Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways
Entrez ID	2327
Gene name	Flavin containing dimethylaniline monoxygenase 2
Gene symbol	FMO2
Synonyms (NCBI Gene)	FMO1B1
Chromosome	1
Chromosome location	1q24.3
Summary	This gene encodes a flavin-containing monooxygenase family member. It is an NADPH-dependent enzyme that catalyzes the N-oxidation of some primary alkylamines through an N-hydroxylamine intermediate. However, some human populations contain an allele (FMO2*

233

Show/Hide all (233)

miRTarBase ID	miRNA	Experiments
MIRT999691	hsa-let-7a	CLIP-seq
MIRT999692	hsa-let-7b	CLIP-seq
MIRT999693	hsa-let-7c	CLIP-seq
MIRT999694	hsa-let-7d	CLIP-seq
MIRT999695	hsa-let-7e	CLIP-seq
MIRT999696	hsa-let-7f	CLIP-seq
MIRT999697	hsa-let-7g	CLIP-seq
MIRT999698	hsa-let-7i	CLIP-seq
MIRT999699	hsa-miR-134	CLIP-seq
MIRT999700	hsa-miR-1343	CLIP-seq
MIRT999701	hsa-miR-140-3p	CLIP-seq
MIRT999702	hsa-miR-1587	CLIP-seq
MIRT999703	hsa-miR-196a	CLIP-seq
MIRT999704	hsa-miR-196b	CLIP-seq
MIRT999705	hsa-miR-2682	CLIP-seq
MIRT999706	hsa-miR-3074-5p	CLIP-seq
MIRT999707	hsa-miR-3118	CLIP-seq
MIRT999708	hsa-miR-3126-5p	CLIP-seq
MIRT999709	hsa-miR-3136-3p	CLIP-seq
MIRT999710	hsa-miR-3136-5p	CLIP-seq
MIRT999711	hsa-miR-3140-3p	CLIP-seq
MIRT999712	hsa-miR-328	CLIP-seq
MIRT999713	hsa-miR-34a	CLIP-seq
MIRT999714	hsa-miR-34c-5p	CLIP-seq
MIRT999715	hsa-miR-3545-3p	CLIP-seq
MIRT999716	hsa-miR-3646	CLIP-seq
MIRT999717	hsa-miR-3659	CLIP-seq
MIRT999718	hsa-miR-4266	CLIP-seq
MIRT999719	hsa-miR-4419a	CLIP-seq
MIRT999720	hsa-miR-4439	CLIP-seq
MIRT999721	hsa-miR-4458	CLIP-seq
MIRT999722	hsa-miR-4481	CLIP-seq
MIRT999723	hsa-miR-4492	CLIP-seq
MIRT999724	hsa-miR-4498	CLIP-seq
MIRT999725	hsa-miR-449a	CLIP-seq
MIRT999726	hsa-miR-449b	CLIP-seq
MIRT999727	hsa-miR-449c	CLIP-seq
MIRT999728	hsa-miR-4500	CLIP-seq
MIRT999729	hsa-miR-4510	CLIP-seq
MIRT999730	hsa-miR-4513	CLIP-seq
MIRT999731	hsa-miR-4514	CLIP-seq
MIRT999732	hsa-miR-4656	CLIP-seq
MIRT999733	hsa-miR-4658	CLIP-seq
MIRT999734	hsa-miR-4662a-3p	CLIP-seq
MIRT999735	hsa-miR-4675	CLIP-seq
MIRT999736	hsa-miR-4692	CLIP-seq
MIRT999737	hsa-miR-4695-5p	CLIP-seq
MIRT999738	hsa-miR-4741	CLIP-seq
MIRT999739	hsa-miR-4745-5p	CLIP-seq
MIRT999740	hsa-miR-4758-5p	CLIP-seq
MIRT999741	hsa-miR-4777-5p	CLIP-seq
MIRT999742	hsa-miR-4779	CLIP-seq
MIRT999743	hsa-miR-574-5p	CLIP-seq
MIRT999744	hsa-miR-630	CLIP-seq
MIRT999745	hsa-miR-651	CLIP-seq
MIRT999746	hsa-miR-762	CLIP-seq
MIRT999747	hsa-miR-9	CLIP-seq
MIRT999748	hsa-miR-98	CLIP-seq
MIRT999691	hsa-let-7a	CLIP-seq
MIRT999692	hsa-let-7b	CLIP-seq
MIRT999693	hsa-let-7c	CLIP-seq
MIRT999694	hsa-let-7d	CLIP-seq
MIRT999695	hsa-let-7e	CLIP-seq
MIRT999696	hsa-let-7f	CLIP-seq
MIRT999697	hsa-let-7g	CLIP-seq
MIRT999698	hsa-let-7i	CLIP-seq
MIRT999699	hsa-miR-134	CLIP-seq
MIRT999703	hsa-miR-196a	CLIP-seq
MIRT999704	hsa-miR-196b	CLIP-seq
MIRT999707	hsa-miR-3118	CLIP-seq
MIRT999710	hsa-miR-3136-5p	CLIP-seq
MIRT999718	hsa-miR-4266	CLIP-seq
MIRT999720	hsa-miR-4439	CLIP-seq
MIRT999721	hsa-miR-4458	CLIP-seq
MIRT999728	hsa-miR-4500	CLIP-seq
MIRT999730	hsa-miR-4513	CLIP-seq
MIRT999737	hsa-miR-4695-5p	CLIP-seq
MIRT999742	hsa-miR-4779	CLIP-seq
MIRT999745	hsa-miR-651	CLIP-seq
MIRT999748	hsa-miR-98	CLIP-seq
MIRT999691	hsa-let-7a	CLIP-seq
MIRT999692	hsa-let-7b	CLIP-seq
MIRT999693	hsa-let-7c	CLIP-seq
MIRT999694	hsa-let-7d	CLIP-seq
MIRT999695	hsa-let-7e	CLIP-seq
MIRT999696	hsa-let-7f	CLIP-seq
MIRT999697	hsa-let-7g	CLIP-seq
MIRT999698	hsa-let-7i	CLIP-seq
MIRT999699	hsa-miR-134	CLIP-seq
MIRT999703	hsa-miR-196a	CLIP-seq
MIRT999704	hsa-miR-196b	CLIP-seq
MIRT999707	hsa-miR-3118	CLIP-seq
MIRT999710	hsa-miR-3136-5p	CLIP-seq
MIRT999718	hsa-miR-4266	CLIP-seq
MIRT999720	hsa-miR-4439	CLIP-seq
MIRT999721	hsa-miR-4458	CLIP-seq
MIRT999728	hsa-miR-4500	CLIP-seq
MIRT999730	hsa-miR-4513	CLIP-seq
MIRT999737	hsa-miR-4695-5p	CLIP-seq
MIRT999742	hsa-miR-4779	CLIP-seq
MIRT999748	hsa-miR-98	CLIP-seq
MIRT1920433	hsa-miR-203	CLIP-seq
MIRT1920434	hsa-miR-4677-3p	CLIP-seq
MIRT1920435	hsa-miR-4679	CLIP-seq
MIRT1920433	hsa-miR-203	CLIP-seq
MIRT1920434	hsa-miR-4677-3p	CLIP-seq
MIRT1920435	hsa-miR-4679	CLIP-seq
MIRT1920433	hsa-miR-203	CLIP-seq
MIRT1920434	hsa-miR-4677-3p	CLIP-seq
MIRT1920435	hsa-miR-4679	CLIP-seq
MIRT999691	hsa-let-7a	CLIP-seq
MIRT999692	hsa-let-7b	CLIP-seq
MIRT999693	hsa-let-7c	CLIP-seq
MIRT999694	hsa-let-7d	CLIP-seq
MIRT999695	hsa-let-7e	CLIP-seq
MIRT999696	hsa-let-7f	CLIP-seq
MIRT999697	hsa-let-7g	CLIP-seq
MIRT999698	hsa-let-7i	CLIP-seq
MIRT999699	hsa-miR-134	CLIP-seq
MIRT999703	hsa-miR-196a	CLIP-seq
MIRT999704	hsa-miR-196b	CLIP-seq
MIRT999707	hsa-miR-3118	CLIP-seq
MIRT999710	hsa-miR-3136-5p	CLIP-seq
MIRT999718	hsa-miR-4266	CLIP-seq
MIRT999720	hsa-miR-4439	CLIP-seq
MIRT999721	hsa-miR-4458	CLIP-seq
MIRT999728	hsa-miR-4500	CLIP-seq
MIRT999730	hsa-miR-4513	CLIP-seq
MIRT999737	hsa-miR-4695-5p	CLIP-seq
MIRT999742	hsa-miR-4779	CLIP-seq
MIRT999745	hsa-miR-651	CLIP-seq
MIRT999748	hsa-miR-98	CLIP-seq
MIRT999691	hsa-let-7a	CLIP-seq
MIRT999692	hsa-let-7b	CLIP-seq
MIRT999693	hsa-let-7c	CLIP-seq
MIRT999694	hsa-let-7d	CLIP-seq
MIRT999695	hsa-let-7e	CLIP-seq
MIRT999696	hsa-let-7f	CLIP-seq
MIRT999697	hsa-let-7g	CLIP-seq
MIRT999698	hsa-let-7i	CLIP-seq
MIRT999699	hsa-miR-134	CLIP-seq
MIRT1996315	hsa-miR-149	CLIP-seq
MIRT999703	hsa-miR-196a	CLIP-seq
MIRT999704	hsa-miR-196b	CLIP-seq
MIRT1996316	hsa-miR-3064-5p	CLIP-seq
MIRT999707	hsa-miR-3118	CLIP-seq
MIRT999710	hsa-miR-3136-5p	CLIP-seq
MIRT999711	hsa-miR-3140-3p	CLIP-seq
MIRT1996317	hsa-miR-3667-3p	CLIP-seq
MIRT1996318	hsa-miR-412	CLIP-seq
MIRT999718	hsa-miR-4266	CLIP-seq
MIRT999720	hsa-miR-4439	CLIP-seq
MIRT1996319	hsa-miR-4448	CLIP-seq
MIRT999721	hsa-miR-4458	CLIP-seq
MIRT999728	hsa-miR-4500	CLIP-seq
MIRT999730	hsa-miR-4513	CLIP-seq
MIRT999737	hsa-miR-4695-5p	CLIP-seq
MIRT1996320	hsa-miR-4720-3p	CLIP-seq
MIRT1996321	hsa-miR-4768-3p	CLIP-seq
MIRT999742	hsa-miR-4779	CLIP-seq
MIRT1996322	hsa-miR-4781-3p	CLIP-seq
MIRT1996323	hsa-miR-4794	CLIP-seq
MIRT1996324	hsa-miR-4796-5p	CLIP-seq
MIRT1996325	hsa-miR-4804-3p	CLIP-seq
MIRT1996326	hsa-miR-494	CLIP-seq
MIRT999748	hsa-miR-98	CLIP-seq
MIRT999691	hsa-let-7a	CLIP-seq
MIRT999692	hsa-let-7b	CLIP-seq
MIRT999693	hsa-let-7c	CLIP-seq
MIRT999694	hsa-let-7d	CLIP-seq
MIRT999695	hsa-let-7e	CLIP-seq
MIRT999696	hsa-let-7f	CLIP-seq
MIRT999697	hsa-let-7g	CLIP-seq
MIRT999698	hsa-let-7i	CLIP-seq
MIRT2230239	hsa-miR-1305	CLIP-seq
MIRT999699	hsa-miR-134	CLIP-seq
MIRT999703	hsa-miR-196a	CLIP-seq
MIRT999704	hsa-miR-196b	CLIP-seq
MIRT2230240	hsa-miR-21	CLIP-seq
MIRT999707	hsa-miR-3118	CLIP-seq
MIRT999710	hsa-miR-3136-5p	CLIP-seq
MIRT2230241	hsa-miR-330-3p	CLIP-seq
MIRT2230242	hsa-miR-3614-3p	CLIP-seq
MIRT2230243	hsa-miR-4257	CLIP-seq
MIRT2230244	hsa-miR-4265	CLIP-seq
MIRT999718	hsa-miR-4266	CLIP-seq
MIRT2230245	hsa-miR-4296	CLIP-seq
MIRT2230246	hsa-miR-4312	CLIP-seq
MIRT2230247	hsa-miR-4322	CLIP-seq
MIRT2230248	hsa-miR-4417	CLIP-seq
MIRT999720	hsa-miR-4439	CLIP-seq
MIRT999721	hsa-miR-4458	CLIP-seq
MIRT999728	hsa-miR-4500	CLIP-seq
MIRT999730	hsa-miR-4513	CLIP-seq
MIRT2230249	hsa-miR-4640-5p	CLIP-seq
MIRT999737	hsa-miR-4695-5p	CLIP-seq
MIRT2230250	hsa-miR-4714-3p	CLIP-seq
MIRT1996320	hsa-miR-4720-3p	CLIP-seq
MIRT2230251	hsa-miR-4726-5p	CLIP-seq
MIRT2230252	hsa-miR-4756-3p	CLIP-seq
MIRT999742	hsa-miR-4779	CLIP-seq
MIRT1996322	hsa-miR-4781-3p	CLIP-seq
MIRT1996324	hsa-miR-4796-5p	CLIP-seq
MIRT1996325	hsa-miR-4804-3p	CLIP-seq
MIRT2230253	hsa-miR-590-5p	CLIP-seq
MIRT2230254	hsa-miR-627	CLIP-seq
MIRT999745	hsa-miR-651	CLIP-seq
MIRT999748	hsa-miR-98	CLIP-seq
MIRT999691	hsa-let-7a	CLIP-seq
MIRT999692	hsa-let-7b	CLIP-seq
MIRT999693	hsa-let-7c	CLIP-seq
MIRT999694	hsa-let-7d	CLIP-seq
MIRT999695	hsa-let-7e	CLIP-seq
MIRT999696	hsa-let-7f	CLIP-seq
MIRT999697	hsa-let-7g	CLIP-seq
MIRT999698	hsa-let-7i	CLIP-seq
MIRT999699	hsa-miR-134	CLIP-seq
MIRT999703	hsa-miR-196a	CLIP-seq
MIRT999704	hsa-miR-196b	CLIP-seq
MIRT999707	hsa-miR-3118	CLIP-seq
MIRT999710	hsa-miR-3136-5p	CLIP-seq
MIRT999718	hsa-miR-4266	CLIP-seq
MIRT999720	hsa-miR-4439	CLIP-seq
MIRT999721	hsa-miR-4458	CLIP-seq
MIRT999728	hsa-miR-4500	CLIP-seq
MIRT999730	hsa-miR-4513	CLIP-seq
MIRT999737	hsa-miR-4695-5p	CLIP-seq
MIRT1996320	hsa-miR-4720-3p	CLIP-seq
MIRT999742	hsa-miR-4779	CLIP-seq
MIRT1996322	hsa-miR-4781-3p	CLIP-seq
MIRT1996324	hsa-miR-4796-5p	CLIP-seq
MIRT1996325	hsa-miR-4804-3p	CLIP-seq
MIRT999748	hsa-miR-98	CLIP-seq

Show/Hide all (21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004497	Function	Monooxygenase activity	IEA
GO:0004499	Function	N,N-dimethylaniline monooxygenase activity	IBA
GO:0004499	Function	N,N-dimethylaniline monooxygenase activity	IDA	11744609
GO:0004499	Function	N,N-dimethylaniline monooxygenase activity	IEA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0006082	Process	Organic acid metabolic process	IDA	11744609
GO:0006739	Process	NADP+ metabolic process	IDA	11744609
GO:0006805	Process	Xenobiotic metabolic process	IBA
GO:0006805	Process	Xenobiotic metabolic process	IDA	11744609
GO:0006805	Process	Xenobiotic metabolic process	IEA
GO:0009404	Process	Toxin metabolic process	IDA	11744609
GO:0016020	Component	Membrane	IDA	9804831
GO:0016020	Component	Membrane	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0046322	Process	Negative regulation of fatty acid oxidation	IEA
GO:0050660	Function	Flavin adenine dinucleotide binding	IEA
GO:0050661	Function	NADP binding	IEA
GO:0072592	Process	Oxygen metabolic process	IEA
GO:0097009	Process	Energy homeostasis	IEA

MIM	HGNC	e!Ensembl
603955	3770	ENSG00000094963

Q99518

Protein name

Flavin-containing monooxygenase 2 (EC 1.14.13.-) (Dimethylaniline oxidase 2) (FMO 1B1) (Pulmonary flavin-containing monooxygenase 2) (FMO 2)

Protein function

Catalyzes the oxidative metabolism of numerous xenobiotics, including mainly therapeutic drugs and insecticides that contain a soft nucleophile, most commonly nitrogen and sulfur and participates to their bioactivation (PubMed:15144220, PubMed:1

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00743	FMO-like	2 → 533	Flavin-binding monooxygenase-like	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in lung (at protein level). Expressed predominantly in lung, and at a much lesser extent in kidney. Also expressed in fetal lung, but not in liver, kidney and brain. {ECO:0000269|PubMed:11042094, ECO:0000269|PubMed:9804831}.

Sequence

MAKKVAVIGAGVSGLISLKCCVDEGLEPTCFERTEDIGGVWRFKENVEDGRASIYQSVVT
NTSKEMSCFSDFPMPEDFPNFLHNSKLLEYFRIFAKKFDLLKYIQFQTTVLSVRKCPDFS
SSGQWKVVTQSNGKEQSAVFDAVMVCSGHHILPHIPLKSFPGMERFKGQYFHSRQYKHPD
GFEGKRILVIGMGNSGSDIAVELSKNAAQVFISTRHGTWVMSRISEDGYPWDSVFHTRFR
SMLRNVLPRTAVKWMIEQQMNRWFNHENYGLEPQNKYIMKEPVLNDDVPSRLLCGAIKVK
STVKELTETSAIFEDGTVEENIDVIIFATGYSFSFPFLEDSLVKVENNMVSLYKYIFPAH
LDKSTLACIGLIQPLGSIFPTAELQARWVTRVFKGLCSLPSERTMMMDIIKRNEKRIDLF
GESQSQTLQTNYVDYLDELALEIGAKPDFCSLLFKDPKLAVRLYFGPCNSYQYRLVGPGQ
WEGARNAIFTQKQRILKPLKTRALKDSSNFSVSFLLKILGLLAVVVAFFCQLQWS

Sequence length

535

Interactions

View interactions

	KEGG		Reactome
	Taurine and hypotaurine metabolism Drug metabolism - cytochrome P450 Metabolic pathways		FMO oxidises nucleophiles

FMO2 (flavin containing dimethylaniline monoxygenase 2)