Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
23291
Gene name Gene Name - the full gene name approved by the HGNC.
F-box and WD repeat domain containing 11
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
FBXW11
Synonyms (NCBI Gene) Gene synonyms aliases
BTRC2, BTRCP2, FBW1B, FBXW1B, Fbw11, Hos, NEDJED
Disease Acronyms (UniProt) Disease acronyms from UniProt database
NEDJED
Chromosome Chromosome number
5
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
5q35.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), w
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT019282 hsa-miR-148b-3p Microarray 17612493
MIRT051087 hsa-miR-16-5p CLASH 23622248
MIRT042396 hsa-miR-450a-5p CLASH 23622248
MIRT442267 hsa-miR-4475 PAR-CLIP 22100165
MIRT442268 hsa-miR-4433b-3p PAR-CLIP 22100165
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000086 Process G2/M transition of mitotic cell cycle TAS
GO:0000132 Process Establishment of mitotic spindle orientation IBA 21873635
GO:0000151 Component Ubiquitin ligase complex NAS 10531035
GO:0000209 Process Protein polyubiquitination IDA 20347421
GO:0000209 Process Protein polyubiquitination TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
605651 13607 ENSG00000072803
Protein
UniProt ID Q9UKB1
Protein name F-box/WD repeat-containing protein 11 (F-box and WD repeats protein beta-TrCP2) (F-box/WD repeat-containing protein 1B) (Homologous to Slimb protein) (HOS)
Protein function Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:10437795, PubMed:10648623, PubMed:11158290
PDB 6WNX
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF12125 Beta-TrCP_D 78 116 D domain of beta-TrCP Domain
PF12937 F-box-like 120 170 F-box-like Domain
PF00400 WD40 228 266 WD domain, G-beta repeat Repeat
PF00400 WD40 270 306 WD domain, G-beta repeat Repeat
PF00400 WD40 310 346 WD domain, G-beta repeat Repeat
PF00400 WD40 353 389 WD domain, G-beta repeat Repeat
PF00400 WD40 393 429 WD domain, G-beta repeat Repeat
PF00400 WD40 433 469 WD domain, G-beta repeat Repeat
PF00400 WD40 483 518 WD domain, G-beta repeat Repeat
Sequence
Sequence length 542
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Oocyte meiosis
Ubiquitin mediated proteolysis
Cellular senescence
Wnt signaling pathway
Hedgehog signaling pathway
Hippo signaling pathway
Circadian rhythm
Shigellosis
Human immunodeficiency virus 1 infection
  Activation of NF-kappaB in B cells
Downstream TCR signaling
Regulation of PLK1 Activity at G2/M Transition
FCERI mediated NF-kB activation
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
NIK-->noncanonical NF-kB signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Neddylation
Antigen processing: Ubiquitination & Proteasome degradation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Developmental delay Global developmental delay rs28941770, rs199469464, rs281865469, rs143747297, rs398123009, rs587777428, rs786205133, rs606231459, rs797044854, rs797045027, rs864309504, rs878853160, rs886039902, rs886042046, rs886041291
View all (32 more)
31402090
Mental retardation Intellectual Disability rs5742905, rs267607136, rs267607137, rs2131714307, rs267607038, rs267607042, rs80338685, rs137853127, rs80338815, rs28940893, rs387906309, rs121908096, rs121908099, rs587784365, rs121918315
View all (1024 more)
31402090
Unknown
Disease term Disease name Evidence References Source
Glioblastoma Glioblastoma CRISPR screening of E3 ubiquitin ligases reveals Ring Finger Protein 185 as a novel tumor suppressor in glioblastoma repressed by promoter hypermethylation and miR-587 GWAS, CBGDA
Associations from Text Mining
Disease Name Relationship Type References
Chondrosarcoma Inhibit 36404534
Cleidocranial Dysplasia Stimulate 37199076
Hereditary Autoinflammatory Diseases Associate 36250618
Inflammatory Bowel Diseases Associate 34251416
Microcephaly with Mental Retardation and Digital Anomalies Associate 31402090
Microphthalmia Syndromic 6 Associate 31402090
Neoplasms Associate 28472177, 37199076
Noonan Syndrome Associate 31402090
Osteosarcoma Associate 37199076
Prostatic Neoplasms Associate 16651270