VPS39 (VPS39 subunit of HOPS complex)
| Gene | |
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Entrez ID
Entrez Gene ID - the GENE ID in NCBI Gene database.
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23339 |
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Gene name
Gene Name - the full gene name approved by the HGNC.
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VPS39 subunit of HOPS complex |
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Gene symbol
Gene Symbol - the official gene symbol approved by the HGNC.
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VPS39 |
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Synonyms (NCBI Gene)
Gene synonyms aliases
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TLP, VAM6, hVam6p |
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Chromosome
Chromosome number
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15 |
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Chromosome location
Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
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15q15.1 |
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Summary
Summary of gene provided in NCBI Entrez Gene.
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This gene encodes a protein that may promote clustering and fusion of late endosomes and lysosomes. The protein may also act as an adaptor protein that modulates the transforming growth factor-beta response by coupling the transforming growth factor-beta |
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miRNA
miRNA information provided by mirtarbase database.
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Gene ontology (GO)
Gene ontology information of associated ontologies with gene provided by GO database.
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Other IDs
Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
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| Protein | |||||||||||||||||||||
| UniProt ID | Q96JC1 | ||||||||||||||||||||
| Protein name | Vam6/Vps39-like protein (TRAP1-like protein) (hVam6p) | ||||||||||||||||||||
| Protein function | Regulator of TGF-beta/activin signaling, inhibiting SMAD3- and activating SMAD2-dependent transcription. Acts by interfering with SMAD3/SMAD4 complex formation, this would lead to inhibition of SMAD3-dependent transcription and relieve SMAD3 inh | ||||||||||||||||||||
| PDB | 6ZE9 | ||||||||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Widely expressed, with highest levels in heart, skeletal muscle, kidney, pancreas, brain, placenta and spleen. {ECO:0000269|PubMed:11448994, ECO:0000269|PubMed:12941698}. | ||||||||||||||||||||
| Sequence |
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| Sequence length | 886 | ||||||||||||||||||||
| Interactions | View interactions | ||||||||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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