NUP160 (nucleoporin 160)

Gene

• Entrez ID: 23279
• Gene name: Nucleoporin 160
• Gene symbol: NUP160
• Synonyms (NCBI Gene): NPHS19
• Chromosome: 11
• Chromosome location: 11p11.2
• Summary: NUP160 is 1 of up to 60 proteins that make up the 120-MD nuclear pore complex, which mediates nucleoplasmic transport.[supplied by OMIM, Apr 2004]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT023922	hsa-miR-1-3p	Proteomics;Microarray	18668037
MIRT031904	hsa-miR-16-5p	Proteomics	18668040
MIRT046496	hsa-miR-15b-5p	CLASH	23622248
MIRT043189	hsa-miR-324-5p	CLASH	23622248
MIRT038904	hsa-miR-93-3p	CLASH	23622248
MIRT1199063	hsa-miR-200b	CLIP-seq
MIRT1199064	hsa-miR-200c	CLIP-seq
MIRT1199065	hsa-miR-298	CLIP-seq
MIRT1199066	hsa-miR-300	CLIP-seq
MIRT1199067	hsa-miR-3166	CLIP-seq
MIRT1199068	hsa-miR-3591-3p	CLIP-seq
MIRT1199069	hsa-miR-3609	CLIP-seq
MIRT1199070	hsa-miR-3613-5p	CLIP-seq
MIRT1199071	hsa-miR-3672	CLIP-seq
MIRT1199072	hsa-miR-3678-3p	CLIP-seq
MIRT1199073	hsa-miR-374c	CLIP-seq
MIRT1199074	hsa-miR-381	CLIP-seq
MIRT1199075	hsa-miR-3944-5p	CLIP-seq
MIRT1199076	hsa-miR-3978	CLIP-seq
MIRT1199077	hsa-miR-409-3p	CLIP-seq
MIRT1199078	hsa-miR-4256	CLIP-seq
MIRT1199079	hsa-miR-429	CLIP-seq
MIRT1199080	hsa-miR-4290	CLIP-seq
MIRT1199081	hsa-miR-4643	CLIP-seq
MIRT1199082	hsa-miR-466	CLIP-seq
MIRT1199083	hsa-miR-4666-3p	CLIP-seq
MIRT1199084	hsa-miR-4667-3p	CLIP-seq
MIRT1199085	hsa-miR-4670-3p	CLIP-seq
MIRT1199086	hsa-miR-4729	CLIP-seq
MIRT1199087	hsa-miR-4771	CLIP-seq
MIRT1199088	hsa-miR-4775	CLIP-seq
MIRT1199089	hsa-miR-4786-5p	CLIP-seq
MIRT1199090	hsa-miR-4789-3p	CLIP-seq
MIRT1199091	hsa-miR-4798-5p	CLIP-seq
MIRT1199092	hsa-miR-4799-5p	CLIP-seq
MIRT1199093	hsa-miR-493	CLIP-seq
MIRT1199094	hsa-miR-499a-5p	CLIP-seq
MIRT1199095	hsa-miR-548ah	CLIP-seq
MIRT1199096	hsa-miR-581	CLIP-seq
MIRT1199097	hsa-miR-582-5p	CLIP-seq
MIRT1199098	hsa-miR-618	CLIP-seq
MIRT1199099	hsa-miR-627	CLIP-seq
MIRT1199100	hsa-miR-645	CLIP-seq
MIRT1199101	hsa-miR-646	CLIP-seq
MIRT1199102	hsa-miR-655	CLIP-seq
MIRT1199103	hsa-miR-718	CLIP-seq
MIRT1199104	hsa-miR-769-5p	CLIP-seq
MIRT1199105	hsa-miR-924	CLIP-seq
MIRT1199106	hsa-miR-935	CLIP-seq
MIRT1199107	hsa-miR-944	CLIP-seq
MIRT2057714	hsa-miR-1234	CLIP-seq
MIRT2057715	hsa-miR-133a	CLIP-seq
MIRT2057716	hsa-miR-133b	CLIP-seq
MIRT2057717	hsa-miR-1911	CLIP-seq
MIRT2057718	hsa-miR-323-3p	CLIP-seq
MIRT2057719	hsa-miR-323b-3p	CLIP-seq
MIRT1199069	hsa-miR-3609	CLIP-seq
MIRT1199072	hsa-miR-3678-3p	CLIP-seq
MIRT1199076	hsa-miR-3978	CLIP-seq
MIRT1199085	hsa-miR-4670-3p	CLIP-seq
MIRT2057720	hsa-miR-4698	CLIP-seq
MIRT1199088	hsa-miR-4775	CLIP-seq
MIRT2057721	hsa-miR-4778-3p	CLIP-seq
MIRT1199093	hsa-miR-493	CLIP-seq
MIRT2057722	hsa-miR-520d-5p	CLIP-seq
MIRT2057723	hsa-miR-524-5p	CLIP-seq
MIRT1199095	hsa-miR-548ah	CLIP-seq
MIRT1199099	hsa-miR-627	CLIP-seq
MIRT1199105	hsa-miR-924	CLIP-seq
MIRT2057714	hsa-miR-1234	CLIP-seq
MIRT2286085	hsa-miR-134	CLIP-seq
MIRT2057717	hsa-miR-1911	CLIP-seq
MIRT1199065	hsa-miR-298	CLIP-seq
MIRT2286086	hsa-miR-29a	CLIP-seq
MIRT2286087	hsa-miR-29b	CLIP-seq
MIRT2286088	hsa-miR-29c	CLIP-seq
MIRT1199066	hsa-miR-300	CLIP-seq
MIRT2286089	hsa-miR-3118	CLIP-seq
MIRT2286090	hsa-miR-3140-3p	CLIP-seq
MIRT2286091	hsa-miR-3152-3p	CLIP-seq
MIRT1199067	hsa-miR-3166	CLIP-seq
MIRT2286092	hsa-miR-323-5p	CLIP-seq
MIRT1199068	hsa-miR-3591-3p	CLIP-seq
MIRT1199071	hsa-miR-3672	CLIP-seq
MIRT1199074	hsa-miR-381	CLIP-seq
MIRT1199075	hsa-miR-3944-5p	CLIP-seq
MIRT2286093	hsa-miR-4504	CLIP-seq
MIRT1199083	hsa-miR-4666-3p	CLIP-seq
MIRT1199087	hsa-miR-4771	CLIP-seq
MIRT1199089	hsa-miR-4786-5p	CLIP-seq
MIRT2286094	hsa-miR-486-5p	CLIP-seq
MIRT1199094	hsa-miR-499a-5p	CLIP-seq
MIRT2057722	hsa-miR-520d-5p	CLIP-seq
MIRT2057723	hsa-miR-524-5p	CLIP-seq
MIRT2286095	hsa-miR-548c-3p	CLIP-seq
MIRT1199096	hsa-miR-581	CLIP-seq
MIRT1199101	hsa-miR-646	CLIP-seq
MIRT1199104	hsa-miR-769-5p	CLIP-seq
MIRT2286096	hsa-miR-876-3p	CLIP-seq
MIRT2391820	hsa-miR-1226	CLIP-seq
MIRT2286086	hsa-miR-29a	CLIP-seq
MIRT2286087	hsa-miR-29b	CLIP-seq
MIRT2286088	hsa-miR-29c	CLIP-seq
MIRT2286091	hsa-miR-3152-3p	CLIP-seq
MIRT2391821	hsa-miR-634	CLIP-seq
MIRT2431757	hsa-miR-1299	CLIP-seq
MIRT2431758	hsa-miR-2113	CLIP-seq
MIRT2431759	hsa-miR-223	CLIP-seq
MIRT2431760	hsa-miR-302f	CLIP-seq
MIRT2286090	hsa-miR-3140-3p	CLIP-seq
MIRT2431761	hsa-miR-3177-5p	CLIP-seq
MIRT2431762	hsa-miR-338-5p	CLIP-seq
MIRT2431763	hsa-miR-33a	CLIP-seq
MIRT2431764	hsa-miR-33b	CLIP-seq
MIRT2431765	hsa-miR-3619-3p	CLIP-seq
MIRT2431766	hsa-miR-378	CLIP-seq
MIRT2431767	hsa-miR-378b	CLIP-seq
MIRT2431768	hsa-miR-378c	CLIP-seq
MIRT2431769	hsa-miR-378d	CLIP-seq
MIRT2431770	hsa-miR-378e	CLIP-seq
MIRT2431771	hsa-miR-378f	CLIP-seq
MIRT2431772	hsa-miR-378h	CLIP-seq
MIRT2431773	hsa-miR-378i	CLIP-seq
MIRT2431774	hsa-miR-422a	CLIP-seq
MIRT2431775	hsa-miR-4277	CLIP-seq
MIRT2431776	hsa-miR-4638-3p	CLIP-seq
MIRT2431777	hsa-miR-4776-5p	CLIP-seq
MIRT2431778	hsa-miR-4782-5p	CLIP-seq
MIRT2431779	hsa-miR-516b	CLIP-seq
MIRT2431780	hsa-miR-552	CLIP-seq
MIRT2431781	hsa-miR-599	CLIP-seq
MIRT2057714	hsa-miR-1234	CLIP-seq
MIRT2583977	hsa-miR-1236	CLIP-seq
MIRT2583978	hsa-miR-1246	CLIP-seq
MIRT2583979	hsa-miR-1267	CLIP-seq
MIRT2583980	hsa-miR-1290	CLIP-seq
MIRT2057717	hsa-miR-1911	CLIP-seq
MIRT2583981	hsa-miR-297	CLIP-seq
MIRT1199065	hsa-miR-298	CLIP-seq
MIRT2583982	hsa-miR-3134	CLIP-seq
MIRT2583983	hsa-miR-3149	CLIP-seq
MIRT1199067	hsa-miR-3166	CLIP-seq
MIRT2583984	hsa-miR-3167	CLIP-seq
MIRT1199070	hsa-miR-3613-5p	CLIP-seq
MIRT2583985	hsa-miR-3664-5p	CLIP-seq
MIRT1199071	hsa-miR-3672	CLIP-seq
MIRT2583986	hsa-miR-376a	CLIP-seq
MIRT2583987	hsa-miR-376b	CLIP-seq
MIRT2583988	hsa-miR-3921	CLIP-seq
MIRT1199075	hsa-miR-3944-5p	CLIP-seq
MIRT1199077	hsa-miR-409-3p	CLIP-seq
MIRT2583989	hsa-miR-4251	CLIP-seq
MIRT2583990	hsa-miR-4267	CLIP-seq
MIRT1199080	hsa-miR-4290	CLIP-seq
MIRT2583991	hsa-miR-4329	CLIP-seq
MIRT2583992	hsa-miR-4522	CLIP-seq
MIRT2583993	hsa-miR-4534	CLIP-seq
MIRT2583994	hsa-miR-4637	CLIP-seq
MIRT2583995	hsa-miR-4639-5p	CLIP-seq
MIRT1199081	hsa-miR-4643	CLIP-seq
MIRT2583996	hsa-miR-4653-5p	CLIP-seq
MIRT1199082	hsa-miR-466	CLIP-seq
MIRT1199084	hsa-miR-4667-3p	CLIP-seq
MIRT1199085	hsa-miR-4670-3p	CLIP-seq
MIRT2583997	hsa-miR-4699-3p	CLIP-seq
MIRT2583998	hsa-miR-4714-5p	CLIP-seq
MIRT1199086	hsa-miR-4729	CLIP-seq
MIRT1199087	hsa-miR-4771	CLIP-seq
MIRT1199090	hsa-miR-4789-3p	CLIP-seq
MIRT2583999	hsa-miR-487a	CLIP-seq
MIRT1199094	hsa-miR-499a-5p	CLIP-seq
MIRT2057722	hsa-miR-520d-5p	CLIP-seq
MIRT2057723	hsa-miR-524-5p	CLIP-seq
MIRT2286095	hsa-miR-548c-3p	CLIP-seq
MIRT2584000	hsa-miR-580	CLIP-seq
MIRT1199096	hsa-miR-581	CLIP-seq
MIRT1199097	hsa-miR-582-5p	CLIP-seq
MIRT2584001	hsa-miR-643	CLIP-seq
MIRT1199103	hsa-miR-718	CLIP-seq
MIRT2584002	hsa-miR-876-5p	CLIP-seq
MIRT1199106	hsa-miR-935	CLIP-seq
MIRT2057714	hsa-miR-1234	CLIP-seq
MIRT2583977	hsa-miR-1236	CLIP-seq
MIRT2583978	hsa-miR-1246	CLIP-seq
MIRT2583979	hsa-miR-1267	CLIP-seq
MIRT2583980	hsa-miR-1290	CLIP-seq
MIRT2057717	hsa-miR-1911	CLIP-seq
MIRT2583981	hsa-miR-297	CLIP-seq
MIRT1199065	hsa-miR-298	CLIP-seq
MIRT2583982	hsa-miR-3134	CLIP-seq
MIRT2583983	hsa-miR-3149	CLIP-seq
MIRT1199067	hsa-miR-3166	CLIP-seq
MIRT2583984	hsa-miR-3167	CLIP-seq
MIRT1199070	hsa-miR-3613-5p	CLIP-seq
MIRT2583985	hsa-miR-3664-5p	CLIP-seq
MIRT1199071	hsa-miR-3672	CLIP-seq
MIRT2583986	hsa-miR-376a	CLIP-seq
MIRT2583987	hsa-miR-376b	CLIP-seq
MIRT2583988	hsa-miR-3921	CLIP-seq
MIRT1199075	hsa-miR-3944-5p	CLIP-seq
MIRT1199077	hsa-miR-409-3p	CLIP-seq
MIRT2583989	hsa-miR-4251	CLIP-seq
MIRT2583990	hsa-miR-4267	CLIP-seq
MIRT1199080	hsa-miR-4290	CLIP-seq
MIRT2583991	hsa-miR-4329	CLIP-seq
MIRT2583992	hsa-miR-4522	CLIP-seq
MIRT2583993	hsa-miR-4534	CLIP-seq
MIRT2583994	hsa-miR-4637	CLIP-seq
MIRT2583995	hsa-miR-4639-5p	CLIP-seq
MIRT1199081	hsa-miR-4643	CLIP-seq
MIRT2583996	hsa-miR-4653-5p	CLIP-seq
MIRT1199082	hsa-miR-466	CLIP-seq
MIRT1199084	hsa-miR-4667-3p	CLIP-seq
MIRT1199085	hsa-miR-4670-3p	CLIP-seq
MIRT2583997	hsa-miR-4699-3p	CLIP-seq
MIRT2583998	hsa-miR-4714-5p	CLIP-seq
MIRT1199086	hsa-miR-4729	CLIP-seq
MIRT1199087	hsa-miR-4771	CLIP-seq
MIRT1199090	hsa-miR-4789-3p	CLIP-seq
MIRT2286094	hsa-miR-486-5p	CLIP-seq
MIRT2583999	hsa-miR-487a	CLIP-seq
MIRT1199094	hsa-miR-499a-5p	CLIP-seq
MIRT2057722	hsa-miR-520d-5p	CLIP-seq
MIRT2057723	hsa-miR-524-5p	CLIP-seq
MIRT2286095	hsa-miR-548c-3p	CLIP-seq
MIRT2584000	hsa-miR-580	CLIP-seq
MIRT1199096	hsa-miR-581	CLIP-seq
MIRT1199097	hsa-miR-582-5p	CLIP-seq
MIRT2584001	hsa-miR-643	CLIP-seq
MIRT1199103	hsa-miR-718	CLIP-seq
MIRT2584002	hsa-miR-876-5p	CLIP-seq
MIRT1199106	hsa-miR-935	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000776	Component	Kinetochore	IDA	15146057
GO:0005515	Function	Protein binding	IPI	15146057, 17043677, 24315095, 25416956, 30179222, 31413325
GO:0005634	Component	Nucleus	IEA
GO:0005635	Component	Nuclear envelope	IDA	24315095
GO:0005635	Component	Nuclear envelope	TAS
GO:0005643	Component	Nuclear pore	IBA
GO:0005643	Component	Nuclear pore	IDA	11564755, 11684705, 17098863
GO:0005643	Component	Nuclear pore	IEA
GO:0005643	Component	Nuclear pore	NAS	24315095
GO:0005829	Component	Cytosol	TAS
GO:0006406	Process	MRNA export from nucleus	IDA	11684705
GO:0006913	Process	Nucleocytoplasmic transport	IEA
GO:0006913	Process	Nucleocytoplasmic transport	NAS	27016207
GO:0015031	Process	Protein transport	IEA
GO:0017056	Function	Structural constituent of nuclear pore	IBA
GO:0017056	Function	Structural constituent of nuclear pore	IDA	11684705
GO:0031080	Component	Nuclear pore outer ring	IDA	17360435
GO:0031080	Component	Nuclear pore outer ring	NAS	15146057, 17363900
GO:0051028	Process	MRNA transport	IEA
GO:0072006	Process	Nephron development	IMP	30179222

Other IDs

• MIM: 607614
• HGNC: 18017
• e!Ensembl: ENSG00000030066

Protein

• UniProt ID: Q12769
• Protein name: Nuclear pore complex protein Nup160 (160 kDa nucleoporin) (Nucleoporin Nup160)
• Protein function: Functions as a component of the nuclear pore complex (NPC) (PubMed:11564755, PubMed:11684705). Involved in poly(A)+ RNA transport.
• PDB: 5A9Q, 7PEQ, 7R5J, 7R5K
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF11715	Nup160	62 → 577		Family

• Sequence:

  MLHLSAAPPAPPPEVTATARPCLCSVGRRGDGGKMAAAGALERSFVELSGAERERPRHFR
  EFTVCSIGTANAVAGAVKYSESAGGFYYVESGKLFSVTRNRFIHWKTSGDTLELMEESLD
  INLLNNAIRLKFQNCSVLPGGVYVSETQNRVIILMLTNQTVHRLLLPHPSRMYRSELVVD
  SQMQSIFTDIGKVDFTDPCNYQLIPAVPGISPNSTASTAWLSSDGEALFALPCASGGIFV
  LKLPPYDIPGMVSVVELKQSSVMQRLLTGWMPTAIRGDQSPSDRPLSLAVHCVEHDAFIF
  ALCQDHKLRMWSYKEQMCLMVADMLEYVPVKKDLRLTAGTGHKLRLAYSPTMGLYLGIYM
  HAPKRGQFCIFQLVSTESNRYSLDHISSLFTSQETLIDFALTSTDIWALWHDAENQTVVK
  YINFEHNVAGQWNPVFMQPLPEEEIVIRDDQDPREMYLQSLFTPGQFTNEALCKALQIFC
  RGTERNLDLSWSELKKEVTLAVENELQGSVTEYEFSQEEFRNLQQEFWCKFYACCLQYQE
  ALSHPLALHLNPHTNMVCLLKKGYLSFLIPSSLVDHLYLLPYENLLTEDETTISDDVDIA
  RDVICLIKCLRLIEESVTVDMSVIMEMSCYNLQSPEKAAEQILEDMITIDVENVMEDICS
  KLQEIRNPIHAIGLLIREMDYETEVEMEKGFNPAQPLNIRMNLTQLYGSNTAGYIVCRGV
  HKIASTRFLICRDLLILQQLLMRLGDAVIWGTGQLFQAQQDLLHRTAPLLLSYYLIKWGS
  ECLATDVPLDTLESNLQHLSVLELTDSGALMANRFVSSPQTIVELFFQEVARKHIISHLF
  SQPKAPLSQTGLNWPEMITAITSYLLQLLWPSNPGCLFLECLMGNCQYVQLQDYIQLLHP
  WCQVNVGSCRFMLGRCYLVTGEGQKALECFCQAASEVGKEEFLDRLIRSEDGEIVSTPRL
  QYYDKVLRLLDVIGLPELVIQLATSAITEAGDDWKSQATLRTCIFKHHLDLGHNSQAYEA
  LTQIPDSSRQLDCLRQLVVVLCERSQLQDLVEFPYVNLHNEVVGIIESRARAVDLMTHNY
  YELLYAFHIYRHNYRKAGTVMFEYGMRLGREVRTLRGLEKQGNCYLAALNCLRLIRPEYA
  WIVQPVSGAVYDRPGASPKRNHDGECTAAPTNRQIEILELEDLEKECSLARIRLTLAQHD
  PSAVAVAGSSSAEEMVTLLVQAGLFDTAISLCQTFKLPLTPVFEGLAFKCIKLQFGGEAA
  QAEAWAWLAANQLSSVITTKESSATDEAWRLLSTYLERYKVQNNLYHHCVINKLLSHGVP
  LPNWLINSYKKVDAAELLRLYLNYDLLEEAVDLVSEYVDAVLGKGHQYFGIEFPLSATAP
  MVWLPYSSIDQLLQALGENSANSHNIALSQKILDKLEDYQQKVDKATRDLLYRRTL

• Sequence length: 1436

Pathways

KEGG:

Nucleocytoplasmic transport
Amyotrophic lateral sclerosis

Reactome:

ISG15 antiviral mechanism
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Transport of the SLBP independent Mature mRNA
Transport of the SLBP Dependant Mature mRNA
Transport of Mature mRNA Derived from an Intronless Transcript
Transport of Mature mRNA derived from an Intron-Containing Transcript
Rev-mediated nuclear export of HIV RNA
Transport of Ribonucleoproteins into the Host Nucleus
NS1 Mediated Effects on Host Pathways
Viral Messenger RNA Synthesis
NEP/NS2 Interacts with the Cellular Export Machinery
Regulation of Glucokinase by Glucokinase Regulatory Protein
Vpr-mediated nuclear import of PICs
snRNP Assembly
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
SUMOylation of DNA damage response and repair proteins
SUMOylation of ubiquitinylation proteins
Nuclear Pore Complex (NPC) Disassembly
Regulation of HSF1-mediated heat shock response
SUMOylation of SUMOylation proteins
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA replication proteins
Transcriptional regulation by small RNAs
Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)
RHO GTPases Activate Formins
tRNA processing in the nucleus
Mitotic Prometaphase
HCMV Early Events
HCMV Late Events
Postmitotic nuclear pore complex (NPC) reformation
EML4 and NUDC in mitotic spindle formation

Associated diseases

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Nephrotic syndrome, type 19	Pathogenic	rs2135334498, rs2135385033	RCV001391129 RCV001844383

Unknown
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
NUP160-related disorder	Benign; Uncertain significance; Likely benign; Conflicting classifications of pathogenicity	rs3816605, rs201500360, rs114776609, rs142325189, rs201495092, rs139328483, rs112693798, rs138083274, rs149988673, rs200466756, rs147712305, rs148589426, rs2097682234, rs759499746, rs199997399, rs61755075, rs146411765, rs773807670, rs1213235579, rs755169593, rs1363565713, rs375040304, rs564280987, rs1251421378, rs564545037, rs760562797, rs114164215, rs766857567, rs749581419, rs376510898, rs56962998, rs149674516, rs186987850	RCV003976181 RCV004752079 RCV003971048 RCV003943800 RCV003953932 RCV003906551 RCV003936429 RCV003936424 RCV003906309 RCV003936387 RCV003396882 RCV003417050 RCV003402956 RCV003906731 RCV003954300 RCV003948911 RCV003893585 RCV003893921 RCV003904508 RCV003904564 RCV003899277 RCV003899379 RCV003944562 RCV003971893 RCV003951703 RCV003961501 RCV003937115 RCV003971382 RCV003969767 RCV003967032 RCV003918511 RCV003950636 RCV003968213
Osteopetrosis	Conflicting classifications of pathogenicity	rs755721902	RCV005235685

Associations from Text Mining
Disease Name	Relationship Type	References
Alzheimer Disease	Associate	27215977
Carcinoma Pancreatic Ductal	Associate	29671412
Leukemia Myelogenous Chronic BCR ABL Positive	Associate	31486501
Nephrotic Syndrome	Associate	30910934
Proteinuria	Associate	30910934