Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
23315
Gene name Gene Name - the full gene name approved by the HGNC.
Solute carrier family 9 member A8
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SLC9A8
Synonyms (NCBI Gene) Gene synonyms aliases
NHE-8, NHE8
Chromosome Chromosome number
20
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
20q13.13
Summary Summary of gene provided in NCBI Entrez Gene.
Sodium-hydrogen exchangers (NHEs), such as SLC9A8, are integral transmembrane proteins that exchange extracellular Na+ for intracellular H+. NHEs have multiple functions, including intracellular pH homeostasis, cell volume regulation, and electroneutral N
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT713755 hsa-miR-4293 HITS-CLIP 19536157
MIRT713754 hsa-miR-596 HITS-CLIP 19536157
MIRT713753 hsa-miR-1199-5p HITS-CLIP 19536157
MIRT713752 hsa-miR-6751-3p HITS-CLIP 19536157
MIRT713751 hsa-miR-4534 HITS-CLIP 19536157
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000139 Component Golgi membrane IDA 15522866
GO:0000139 Component Golgi membrane IEA
GO:0000139 Component Golgi membrane TAS
GO:0001669 Component Acrosomal vesicle IEA
GO:0001669 Component Acrosomal vesicle ISS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
612730 20728 ENSG00000197818
Protein
UniProt ID Q9Y2E8
Protein name Sodium/hydrogen exchanger 8 (Na(+)/H(+) exchanger 8) (NHE-8) (Solute carrier family 9 member 8)
Protein function Na(+)/H(+) antiporter. Mediates the electoneutral exchange of intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry (PubMed:15522866). Acts as an Na(+)/H(+) exchanger in the trans-Golgi. Contributes to the regulation of pH regulat
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00999 Na_H_Exchanger 62 473 Sodium/hydrogen exchanger family Family
Tissue specificity TISSUE SPECIFICITY: Ubiquitous. Strongly expressed in skeletal muscle and kidney (PubMed:15522866). Detected throughout the entire gastrointestinal tract, with high expression detected in stomach, duodenum and ascending colon (PubMed:18209477). {ECO:00002
Sequence
Sequence length 581
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Sodium/Proton exchangers
<
Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Amyotrophic Lateral Sclerosis Amyotrophic lateral sclerosis N/A N/A GWAS
Coronary artery disease Coronary artery disease N/A N/A GWAS
Multiple Sclerosis Multiple sclerosis N/A N/A GWAS
Psoriasis Psoriasis N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Amyotrophic Lateral Sclerosis Associate 33541344
Colitis Associate 40434024
Colitis Ulcerative Inhibit 40434024
Colorectal Neoplasms Associate 34965262
Frontotemporal Dementia Associate 37979250
Inflammation Inhibit 26564720