Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	23266
Gene name Gene Name - the full gene name approved by the HGNC.	Adhesion G protein-coupled receptor L2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	ADGRL2
Synonyms (NCBI Gene) Gene synonyms aliases	CIRL2, CL2, LEC1, LPHH1, LPHN2
Chromosome Chromosome number	1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	1p31.1
Summary Summary of gene provided in NCBI Entrez Gene.	This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors. The encoded protein participates in the regulation of exocytosis. The proprotein is thought to be further cleaved within a cysteine-rich G-protein-coupled receptor pro

Show/Hide all(134)

miRTarBase ID	miRNA	Experiments	Reference
MIRT740666	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT740667	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT740668	hsa-miR-656-3p	HITS-CLIP	21572407
MIRT740669	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT740670	hsa-miR-3924	HITS-CLIP	21572407
MIRT740666	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT740667	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT740668	hsa-miR-656-3p	HITS-CLIP	21572407
MIRT740669	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT740670	hsa-miR-3924	HITS-CLIP	21572407
MIRT740956	hsa-miR-490-3p	HITS-CLIP	23313552
MIRT740957	hsa-miR-7851-3p	HITS-CLIP	23313552
MIRT740958	hsa-miR-216b-3p	HITS-CLIP	23313552
MIRT740959	hsa-miR-3192-5p	HITS-CLIP	23313552
MIRT740960	hsa-miR-589-5p	HITS-CLIP	23313552
MIRT740961	hsa-miR-146a-5p	HITS-CLIP	23313552
MIRT740962	hsa-miR-146b-5p	HITS-CLIP	23313552
MIRT740963	hsa-miR-7153-5p	HITS-CLIP	23313552
MIRT740964	hsa-miR-4537	HITS-CLIP	23313552
MIRT740965	hsa-miR-6087	HITS-CLIP	23313552
MIRT740966	hsa-miR-377-5p	HITS-CLIP	23313552
MIRT740967	hsa-miR-6086	HITS-CLIP	23313552
MIRT740968	hsa-miR-6499-3p	HITS-CLIP	23313552
MIRT740969	hsa-miR-658	HITS-CLIP	23313552
MIRT740970	hsa-miR-25-5p	HITS-CLIP	23313552
MIRT740971	hsa-miR-7106-5p	HITS-CLIP	23313552
MIRT740972	hsa-miR-149-3p	HITS-CLIP	23313552
MIRT740973	hsa-miR-4728-5p	HITS-CLIP	23313552
MIRT740974	hsa-miR-6785-5p	HITS-CLIP	23313552
MIRT740975	hsa-miR-6883-5p	HITS-CLIP	23313552
MIRT740976	hsa-miR-6799-5p	HITS-CLIP	23313552
MIRT740977	hsa-miR-455-3p	HITS-CLIP	23313552
MIRT740978	hsa-miR-1273h-5p	HITS-CLIP	23313552
MIRT740979	hsa-miR-30b-3p	HITS-CLIP	23313552
MIRT740980	hsa-miR-3689a-3p	HITS-CLIP	23313552
MIRT740981	hsa-miR-3689b-3p	HITS-CLIP	23313552
MIRT740982	hsa-miR-3689c	HITS-CLIP	23313552
MIRT740983	hsa-miR-6779-5p	HITS-CLIP	23313552
MIRT740984	hsa-miR-6780a-5p	HITS-CLIP	23313552
MIRT740985	hsa-miR-6516-5p	HITS-CLIP	23313552
MIRT740986	hsa-miR-4459	HITS-CLIP	23313552
MIRT741941	hsa-miR-8485	HITS-CLIP	23824327
MIRT741942	hsa-miR-6782-5p	HITS-CLIP	23824327
MIRT741943	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT741944	hsa-miR-642a-3p	HITS-CLIP	23824327
MIRT741945	hsa-miR-642b-3p	HITS-CLIP	23824327
MIRT741946	hsa-miR-518d-5p	HITS-CLIP	23824327
MIRT741947	hsa-miR-518e-5p	HITS-CLIP	23824327
MIRT741948	hsa-miR-518f-5p	HITS-CLIP	23824327
MIRT741949	hsa-miR-519a-5p	HITS-CLIP	23824327
MIRT741950	hsa-miR-519b-5p	HITS-CLIP	23824327
MIRT741951	hsa-miR-519c-5p	HITS-CLIP	23824327
MIRT741952	hsa-miR-520c-5p	HITS-CLIP	23824327
MIRT741953	hsa-miR-522-5p	HITS-CLIP	23824327
MIRT741954	hsa-miR-523-5p	HITS-CLIP	23824327
MIRT741955	hsa-miR-526a	HITS-CLIP	23824327
MIRT741956	hsa-miR-4777-5p	HITS-CLIP	23824327
MIRT740666	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT740667	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT740668	hsa-miR-656-3p	PAR-CLIP	20371350
MIRT740669	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT740670	hsa-miR-3924	PAR-CLIP	20371350
MIRT754136	hsa-miR-19b-3p	PAR-CLIP	20371350
MIRT754137	hsa-miR-19a-3p	PAR-CLIP	20371350
MIRT754138	hsa-miR-208a-5p	PAR-CLIP	20371350
MIRT754139	hsa-miR-208b-5p	PAR-CLIP	20371350
MIRT754140	hsa-miR-335-5p	PAR-CLIP	20371350
MIRT754141	hsa-miR-513b-5p	PAR-CLIP	20371350
MIRT754142	hsa-miR-5096	PAR-CLIP	20371350
MIRT754136	hsa-miR-19b-3p	PAR-CLIP	21572407
MIRT754137	hsa-miR-19a-3p	PAR-CLIP	21572407
MIRT754230	hsa-miR-338-5p	PAR-CLIP	21572407
MIRT754138	hsa-miR-208a-5p	PAR-CLIP	21572407
MIRT754139	hsa-miR-208b-5p	PAR-CLIP	21572407
MIRT754140	hsa-miR-335-5p	PAR-CLIP	21572407
MIRT754231	hsa-miR-16-2-3p	PAR-CLIP	21572407
MIRT754232	hsa-miR-195-3p	PAR-CLIP	21572407
MIRT754233	hsa-miR-4639-3p	PAR-CLIP	21572407
MIRT754234	hsa-miR-412-3p	PAR-CLIP	21572407
MIRT754235	hsa-miR-6754-3p	PAR-CLIP	21572407
MIRT754236	hsa-miR-6837-3p	PAR-CLIP	21572407
MIRT754141	hsa-miR-513b-5p	PAR-CLIP	21572407
MIRT754237	hsa-miR-6794-3p	PAR-CLIP	21572407
MIRT754238	hsa-miR-6875-3p	PAR-CLIP	21572407
MIRT754239	hsa-miR-4659a-3p	PAR-CLIP	21572407
MIRT754240	hsa-miR-4659b-3p	PAR-CLIP	21572407
MIRT754142	hsa-miR-5096	PAR-CLIP	21572407
MIRT740666	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT740667	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT740668	hsa-miR-656-3p	PAR-CLIP	21572407
MIRT740669	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT740670	hsa-miR-3924	PAR-CLIP	21572407
MIRT754136	hsa-miR-19b-3p	PAR-CLIP	21572407
MIRT754137	hsa-miR-19a-3p	PAR-CLIP	21572407
MIRT754138	hsa-miR-208a-5p	PAR-CLIP	21572407
MIRT754139	hsa-miR-208b-5p	PAR-CLIP	21572407
MIRT754140	hsa-miR-335-5p	PAR-CLIP	21572407
MIRT754141	hsa-miR-513b-5p	PAR-CLIP	21572407
MIRT754142	hsa-miR-5096	PAR-CLIP	21572407
MIRT740666	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT740667	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT740668	hsa-miR-656-3p	PAR-CLIP	21572407
MIRT740669	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT740670	hsa-miR-3924	PAR-CLIP	21572407
MIRT754432	hsa-miR-124-3p	PAR-CLIP	22012620
MIRT754433	hsa-miR-3714	PAR-CLIP	22012620
MIRT754434	hsa-miR-3910	PAR-CLIP	22012620
MIRT754435	hsa-miR-4475	PAR-CLIP	22012620
MIRT754436	hsa-miR-3200-3p	PAR-CLIP	22012620
MIRT754437	hsa-miR-6813-3p	PAR-CLIP	22012620
MIRT754432	hsa-miR-124-3p	PAR-CLIP	22012620
MIRT754438	hsa-miR-506-3p	PAR-CLIP	22012620
MIRT754439	hsa-miR-6892-5p	PAR-CLIP	22012620
MIRT754440	hsa-miR-4477b	PAR-CLIP	22012620
MIRT754441	hsa-miR-7856-5p	PAR-CLIP	22012620
MIRT740666	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT740667	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT740668	hsa-miR-656-3p	PAR-CLIP	23446348
MIRT754603	hsa-miR-501-3p	PAR-CLIP	23446348
MIRT754604	hsa-miR-502-3p	PAR-CLIP	23446348
MIRT740669	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT740670	hsa-miR-3924	PAR-CLIP	23446348
MIRT754136	hsa-miR-19b-3p	PAR-CLIP	23446348
MIRT754137	hsa-miR-19a-3p	PAR-CLIP	23446348
MIRT754138	hsa-miR-208a-5p	PAR-CLIP	23446348
MIRT754139	hsa-miR-208b-5p	PAR-CLIP	23446348
MIRT754140	hsa-miR-335-5p	PAR-CLIP	23446348
MIRT754141	hsa-miR-513b-5p	PAR-CLIP	23446348
MIRT754142	hsa-miR-5096	PAR-CLIP	23446348
MIRT740667	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT740668	hsa-miR-656-3p	PAR-CLIP	23446348
MIRT740669	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT740670	hsa-miR-3924	PAR-CLIP	23446348
MIRT740666	hsa-miR-1277-5p	PAR-CLIP	23446348

Show/Hide all(15)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004930	Function	G protein-coupled receptor activity	IBA	21873635
GO:0005887	Component	Integral component of plasma membrane	IBA	21873635
GO:0007166	Process	Cell surface receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	NAS	10030676
GO:0007189	Process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA	21873635
GO:0007420	Process	Brain development	IBA	21873635
GO:0009617	Process	Response to bacterium	IEA
GO:0016021	Component	Integral component of membrane	NAS	10030676
GO:0016524	Function	Latrotoxin receptor activity	NAS	10030676
GO:0030246	Function	Carbohydrate binding	IEA
GO:0043005	Component	Neuron projection	IBA	21873635
GO:0050808	Process	Synapse organization	IEA
GO:0051965	Process	Positive regulation of synapse assembly	IEA
GO:0098978	Component	Glutamatergic synapse	IEA
GO:0099055	Component	Integral component of postsynaptic membrane	IEA

MIM	HGNC	e!Ensembl
607018	18582	ENSG00000117114

Protein

UniProt ID

O95490

Protein name

Adhesion G protein-coupled receptor L2 (Calcium-independent alpha-latrotoxin receptor 2) (CIRL-2) (Latrophilin homolog 1) (Latrophilin-2) (Lectomedin-1)

Protein function

Orphan adhesion G-protein coupled receptor (aGPCR), which mediates synapse specificity (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the ac

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02140	Gal_Lectin	49 → 129	Galactose binding lectin domain	Domain
PF02191	OLF	140 → 392	Olfactomedin-like domain	Family
PF02793	HRM	466 → 524	Hormone receptor domain	Family
PF16489	GAIN	538 → 760	GPCR-Autoproteolysis INducing (GAIN) domain	Domain
PF01825	GPS	786 → 830	GPCR proteolysis site, GPS, motif	Motif
PF00002	7tm_2	844 → 1080	7 transmembrane receptor (Secretin family)	Family
PF02354	Latrophilin	1100 → 1459	Latrophilin Cytoplasmic C-terminal region	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed very widely in all normal tissues tested. Expression is variable in tumor cell lines, apparently elevated in some lines and absent or markedly reduced in others. {ECO:0000269|PubMed:10030676}.

Sequence

MVSSGCRMRSLWFIIVISFLPNTEGFSRAALPFGLVRRELSCEGYSIDLRCPGSDVIMIE
SANYGRTDDKICDADPFQMENTDCYLPDAFKIMTQRCNNRTQCIVVTGSDVFPDPCPGTY
KYLEVQYECVPYIFVCPGTLKAIVDSPCIYEAEQKAGAWCKDPLQAADKIYFMPWTPYRT
DTLIEYASLEDFQNSRQTTTYKLPNRVDGTGFVVYDGAVFFNKERTRNIVKFDLRTRIKS
GEAIINYANYHDTSPYRWGGKTDIDLAVDENGLWVIYATEQNNGMIVISQLNPYTLRFEA
TWETVYDKRAASNAFMICGVLYVVRSVYQDNESETGKNSIDYIYNTRLNRGEYVDVPFPN
QYQYIAAVDYNPRDNQLYVWNNNFILRYSLEFGPPDPAQVPTTAVTITSSAELFKTIIST
TSTTSQKGPMSTTVAGSQEGSKGTKPPPAVSTTKIPPITNIFPLPERFCEALDSKGIKWP
QTQRGMMVERPCPKGTRGTASYLCMISTGTWNPKGPDLSNCTSHWVNQLAQKIRSGENAA
SLANELAKHTKGPVFAGDVSSSVRLMEQLVDILDAQLQELKPSEKDSAGRSYNKLQKREK
TCRAYLKAIVDTVDNLLRPEALESWKHMNSSEQAHTATMLLDTLEEGAFVLADNLLEPTR
VSMPTENIVLEVAVLSTEGQIQDFKFPLGIKGAGSSIQLSANTVKQNSRNGLAKLVFIIY
RSLGQFLSTENATIKLGADFIGRNSTIAVNSHVISVSINKESSRVYLTDPVLFTLPHIDP
DNYFNANCSFWNYSERTMMGYWSTQGCKLVDTNKTRTTCACSHLTNFAILMAHREIAYKD
GVHELLLTVITWVGIVISLVCLAICIFTFCFFRGLQSDRNTIHKNLCINLFIAEFIFLIG
IDKTKYAIACPIFAGLLHFFFLAAFAWMCLEGVQLYLMLVEVFESEYSRKKYYYVAGYLF
PATVVGVSAAIDYKSYGTEKACWLHVDNYFIWSFIGPVTFIILLNIIFLVITLCKMVKHS
NTLKPDSSRLENIKSWVLGAFALLCLLGLTWSFGLLFINEETIVMAYLFTIFNAFQGVFI
FIFHCALQKKVRKEYGKCFRHSYCCGGLPTESPHSSVKASTTRTSARYSSGTQSRIRRMW
NDTVRKQSESSFISGDINSTSTLNQGMTGNYLLTNPLLRPHGTNNPYNTLLAETVVCNAP
SAPVFNSPGHSLNNARDTSAMDTLPLNGNFNNSYSLHKGDYNDSVQVVDCGLSLNDTAFE
KMIISELVHNNLRGSSKTHNLELTLPVKPVIGGSSSEDDAIVADASSLMHSDNPGLELHH
KELEAPLIPQRTHSLLYQPQKKVKSEGTDSYVSQLTAEAEDHLQSPNRDSLYTSMPNLRD
SPYPESSPDMEEDLSPSRRSENEDIYYKSMPNLGAGHQLQMCYQISRGNSDGYIIPINKE
GCIPEGDVREGQMQLVTSL

Sequence length

1459

Interactions

View interactions

Show/Hide Causal Diseases (5)

Disease term	Disease name	dbSNP ID	References
Causal
Arthritis	Juvenile arthritis	rs1594890601, rs1594882933, rs184370809, rs776489319, rs1594883470	26301688
Autoimmune diseases	Autoimmune Diseases, AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 1, AUTOIMMUNE DISEASE, MULTISYSTEM, INFANTILE-ONSET, 2	rs869025224	26301688
Common variable immunodeficiency	Common Variable Immunodeficiency	rs72553883, rs121908379, rs104894650, rs587776775, rs398122863, rs398122864, rs397514332, rs397514331, rs727502786, rs727502787, rs72553882, rs869320688, rs869320689, rs869320754, rs773694113 View all (35 more)	26301688
Diabetes mellitus	Diabetes Mellitus, Insulin-Dependent	rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237 View all (293 more)	26301688
Psoriasis	Psoriasis	rs281875215, rs587777763, rs281875213, rs281875212	26301688

Show/Hide Unknown Diseases (10)

Disease term	Disease name	Evidence	References	Source
Unknown
Celiac disease	Celiac Disease		26301688	ClinVar
Crohn disease	Crohn Disease		26301688	ClinVar
Coronary artery disease	Coronary artery disease			GWAS
Metabolic Syndrome	Metabolic Syndrome			GWAS
Breast Cancer	Breast Cancer	Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients		GWAS, CBGDA
Diabetes	Diabetes			GWAS
Dental caries	Dental caries			GWAS
Prostate cancer	Prostate cancer	Together, these results show that PRRX2 is an oncogene and might play a role in the aggressiveness of PC within the DNPC population.		GWAS, CBGDA
Myocardial Infarction	Myocardial Infarction			GWAS
Dyslexia	Dyslexia			GWAS

Show/Hide Text Mining Associations (11)

Disease Name	Relationship Type	References
Associations from Text Mining
Breast Neoplasms	Associate	22479588
Colonic Neoplasms	Associate	26511811
Depressive Disorder	Associate	34972135
Dyspepsia	Associate	29143724
Emphysema	Associate	28459279
Gastrointestinal Neoplasms	Associate	26511811
Inflammation	Associate	30332657
Neoplasms	Associate	26511811
Orofacial Cleft 1	Associate	26868259
Stomach Neoplasms	Associate	26511811
Stomach Neoplasms	Inhibit	28657541

ADGRL2 (adhesion G protein-coupled receptor L2)