FMO4 (flavin containing dimethylaniline monoxygenase 4)

Gene
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
2329
Gene name Gene Name - the full gene name approved by the HGNC.
Flavin containing dimethylaniline monoxygenase 4
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
FMO4
Synonyms (NCBI Gene) Gene synonyms aliases
FMO2
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1q24.3
Summary Summary of gene provided in NCBI Entrez Gene.
Metabolic N-oxidation of diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man. This results in a small subpopulation with reduced TMA N-oxidation capacity and causes
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(122)
miRTarBase ID miRNA Experiments Reference
MIRT617864 hsa-miR-888-3p HITS-CLIP 23824327
MIRT617862 hsa-miR-4695-5p HITS-CLIP 23824327
MIRT617861 hsa-miR-4779 HITS-CLIP 23824327
MIRT617860 hsa-miR-196a-5p HITS-CLIP 23824327
MIRT617859 hsa-miR-196b-5p HITS-CLIP 23824327
Transcription factors
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(1)
Transcription factor Regulation Reference
FOS Activation 20188076
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(15)
GO ID Ontology Definition Evidence Reference
GO:0004497 Function Monooxygenase activity IEA
GO:0004499 Function N,N-dimethylaniline monooxygenase activity IBA
GO:0004499 Function N,N-dimethylaniline monooxygenase activity IEA
GO:0004499 Function N,N-dimethylaniline monooxygenase activity NAS 1417778
GO:0005515 Function Protein binding IPI 32296183
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
136131 3772 ENSG00000076258
Protein
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID P31512
Protein name Dimethylaniline monooxygenase [N-oxide-forming] 4 (EC 1.14.13.8) (Dimethylaniline oxidase 4) (Hepatic flavin-containing monooxygenase 4) (FMO 4)
Protein function This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00743 FMO-like 2 → 532 Flavin-binding monooxygenase-like Family
Tissue specificity TISSUE SPECIFICITY: Liver.
Sequence
Sequence length 558
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  
  Taurine and hypotaurine metabolism
Drug metabolism - cytochrome P450
Metabolic pathways 		 
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Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Unknown Diseases (2)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Diabetes Type 2 diabetes (age of onset) N/A N/A GWAS
Intracranial Aneurysm Intracranial aneurysm N/A N/A GWAS