Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	2327
Gene name Gene Name - the full gene name approved by the HGNC.	Flavin containing dimethylaniline monoxygenase 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	FMO2
Synonyms (NCBI Gene) Gene synonyms aliases	FMO1B1
Chromosome Chromosome number	1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	1q24.3
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a flavin-containing monooxygenase family member. It is an NADPH-dependent enzyme that catalyzes the N-oxidation of some primary alkylamines through an N-hydroxylamine intermediate. However, some human populations contain an allele (FMO2*

Show/Hide all(233)

miRTarBase ID	miRNA	Experiments
MIRT999691	hsa-let-7a	CLIP-seq
MIRT999692	hsa-let-7b	CLIP-seq
MIRT999693	hsa-let-7c	CLIP-seq
MIRT999694	hsa-let-7d	CLIP-seq
MIRT999695	hsa-let-7e	CLIP-seq
MIRT999696	hsa-let-7f	CLIP-seq
MIRT999697	hsa-let-7g	CLIP-seq
MIRT999698	hsa-let-7i	CLIP-seq
MIRT999699	hsa-miR-134	CLIP-seq
MIRT999700	hsa-miR-1343	CLIP-seq
MIRT999701	hsa-miR-140-3p	CLIP-seq
MIRT999702	hsa-miR-1587	CLIP-seq
MIRT999703	hsa-miR-196a	CLIP-seq
MIRT999704	hsa-miR-196b	CLIP-seq
MIRT999705	hsa-miR-2682	CLIP-seq
MIRT999706	hsa-miR-3074-5p	CLIP-seq
MIRT999707	hsa-miR-3118	CLIP-seq
MIRT999708	hsa-miR-3126-5p	CLIP-seq
MIRT999709	hsa-miR-3136-3p	CLIP-seq
MIRT999710	hsa-miR-3136-5p	CLIP-seq
MIRT999711	hsa-miR-3140-3p	CLIP-seq
MIRT999712	hsa-miR-328	CLIP-seq
MIRT999713	hsa-miR-34a	CLIP-seq
MIRT999714	hsa-miR-34c-5p	CLIP-seq
MIRT999715	hsa-miR-3545-3p	CLIP-seq
MIRT999716	hsa-miR-3646	CLIP-seq
MIRT999717	hsa-miR-3659	CLIP-seq
MIRT999718	hsa-miR-4266	CLIP-seq
MIRT999719	hsa-miR-4419a	CLIP-seq
MIRT999720	hsa-miR-4439	CLIP-seq
MIRT999721	hsa-miR-4458	CLIP-seq
MIRT999722	hsa-miR-4481	CLIP-seq
MIRT999723	hsa-miR-4492	CLIP-seq
MIRT999724	hsa-miR-4498	CLIP-seq
MIRT999725	hsa-miR-449a	CLIP-seq
MIRT999726	hsa-miR-449b	CLIP-seq
MIRT999727	hsa-miR-449c	CLIP-seq
MIRT999728	hsa-miR-4500	CLIP-seq
MIRT999729	hsa-miR-4510	CLIP-seq
MIRT999730	hsa-miR-4513	CLIP-seq
MIRT999731	hsa-miR-4514	CLIP-seq
MIRT999732	hsa-miR-4656	CLIP-seq
MIRT999733	hsa-miR-4658	CLIP-seq
MIRT999734	hsa-miR-4662a-3p	CLIP-seq
MIRT999735	hsa-miR-4675	CLIP-seq
MIRT999736	hsa-miR-4692	CLIP-seq
MIRT999737	hsa-miR-4695-5p	CLIP-seq
MIRT999738	hsa-miR-4741	CLIP-seq
MIRT999739	hsa-miR-4745-5p	CLIP-seq
MIRT999740	hsa-miR-4758-5p	CLIP-seq
MIRT999741	hsa-miR-4777-5p	CLIP-seq
MIRT999742	hsa-miR-4779	CLIP-seq
MIRT999743	hsa-miR-574-5p	CLIP-seq
MIRT999744	hsa-miR-630	CLIP-seq
MIRT999745	hsa-miR-651	CLIP-seq
MIRT999746	hsa-miR-762	CLIP-seq
MIRT999747	hsa-miR-9	CLIP-seq
MIRT999748	hsa-miR-98	CLIP-seq
MIRT999691	hsa-let-7a	CLIP-seq
MIRT999692	hsa-let-7b	CLIP-seq
MIRT999693	hsa-let-7c	CLIP-seq
MIRT999694	hsa-let-7d	CLIP-seq
MIRT999695	hsa-let-7e	CLIP-seq
MIRT999696	hsa-let-7f	CLIP-seq
MIRT999697	hsa-let-7g	CLIP-seq
MIRT999698	hsa-let-7i	CLIP-seq
MIRT999699	hsa-miR-134	CLIP-seq
MIRT999703	hsa-miR-196a	CLIP-seq
MIRT999704	hsa-miR-196b	CLIP-seq
MIRT999707	hsa-miR-3118	CLIP-seq
MIRT999710	hsa-miR-3136-5p	CLIP-seq
MIRT999718	hsa-miR-4266	CLIP-seq
MIRT999720	hsa-miR-4439	CLIP-seq
MIRT999721	hsa-miR-4458	CLIP-seq
MIRT999728	hsa-miR-4500	CLIP-seq
MIRT999730	hsa-miR-4513	CLIP-seq
MIRT999737	hsa-miR-4695-5p	CLIP-seq
MIRT999742	hsa-miR-4779	CLIP-seq
MIRT999745	hsa-miR-651	CLIP-seq
MIRT999748	hsa-miR-98	CLIP-seq
MIRT999691	hsa-let-7a	CLIP-seq
MIRT999692	hsa-let-7b	CLIP-seq
MIRT999693	hsa-let-7c	CLIP-seq
MIRT999694	hsa-let-7d	CLIP-seq
MIRT999695	hsa-let-7e	CLIP-seq
MIRT999696	hsa-let-7f	CLIP-seq
MIRT999697	hsa-let-7g	CLIP-seq
MIRT999698	hsa-let-7i	CLIP-seq
MIRT999699	hsa-miR-134	CLIP-seq
MIRT999703	hsa-miR-196a	CLIP-seq
MIRT999704	hsa-miR-196b	CLIP-seq
MIRT999707	hsa-miR-3118	CLIP-seq
MIRT999710	hsa-miR-3136-5p	CLIP-seq
MIRT999718	hsa-miR-4266	CLIP-seq
MIRT999720	hsa-miR-4439	CLIP-seq
MIRT999721	hsa-miR-4458	CLIP-seq
MIRT999728	hsa-miR-4500	CLIP-seq
MIRT999730	hsa-miR-4513	CLIP-seq
MIRT999737	hsa-miR-4695-5p	CLIP-seq
MIRT999742	hsa-miR-4779	CLIP-seq
MIRT999748	hsa-miR-98	CLIP-seq
MIRT1920433	hsa-miR-203	CLIP-seq
MIRT1920434	hsa-miR-4677-3p	CLIP-seq
MIRT1920435	hsa-miR-4679	CLIP-seq
MIRT1920433	hsa-miR-203	CLIP-seq
MIRT1920434	hsa-miR-4677-3p	CLIP-seq
MIRT1920435	hsa-miR-4679	CLIP-seq
MIRT1920433	hsa-miR-203	CLIP-seq
MIRT1920434	hsa-miR-4677-3p	CLIP-seq
MIRT1920435	hsa-miR-4679	CLIP-seq
MIRT999691	hsa-let-7a	CLIP-seq
MIRT999692	hsa-let-7b	CLIP-seq
MIRT999693	hsa-let-7c	CLIP-seq
MIRT999694	hsa-let-7d	CLIP-seq
MIRT999695	hsa-let-7e	CLIP-seq
MIRT999696	hsa-let-7f	CLIP-seq
MIRT999697	hsa-let-7g	CLIP-seq
MIRT999698	hsa-let-7i	CLIP-seq
MIRT999699	hsa-miR-134	CLIP-seq
MIRT999703	hsa-miR-196a	CLIP-seq
MIRT999704	hsa-miR-196b	CLIP-seq
MIRT999707	hsa-miR-3118	CLIP-seq
MIRT999710	hsa-miR-3136-5p	CLIP-seq
MIRT999718	hsa-miR-4266	CLIP-seq
MIRT999720	hsa-miR-4439	CLIP-seq
MIRT999721	hsa-miR-4458	CLIP-seq
MIRT999728	hsa-miR-4500	CLIP-seq
MIRT999730	hsa-miR-4513	CLIP-seq
MIRT999737	hsa-miR-4695-5p	CLIP-seq
MIRT999742	hsa-miR-4779	CLIP-seq
MIRT999745	hsa-miR-651	CLIP-seq
MIRT999748	hsa-miR-98	CLIP-seq
MIRT999691	hsa-let-7a	CLIP-seq
MIRT999692	hsa-let-7b	CLIP-seq
MIRT999693	hsa-let-7c	CLIP-seq
MIRT999694	hsa-let-7d	CLIP-seq
MIRT999695	hsa-let-7e	CLIP-seq
MIRT999696	hsa-let-7f	CLIP-seq
MIRT999697	hsa-let-7g	CLIP-seq
MIRT999698	hsa-let-7i	CLIP-seq
MIRT999699	hsa-miR-134	CLIP-seq
MIRT1996315	hsa-miR-149	CLIP-seq
MIRT999703	hsa-miR-196a	CLIP-seq
MIRT999704	hsa-miR-196b	CLIP-seq
MIRT1996316	hsa-miR-3064-5p	CLIP-seq
MIRT999707	hsa-miR-3118	CLIP-seq
MIRT999710	hsa-miR-3136-5p	CLIP-seq
MIRT999711	hsa-miR-3140-3p	CLIP-seq
MIRT1996317	hsa-miR-3667-3p	CLIP-seq
MIRT1996318	hsa-miR-412	CLIP-seq
MIRT999718	hsa-miR-4266	CLIP-seq
MIRT999720	hsa-miR-4439	CLIP-seq
MIRT1996319	hsa-miR-4448	CLIP-seq
MIRT999721	hsa-miR-4458	CLIP-seq
MIRT999728	hsa-miR-4500	CLIP-seq
MIRT999730	hsa-miR-4513	CLIP-seq
MIRT999737	hsa-miR-4695-5p	CLIP-seq
MIRT1996320	hsa-miR-4720-3p	CLIP-seq
MIRT1996321	hsa-miR-4768-3p	CLIP-seq
MIRT999742	hsa-miR-4779	CLIP-seq
MIRT1996322	hsa-miR-4781-3p	CLIP-seq
MIRT1996323	hsa-miR-4794	CLIP-seq
MIRT1996324	hsa-miR-4796-5p	CLIP-seq
MIRT1996325	hsa-miR-4804-3p	CLIP-seq
MIRT1996326	hsa-miR-494	CLIP-seq
MIRT999748	hsa-miR-98	CLIP-seq
MIRT999691	hsa-let-7a	CLIP-seq
MIRT999692	hsa-let-7b	CLIP-seq
MIRT999693	hsa-let-7c	CLIP-seq
MIRT999694	hsa-let-7d	CLIP-seq
MIRT999695	hsa-let-7e	CLIP-seq
MIRT999696	hsa-let-7f	CLIP-seq
MIRT999697	hsa-let-7g	CLIP-seq
MIRT999698	hsa-let-7i	CLIP-seq
MIRT2230239	hsa-miR-1305	CLIP-seq
MIRT999699	hsa-miR-134	CLIP-seq
MIRT999703	hsa-miR-196a	CLIP-seq
MIRT999704	hsa-miR-196b	CLIP-seq
MIRT2230240	hsa-miR-21	CLIP-seq
MIRT999707	hsa-miR-3118	CLIP-seq
MIRT999710	hsa-miR-3136-5p	CLIP-seq
MIRT2230241	hsa-miR-330-3p	CLIP-seq
MIRT2230242	hsa-miR-3614-3p	CLIP-seq
MIRT2230243	hsa-miR-4257	CLIP-seq
MIRT2230244	hsa-miR-4265	CLIP-seq
MIRT999718	hsa-miR-4266	CLIP-seq
MIRT2230245	hsa-miR-4296	CLIP-seq
MIRT2230246	hsa-miR-4312	CLIP-seq
MIRT2230247	hsa-miR-4322	CLIP-seq
MIRT2230248	hsa-miR-4417	CLIP-seq
MIRT999720	hsa-miR-4439	CLIP-seq
MIRT999721	hsa-miR-4458	CLIP-seq
MIRT999728	hsa-miR-4500	CLIP-seq
MIRT999730	hsa-miR-4513	CLIP-seq
MIRT2230249	hsa-miR-4640-5p	CLIP-seq
MIRT999737	hsa-miR-4695-5p	CLIP-seq
MIRT2230250	hsa-miR-4714-3p	CLIP-seq
MIRT1996320	hsa-miR-4720-3p	CLIP-seq
MIRT2230251	hsa-miR-4726-5p	CLIP-seq
MIRT2230252	hsa-miR-4756-3p	CLIP-seq
MIRT999742	hsa-miR-4779	CLIP-seq
MIRT1996322	hsa-miR-4781-3p	CLIP-seq
MIRT1996324	hsa-miR-4796-5p	CLIP-seq
MIRT1996325	hsa-miR-4804-3p	CLIP-seq
MIRT2230253	hsa-miR-590-5p	CLIP-seq
MIRT2230254	hsa-miR-627	CLIP-seq
MIRT999745	hsa-miR-651	CLIP-seq
MIRT999748	hsa-miR-98	CLIP-seq
MIRT999691	hsa-let-7a	CLIP-seq
MIRT999692	hsa-let-7b	CLIP-seq
MIRT999693	hsa-let-7c	CLIP-seq
MIRT999694	hsa-let-7d	CLIP-seq
MIRT999695	hsa-let-7e	CLIP-seq
MIRT999696	hsa-let-7f	CLIP-seq
MIRT999697	hsa-let-7g	CLIP-seq
MIRT999698	hsa-let-7i	CLIP-seq
MIRT999699	hsa-miR-134	CLIP-seq
MIRT999703	hsa-miR-196a	CLIP-seq
MIRT999704	hsa-miR-196b	CLIP-seq
MIRT999707	hsa-miR-3118	CLIP-seq
MIRT999710	hsa-miR-3136-5p	CLIP-seq
MIRT999718	hsa-miR-4266	CLIP-seq
MIRT999720	hsa-miR-4439	CLIP-seq
MIRT999721	hsa-miR-4458	CLIP-seq
MIRT999728	hsa-miR-4500	CLIP-seq
MIRT999730	hsa-miR-4513	CLIP-seq
MIRT999737	hsa-miR-4695-5p	CLIP-seq
MIRT1996320	hsa-miR-4720-3p	CLIP-seq
MIRT999742	hsa-miR-4779	CLIP-seq
MIRT1996322	hsa-miR-4781-3p	CLIP-seq
MIRT1996324	hsa-miR-4796-5p	CLIP-seq
MIRT1996325	hsa-miR-4804-3p	CLIP-seq
MIRT999748	hsa-miR-98	CLIP-seq

Show/Hide all(15)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004497	Function	Monooxygenase activity	IBA	21873635
GO:0004499	Function	N,N-dimethylaniline monooxygenase activity	IDA	11744609
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0006082	Process	Organic acid metabolic process	IDA	11744609
GO:0006739	Process	NADP metabolic process	IDA	11744609
GO:0006805	Process	Xenobiotic metabolic process	IDA	11744609
GO:0006805	Process	Xenobiotic metabolic process	TAS
GO:0009404	Process	Toxin metabolic process	IDA	11744609
GO:0016020	Component	Membrane	IDA	9804831
GO:0016021	Component	Integral component of membrane	IEA
GO:0017144	Process	Drug metabolic process	IDA	11744609
GO:0050660	Function	Flavin adenine dinucleotide binding	IEA
GO:0050661	Function	NADP binding	IEA
GO:0070995	Process	NADPH oxidation	IDA	9804831, 15144220
GO:0072592	Process	Oxygen metabolic process	IEA

MIM	HGNC	e!Ensembl
603955	3770	ENSG00000094963

Protein

UniProt ID

Q99518

Protein name

Flavin-containing monooxygenase 2 (EC 1.14.13.-) (Dimethylaniline oxidase 2) (FMO 1B1) (Pulmonary flavin-containing monooxygenase 2) (FMO 2)

Protein function

Catalyzes the oxidative metabolism of numerous xenobiotics, including mainly therapeutic drugs and insecticides that contain a soft nucleophile, most commonly nitrogen and sulfur and participates to their bioactivation (PubMed:15144220, PubMed:1

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00743	FMO-like	2 → 533	Flavin-binding monooxygenase-like	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in lung (at protein level). Expressed predominantly in lung, and at a much lesser extent in kidney. Also expressed in fetal lung, but not in liver, kidney and brain. {ECO:0000269|PubMed:11042094, ECO:0000269|PubMed:9804831}.

Sequence

MAKKVAVIGAGVSGLISLKCCVDEGLEPTCFERTEDIGGVWRFKENVEDGRASIYQSVVT
NTSKEMSCFSDFPMPEDFPNFLHNSKLLEYFRIFAKKFDLLKYIQFQTTVLSVRKCPDFS
SSGQWKVVTQSNGKEQSAVFDAVMVCSGHHILPHIPLKSFPGMERFKGQYFHSRQYKHPD
GFEGKRILVIGMGNSGSDIAVELSKNAAQVFISTRHGTWVMSRISEDGYPWDSVFHTRFR
SMLRNVLPRTAVKWMIEQQMNRWFNHENYGLEPQNKYIMKEPVLNDDVPSRLLCGAIKVK
STVKELTETSAIFEDGTVEENIDVIIFATGYSFSFPFLEDSLVKVENNMVSLYKYIFPAH
LDKSTLACIGLIQPLGSIFPTAELQARWVTRVFKGLCSLPSERTMMMDIIKRNEKRIDLF
GESQSQTLQTNYVDYLDELALEIGAKPDFCSLLFKDPKLAVRLYFGPCNSYQYRLVGPGQ
WEGARNAIFTQKQRILKPLKTRALKDSSNFSVSFLLKILGLLAVVVAFFCQLQWS

Sequence length

535

Interactions

View interactions

	KEGG		Reactome
	Taurine and hypotaurine metabolism Drug metabolism - cytochrome P450 Metabolic pathways		FMO oxidises nucleophiles

Show/Hide Unknown Diseases (2)

Disease term	Disease name	References	Source
Unknown
Endometriosis	Endometriosis	20864642	ClinVar
Hyperopia	Hyperopia		GWAS

Show/Hide Text Mining Associations (5)

Disease Name	Relationship Type	References
Associations from Text Mining
Adenocarcinoma of Lung	Associate	33870858, 37814902
Breast Neoplasms	Inhibit	37963835
Carcinogenesis	Associate	37963835
Neoplasm Metastasis	Inhibit	37963835
Neoplasms	Inhibit	35422093

FMO2 (flavin containing dimethylaniline monoxygenase 2)