Gene Gene information from NCBI Gene database.
Entrez ID 23264
Gene name Zinc finger CCCH-type containing 7B
Gene symbol ZC3H7B
Synonyms (NCBI Gene)
ROXAN1RoXaN
Chromosome 22
Chromosome location 22q13.2
Summary This gene encodes a protein that contains a tetratricopeptide repeat domain. The encoded protein also interacts with the rotavirus non-structural protein NSP3. [provided by RefSeq, Jul 2008]
miRNA miRNA information provided by mirtarbase database.
295
miRTarBase ID miRNA Experiments Reference
MIRT042116 hsa-miR-484 CLASH 23622248
MIRT041480 hsa-miR-193b-3p CLASH 23622248
MIRT039423 hsa-miR-421 CLASH 23622248
MIRT038605 hsa-miR-193a-5p CLASH 23622248
MIRT038598 hsa-miR-106b-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
13
GO ID Ontology Definition Evidence Reference
GO:0003723 Function RNA binding HDA 22658674, 22681889
GO:0005515 Function Protein binding IPI 15047801
GO:0005634 Component Nucleus IEA
GO:0008270 Function Zinc ion binding IEA
GO:0010608 Process Post-transcriptional regulation of gene expression IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
618206 30869 ENSG00000100403
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9UGR2
Protein name Zinc finger CCCH domain-containing protein 7B (Rotavirus 'X'-associated non-structural protein) (RoXaN)
Protein function May be a specific regulator of miRNA biogenesis. Binds to microRNAs MIR7-1, MIR16-2 and MIR29A hairpins recognizing the 'ATA(A/T)' motif in the apical loop.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF13181 TPR_8 83 115 Tetratricopeptide repeat Repeat
PF00642 zf-CCCH 755 781 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Family
PF00642 zf-CCCH 888 913 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Family
Sequence
MERQKRKADIEKGLQFIQSTLPLKQEEYEAFLLKLVQNLFAEGNDLFREKDYKQALVQYM
EGLNVADYAASDQVALPRELLCKLHVNRAACYFTMGLYEKALEDSEKALGLDSESIRALF
RKARALNELGRHKEAYECSSRCSLALPHDESVTQLGQELAQKLGLRVRKAYKRPQELETF
SLLSNGTAAGVADQGTSNGLGSIDDIETDCYVDPRGSPALLPSTPTMPLFPHVLDLLAPL
DSSRTLPSTDSLDDFSDGDVFGPELDTLLDSLSLVQGGLSGSGVPSELPQLIPVFPGGTP
LLPPVVGGSIPVSSPLPPASFGLVMDPSKKLAASVLDALDPPGPTLDPLDLLPYSETRLD
ALDSFGSTRGSLDKPDSFMEETNSQDHRPPSGAQKPAPSPEPCMPNTALLIKNPLAATHE
FKQACQLCYPKTGPRAGDYTYREGLEHKCKRDILLGRLRSSEDQTWKRIRPRPTKTSFVG
SYYLCKDMINKQDCKYGDNCTFAYHQEEIDVWTEERKGTLNRDLLFDPLGGVKRGSLTIA
KLLKEHQGIFTFLCEICFDSKPRIISKGTKDSPSVCSNLAAKHSFYNNKCLVHIVRSTSL
KYSKIRQFQEHFQFDVCRHEVRYGCLREDSCHFAHSFIELKVWLLQQYSGMTHEDIVQES
KKYWQQMEAHAGKASSSMGAPRTHGPSTFDLQMKFVCGQCWRNGQVVEPDKDLKYCSAKA
RHCWTKERRVLLVMSKAKRKWVSVRPLPSIRNFPQQYDLCIHAQNGRKCQYVGNCSFAHS
P
EERDMWTFMKENKILDMQQTYDMWLKKHNPGKPGEGTPISSREGEKQIQMPTDYADIMM
GYHCWLCGKNSNSKKQWQQHIQSEKHKEKVFTSDSDASGWAFRFPMGEFRLCDRLQKGKA
CPDGDKCRCAHGQ
EELNEWLDRREVLKQKLAKARKDMLLCPRDDDFGKYNFLLQEDGDLA
GATPEAPAAAATATTGE
Sequence length 977
Interactions View interactions
Associated diseases Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
3
Unknown Diseases with uncertain, conflicting, or no pathogenic evidence in ClinVar
Phenotype Name Clinical Significance dbSNP ID RCV Accession
Malignant tumor of esophagus Uncertain significance rs148237320 RCV005928898
Sarcoma Uncertain significance rs148237320 RCV005928899
Thyroid cancer, nonmedullary, 1 Uncertain significance rs148237320 RCV005928900
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References
Carcinoma Associate 29192652, 30789359
Desmoplastic Small Round Cell Tumor Associate 26752546
Endometrial Stromal Tumors Associate 33077922, 36731460
Leiomyosarcoma Associate 29192652
Neoplasms Associate 24285434, 29192652, 32034283, 36864468
Sarcoma Associate 26752546, 29104083, 31189997
Sarcoma Endometrial Stromal Associate 24285434, 27631520, 29192652, 33077922, 36731460, 36864468, 38084541
Smooth Muscle Tumor Associate 31189997