JADE2 (jade family PHD finger 2)

Gene

• Entrez ID: 23338
• Gene name: Jade family PHD finger 2
• Gene symbol: JADE2
• Synonyms (NCBI Gene): JADE-2, PHF15
• Chromosome: 5
• Chromosome location: 5q31.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT441674	hsa-miR-4761-3p	PAR-CLIP	23708386
MIRT441673	hsa-miR-663b	PAR-CLIP	23708386
MIRT441672	hsa-miR-4435	PAR-CLIP	23708386
MIRT441671	hsa-miR-7108-5p	PAR-CLIP	23708386
MIRT487361	hsa-miR-3714	PAR-CLIP	23592263
MIRT487360	hsa-miR-6808-5p	PAR-CLIP	23592263
MIRT487359	hsa-miR-6893-5p	PAR-CLIP	23592263
MIRT487358	hsa-miR-940	PAR-CLIP	23592263
MIRT487357	hsa-miR-1286	PAR-CLIP	23592263
MIRT487356	hsa-miR-1207-5p	PAR-CLIP	23592263
MIRT487355	hsa-miR-4763-3p	PAR-CLIP	23592263
MIRT487354	hsa-miR-4736	PAR-CLIP	23592263
MIRT487353	hsa-miR-1908-5p	PAR-CLIP	23592263
MIRT487351	hsa-miR-663a	PAR-CLIP	23592263
MIRT487352	hsa-miR-6787-5p	PAR-CLIP	23592263
MIRT487350	hsa-miR-4525	PAR-CLIP	23592263
MIRT487349	hsa-miR-5010-5p	PAR-CLIP	23592263
MIRT487348	hsa-miR-6795-5p	PAR-CLIP	23592263
MIRT487347	hsa-miR-6887-5p	PAR-CLIP	23592263
MIRT487346	hsa-miR-7150	PAR-CLIP	23592263
MIRT487345	hsa-miR-4655-5p	PAR-CLIP	23592263
MIRT441674	hsa-miR-4761-3p	PAR-CLIP	22100165
MIRT441673	hsa-miR-663b	PAR-CLIP	22100165
MIRT441672	hsa-miR-4435	PAR-CLIP	22100165
MIRT441671	hsa-miR-7108-5p	PAR-CLIP	22100165
MIRT441674	hsa-miR-4761-3p	PAR-CLIP	22100165
MIRT441673	hsa-miR-663b	PAR-CLIP	22100165
MIRT441672	hsa-miR-4435	PAR-CLIP	22100165
MIRT441671	hsa-miR-7108-5p	PAR-CLIP	22100165
MIRT755003	hsa-miR-3714	PAR-CLIP	26701625
MIRT754827	hsa-miR-4761-3p	PAR-CLIP	23708386
MIRT754828	hsa-miR-663b	PAR-CLIP	23708386
MIRT754829	hsa-miR-4435	PAR-CLIP	23708386
MIRT754830	hsa-miR-7108-5p	PAR-CLIP	23708386
MIRT755003	hsa-miR-3714	PAR-CLIP	23592263
MIRT755004	hsa-miR-6808-5p	PAR-CLIP	23592263
MIRT755005	hsa-miR-6893-5p	PAR-CLIP	23592263
MIRT755006	hsa-miR-940	PAR-CLIP	23592263
MIRT755007	hsa-miR-1286	PAR-CLIP	23592263
MIRT755008	hsa-miR-1207-5p	PAR-CLIP	23592263
MIRT755009	hsa-miR-4763-3p	PAR-CLIP	23592263
MIRT755010	hsa-miR-4736	PAR-CLIP	23592263
MIRT755011	hsa-miR-1908-5p	PAR-CLIP	23592263
MIRT755012	hsa-miR-663a	PAR-CLIP	23592263
MIRT755013	hsa-miR-6787-5p	PAR-CLIP	23592263
MIRT755014	hsa-miR-4525	PAR-CLIP	23592263
MIRT755015	hsa-miR-5010-5p	PAR-CLIP	23592263
MIRT755016	hsa-miR-6795-5p	PAR-CLIP	23592263
MIRT755017	hsa-miR-6887-5p	PAR-CLIP	23592263
MIRT755018	hsa-miR-7150	PAR-CLIP	23592263
MIRT755019	hsa-miR-4655-5p	PAR-CLIP	23592263
MIRT754827	hsa-miR-4761-3p	PAR-CLIP	22100165
MIRT754828	hsa-miR-663b	PAR-CLIP	22100165
MIRT754829	hsa-miR-4435	PAR-CLIP	22100165
MIRT754830	hsa-miR-7108-5p	PAR-CLIP	22100165
MIRT754827	hsa-miR-4761-3p	PAR-CLIP	22100165
MIRT754828	hsa-miR-663b	PAR-CLIP	22100165
MIRT754829	hsa-miR-4435	PAR-CLIP	22100165
MIRT754830	hsa-miR-7108-5p	PAR-CLIP	22100165

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000123	Component	Histone acetyltransferase complex	IBA	21873635
GO:0000123	Component	Histone acetyltransferase complex	IDA	16387653
GO:0005515	Function	Protein binding	IPI	24981860, 25416956
GO:0005654	Component	Nucleoplasm	IDA
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0043966	Process	Histone H3 acetylation	IBA	21873635
GO:0043966	Process	Histone H3 acetylation	IDA	16387653
GO:0043981	Process	Histone H4-K5 acetylation	IBA	21873635
GO:0043981	Process	Histone H4-K5 acetylation	IDA	16387653
GO:0043982	Process	Histone H4-K8 acetylation	IBA	21873635
GO:0043982	Process	Histone H4-K8 acetylation	IDA	16387653
GO:0043983	Process	Histone H4-K12 acetylation	IDA	16387653
GO:0043984	Process	Histone H4-K16 acetylation	IDA	16387653
GO:0046872	Function	Metal ion binding	IEA
GO:0070062	Component	Extracellular exosome	HDA	19056867

Other IDs

• MIM: 610515
• HGNC: 22984
• e!Ensembl: ENSG00000043143

Protein

• UniProt ID: Q9NQC1
• Protein name: E3 ubiquitin-protein ligase Jade-2 (EC 2.3.2.27) (Jade family PHD finger protein 2) (PHD finger protein 15)
• Protein function: Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity (PubMed:16387653). Acts as an E3 ubiquitin-protein ligase mediating the ubiquitination and subsequent proteasomal degradation of target protein histone d
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF10513	EPL1	1 → 176	Enhancer of polycomb-like	Family
  PF13831	PHD_2	213 → 247		Family
  PF13832	zf-HC5HC2H_2	252 → 364		Domain

• Sequence:

  MEEKRRKYSISSDNSDTTDSHATSTSASRCSKLPSSTKSGWPRQNEKKPSEVFRTDLITA
  MKIPDSYQLSPDDYYILADPWRQEWEKGVQVPAGAEAIPEPVVRILPPLEGPPAQASPSS
  TMLGEGSQPDWPGGSRYDLDEIDAYWLELINSELKEMERPELDELTLERVLEELETLCHQ
  NMARAIETQEGLGIEYDEDVVCDVCRSPEGEDGNEMVFCDKCNVCVHQACYGILKVPTGS
  WLCRTCALGVQPKCLLCPKRGGALKPTRSGTKWVHVSCALWIPEVSIGCPEKMEPITKIS
  HIPASRWALSCSLCKECTGTCIQCSMPSCVTAFHVTCAFDHGLEMRTILADNDEVKFKSF
  CQEHSDGGPRNEPTSEPTEPSQAGEDLEKVTLRKQRLQQLEEDFYELVEPAEVAERLDLA
  EALVDFIYQYWKLKRKANANQPLLTPKTDEVDNLAQQEQDVLYRRLKLFTHLRQDLERVR
  NLCYMVTRRERTKHAICKLQEQIFHLQMKLIEQDLCRGLSTSFPIDGTFFNSWLAQSVQI
  TAENMAMSEWPLNNGHREDPAPGLLSEELLQDEETLLSFMRDPSLRPGDPARKARGRTRL
  PAKKKPPPPPPQDGPGSRTTPDKAPKKTWGQDAGSGKGGQGPPTRKPPRRTSSHLPSSPA
  AGDCPILATPESPPPLAPETPDEAASVAADSDVQVPGPAASPKPLGRLRPPRESKVTRRL
  PGARPDAGMGPPSAVAERPKVSLHFDTETDGYFSDGEMSDSDVEAEDGGVQRGPREAGAE
  EVVRMGVLAS

• Sequence length: 790

Pathways

Reactome:

HATs acetylate histones

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Diabetes mellitus	Diabetes Mellitus, Non-Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237, rs80356613, rs387906407, rs151344623, rs28938469, rs28936371, rs137852672, rs80356637, rs80356642, rs80356653, rs137852673, rs137852674, rs80356634, rs80356651, rs193929360, rs137853334, rs137853335, rs137853336, rs1600731198, rs137853338, rs121964882, rs121964883, rs387906511, rs121964884, rs121964885, rs2147483647, rs387906512, rs121964887, rs121964888, rs121964889, rs121964890, rs121964891, rs28934878, rs74315383, rs121964893, rs886037620, rs886037621, rs121434593, rs121913150, rs587776825, rs137853236, rs2135842335, rs137853237, rs137853238, rs2135818776, rs1566092470, rs1463923467, rs137853243, rs137853244, rs2135839114, rs137853245, rs2135847417, rs121918407, rs104894005, rs104894006, rs80356655, rs104894008, rs104894009, rs104894010, rs104894011, rs80356654, rs104894016, rs193929376, rs193929374, rs193929375, rs193929373, rs80356669, rs80356664, rs193929366, rs1048095, rs193929355, rs193929356, rs1259467443, rs104893642, rs387906777, rs193922396, rs193922400, rs193922401, rs137852676, rs193922407, rs193922638, rs193922257, rs193922258, rs193922259, rs193922260, rs193922261, rs193922262, rs193922263, rs193922264, rs193922265, rs193922268, rs193921338, rs193922269, rs193922272, rs193922273, rs193922275, rs193922278, rs193922279, rs193922280, rs193922281, rs193922282, rs193922283, rs193922284, rs193922286, rs193922287, rs193922289, rs193922291, rs193922295, rs193922297, rs193922300, rs193922302, rs193922303, rs193922308, rs193922313, rs193922314, rs144723656, rs193922315, rs193922316, rs193922317, rs148311934, rs193922319, rs193922320, rs193922326, rs193922329, rs193922330, rs193922331, rs193922335, rs193922336, rs193922338, rs193922340, rs193922341, rs193922471, rs193922475, rs193922476, rs193922479, rs80356663, rs193922355, rs193922356, rs193922576, rs193922578, rs193922582, rs193922588, rs193922592, rs193922594, rs193922596, rs386134267, rs193922598, rs193922599, rs193922600, rs193922604, rs193922605, rs397514580, rs397515519, rs267601516, rs587780343, rs587780345, rs587780346, rs587780347, rs587780357, rs148954387, rs587783672, rs587783669, rs786204676, rs794727236, rs151344624, rs794727775, rs794727839, rs199946797, rs869320673, rs796065047, rs759072800, rs797045595, rs797045209, rs797045207, rs797045213, rs863225280, rs149703259, rs864321656, rs139964066, rs777870079, rs878853246, rs769268803, rs886039380, rs886041392, rs886041391, rs886042610, rs143064649, rs1057516192, rs746480424, rs1057516281, rs576684889, rs754728827, rs1057520291, rs1057520779, rs893256143, rs1057520504, rs1057524790, rs1057524902, rs1057524904, rs1057524905, rs764232985, rs1064793998, rs1064794268, rs769086289, rs369429452, rs1085307913, rs1131691416, rs765432081, rs1131692182, rs748749585, rs1554335441, rs762263694, rs1312678560, rs767565869, rs1375656631, rs1554335391, rs1360415315, rs1554335616, rs1554335752, rs1554909277, rs769518471, rs757171524, rs768951263, rs762703502, rs1555212248, rs1555212359, rs1555813319, rs1555816654, rs371977235, rs1415041911, rs1554334894, rs1260178539, rs1554335421, rs1555211904, rs779184183, rs1554335564, rs200670692, rs1400535021, rs1554334872, rs1555212749, rs1553876668, rs1553878211, rs954727530, rs1554924035, rs372307320, rs925231098, rs1554913069, rs1554933565, rs766431403, rs746714109, rs751279984, rs770664202, rs1008906426, rs758844607, rs1554924540, rs1566092307, rs753998395, rs1565885935, rs1167124132, rs1376796469, rs556436603, rs1562715657, rs1486280029, rs1564869850, rs755259997, rs769569410, rs1172328722, rs1286294151, rs1375557127, rs1568731279, rs1562715426, rs556581174, rs1564865302, rs1565886545, rs1568724014, rs1392795567, rs781260712, rs1562719705, rs1382448285, rs1564977373, rs750586210, rs1598842892, rs1583592247, rs780612692, rs1593060859, rs1476637197, rs751279776, rs1593060890, rs1191912908, rs1167675604, rs1583601110, rs1593058932, rs778611627, rs753296261	28869590
Prostate cancer	Malignant neoplasm of prostate	rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582	29610475

Unknown
Disease term	Disease name	Evidence	References	Source
Diabetes	Diabetes			GWAS
Bipolar Disorder	Bipolar Disorder			GWAS
Hypertension	Hypertension			GWAS
Multiple Sclerosis	Multiple Sclerosis			GWAS
Glioblastoma	Glioblastoma	CRISPR screening of E3 ubiquitin ligases reveals Ring Finger Protein 185 as a novel tumor suppressor in glioblastoma repressed by promoter hypermethylation and miR-587		GWAS, CBGDA

Associations from Text Mining
Disease Name	Relationship Type	References
Brain Neoplasms	Associate	34008756
Leukemia Myeloid Acute	Associate	34673934
Leukemia Promyelocytic Acute	Associate	34673934
Neoplasms	Associate	34008756