hsa-let-7b	CLIP-seq
MIRT982481	hsa-let-7c	CLIP-seq
MIRT982482	hsa-let-7d	CLIP-seq
MIRT982483	hsa-let-7e	CLIP-seq
MIRT982484	hsa-let-7f	CLIP-seq
MIRT982485	hsa-let-7g	CLIP-seq
MIRT982486	hsa-let-7i	CLIP-seq
MIRT982487	hsa-miR-1193	CLIP-seq
MIRT738458	hsa-miR-1270	CLIP-seq
MIRT982488	hsa-miR-1275	CLIP-seq
MIRT982489	hsa-miR-202	CLIP-seq
MIRT982490	hsa-miR-2861	CLIP-seq
MIRT982491	hsa-miR-3190	CLIP-seq
MIRT982492	hsa-miR-323-3p	CLIP-seq
MIRT982493	hsa-miR-3670	CLIP-seq
MIRT982494	hsa-miR-3691-5p	CLIP-seq
MIRT738461	hsa-miR-3919	CLIP-seq
MIRT982495	hsa-miR-3940-3p	CLIP-seq
MIRT982496	hsa-miR-3944-5p	CLIP-seq
MIRT982497	hsa-miR-4300	CLIP-seq
MIRT982498	hsa-miR-4323	CLIP-seq
MIRT982499	hsa-miR-4433	CLIP-seq
MIRT982500	hsa-miR-4458	CLIP-seq
MIRT982501	hsa-miR-4477a	CLIP-seq
MIRT982502	hsa-miR-4500	CLIP-seq
MIRT982503	hsa-miR-4525	CLIP-seq
MIRT982504	hsa-miR-4528	CLIP-seq
MIRT982505	hsa-miR-4532	CLIP-seq
MIRT982506	hsa-miR-4663	CLIP-seq
MIRT982507	hsa-miR-4665-5p	CLIP-seq
MIRT738459	hsa-miR-4683	CLIP-seq
MIRT982508	hsa-miR-4715-3p	CLIP-seq
MIRT982509	hsa-miR-4723-5p	CLIP-seq
MIRT738462	hsa-miR-4756-3p	CLIP-seq
MIRT982510	hsa-miR-4758-3p	CLIP-seq
MIRT982511	hsa-miR-570	CLIP-seq
MIRT982512	hsa-miR-587	CLIP-seq
MIRT738460	hsa-miR-620	CLIP-seq
MIRT982513	hsa-miR-625	CLIP-seq
MIRT982514	hsa-miR-652	CLIP-seq
MIRT982515	hsa-miR-661	CLIP-seq
MIRT982516	hsa-miR-665	CLIP-seq
MIRT982517	hsa-miR-7	CLIP-seq
MIRT982518	hsa-miR-920	CLIP-seq
MIRT982519	hsa-miR-939	CLIP-seq
MIRT982520	hsa-miR-98	CLIP-seq
MIRT738458	hsa-miR-1270	CLIP-seq
MIRT738461	hsa-miR-3919	CLIP-seq
MIRT738459	hsa-miR-4683	CLIP-seq
MIRT738462	hsa-miR-4756-3p	CLIP-seq
MIRT738460	hsa-miR-620	CLIP-seq
MIRT1991280	hsa-miR-1207-5p	CLIP-seq
MIRT1991281	hsa-miR-1266	CLIP-seq
MIRT1991282	hsa-miR-135a	CLIP-seq
MIRT1991283	hsa-miR-135b	CLIP-seq
MIRT1991284	hsa-miR-1909	CLIP-seq
MIRT1991285	hsa-miR-361-5p	CLIP-seq
MIRT1991286	hsa-miR-3616-3p	CLIP-seq
MIRT1991287	hsa-miR-3649	CLIP-seq
MIRT1991288	hsa-miR-3664-3p	CLIP-seq
MIRT738461	hsa-miR-3919	CLIP-seq
MIRT1991289	hsa-miR-4271	CLIP-seq
MIRT1991290	hsa-miR-4436b-3p	CLIP-seq
MIRT1991291	hsa-miR-4475	CLIP-seq
MIRT1991292	hsa-miR-4480	CLIP-seq
MIRT1991293	hsa-miR-4518	CLIP-seq
MIRT1991294	hsa-miR-4725-3p	CLIP-seq
MIRT1991295	hsa-miR-4727-5p	CLIP-seq
MIRT1991296	hsa-miR-4728-5p	CLIP-seq
MIRT738462	hsa-miR-4756-3p	CLIP-seq
MIRT1991297	hsa-miR-4763-3p	CLIP-seq
MIRT1991298	hsa-miR-4769-3p	CLIP-seq
MIRT1991299	hsa-miR-492	CLIP-seq
MIRT2225348	hsa-miR-106a	CLIP-seq
MIRT2225349	hsa-miR-106b	CLIP-seq
MIRT2225350	hsa-miR-1321	CLIP-seq
MIRT2225351	hsa-miR-17	CLIP-seq
MIRT2225352	hsa-miR-20a	CLIP-seq
MIRT2225353	hsa-miR-20b	CLIP-seq
MIRT2225354	hsa-miR-22	CLIP-seq
MIRT2225355	hsa-miR-3612	CLIP-seq
MIRT1991285	hsa-miR-361-5p	CLIP-seq
MIRT1991287	hsa-miR-3649	CLIP-seq
MIRT2225356	hsa-miR-3921	CLIP-seq
MIRT2225357	hsa-miR-4251	CLIP-seq
MIRT2225358	hsa-miR-4270	CLIP-seq
MIRT2225359	hsa-miR-4310	CLIP-seq
MIRT2225360	hsa-miR-4329	CLIP-seq
MIRT2225361	hsa-miR-4441	CLIP-seq
MIRT1991291	hsa-miR-4475	CLIP-seq
MIRT2225362	hsa-miR-4653-5p	CLIP-seq
MIRT2225363	hsa-miR-4693-3p	CLIP-seq
MIRT982508	hsa-miR-4715-3p	CLIP-seq
MIRT2225364	hsa-miR-4731-5p	CLIP-seq
MIRT2225365	hsa-miR-4739	CLIP-seq
MIRT2225366	hsa-miR-4756-5p	CLIP-seq
MIRT2225367	hsa-miR-486-3p	CLIP-seq
MIRT1991299	hsa-miR-492	CLIP-seq
MIRT2225368	hsa-miR-519d	CLIP-seq
MIRT982513	hsa-miR-625	CLIP-seq
MIRT2225369	hsa-miR-646	CLIP-seq
MIRT2225370	hsa-miR-650	CLIP-seq
MIRT2225371	hsa-miR-93	CLIP-seq
MIRT2387807	hsa-miR-3665	CLIP-seq
MIRT2387808	hsa-miR-378g	CLIP-seq
MIRT2680613	hsa-miR-3942-3p	CLIP-seq
MIRT2680614	hsa-miR-4488	CLIP-seq
MIRT2680615	hsa-miR-4489	CLIP-seq
MIRT2680616	hsa-miR-4697-5p	CLIP-seq
MIRT982511	hsa-miR-570	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0016020	Component	Membrane	IEA

Other IDs

• MIM: 620052
• HGNC: 29075
• e!Ensembl: ENSG00000104059

Protein

• UniProt ID: O60320
• Protein name: Protein ENTREP2 (Endosomal transmembrane epsin interactor 2) (Transmembrane protein 228)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF04103	CD20	34 → 199	CD20-like family	Family

• Sequence:

  MPPAGGPRAPRPAALPRSLSRLRECPGRSRIVLALGATQMALGCLIVAVSFAALALTTSA
  RVRHSCPFWAGFSVLLSGLIGVVSWKRPLSLVITFFMLLSAVCVMLNLAGSILSCQNAQL
  VNSLEGCQLIKFDSVEVCVCCELQHQSSGCSNLGETLKLNPLQENCNAVRLTLKDLLFSV
  CALNVLSTIVCALATAMCCMQMVSSDVLQMFLPQRSHPANPTCVTPHGTVLHQTLDFDEF
  IPPLPPPPYYPPEYTCTPSTEAQRGLHLDFAPSPFGTLYDVAINSPGLLYPAELPPPYEA
  VVGQPPASQVTSIGQQVAESSSGDPNTSAGFSTPVPADSTSLLVSEGTATPGSSPSPDGP
  VGAPAPSEPALPPGHVSPEDPGMGSQVQPGPGRVSRSTSDPTLCTSSMAGDASSHRPSCS
  QDLEAGLSEAVPGSASMSRSATAACRAQLSPAGDPDTWKTDQRPTPEPFPATSKERPRSL
  VDSKAYADARVLVAKFLEHSHCALPTEAQHMVGAMRLAVTNEERLEEEAVFGADVLDQV

• Sequence length: 539

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ANXIETY DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ASTHMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARDIAC ARRHYTHMIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEMENTIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG DISEASE, IMMUNODEFICIENCY, AND CHROMOSOME BREAKAGE SYNDROME	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OLIGODENDROGLIOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations