Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
23331
Gene name Gene Name - the full gene name approved by the HGNC.
Tetratricopeptide repeat domain 28
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
TTC28
Synonyms (NCBI Gene) Gene synonyms aliases
TPRBK
Chromosome Chromosome number
22
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
22q12.1
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT047205 hsa-miR-182-5p CLASH 23622248
MIRT043918 hsa-miR-378a-3p CLASH 23622248
MIRT672876 hsa-miR-548c-3p HITS-CLIP 23824327
MIRT672875 hsa-miR-6771-3p HITS-CLIP 23824327
MIRT672874 hsa-miR-3675-3p HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000922 Component Spindle pole IEA
GO:0005737 Component Cytoplasm IEA
GO:0005813 Component Centrosome IEA
GO:0005819 Component Spindle IEA
GO:0005856 Component Cytoskeleton IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
615098 29179 ENSG00000100154
Protein
UniProt ID Q96AY4
Protein name Tetratricopeptide repeat protein 28 (TPR repeat protein 28) (TPR repeat-containing big gene cloned at Keio)
Protein function During mitosis, may be involved in the condensation of spindle midzone microtubules, leading to the formation of midbody.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13176 TPR_7 276 311 Tetratricopeptide repeat Repeat
PF13424 TPR_12 311 386 Repeat
PF13424 TPR_12 351 426 Repeat
PF13424 TPR_12 472 546 Repeat
PF13424 TPR_12 552 626 Repeat
PF13424 TPR_12 636 706 Repeat
PF13424 TPR_12 713 786 Repeat
PF13424 TPR_12 832 909 Repeat
PF13424 TPR_12 915 989 Repeat
PF13424 TPR_12 995 1069 Repeat
PF13424 TPR_12 1075 1149 Repeat
PF12770 CHAT 1390 1713 CHAT domain Domain
Tissue specificity TISSUE SPECIFICITY: Widely expressed in fetal tissues. In adult tissues, expressed in testis and ovary and, at much lower levels, in kidney and pancreas. {ECO:0000269|PubMed:23036704}.
Sequence
MEQSPPPAPEPTQGPTPARSRRRREPESPPASAPIPLFGADTIGQRSPDGPVLSKAEFVE
KVRQSNQACHDGDFHTAIVLYNEALAVDPQNCILYSNRSAAYMKIQQYDKALDDAIKARL
LNPKWPKAYFRQGVALQYLGRHADALAAFASGLAQDPKSLQLLVGMVEAAMKSPMRDSLE
PTYQQLQKMKLDKSPFVVVSVVGQELLTAGHHGASVVVLEAALKIGTCSLKLRGSVFSAL
SSAYWSLGNTEKSTGYMQQDLDVAKTLGDQTGECRAHGNLGSAFFSKGNYREALTNHRHQ
LVLAMKLKDR
EAASSALSSLGHVYTAIGDYPNALASHKQCVLLAKQSKDELSEARELGNM
GAVYIAMGDFENAVQCHEQHLKIAKD
LGNKREEARAYSNLGSAYHYRRNFDKAMSYHNYV
LELAQE
LMEKAIEMRAYAGLGHAARCMQDLERAKQYHEQQLGIAEDLKDRAAEGRASSNL
GIIHQMKGDYDTALKLHKTHLCIAQELSDYAAQGRAYGNMGNAYNALGMYDQAVKYHRQE
LQISME
VNDRASQASTHGNLAVAYQALGAHDRALQHYQNHLNIARELRDIQSEARALSNL
GNFHCSRGEYVQAAPYYEQYLRLAPD
LQDMEGEGKVCHNLGYAHYCLGNYQEAVKYYEQD
LALAKDLHDKLSQAKAYCNLGLAFKALLNFSKAEECQKYLLSLAQS
LNNSQAKFRALGNL
GDIFICKKDINGAIKFYEQQLGLAHQVKDRRLEASAYAALGTAYRMIQKYDKALGYHTQE
LEVYQE
LSDLPGECRAHGHLAAVYMALGKYTMAFKCYEEQLDLGQKLKDPSLEAQVYGNM
GITKMNMNVMEEAIGYFEQQLAMLQQLSGNESVLDRGRAYGNLGDCYEALGDYEEAIKYY
EQYLSVAQS
LNRMQDQAKAYRGLGNGHRAMGSLQQALVCFEKRLVVAHELGEAFNKAQAY
GELGSLHSQLGNYEQAISCLERQLNIARD
MKDRALESDAACGLGGVYQQMGEYDTALQYH
QLDLQIAEETNNPTCQGRAYGNLGLTYESLGTFERAVVYQEQHLSIAAQ
MNDLAAKTVSY
SSLGRTHHALQNYSQAVMYLQEGLRLAEQLGRREDEAKIRHGLGLSLWASGNLEEAQHQL
YRASALFET
IRHEAQLSTDYKLSLFDLQTSSYQALQRVLVSLGHHDEALAVAERGRTRAF
ADLLVERQTGQQDSDPYSPVTIDQILEMVNGQRGLVLYYSLAAGYLYSWLLAPGAGIVKF
HEHYLGENTVENSSDFQASSSVTLPTATGSALEQHIASVREALGVESHYSRACASSETES
EAGDIMDQQFEEMNNKLNSVTDPTGFLRMVRRNNLFNRSCQSMTSLFSNTVSPTQDGTSS
LPRRQSSFAKPPLRALYDLLIAPMEGGLMHSSGPVGRHRQLILVLEGELYLIPFALLKGS
SSNEYLYERFGLLAVPSIRSLSVQSKSHLRKNPPTYSSSTSMAAVIGNPKLPSAVMDRWL
WGPMPSAEEEAYMVSELLGCQPLVGSVATKERVMSALTQAECVHFATHISWKLSALVLTP
SMDGNPASSKSSFGHPYTIPESLRVQDDASDGESISDCPPLQELLLTAADVLDLQLPVKL
VVLGSSQESNSKVTADGVIALTRAFLAAGAQCVLVSLWPVPVAASKMFIHAFYSSLLNGL
KASAALGEAMKVVQSSKAFSHPSNWAGFMLIGS
DVKLNSPSSLIGQALTEILQHPERARD
ALRVLLHLVEKSLQRIQNGQRNAMYTSQQSVENKVGGIPGWQALLTAVGFRLDPPTSGLP
AAVFFPTSDPGDRLQQCSSTLQSLLGLPNPALQALCKLITASETGEQLISRAVKNMVGML
HQVLVQLQAGEKEQDLASAPIQVSISVQLWRLPGCHEFLAALGFDLCEVGQEEVILKTGK
QANRRTVHFALQSLLSLFDSTELPKRLSLDSSSSLESLASAQSVSNALPLGYQQPPFSPT
GADSIASDAISVYSLSSIASSMSFVSKPEGGSEGGGPGGRQDHDRSKNAYLQRSTLPRSQ
LPPQTRPAGNKDEEEYEGFSIISNEPLATYQENRNTCFSPDHKQPQPGTAGGMRVSVSSK
GSISTPNSPVKMTLIPSPNSPFQKVGKLASSDTGESDQSSTETDSTVKSQEESNPKLDPQ
ELAQKILEETQSHLIAVERLQRSGGQVSKSNNPEDGVQAPSSTAVFRASETSAFSRPVLS
HQKSQPSPVTVKPKPPARSSSLPKVSSGYSSPTTSEMSIKDSPSQHSGRPSPGCDSQTSQ
LDQPLFKLKYPSSPYSAHISKSPRNMSPSSGHQSPAGSAPSPALSYSSAGSARSSPADAP
DIDKLKMAAIDEKVQAVHNLKMFWQSTPQHSTGPMKIFRGAPGTMTSKRDVLSLLNLSPR
HNKKEEGVDKLELKELSLQQHDGAPPKAPPNGHWRTETTSLGSLPLPAGPPATAPARPLR
LPSGNGYKFLSPGRFFPSSKC
Sequence length 2481
Interactions View interactions
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Alzheimer disease Alzheimer's disease or family history of Alzheimer's disease N/A N/A GWAS
Asthma Age of onset of adult onset asthma N/A N/A GWAS
Breast Cancer Breast cancer specific mortality in estrogen receptor positive breast cancer, Illnesses of mother: Breast cancer (UKB data field 20110_5), Cancer code, self-reported: breast cancer (UKB data field 20001_1002), Postmenopausal breast cancer, Breast cancer (PheCode 174), Breast cancer specific mortality in breast cancer N/A N/A GWAS
Breast cancer Breast cancer N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Carcinoma Hepatocellular Associate 36906605
Colorectal Neoplasms Associate 24553397
Esophageal Neoplasms Associate 28548104
Glaucoma Associate 36982708
Multiple Sclerosis Associate 36232761
Orofacial Cleft 1 Associate 26561393
Otofaciocervical Syndrome Associate 26561393
Ovarian Neoplasms Associate 20386703
Precursor Cell Lymphoblastic Leukemia Lymphoma Associate 34106877
Syndrome Associate 26633546