Gene Gene information from NCBI Gene database.
Entrez ID 23291
Gene name F-box and WD repeat domain containing 11
Gene symbol FBXW11
Synonyms (NCBI Gene)
BTRC2BTRCP2FBW1BFBXW1BFbw11HosNEDJED
Chromosome 5
Chromosome location 5q35.1
Summary This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), w
miRNA miRNA information provided by mirtarbase database.
684
miRTarBase ID miRNA Experiments Reference
MIRT019282 hsa-miR-148b-3p Microarray 17612493
MIRT051087 hsa-miR-16-5p CLASH 23622248
MIRT042396 hsa-miR-450a-5p CLASH 23622248
MIRT442267 hsa-miR-4475 PAR-CLIP 22100165
MIRT442268 hsa-miR-4433b-3p PAR-CLIP 22100165
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
50
GO ID Ontology Definition Evidence Reference
GO:0000132 Process Establishment of mitotic spindle orientation IBA
GO:0000151 Component Ubiquitin ligase complex NAS 10531035
GO:0000209 Process Protein polyubiquitination IDA 20347421
GO:0000209 Process Protein polyubiquitination IEA
GO:0000776 Component Kinetochore IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
605651 13607 ENSG00000072803
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9UKB1
Protein name F-box/WD repeat-containing protein 11 (F-box and WD repeats protein beta-TrCP2) (F-box/WD repeat-containing protein 1B) (Homologous to Slimb protein) (HOS)
Protein function Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:10437795, PubMed:10648623, PubMed:11158290
PDB 6WNX
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF12125 Beta-TrCP_D 78 116 D domain of beta-TrCP Domain
PF12937 F-box-like 120 170 F-box-like Domain
PF00400 WD40 228 266 WD domain, G-beta repeat Repeat
PF00400 WD40 270 306 WD domain, G-beta repeat Repeat
PF00400 WD40 310 346 WD domain, G-beta repeat Repeat
PF00400 WD40 353 389 WD domain, G-beta repeat Repeat
PF00400 WD40 393 429 WD domain, G-beta repeat Repeat
PF00400 WD40 433 469 WD domain, G-beta repeat Repeat
PF00400 WD40 483 518 WD domain, G-beta repeat Repeat
Sequence
Sequence length 542
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Oocyte meiosis
Ubiquitin mediated proteolysis
Cellular senescence
Wnt signaling pathway
Hedgehog signaling pathway
Hippo signaling pathway
Circadian rhythm
Shigellosis
Human immunodeficiency virus 1 infection
  Activation of NF-kappaB in B cells
Downstream TCR signaling
Regulation of PLK1 Activity at G2/M Transition
FCERI mediated NF-kB activation
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
NIK-->noncanonical NF-kB signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
28
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Neurodevelopmental, jaw, eye, and digital syndrome Likely pathogenic; Pathogenic rs1757708758, rs2113754835, rs2113777419, rs1758081491, rs1759346639 RCV001374430
RCV001374429
RCV001374428
RCV001374427
RCV001175173
RCV001175174
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
FBXW11-related disorder Uncertain significance; Benign; Likely benign rs1766783775, rs1760009270, rs1294517861, rs756313939, rs61749649 RCV003412396
RCV003402994
RCV003894494
RCV003952043
RCV003935811
FBXW11-related neurodevelopmental, brain, eye, and digit anomalies Conflicting classifications of pathogenicity rs1758225061 RCV001095749
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Chondrosarcoma Inhibit 36404534
Cleidocranial Dysplasia Stimulate 37199076
Hereditary Autoinflammatory Diseases Associate 36250618
Inflammatory Bowel Diseases Associate 34251416
Microcephaly with Mental Retardation and Digital Anomalies Associate 31402090
Microphthalmia Syndromic 6 Associate 31402090
Neoplasms Associate 28472177, 37199076
Noonan Syndrome Associate 31402090
Osteosarcoma Associate 37199076
Prostatic Neoplasms Associate 16651270