Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	23266
Gene name	Adhesion G protein-coupled receptor L2
Gene symbol	ADGRL2
Synonyms (NCBI Gene)	CIRL2CL2LEC1LPHH1LPHN2
Chromosome	1
Chromosome location	1p31.1
Summary	This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors. The encoded protein participates in the regulation of exocytosis. The proprotein is thought to be further cleaved within a cysteine-rich G-protein-coupled receptor pro

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Show/Hide all (134)

miRTarBase ID	miRNA	Experiments	Reference
MIRT740666	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT740667	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT740668	hsa-miR-656-3p	HITS-CLIP	21572407
MIRT740669	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT740670	hsa-miR-3924	HITS-CLIP	21572407
MIRT740666	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT740667	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT740668	hsa-miR-656-3p	HITS-CLIP	21572407
MIRT740669	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT740670	hsa-miR-3924	HITS-CLIP	21572407
MIRT740956	hsa-miR-490-3p	HITS-CLIP	23313552
MIRT740957	hsa-miR-7851-3p	HITS-CLIP	23313552
MIRT740958	hsa-miR-216b-3p	HITS-CLIP	23313552
MIRT740959	hsa-miR-3192-5p	HITS-CLIP	23313552
MIRT740960	hsa-miR-589-5p	HITS-CLIP	23313552
MIRT740961	hsa-miR-146a-5p	HITS-CLIP	23313552
MIRT740962	hsa-miR-146b-5p	HITS-CLIP	23313552
MIRT740963	hsa-miR-7153-5p	HITS-CLIP	23313552
MIRT740964	hsa-miR-4537	HITS-CLIP	23313552
MIRT740965	hsa-miR-6087	HITS-CLIP	23313552
MIRT740966	hsa-miR-377-5p	HITS-CLIP	23313552
MIRT740967	hsa-miR-6086	HITS-CLIP	23313552
MIRT740968	hsa-miR-6499-3p	HITS-CLIP	23313552
MIRT740969	hsa-miR-658	HITS-CLIP	23313552
MIRT740970	hsa-miR-25-5p	HITS-CLIP	23313552
MIRT740971	hsa-miR-7106-5p	HITS-CLIP	23313552
MIRT740972	hsa-miR-149-3p	HITS-CLIP	23313552
MIRT740973	hsa-miR-4728-5p	HITS-CLIP	23313552
MIRT740974	hsa-miR-6785-5p	HITS-CLIP	23313552
MIRT740975	hsa-miR-6883-5p	HITS-CLIP	23313552
MIRT740976	hsa-miR-6799-5p	HITS-CLIP	23313552
MIRT740977	hsa-miR-455-3p	HITS-CLIP	23313552
MIRT740978	hsa-miR-1273h-5p	HITS-CLIP	23313552
MIRT740979	hsa-miR-30b-3p	HITS-CLIP	23313552
MIRT740980	hsa-miR-3689a-3p	HITS-CLIP	23313552
MIRT740981	hsa-miR-3689b-3p	HITS-CLIP	23313552
MIRT740982	hsa-miR-3689c	HITS-CLIP	23313552
MIRT740983	hsa-miR-6779-5p	HITS-CLIP	23313552
MIRT740984	hsa-miR-6780a-5p	HITS-CLIP	23313552
MIRT740985	hsa-miR-6516-5p	HITS-CLIP	23313552
MIRT740986	hsa-miR-4459	HITS-CLIP	23313552
MIRT741941	hsa-miR-8485	HITS-CLIP	23824327
MIRT741942	hsa-miR-6782-5p	HITS-CLIP	23824327
MIRT741943	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT741944	hsa-miR-642a-3p	HITS-CLIP	23824327
MIRT741945	hsa-miR-642b-3p	HITS-CLIP	23824327
MIRT741946	hsa-miR-518d-5p	HITS-CLIP	23824327
MIRT741947	hsa-miR-518e-5p	HITS-CLIP	23824327
MIRT741948	hsa-miR-518f-5p	HITS-CLIP	23824327
MIRT741949	hsa-miR-519a-5p	HITS-CLIP	23824327
MIRT741950	hsa-miR-519b-5p	HITS-CLIP	23824327
MIRT741951	hsa-miR-519c-5p	HITS-CLIP	23824327
MIRT741952	hsa-miR-520c-5p	HITS-CLIP	23824327
MIRT741953	hsa-miR-522-5p	HITS-CLIP	23824327
MIRT741954	hsa-miR-523-5p	HITS-CLIP	23824327
MIRT741955	hsa-miR-526a	HITS-CLIP	23824327
MIRT741956	hsa-miR-4777-5p	HITS-CLIP	23824327
MIRT740666	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT740667	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT740668	hsa-miR-656-3p	PAR-CLIP	20371350
MIRT740669	hsa-miR-190a-3p	PAR-CLIP	20371350
MIRT740670	hsa-miR-3924	PAR-CLIP	20371350
MIRT754136	hsa-miR-19b-3p	PAR-CLIP	20371350
MIRT754137	hsa-miR-19a-3p	PAR-CLIP	20371350
MIRT754138	hsa-miR-208a-5p	PAR-CLIP	20371350
MIRT754139	hsa-miR-208b-5p	PAR-CLIP	20371350
MIRT754140	hsa-miR-335-5p	PAR-CLIP	20371350
MIRT754141	hsa-miR-513b-5p	PAR-CLIP	20371350
MIRT754142	hsa-miR-5096	PAR-CLIP	20371350
MIRT754136	hsa-miR-19b-3p	PAR-CLIP	21572407
MIRT754137	hsa-miR-19a-3p	PAR-CLIP	21572407
MIRT754230	hsa-miR-338-5p	PAR-CLIP	21572407
MIRT754138	hsa-miR-208a-5p	PAR-CLIP	21572407
MIRT754139	hsa-miR-208b-5p	PAR-CLIP	21572407
MIRT754140	hsa-miR-335-5p	PAR-CLIP	21572407
MIRT754231	hsa-miR-16-2-3p	PAR-CLIP	21572407
MIRT754232	hsa-miR-195-3p	PAR-CLIP	21572407
MIRT754233	hsa-miR-4639-3p	PAR-CLIP	21572407
MIRT754234	hsa-miR-412-3p	PAR-CLIP	21572407
MIRT754235	hsa-miR-6754-3p	PAR-CLIP	21572407
MIRT754236	hsa-miR-6837-3p	PAR-CLIP	21572407
MIRT754141	hsa-miR-513b-5p	PAR-CLIP	21572407
MIRT754237	hsa-miR-6794-3p	PAR-CLIP	21572407
MIRT754238	hsa-miR-6875-3p	PAR-CLIP	21572407
MIRT754239	hsa-miR-4659a-3p	PAR-CLIP	21572407
MIRT754240	hsa-miR-4659b-3p	PAR-CLIP	21572407
MIRT754142	hsa-miR-5096	PAR-CLIP	21572407
MIRT740666	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT740667	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT740668	hsa-miR-656-3p	PAR-CLIP	21572407
MIRT740669	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT740670	hsa-miR-3924	PAR-CLIP	21572407
MIRT754136	hsa-miR-19b-3p	PAR-CLIP	21572407
MIRT754137	hsa-miR-19a-3p	PAR-CLIP	21572407
MIRT754138	hsa-miR-208a-5p	PAR-CLIP	21572407
MIRT754139	hsa-miR-208b-5p	PAR-CLIP	21572407
MIRT754140	hsa-miR-335-5p	PAR-CLIP	21572407
MIRT754141	hsa-miR-513b-5p	PAR-CLIP	21572407
MIRT754142	hsa-miR-5096	PAR-CLIP	21572407
MIRT740666	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT740667	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT740668	hsa-miR-656-3p	PAR-CLIP	21572407
MIRT740669	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT740670	hsa-miR-3924	PAR-CLIP	21572407
MIRT754432	hsa-miR-124-3p	PAR-CLIP	22012620
MIRT754433	hsa-miR-3714	PAR-CLIP	22012620
MIRT754434	hsa-miR-3910	PAR-CLIP	22012620
MIRT754435	hsa-miR-4475	PAR-CLIP	22012620
MIRT754436	hsa-miR-3200-3p	PAR-CLIP	22012620
MIRT754437	hsa-miR-6813-3p	PAR-CLIP	22012620
MIRT754432	hsa-miR-124-3p	PAR-CLIP	22012620
MIRT754438	hsa-miR-506-3p	PAR-CLIP	22012620
MIRT754439	hsa-miR-6892-5p	PAR-CLIP	22012620
MIRT754440	hsa-miR-4477b	PAR-CLIP	22012620
MIRT754441	hsa-miR-7856-5p	PAR-CLIP	22012620
MIRT740666	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT740667	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT740668	hsa-miR-656-3p	PAR-CLIP	23446348
MIRT754603	hsa-miR-501-3p	PAR-CLIP	23446348
MIRT754604	hsa-miR-502-3p	PAR-CLIP	23446348
MIRT740669	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT740670	hsa-miR-3924	PAR-CLIP	23446348
MIRT754136	hsa-miR-19b-3p	PAR-CLIP	23446348
MIRT754137	hsa-miR-19a-3p	PAR-CLIP	23446348
MIRT754138	hsa-miR-208a-5p	PAR-CLIP	23446348
MIRT754139	hsa-miR-208b-5p	PAR-CLIP	23446348
MIRT754140	hsa-miR-335-5p	PAR-CLIP	23446348
MIRT754141	hsa-miR-513b-5p	PAR-CLIP	23446348
MIRT754142	hsa-miR-5096	PAR-CLIP	23446348
MIRT740667	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT740668	hsa-miR-656-3p	PAR-CLIP	23446348
MIRT740669	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT740670	hsa-miR-3924	PAR-CLIP	23446348
MIRT740666	hsa-miR-1277-5p	PAR-CLIP	23446348

Show/Hide all (21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004888	Function	Transmembrane signaling receptor activity	IEA
GO:0004930	Function	G protein-coupled receptor activity	IBA
GO:0004930	Function	G protein-coupled receptor activity	IEA
GO:0004930	Function	G protein-coupled receptor activity	TAS	15203201
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0007166	Process	Cell surface receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IBA
GO:0007186	Process	G protein-coupled receptor signaling pathway	IEA
GO:0007186	Process	G protein-coupled receptor signaling pathway	NAS	10030676
GO:0007186	Process	G protein-coupled receptor signaling pathway	TAS	15203201
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	NAS	10030676
GO:0016020	Component	Membrane	TAS	15203201
GO:0016524	Function	Latrotoxin receptor activity	NAS	10030676
GO:0030246	Function	Carbohydrate binding	IEA
GO:0045202	Component	Synapse	IEA
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0045211	Component	Postsynaptic membrane	ISS
GO:1904861	Process	Excitatory synapse assembly	ISS

MIM	HGNC	e!Ensembl
607018	18582	ENSG00000117114

O95490

Protein name

Adhesion G protein-coupled receptor L2 (Calcium-independent alpha-latrotoxin receptor 2) (CIRL-2) (Latrophilin homolog 1) (Latrophilin-2) (Lectomedin-1)

Protein function

Orphan adhesion G-protein coupled receptor (aGPCR), which mediates synapse specificity (By similarity). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the ac

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02140	Gal_Lectin	49 → 129	Galactose binding lectin domain	Domain
PF02191	OLF	140 → 392	Olfactomedin-like domain	Family
PF02793	HRM	466 → 524	Hormone receptor domain	Family
PF16489	GAIN	538 → 760	GPCR-Autoproteolysis INducing (GAIN) domain	Domain
PF01825	GPS	786 → 830	GPCR proteolysis site, GPS, motif	Motif
PF00002	7tm_2	844 → 1080	7 transmembrane receptor (Secretin family)	Family
PF02354	Latrophilin	1100 → 1459	Latrophilin Cytoplasmic C-terminal region	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed very widely in all normal tissues tested. Expression is variable in tumor cell lines, apparently elevated in some lines and absent or markedly reduced in others. {ECO:0000269|PubMed:10030676}.

Sequence

MVSSGCRMRSLWFIIVISFLPNTEGFSRAALPFGLVRRELSCEGYSIDLRCPGSDVIMIE
SANYGRTDDKICDADPFQMENTDCYLPDAFKIMTQRCNNRTQCIVVTGSDVFPDPCPGTY
KYLEVQYECVPYIFVCPGTLKAIVDSPCIYEAEQKAGAWCKDPLQAADKIYFMPWTPYRT
DTLIEYASLEDFQNSRQTTTYKLPNRVDGTGFVVYDGAVFFNKERTRNIVKFDLRTRIKS
GEAIINYANYHDTSPYRWGGKTDIDLAVDENGLWVIYATEQNNGMIVISQLNPYTLRFEA
TWETVYDKRAASNAFMICGVLYVVRSVYQDNESETGKNSIDYIYNTRLNRGEYVDVPFPN
QYQYIAAVDYNPRDNQLYVWNNNFILRYSLEFGPPDPAQVPTTAVTITSSAELFKTIIST
TSTTSQKGPMSTTVAGSQEGSKGTKPPPAVSTTKIPPITNIFPLPERFCEALDSKGIKWP
QTQRGMMVERPCPKGTRGTASYLCMISTGTWNPKGPDLSNCTSHWVNQLAQKIRSGENAA
SLANELAKHTKGPVFAGDVSSSVRLMEQLVDILDAQLQELKPSEKDSAGRSYNKLQKREK
TCRAYLKAIVDTVDNLLRPEALESWKHMNSSEQAHTATMLLDTLEEGAFVLADNLLEPTR
VSMPTENIVLEVAVLSTEGQIQDFKFPLGIKGAGSSIQLSANTVKQNSRNGLAKLVFIIY
RSLGQFLSTENATIKLGADFIGRNSTIAVNSHVISVSINKESSRVYLTDPVLFTLPHIDP
DNYFNANCSFWNYSERTMMGYWSTQGCKLVDTNKTRTTCACSHLTNFAILMAHREIAYKD
GVHELLLTVITWVGIVISLVCLAICIFTFCFFRGLQSDRNTIHKNLCINLFIAEFIFLIG
IDKTKYAIACPIFAGLLHFFFLAAFAWMCLEGVQLYLMLVEVFESEYSRKKYYYVAGYLF
PATVVGVSAAIDYKSYGTEKACWLHVDNYFIWSFIGPVTFIILLNIIFLVITLCKMVKHS
NTLKPDSSRLENIKSWVLGAFALLCLLGLTWSFGLLFINEETIVMAYLFTIFNAFQGVFI
FIFHCALQKKVRKEYGKCFRHSYCCGGLPTESPHSSVKASTTRTSARYSSGTQSRIRRMW
NDTVRKQSESSFISGDINSTSTLNQGMTGNYLLTNPLLRPHGTNNPYNTLLAETVVCNAP
SAPVFNSPGHSLNNARDTSAMDTLPLNGNFNNSYSLHKGDYNDSVQVVDCGLSLNDTAFE
KMIISELVHNNLRGSSKTHNLELTLPVKPVIGGSSSEDDAIVADASSLMHSDNPGLELHH
KELEAPLIPQRTHSLLYQPQKKVKSEGTDSYVSQLTAEAEDHLQSPNRDSLYTSMPNLRD
SPYPESSPDMEEDLSPSRRSENEDIYYKSMPNLGAGHQLQMCYQISRGNSDGYIIPINKE
GCIPEGDVREGQMQLVTSL

Sequence length

1459

Interactions

View interactions

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
ADGRL2-related disorder	Uncertain significance; Likely benign; Benign	rs142415541, rs149165038, rs150187776, rs201068501, rs757239872, rs41292984, rs368142284, rs372868281, rs74098542, rs774334338, rs183237089, rs764749995, rs148181687, rs72719419, rs142267708 View all (14 more)	RCV003918956 RCV003966342 RCV003906714 RCV003921897 RCV003911741 RCV003914232 RCV003909668 RCV003947340 RCV003919392 RCV003931646 RCV003941707 RCV003959385 RCV003944510 RCV003924437 RCV003936918 RCV003937168 RCV003922091 RCV003942230 RCV003949129 RCV003937385 RCV003964314 RCV003976940 RCV003971622 RCV003971779 RCV003976693 RCV003966821 RCV003981347 RCV003926115 RCV003916221
Cholangiocarcinoma	Likely benign	rs141656433	RCV005933466
Colon adenocarcinoma	Likely benign	rs141656433	RCV005933463
Gastric cancer	Likely benign	rs141656433	RCV005933465
Sarcoma	Likely benign	rs141656433	RCV005933464

Show/Hide Text Mining Associations (11)

Disease Name	Relationship Type	References
Associations from Text MiningDisease associations identified through Pubtator
Breast Neoplasms	Associate	22479588
Colonic Neoplasms	Associate	26511811
Depressive Disorder	Associate	34972135
Dyspepsia	Associate	29143724
Emphysema	Associate	28459279
Gastrointestinal Neoplasms	Associate	26511811
Inflammation	Associate	30332657
Neoplasms	Associate	26511811
Orofacial Cleft 1	Associate	26868259
Stomach Neoplasms	Associate	26511811
Stomach Neoplasms	Inhibit	28657541

ADGRL2 (adhesion G protein-coupled receptor L2)