Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	23274
Gene name	C-type lectin domain containing 16A
Gene symbol	CLEC16A
Synonyms (NCBI Gene)	Gop-1KIAA0350
Chromosome	16
Chromosome location	16p13.13
Summary	This gene encodes a member of the C-type lectin domain containing family. Single nucleotide polymorphisms in introns of this gene have been associated with diabetes mellitus, multiple sclerosis and rheumatoid arthritis. Multiple transcript variants encodi

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Show/Hide all (232)

miRTarBase ID	miRNA	Experiments	Reference
MIRT043317	hsa-miR-331-3p	CLASH	23622248
MIRT041783	hsa-miR-484	CLASH	23622248
MIRT440937	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440937	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT895659	hsa-miR-1178	CLIP-seq
MIRT895660	hsa-miR-1251	CLIP-seq
MIRT895661	hsa-miR-1275	CLIP-seq
MIRT895662	hsa-miR-127-5p	CLIP-seq
MIRT895663	hsa-miR-1302	CLIP-seq
MIRT895664	hsa-miR-1323	CLIP-seq
MIRT895665	hsa-miR-1324	CLIP-seq
MIRT895666	hsa-miR-138	CLIP-seq
MIRT895667	hsa-miR-150	CLIP-seq
MIRT895668	hsa-miR-1587	CLIP-seq
MIRT895669	hsa-miR-1913	CLIP-seq
MIRT895670	hsa-miR-2277-3p	CLIP-seq
MIRT895671	hsa-miR-2467-3p	CLIP-seq
MIRT895672	hsa-miR-2861	CLIP-seq
MIRT895673	hsa-miR-3121-5p	CLIP-seq
MIRT895674	hsa-miR-3126-5p	CLIP-seq
MIRT895675	hsa-miR-3158-3p	CLIP-seq
MIRT895676	hsa-miR-3169	CLIP-seq
MIRT895677	hsa-miR-3184	CLIP-seq
MIRT895678	hsa-miR-3189-5p	CLIP-seq
MIRT895679	hsa-miR-3199	CLIP-seq
MIRT895680	hsa-miR-3202	CLIP-seq
MIRT895681	hsa-miR-324-3p	CLIP-seq
MIRT895682	hsa-miR-3619-3p	CLIP-seq
MIRT895683	hsa-miR-3622a-3p	CLIP-seq
MIRT895684	hsa-miR-3622b-3p	CLIP-seq
MIRT895685	hsa-miR-3652	CLIP-seq
MIRT895686	hsa-miR-3661	CLIP-seq
MIRT895687	hsa-miR-3689d	CLIP-seq
MIRT895688	hsa-miR-370	CLIP-seq
MIRT895689	hsa-miR-378g	CLIP-seq
MIRT895690	hsa-miR-3918	CLIP-seq
MIRT895691	hsa-miR-423-5p	CLIP-seq
MIRT895692	hsa-miR-4263	CLIP-seq
MIRT895693	hsa-miR-4271	CLIP-seq
MIRT895694	hsa-miR-4298	CLIP-seq
MIRT895695	hsa-miR-4430	CLIP-seq
MIRT895696	hsa-miR-4480	CLIP-seq
MIRT895697	hsa-miR-4488	CLIP-seq
MIRT895698	hsa-miR-4492	CLIP-seq
MIRT895699	hsa-miR-4497	CLIP-seq
MIRT895700	hsa-miR-4498	CLIP-seq
MIRT895701	hsa-miR-4502	CLIP-seq
MIRT895702	hsa-miR-4505	CLIP-seq
MIRT895703	hsa-miR-4512	CLIP-seq
MIRT895704	hsa-miR-4515	CLIP-seq
MIRT895705	hsa-miR-4521	CLIP-seq
MIRT895706	hsa-miR-4532	CLIP-seq
MIRT895707	hsa-miR-4640-5p	CLIP-seq
MIRT895708	hsa-miR-4649-3p	CLIP-seq
MIRT895709	hsa-miR-4656	CLIP-seq
MIRT895710	hsa-miR-4665-5p	CLIP-seq
MIRT895711	hsa-miR-4667-3p	CLIP-seq
MIRT895712	hsa-miR-4675	CLIP-seq
MIRT895713	hsa-miR-4684-5p	CLIP-seq
MIRT895714	hsa-miR-4685-5p	CLIP-seq
MIRT895715	hsa-miR-4697-5p	CLIP-seq
MIRT895716	hsa-miR-4698	CLIP-seq
MIRT895717	hsa-miR-4711-3p	CLIP-seq
MIRT895718	hsa-miR-4721	CLIP-seq
MIRT895719	hsa-miR-4725-3p	CLIP-seq
MIRT895720	hsa-miR-4726-5p	CLIP-seq
MIRT895721	hsa-miR-4740-5p	CLIP-seq
MIRT895722	hsa-miR-4741	CLIP-seq
MIRT895723	hsa-miR-4747-5p	CLIP-seq
MIRT895724	hsa-miR-4749-3p	CLIP-seq
MIRT895725	hsa-miR-4758-3p	CLIP-seq
MIRT895726	hsa-miR-4776-5p	CLIP-seq
MIRT895727	hsa-miR-4779	CLIP-seq
MIRT895728	hsa-miR-4786-3p	CLIP-seq
MIRT895729	hsa-miR-4797-5p	CLIP-seq
MIRT895730	hsa-miR-4800-5p	CLIP-seq
MIRT895731	hsa-miR-500a	CLIP-seq
MIRT895732	hsa-miR-513a-3p	CLIP-seq
MIRT895733	hsa-miR-544	CLIP-seq
MIRT895734	hsa-miR-548o	CLIP-seq
MIRT895735	hsa-miR-607	CLIP-seq
MIRT895736	hsa-miR-618	CLIP-seq
MIRT895737	hsa-miR-624	CLIP-seq
MIRT895738	hsa-miR-631	CLIP-seq
MIRT895739	hsa-miR-635	CLIP-seq
MIRT895740	hsa-miR-661	CLIP-seq
MIRT895741	hsa-miR-662	CLIP-seq
MIRT895742	hsa-miR-762	CLIP-seq
MIRT895743	hsa-miR-767-3p	CLIP-seq
MIRT895702	hsa-miR-4505	CLIP-seq
MIRT1965558	hsa-miR-1207-5p	CLIP-seq
MIRT1965559	hsa-miR-1237	CLIP-seq
MIRT1965560	hsa-miR-1248	CLIP-seq
MIRT1965561	hsa-miR-125a-5p	CLIP-seq
MIRT1965562	hsa-miR-125b	CLIP-seq
MIRT1965563	hsa-miR-137	CLIP-seq
MIRT895666	hsa-miR-138	CLIP-seq
MIRT1965564	hsa-miR-145	CLIP-seq
MIRT1965565	hsa-miR-1539	CLIP-seq
MIRT1965566	hsa-miR-1825	CLIP-seq
MIRT1965567	hsa-miR-199a-5p	CLIP-seq
MIRT1965568	hsa-miR-199b-5p	CLIP-seq
MIRT1965569	hsa-miR-205	CLIP-seq
MIRT1965570	hsa-miR-23a	CLIP-seq
MIRT1965571	hsa-miR-23b	CLIP-seq
MIRT1965572	hsa-miR-23c	CLIP-seq
MIRT895671	hsa-miR-2467-3p	CLIP-seq
MIRT1965573	hsa-miR-3074-3p	CLIP-seq
MIRT1965574	hsa-miR-3074-5p	CLIP-seq
MIRT1965575	hsa-miR-3122	CLIP-seq
MIRT1965576	hsa-miR-3144-5p	CLIP-seq
MIRT1965577	hsa-miR-3180-5p	CLIP-seq
MIRT1965578	hsa-miR-3182	CLIP-seq
MIRT1965579	hsa-miR-3183	CLIP-seq
MIRT1965580	hsa-miR-3191	CLIP-seq
MIRT1965581	hsa-miR-3193	CLIP-seq
MIRT1965582	hsa-miR-323-3p	CLIP-seq
MIRT1965583	hsa-miR-326	CLIP-seq
MIRT1965584	hsa-miR-330-5p	CLIP-seq
MIRT1965585	hsa-miR-3591-5p	CLIP-seq
MIRT895683	hsa-miR-3622a-3p	CLIP-seq
MIRT895684	hsa-miR-3622b-3p	CLIP-seq
MIRT1965586	hsa-miR-3647-3p	CLIP-seq
MIRT1965587	hsa-miR-3662	CLIP-seq
MIRT1965588	hsa-miR-3689a-3p	CLIP-seq
MIRT1965589	hsa-miR-3689c	CLIP-seq
MIRT895688	hsa-miR-370	CLIP-seq
MIRT1965590	hsa-miR-3913-3p	CLIP-seq
MIRT1965591	hsa-miR-3913-5p	CLIP-seq
MIRT1965592	hsa-miR-4255	CLIP-seq
MIRT1965593	hsa-miR-4283	CLIP-seq
MIRT1965594	hsa-miR-4319	CLIP-seq
MIRT1965595	hsa-miR-4328	CLIP-seq
MIRT1965596	hsa-miR-4464	CLIP-seq
MIRT1965597	hsa-miR-4476	CLIP-seq
MIRT895696	hsa-miR-4480	CLIP-seq
MIRT1965598	hsa-miR-4489	CLIP-seq
MIRT895698	hsa-miR-4492	CLIP-seq
MIRT895700	hsa-miR-4498	CLIP-seq
MIRT1965599	hsa-miR-4528	CLIP-seq
MIRT895706	hsa-miR-4532	CLIP-seq
MIRT1965600	hsa-miR-4652-5p	CLIP-seq
MIRT1965601	hsa-miR-4659a-3p	CLIP-seq
MIRT1965602	hsa-miR-4659b-3p	CLIP-seq
MIRT1965603	hsa-miR-4660	CLIP-seq
MIRT1965604	hsa-miR-4667-5p	CLIP-seq
MIRT1965605	hsa-miR-4700-5p	CLIP-seq
MIRT1965606	hsa-miR-4701-5p	CLIP-seq
MIRT1965607	hsa-miR-4717-3p	CLIP-seq
MIRT1965608	hsa-miR-4723-3p	CLIP-seq
MIRT1965609	hsa-miR-4732-3p	CLIP-seq
MIRT1965610	hsa-miR-4736	CLIP-seq
MIRT1965611	hsa-miR-4748	CLIP-seq
MIRT1965612	hsa-miR-4763-3p	CLIP-seq
MIRT1965613	hsa-miR-4768-5p	CLIP-seq
MIRT1965614	hsa-miR-4795-3p	CLIP-seq
MIRT1965615	hsa-miR-489	CLIP-seq
MIRT1965616	hsa-miR-5096	CLIP-seq
MIRT895732	hsa-miR-513a-3p	CLIP-seq
MIRT1965617	hsa-miR-556-3p	CLIP-seq
MIRT1965618	hsa-miR-588	CLIP-seq
MIRT895737	hsa-miR-624	CLIP-seq
MIRT1965619	hsa-miR-637	CLIP-seq
MIRT1965620	hsa-miR-665	CLIP-seq
MIRT1965621	hsa-miR-670	CLIP-seq
MIRT895742	hsa-miR-762	CLIP-seq
MIRT1965622	hsa-miR-873	CLIP-seq
MIRT1965623	hsa-miR-942	CLIP-seq
MIRT1965559	hsa-miR-1237	CLIP-seq
MIRT1965560	hsa-miR-1248	CLIP-seq
MIRT895670	hsa-miR-2277-3p	CLIP-seq
MIRT1965570	hsa-miR-23a	CLIP-seq
MIRT1965571	hsa-miR-23b	CLIP-seq
MIRT1965572	hsa-miR-23c	CLIP-seq
MIRT1965574	hsa-miR-3074-5p	CLIP-seq
MIRT1965575	hsa-miR-3122	CLIP-seq
MIRT2201504	hsa-miR-3136-3p	CLIP-seq
MIRT2201505	hsa-miR-330-3p	CLIP-seq
MIRT1965588	hsa-miR-3689a-3p	CLIP-seq
MIRT1965589	hsa-miR-3689c	CLIP-seq
MIRT1965590	hsa-miR-3913-3p	CLIP-seq
MIRT1965591	hsa-miR-3913-5p	CLIP-seq
MIRT1965596	hsa-miR-4464	CLIP-seq
MIRT895717	hsa-miR-4711-3p	CLIP-seq
MIRT1965607	hsa-miR-4717-3p	CLIP-seq
MIRT2201506	hsa-miR-4728-5p	CLIP-seq
MIRT1965611	hsa-miR-4748	CLIP-seq
MIRT895728	hsa-miR-4786-3p	CLIP-seq
MIRT1965615	hsa-miR-489	CLIP-seq
MIRT1965616	hsa-miR-5096	CLIP-seq
MIRT2386170	hsa-miR-3189-3p	CLIP-seq
MIRT895688	hsa-miR-370	CLIP-seq
MIRT2447153	hsa-miR-3915	CLIP-seq
MIRT2447154	hsa-miR-3928	CLIP-seq
MIRT2447155	hsa-miR-4709-3p	CLIP-seq
MIRT2447156	hsa-miR-539	CLIP-seq
MIRT2447153	hsa-miR-3915	CLIP-seq
MIRT2447154	hsa-miR-3928	CLIP-seq
MIRT2447155	hsa-miR-4709-3p	CLIP-seq
MIRT2447156	hsa-miR-539	CLIP-seq
MIRT2504455	hsa-miR-1262	CLIP-seq
MIRT895662	hsa-miR-127-5p	CLIP-seq
MIRT2504456	hsa-miR-1294	CLIP-seq
MIRT895666	hsa-miR-138	CLIP-seq
MIRT895673	hsa-miR-3121-5p	CLIP-seq
MIRT2201504	hsa-miR-3136-3p	CLIP-seq
MIRT1965576	hsa-miR-3144-5p	CLIP-seq
MIRT1965580	hsa-miR-3191	CLIP-seq
MIRT895685	hsa-miR-3652	CLIP-seq
MIRT895686	hsa-miR-3661	CLIP-seq
MIRT2447153	hsa-miR-3915	CLIP-seq
MIRT2447154	hsa-miR-3928	CLIP-seq
MIRT895695	hsa-miR-4430	CLIP-seq
MIRT2504457	hsa-miR-4456	CLIP-seq
MIRT895702	hsa-miR-4505	CLIP-seq
MIRT1965600	hsa-miR-4652-5p	CLIP-seq
MIRT895716	hsa-miR-4698	CLIP-seq
MIRT2504458	hsa-miR-4701-3p	CLIP-seq
MIRT2447155	hsa-miR-4709-3p	CLIP-seq
MIRT2504459	hsa-miR-4710	CLIP-seq
MIRT2504460	hsa-miR-4757-5p	CLIP-seq
MIRT895728	hsa-miR-4786-3p	CLIP-seq
MIRT2504461	hsa-miR-4786-5p	CLIP-seq
MIRT2447156	hsa-miR-539	CLIP-seq
MIRT2504462	hsa-miR-615-5p	CLIP-seq
MIRT895738	hsa-miR-631	CLIP-seq
MIRT2504463	hsa-miR-769-5p	CLIP-seq
MIRT2504464	hsa-miR-938	CLIP-seq
MIRT2447153	hsa-miR-3915	CLIP-seq
MIRT2447154	hsa-miR-3928	CLIP-seq
MIRT2447155	hsa-miR-4709-3p	CLIP-seq
MIRT2447156	hsa-miR-539	CLIP-seq

Show/Hide all (19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000423	Process	Mitophagy	IDA	35604110
GO:0005515	Function	Protein binding	IPI	36538041
GO:0005764	Component	Lysosome	IEA
GO:0005765	Component	Lysosomal membrane	IEA
GO:0005768	Component	Endosome	IEA
GO:0005770	Component	Late endosome	IBA
GO:0005794	Component	Golgi apparatus	IBA
GO:0005794	Component	Golgi apparatus	IDA	28223137
GO:0005829	Component	Cytosol	IDA	28223137
GO:0006914	Process	Autophagy	IEA
GO:0007034	Process	Vacuolar transport	IBA
GO:0009267	Process	Cellular response to starvation	IMP	28223137
GO:0010008	Component	Endosome membrane	IEA
GO:0016020	Component	Membrane	IEA
GO:0016197	Process	Endosomal transport	IBA
GO:0031982	Component	Vesicle	IDA	28223137
GO:1901096	Process	Regulation of autophagosome maturation	IBA
GO:1901097	Process	Negative regulation of autophagosome maturation	IMP	28223137
GO:1904263	Process	Positive regulation of TORC1 signaling	IMP	28223137

MIM	HGNC	e!Ensembl
611303	29013	ENSG00000038532

Q2KHT3

Protein name

Protein CLEC16A (C-type lectin domain family 16 member A)

Protein function

Regulator of mitophagy through the upstream regulation of the RNF41/NRDP1-PRKN pathway. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control. The RNF41/NRDP1-PRKN pathway regulates autophagosome-lysosome fusion

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF09758	FPL	51 → 198	Uncharacterised conserved protein	Family

Tissue specificity

TISSUE SPECIFICITY: Almost exclusively expressed in immune cells, including dendritic cells, B-lymphocytes and natural killer cells. {ECO:0000269|PubMed:17632545}.

Sequence

MFGRSRSWVGGGHGKTSRNIHSLDHLKYLYHVLTKNTTVTEQNRNLLVETIRSITEILIW
GDQNDSSVFDFFLEKNMFVFFLNILRQKSGRYVCVQLLQTLNILFENISHETSLYYLLSN
NYVNSIIVHKFDFSDEEIMAYYISFLKTLSLKLNNHTVHFFYNEHTNDFALYTEAIKFFN
HPESMVRIAVRTITLNVYKVSLDNQAMLHYIRDKTAVPYFSNLVWFIGSHVIELDDCVQT
DEEHRNRGKLSDLVAEHLDHLHYLNDILIINCEFLNDVLTDHLLNRLFLPLYVYSLENQD
KGGERPKISLPVSLYLLSQVFLIIHHAPLVNSLAEVILNGDLSEMYAKTEQDIQRSSAKP
SIRCFIKPTETLERSLEMNKHKGKRRVQKRPNYKNVGEEEDEEKGPTEDAQEDAEKAKGT
EGGSKGIKTSGESEEIEMVIMERSKLSELAASTSVQEQNTTDEEKSAAATCSESTQWSRP
FLDMVYHALDSPDDDYHALFVLCLLYAMSHNKGMDPEKLERIQLPVPNAAEKTTYNHPLA
ERLIRIMNNAAQPDGKIRLATLELSCLLLKQQVLMSAGCIMKDVHLACLEGAREESVHLV
RHFYKGEDIFLDMFEDEYRSMTMKPMNVEYLMMDASILLPPTGTPLTGIDFVKRLPCGDV
EKTRRAIRVFFMLRSLSLQLRGEPETQLPLTREEDLIKTDDVLDLNNSDLIACTVITKDG
GMVQRFLAVDIYQMSLVEPDVSRLGWGVVKFAGLLQDMQVTGVEDDSRALNITIHKPASS
PHSKPFPILQATFIFSDHIRCIIAKQRLAKGRIQARRMKMQRIAALLDLPIQPTTEVLGF
GLGSSTSTQHLPFRFYDQGRRGSSDPTVQRSVFASVDKVPGFAVAQCINQHSSPSLSSQS
PPSASGSPSGSGSTSHCDSGGTSSSSTPSTAQSPADAPMSPELPKPHLPDQLVIVNETEA
DSKPSKNVARSAAVETASLSPSLVPARQPTISLLCEDTADTLSVESLTLVPPVDPHSLRS
LTGMPPLSTPAAACTEPVGEEAACAEPVGTAED

Sequence length

1053

Interactions

View interactions

Show/Hide Unknown Diseases (10)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Acute myeloid leukemia	Benign; Likely benign	rs45464291	RCV005902825
Clear cell carcinoma of kidney	Benign; Likely benign	rs45464291	RCV005902827
Familial cancer of breast	Benign; Likely benign	rs45464291	RCV005902824
Gastric cancer	Benign; Likely benign	rs45464291	RCV005902828
Lung cancer	Benign; Likely benign	rs45464291	RCV005902832
Melanoma	Benign; Likely benign	rs45464291	RCV005902831
Meniere disease	Uncertain significance	rs74163607, rs202155030, rs781571686	RCV004574905 RCV004574907 RCV004574908
Nonpapillary renal cell carcinoma	Benign; Likely benign	rs45464291	RCV005902826
Ovarian serous cystadenocarcinoma	Benign; Likely benign	rs45464291	RCV005902829
Thyroid cancer, nonmedullary, 1	Benign; Likely benign	rs45464291	RCV005902830

Show/Hide Text Mining Associations (27)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Addison Disease	Associate	19734133, 20220768
Adenoma Islet Cell	Associate	36622793
Arthritis Juvenile	Associate	19734133, 34101054
Arthritis Rheumatoid	Associate	19734133
Asthma	Associate	24388013
Autoimmune Diseases	Associate	19734133, 21989056, 25823473, 34643957
Bone Diseases	Associate	23133532
Celiac Disease	Associate	20190752
Colitis Ulcerative	Associate	19337309
Crohn Disease	Associate	19337309, 20220768
Diabetes Mellitus	Associate	19337309, 21873553, 31570815
Diabetes Mellitus Type 1	Associate	18647951, 19337309, 19734133, 20220768, 21270831, 21873553, 21989056, 24237155, 25008175, 26782299, 30628751, 30970177, 31570815, 36622793
Drug Hypersensitivity	Associate	24388013
Fractures Bone	Associate	23133532
Graves Disease	Associate	24646814
Hashimoto Disease	Associate	24646814
Hepatitis B	Associate	39237981
Hip Fractures	Associate	23133532
Inflammation	Associate	23133532
Inflammatory Bowel Diseases	Associate	19337309
Liver Cirrhosis Biliary	Associate	22257840
Lupus Erythematosus Systemic	Associate	19838195, 26121298, 39796169
Multiple Sclerosis	Associate	18987646, 19337309, 19865102, 20220768, 20368992, 21653641, 21989056, 25823473, 26203907, 31228212, 34246256, 34643957, 36282535
Muscular Dystrophy Duchenne	Associate	23133532
Osteoporotic Fractures	Associate	23133532
Rhinitis Allergic Seasonal	Associate	24388013
Thyroiditis Autoimmune	Associate	24646814

CLEC16A (C-type lectin domain containing 16A)