Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
23353
Gene name Gene Name - the full gene name approved by the HGNC.
Sad1 and UNC84 domain containing 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SUN1
Synonyms (NCBI Gene) Gene synonyms aliases
UNC84A
Chromosome Chromosome number
7
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
7p22.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene is a member of the unc-84 homolog family and encodes a nuclear envelope protein with an Unc84 (SUN) domain. The protein is involved in nuclear anchorage and migration. Alternatively spliced transcript variants have been described. [provided by R
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT029149 hsa-miR-26b-5p Microarray 19088304
MIRT041459 hsa-miR-193b-3p CLASH 23622248
MIRT040822 hsa-miR-18a-3p CLASH 23622248
MIRT171597 hsa-miR-15a-5p HITS-CLIP 22473208
MIRT171603 hsa-miR-15b-5p HITS-CLIP 22473208
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000781 Component Chromosome, telomeric region IEA
GO:0001503 Process Ossification IEA
GO:0005515 Function Protein binding IPI 18396275, 22632968, 24375709, 28716842, 33393904, 33961781, 38291267
GO:0005521 Function Lamin binding IEA
GO:0005634 Component Nucleus IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
607723 18587 ENSG00000164828
Protein
UniProt ID O94901
Protein name SUN domain-containing protein 1 (Protein unc-84 homolog A) (Sad1/unc-84 protein-like 1)
Protein function As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton (PubMed:18039933, PubMed:18396275). The nucleocytoplasmic interactions established by the L
PDB 6R15 , 6R16 , 6R2I , 7E34 , 7Z8Y , 8AU0 , 8B46 , 8B5X
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF09387 MRP 62 318 Mitochondrial RNA binding protein MRP Domain
PF18580 HTH_SUN2 574 632 SUN2 helix-turn-helix domain Domain
PF07738 Sad1_UNC 675 810 Sad1 / UNC-like C-terminal Family
Sequence
MDFSRLHMYSPPQCVPENTGYTYALSSSYSSDALDFETEHKLDPVFDSPRMSRRSLRLAT
TACTLGDGEAVGADSGTSSAVSLKNRAARTTKQRRSTNKSAFSINHVSRQVTSSGVSHGG
TVSLQDAVTRRPPVLDESWIREQTTVDHFWGLDDDGDLKGGNKAAIQGNGDVGAAAATAH
NGFSCSNCSMLSERKDVLTAHPAAPGPVSRVYSRDRNQKCDDCKGKRHLDAHPGRAGTLW
HIWACAGYFLLQILRRIGAVGQAVSRTAWSALWLAVVAPGKAASGVFWWLGIGWYQFVTL
ISWLNVFLLTRCLRNICK
FLVLLIPLFLLLAGLSLRGQGNFFSFLPVLNWASMHRTQRVD
DPQDVFKPTTSRLKQPLQGDSEAFPWHWMSGVEQQVASLSGQCHHHGENLRELTTLLQKL
QARVDQMEGGAAGPSASVRDAVGQPPRETDFMAFHQEHEVRMSHLEDILGKLREKSEAIQ
KELEQTKQKTISAVGEQLLPTVEHLQLELDQLKSELSSWRHVKTGCETVDAVQERVDVQV
REMVKLLFSEDQQGGSLEQLLQRFSSQFVSKGDLQTMLRDLQLQILRNVTHHVSVTKQLP
TSEAVVSAVSEAGASGITEAQARAIVNSALKL
YSQDKTGMVDFALESGGGSILSTRCSET
YETKTALMSLFGIPLWYFSQSPRVVIQPDIYPGNCWAFKGSQGYLVVRLSMMIHPAAFTL
EHIPKTLSPTGNISSAPKDFAVYGLENEYQEEGQLLGQFTYDQDGESLQMFQALKRPDDT
AFQIVELRIFSNWGHPEYTCLYRFRVHGEP
VK
Sequence length 812
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  
  Cytoskeleton in muscle cells  
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Atrial Fibrillation Atrial fibrillation N/A N/A GWAS
emery-dreifuss muscular dystrophy Emery-Dreifuss muscular dystrophy N/A N/A ClinVar
Insomnia Insomnia N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Aging Premature Associate 30474255
Breast Neoplasms Inhibit 26175118
Breast Neoplasms Associate 26474971, 26962703
Cardiomyopathy Dilated Associate 37840136
Carotid Stenosis Associate 31589004
Charcot Marie Tooth Disease Associate 22555292
Charcot Marie Tooth disease Type 2B Associate 22555292
Fibrosis Inhibit 37840136
Heart Failure Inhibit 37840136
HIV Infections Inhibit 34592156