FMO1 (flavin containing dimethylaniline monoxygenase 1)

Gene
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
2326
Gene name Gene Name - the full gene name approved by the HGNC.
Flavin containing dimethylaniline monoxygenase 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
FMO1
Synonyms (NCBI Gene) Gene synonyms aliases
-
Chromosome Chromosome number
1
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
1q24.3
Summary Summary of gene provided in NCBI Entrez Gene.
Metabolic N-oxidation of the diet-derived amino-trimethylamine (TMA) is mediated by flavin-containing monooxygenase and is subject to an inherited FMO3 polymorphism in man resulting in a small subpopulation with reduced TMA N-oxidation capacity resulting
miRNA miRNA information provided by mirtarbase database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(5)
miRTarBase ID miRNA Experiments Reference
MIRT044436 hsa-miR-320a CLASH 23622248
MIRT2534084 hsa-miR-4464 CLIP-seq
MIRT2534085 hsa-miR-4748 CLIP-seq
MIRT2534084 hsa-miR-4464 CLIP-seq
MIRT2534085 hsa-miR-4748 CLIP-seq
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all(16)
GO ID Ontology Definition Evidence Reference
GO:0004497 Function Monooxygenase activity IBA 21873635
GO:0004497 Function Monooxygenase activity IDA 19262426
GO:0004499 Function N,N-dimethylaniline monooxygenase activity IDA 15144220
GO:0005515 Function Protein binding IPI 25910212, 32296183
GO:0005788 Component Endoplasmic reticulum lumen TAS
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
136130 3769 ENSG00000010932
Protein
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Q01740
Protein name Flavin-containing monooxygenase 1 (EC 1.14.13.148) (EC 1.14.13.8) (Dimethylaniline monooxygenase [N-oxide-forming] 1) (Dimethylaniline oxidase 1) (Fetal hepatic flavin-containing monooxygenase 1) (FMO 1) (Trimethylamine monooxygenase)
Protein function Broad spectrum monooxygenase that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including xenobiotics (PubMed:32156684). Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyt
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00743 FMO-like 2 → 532 Flavin-binding monooxygenase-like Family
Tissue specificity TISSUE SPECIFICITY: Expressed mainly in fetal and adult liver. {ECO:0000269|PubMed:1712018}.
Sequence
Sequence length 532
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG   Reactome
  Taurine and hypotaurine metabolism
Drug metabolism - cytochrome P450
Metabolic pathways 		  FMO oxidises nucleophiles
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide Causal Diseases (2)
Causal
Disease term Disease name dbSNP ID References
Amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis, Familial rs267607084, rs312262720, rs312262752, rs121908287, rs121908288, rs29001584, rs28941475, rs121434378, rs386134173, rs386134174, rs80356730, rs80356727, rs4884357, rs80356717, rs80356733
View all (171 more)		 17127561
Lateral sclerosis AMYOTROPHIC LATERAL SCLEROSIS 1, Amyotrophic Lateral Sclerosis, Sporadic rs386134181, rs386134176, rs386134174, rs386134184, rs386134178, rs1693780539, rs1574698048 17127561
Show/Hide Text Mining Associations (1)
Associations from Text Mining
Disease Name Relationship Type References
Non alcoholic Fatty Liver Disease Associate 37697333