Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
23264
Gene name Gene Name - the full gene name approved by the HGNC.
Zinc finger CCCH-type containing 7B
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
ZC3H7B
Synonyms (NCBI Gene) Gene synonyms aliases
ROXAN1, RoXaN
Chromosome Chromosome number
22
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
22q13.2
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a protein that contains a tetratricopeptide repeat domain. The encoded protein also interacts with the rotavirus non-structural protein NSP3. [provided by RefSeq, Jul 2008]
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT042116 hsa-miR-484 CLASH 23622248
MIRT041480 hsa-miR-193b-3p CLASH 23622248
MIRT039423 hsa-miR-421 CLASH 23622248
MIRT038605 hsa-miR-193a-5p CLASH 23622248
MIRT038598 hsa-miR-106b-3p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003723 Function RNA binding HDA 22658674, 22681889
GO:0005515 Function Protein binding IPI 15047801
GO:0005634 Component Nucleus IEA
GO:0010608 Process Posttranscriptional regulation of gene expression IMP 28431233
GO:0016032 Process Viral process IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
618206 30869 ENSG00000100403
Protein
UniProt ID Q9UGR2
Protein name Zinc finger CCCH domain-containing protein 7B (Rotavirus 'X'-associated non-structural protein) (RoXaN)
Protein function May be a specific regulator of miRNA biogenesis. Binds to microRNAs MIR7-1, MIR16-2 and MIR29A hairpins recognizing the 'ATA(A/T)' motif in the apical loop.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13181 TPR_8 83 115 Tetratricopeptide repeat Repeat
PF00642 zf-CCCH 755 781 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Family
PF00642 zf-CCCH 888 913 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Family
Sequence
MERQKRKADIEKGLQFIQSTLPLKQEEYEAFLLKLVQNLFAEGNDLFREKDYKQALVQYM
EGLNVADYAASDQVALPRELLCKLHVNRAACYFTMGLYEKALEDSEKALGLDSESIRALF
RKARALNELGRHKEAYECSSRCSLALPHDESVTQLGQELAQKLGLRVRKAYKRPQELETF
SLLSNGTAAGVADQGTSNGLGSIDDIETDCYVDPRGSPALLPSTPTMPLFPHVLDLLAPL
DSSRTLPSTDSLDDFSDGDVFGPELDTLLDSLSLVQGGLSGSGVPSELPQLIPVFPGGTP
LLPPVVGGSIPVSSPLPPASFGLVMDPSKKLAASVLDALDPPGPTLDPLDLLPYSETRLD
ALDSFGSTRGSLDKPDSFMEETNSQDHRPPSGAQKPAPSPEPCMPNTALLIKNPLAATHE
FKQACQLCYPKTGPRAGDYTYREGLEHKCKRDILLGRLRSSEDQTWKRIRPRPTKTSFVG
SYYLCKDMINKQDCKYGDNCTFAYHQEEIDVWTEERKGTLNRDLLFDPLGGVKRGSLTIA
KLLKEHQGIFTFLCEICFDSKPRIISKGTKDSPSVCSNLAAKHSFYNNKCLVHIVRSTSL
KYSKIRQFQEHFQFDVCRHEVRYGCLREDSCHFAHSFIELKVWLLQQYSGMTHEDIVQES
KKYWQQMEAHAGKASSSMGAPRTHGPSTFDLQMKFVCGQCWRNGQVVEPDKDLKYCSAKA
RHCWTKERRVLLVMSKAKRKWVSVRPLPSIRNFPQQYDLCIHAQNGRKCQYVGNCSFAHS
P
EERDMWTFMKENKILDMQQTYDMWLKKHNPGKPGEGTPISSREGEKQIQMPTDYADIMM
GYHCWLCGKNSNSKKQWQQHIQSEKHKEKVFTSDSDASGWAFRFPMGEFRLCDRLQKGKA
CPDGDKCRCAHGQ
EELNEWLDRREVLKQKLAKARKDMLLCPRDDDFGKYNFLLQEDGDLA
GATPEAPAAAATATTGE
Sequence length 977
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast carcinoma Breast Carcinoma rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451
View all (71 more)
29059683
Unknown
Disease term Disease name Evidence References Source
Neuroticism Neuroticism GWAS
Hypothyroidism Hypothyroidism GWAS
Schizophrenia Schizophrenia GWAS
Vitiligo Vitiligo GWAS
Associations from Text Mining
Disease Name Relationship Type References
Carcinoma Associate 29192652, 30789359
Desmoplastic Small Round Cell Tumor Associate 26752546
Endometrial Stromal Tumors Associate 33077922, 36731460
Leiomyosarcoma Associate 29192652
Neoplasms Associate 24285434, 29192652, 32034283, 36864468
Sarcoma Associate 26752546, 29104083, 31189997
Sarcoma Endometrial Stromal Associate 24285434, 27631520, 29192652, 33077922, 36731460, 36864468, 38084541
Smooth Muscle Tumor Associate 31189997