Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	23307
Gene name	FKBP prolyl isomerase family member 15
Gene symbol	FKBP15
Synonyms (NCBI Gene)	FKBP133KIAA0674PPP1R76
Chromosome	9
Chromosome location	9q32

141

Show/Hide all (141)

miRTarBase ID	miRNA	Experiments	Reference
MIRT026296	hsa-miR-192-5p	Microarray	19074876
MIRT040103	hsa-miR-615-3p	CLASH	23622248
MIRT703544	hsa-miR-6782-3p	HITS-CLIP	23313552
MIRT703543	hsa-miR-3919	HITS-CLIP	23313552
MIRT703542	hsa-miR-3121-5p	HITS-CLIP	23313552
MIRT703541	hsa-miR-2467-3p	HITS-CLIP	23313552
MIRT703540	hsa-miR-500a-3p	HITS-CLIP	23313552
MIRT703513	hsa-miR-1273h-3p	HITS-CLIP	23313552
MIRT703512	hsa-miR-3678-3p	HITS-CLIP	23313552
MIRT703539	hsa-miR-507	HITS-CLIP	23313552
MIRT703538	hsa-miR-557	HITS-CLIP	23313552
MIRT703537	hsa-miR-19a-3p	HITS-CLIP	23313552
MIRT703536	hsa-miR-19b-3p	HITS-CLIP	23313552
MIRT703535	hsa-miR-5584-5p	HITS-CLIP	23313552
MIRT703534	hsa-miR-6750-5p	HITS-CLIP	23313552
MIRT703533	hsa-miR-6822-5p	HITS-CLIP	23313552
MIRT703532	hsa-miR-296-3p	HITS-CLIP	23313552
MIRT703531	hsa-miR-8063	HITS-CLIP	23313552
MIRT703530	hsa-miR-6823-5p	HITS-CLIP	23313552
MIRT703529	hsa-miR-1915-3p	HITS-CLIP	23313552
MIRT703528	hsa-miR-6764-5p	HITS-CLIP	23313552
MIRT703527	hsa-miR-548aj-5p	HITS-CLIP	23313552
MIRT703526	hsa-miR-548f-5p	HITS-CLIP	23313552
MIRT703525	hsa-miR-548g-5p	HITS-CLIP	23313552
MIRT703524	hsa-miR-548x-5p	HITS-CLIP	23313552
MIRT703523	hsa-miR-1468-3p	HITS-CLIP	23313552
MIRT703522	hsa-miR-3202	HITS-CLIP	23313552
MIRT703521	hsa-miR-7974	HITS-CLIP	23313552
MIRT703520	hsa-miR-4687-3p	HITS-CLIP	23313552
MIRT703519	hsa-miR-4747-5p	HITS-CLIP	23313552
MIRT703518	hsa-miR-5196-5p	HITS-CLIP	23313552
MIRT703517	hsa-miR-203a-5p	HITS-CLIP	23313552
MIRT703516	hsa-miR-1273g-5p	HITS-CLIP	23313552
MIRT703515	hsa-miR-3162-5p	HITS-CLIP	23313552
MIRT703514	hsa-miR-548aw	HITS-CLIP	23313552
MIRT703513	hsa-miR-1273h-3p	HITS-CLIP	23313552
MIRT703512	hsa-miR-3678-3p	HITS-CLIP	23313552
MIRT703511	hsa-miR-647	HITS-CLIP	23313552
MIRT703510	hsa-miR-6842-3p	HITS-CLIP	23313552
MIRT537350	hsa-miR-4499	PAR-CLIP	22012620
MIRT537349	hsa-miR-4463	PAR-CLIP	22012620
MIRT537348	hsa-miR-6734-3p	PAR-CLIP	22012620
MIRT537347	hsa-miR-3667-3p	PAR-CLIP	22012620
MIRT537346	hsa-miR-6857-3p	PAR-CLIP	22012620
MIRT537345	hsa-miR-3670	PAR-CLIP	22012620
MIRT537344	hsa-miR-4448	PAR-CLIP	22012620
MIRT537343	hsa-miR-151a-3p	PAR-CLIP	22012620
MIRT703537	hsa-miR-19a-3p	HITS-CLIP	22473208
MIRT703536	hsa-miR-19b-3p	HITS-CLIP	22473208
MIRT703544	hsa-miR-6782-3p	HITS-CLIP	23313552
MIRT703543	hsa-miR-3919	HITS-CLIP	23313552
MIRT703542	hsa-miR-3121-5p	HITS-CLIP	23313552
MIRT703541	hsa-miR-2467-3p	HITS-CLIP	23313552
MIRT703540	hsa-miR-500a-3p	HITS-CLIP	23313552
MIRT703513	hsa-miR-1273h-3p	HITS-CLIP	23313552
MIRT703512	hsa-miR-3678-3p	HITS-CLIP	23313552
MIRT703539	hsa-miR-507	HITS-CLIP	23313552
MIRT703538	hsa-miR-557	HITS-CLIP	23313552
MIRT703537	hsa-miR-19a-3p	HITS-CLIP	23313552
MIRT703536	hsa-miR-19b-3p	HITS-CLIP	23313552
MIRT703535	hsa-miR-5584-5p	HITS-CLIP	23313552
MIRT703534	hsa-miR-6750-5p	HITS-CLIP	23313552
MIRT703533	hsa-miR-6822-5p	HITS-CLIP	23313552
MIRT703532	hsa-miR-296-3p	HITS-CLIP	23313552
MIRT703531	hsa-miR-8063	HITS-CLIP	23313552
MIRT703530	hsa-miR-6823-5p	HITS-CLIP	23313552
MIRT703529	hsa-miR-1915-3p	HITS-CLIP	23313552
MIRT703528	hsa-miR-6764-5p	HITS-CLIP	23313552
MIRT703527	hsa-miR-548aj-5p	HITS-CLIP	23313552
MIRT703526	hsa-miR-548f-5p	HITS-CLIP	23313552
MIRT703525	hsa-miR-548g-5p	HITS-CLIP	23313552
MIRT703524	hsa-miR-548x-5p	HITS-CLIP	23313552
MIRT703523	hsa-miR-1468-3p	HITS-CLIP	23313552
MIRT703522	hsa-miR-3202	HITS-CLIP	23313552
MIRT703521	hsa-miR-7974	HITS-CLIP	23313552
MIRT703520	hsa-miR-4687-3p	HITS-CLIP	23313552
MIRT703519	hsa-miR-4747-5p	HITS-CLIP	23313552
MIRT703518	hsa-miR-5196-5p	HITS-CLIP	23313552
MIRT703517	hsa-miR-203a-5p	HITS-CLIP	23313552
MIRT703516	hsa-miR-1273g-5p	HITS-CLIP	23313552
MIRT703515	hsa-miR-3162-5p	HITS-CLIP	23313552
MIRT703514	hsa-miR-548aw	HITS-CLIP	23313552
MIRT703513	hsa-miR-1273h-3p	HITS-CLIP	23313552
MIRT703512	hsa-miR-3678-3p	HITS-CLIP	23313552
MIRT703511	hsa-miR-647	HITS-CLIP	23313552
MIRT703510	hsa-miR-6842-3p	HITS-CLIP	23313552
MIRT537350	hsa-miR-4499	PAR-CLIP	22012620
MIRT537349	hsa-miR-4463	PAR-CLIP	22012620
MIRT537348	hsa-miR-6734-3p	PAR-CLIP	22012620
MIRT537347	hsa-miR-3667-3p	PAR-CLIP	22012620
MIRT537346	hsa-miR-6857-3p	PAR-CLIP	22012620
MIRT537345	hsa-miR-3670	PAR-CLIP	22012620
MIRT537344	hsa-miR-4448	PAR-CLIP	22012620
MIRT537343	hsa-miR-151a-3p	PAR-CLIP	22012620
MIRT997227	hsa-miR-1915	CLIP-seq
MIRT997228	hsa-miR-3185	CLIP-seq
MIRT997229	hsa-miR-4666-5p	CLIP-seq
MIRT997230	hsa-miR-4717-5p	CLIP-seq
MIRT997231	hsa-miR-4726-3p	CLIP-seq
MIRT997232	hsa-miR-4755-3p	CLIP-seq
MIRT997233	hsa-miR-4759	CLIP-seq
MIRT2229671	hsa-miR-1226	CLIP-seq
MIRT2229672	hsa-miR-1305	CLIP-seq
MIRT2229673	hsa-miR-1908	CLIP-seq
MIRT2229674	hsa-miR-192	CLIP-seq
MIRT2229675	hsa-miR-197	CLIP-seq
MIRT2229676	hsa-miR-215	CLIP-seq
MIRT2229677	hsa-miR-216a	CLIP-seq
MIRT2229678	hsa-miR-216b	CLIP-seq
MIRT2229679	hsa-miR-24	CLIP-seq
MIRT2229680	hsa-miR-3151	CLIP-seq
MIRT2229681	hsa-miR-3973	CLIP-seq
MIRT2229682	hsa-miR-4283	CLIP-seq
MIRT2229683	hsa-miR-4437	CLIP-seq
MIRT2229684	hsa-miR-4489	CLIP-seq
MIRT2229685	hsa-miR-4651	CLIP-seq
MIRT997231	hsa-miR-4726-3p	CLIP-seq
MIRT2229686	hsa-miR-4733-3p	CLIP-seq
MIRT2229687	hsa-miR-4787-5p	CLIP-seq
MIRT2229688	hsa-miR-4793-3p	CLIP-seq
MIRT2229689	hsa-miR-520g	CLIP-seq
MIRT2229690	hsa-miR-520h	CLIP-seq
MIRT2229691	hsa-miR-607	CLIP-seq
MIRT2229692	hsa-miR-608	CLIP-seq
MIRT2229693	hsa-miR-616	CLIP-seq
MIRT2229694	hsa-miR-663	CLIP-seq
MIRT2229677	hsa-miR-216a	CLIP-seq
MIRT2229678	hsa-miR-216b	CLIP-seq
MIRT2533613	hsa-miR-3168	CLIP-seq
MIRT2533614	hsa-miR-4270	CLIP-seq
MIRT2533615	hsa-miR-4287	CLIP-seq
MIRT2533616	hsa-miR-4423-5p	CLIP-seq
MIRT2533617	hsa-miR-4441	CLIP-seq
MIRT2533618	hsa-miR-4469	CLIP-seq
MIRT2533619	hsa-miR-4685-3p	CLIP-seq
MIRT2533620	hsa-miR-4690-3p	CLIP-seq
MIRT997231	hsa-miR-4726-3p	CLIP-seq
MIRT2533621	hsa-miR-4760-5p	CLIP-seq
MIRT2229688	hsa-miR-4793-3p	CLIP-seq
MIRT2533622	hsa-miR-769-5p	CLIP-seq
MIRT997231	hsa-miR-4726-3p	CLIP-seq

Show/Hide all (14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003755	Function	Peptidyl-prolyl cis-trans isomerase activity	IEA
GO:0003779	Function	Actin binding	IEA
GO:0005515	Function	Protein binding	IPI	20923837, 22070227, 29084197
GO:0005737	Component	Cytoplasm	IEA
GO:0005768	Component	Endosome	IEA
GO:0005769	Component	Early endosome	IEA
GO:0006897	Process	Endocytosis	IEA
GO:0015629	Component	Actin cytoskeleton	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IDA	22070227
GO:0030424	Component	Axon	IEA
GO:0030426	Component	Growth cone	IBA
GO:0030426	Component	Growth cone	IEA
GO:0042995	Component	Cell projection	IEA

MIM	HGNC	e!Ensembl
617398	23397	ENSG00000119321

Q5T1M5

Protein name

FK506-binding protein 15 (FKBP-15) (133 kDa FK506-binding protein) (133 kDa FKBP) (FKBP-133) (WASP- and FKBP-like protein) (WAFL)

Protein function

May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity). Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule-base

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00254	FKBP_C	191 → 287	FKBP-type peptidyl-prolyl cis-trans isomerase	Domain

Sequence

MFGAGDEDDTDFLSPSGGARLASLFGLDQAAAGHGNEFFQYTAPKQPKKGQGTAATGNQA
TPKTAPATMSTPTILVATAVHAYRYTNGQYVKQGKFGAAVLGNHTAREYRILLYISQQQP
VTVARIHVNFELMVRPNNYSTFYDDQRQNWSIMFESEKAAVEFNKQVCIAKCNSTSSLDA
VLSQDLIVADGPAVEVGDSLEVAYTGWLFQNHVLGQVFDSTANKDKLLRLKLGSGKVIKG
WEDGMLGMKKGGKRLLIVPPACAVGSEGVIGWTQATDSILVFEVEVRRVKFARDSGSDGH
SVSSRDSAAPSPIPGADNLSADPVVSPPTSIPFKSGEPALRTKSNSLSEQLAINTSPDAV
KAKLISRMAKMGQPMLPILPPQLDSNDSEIEDVNTLQGGGQPVVTPSVQPSLHPAHPALP
QMTSQAPQPSVTGLQAPSAALMQVSSLDSHSAVSGNAQSFQPYAGMQAYAYPQASAVTSQ
LQPVRPLYPAPLSQPPHFQGSGDMASFLMTEARQHNTEIRMAVSKVADKMDHLMTKVEEL
QKHSAGNSMLIPSMSVTMETSMIMSNIQRIIQENERLKQEILEKSNRIEEQNDKISELIE
RNQRYVEQSNLMMEKRNNSLQTATENTQARVLHAEQEKAKVTEELAAATAQVSHLQLKMT
AHQKKETELQMQLTESLKETDLLRGQLTKVQAKLSELQETSEQAQSKFKSEKQNRKQLEL
KVTSLEEELTDLRVEKESLEKNLSERKKKSAQERSQAEEEIDEIRKSYQEELDKLRQLLK
KTRVSTDQAAAEQLSLVQAELQTQWEAKCEHLLASAKDEHLQQYQEVCAQRDAYQQKLVQ
LQEKCLALQAQITALTKQNEQHIKELEKNKSQMSGVEAAASDPSEKVKKIMNQVFQSLRR
EFELEESYNGRTILGTIMNTIKMVTLQLLNQQEQEKEESSSEEEEEKAEERPRRPSQEQS
ASASSGQPQAPLNRERPESPMVPSEQVVEEAVPLPPQALTTSQDGHRRKGDSEAEALSEI
KDGSLPPELSCIPSHRVLGPPTSIPPEPLGPVSMDSECEESLAASPMAAKPDNPSGKVCV
REVAPDGPLQESSTRLSLTSDPEEGDPLALGPESPGEPQPPQLKKDDVTSSTGPHKELSS
TEAGSTVAGAALRPSHHSQRSSLSGDEEDELFKGATLKALRPKAQPEEEDEDEVSMKGRP
PPTPLFGDDDDDDDIDWLG

Sequence length

1219

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
AMPHETAMINE OR RELATED ACTING SYMPATHOMIMETIC ABUSE	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AMPHETAMINE-RELATED DISORDERS	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (3)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Colitis Ulcerative	Associate	20376207	★★★★★ ★☆☆☆☆ Found in Text Mining only
Gallbladder Neoplasms	Associate	17595796	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hepatitis C Chronic	Associate	20164022	★★★★★ ★☆☆☆☆ Found in Text Mining only

FKBP15 (FKBP prolyl isomerase family member 15)