KAZN (kazrin, periplakin interacting protein)

Gene

• Entrez ID: 23254
• Gene name: Kazrin, periplakin interacting protein
• Gene symbol: KAZN
• Synonyms (NCBI Gene): C1orf196, KAZ
• Chromosome: 1
• Chromosome location: 1p36.21
• Summary: This gene encodes a protein that plays a role in desmosome assembly, cell adhesion, cytoskeletal organization, and epidermal differentiation. This protein co-localizes with desmoplakin and the cytolinker protein periplakin. In general, this protein locali

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1079251	hsa-miR-103a	CLIP-seq
MIRT1079252	hsa-miR-106a	CLIP-seq
MIRT1079253	hsa-miR-106b	CLIP-seq
MIRT1079254	hsa-miR-107	CLIP-seq
MIRT1079255	hsa-miR-1178	CLIP-seq
MIRT1079256	hsa-miR-1182	CLIP-seq
MIRT1079257	hsa-miR-1225-5p	CLIP-seq
MIRT1079258	hsa-miR-1273g	CLIP-seq
MIRT1079259	hsa-miR-15a	CLIP-seq
MIRT1079260	hsa-miR-15b	CLIP-seq
MIRT1079261	hsa-miR-16	CLIP-seq
MIRT1079262	hsa-miR-17	CLIP-seq
MIRT1079263	hsa-miR-188-3p	CLIP-seq
MIRT1079264	hsa-miR-194	CLIP-seq
MIRT1079265	hsa-miR-195	CLIP-seq
MIRT1079266	hsa-miR-20a	CLIP-seq
MIRT1079267	hsa-miR-20b	CLIP-seq
MIRT1079268	hsa-miR-2113	CLIP-seq
MIRT1079269	hsa-miR-3065-3p	CLIP-seq
MIRT1079270	hsa-miR-3126-5p	CLIP-seq
MIRT1079271	hsa-miR-3132	CLIP-seq
MIRT1079272	hsa-miR-3148	CLIP-seq
MIRT1079273	hsa-miR-3164	CLIP-seq
MIRT1079274	hsa-miR-3178	CLIP-seq
MIRT1079275	hsa-miR-3180	CLIP-seq
MIRT1079276	hsa-miR-3180-3p	CLIP-seq
MIRT1079277	hsa-miR-3196	CLIP-seq
MIRT1079278	hsa-miR-3609	CLIP-seq
MIRT1079279	hsa-miR-3613-3p	CLIP-seq
MIRT1079280	hsa-miR-361-3p	CLIP-seq
MIRT1079281	hsa-miR-3663-5p	CLIP-seq
MIRT1079282	hsa-miR-377	CLIP-seq
MIRT1079283	hsa-miR-3913-3p	CLIP-seq
MIRT1079284	hsa-miR-424	CLIP-seq
MIRT1079285	hsa-miR-4259	CLIP-seq
MIRT1079286	hsa-miR-4281	CLIP-seq
MIRT1079287	hsa-miR-4321	CLIP-seq
MIRT1079288	hsa-miR-4433	CLIP-seq
MIRT1079289	hsa-miR-4436a	CLIP-seq
MIRT1079290	hsa-miR-4488	CLIP-seq
MIRT1079291	hsa-miR-4520b-3p	CLIP-seq
MIRT1079292	hsa-miR-4524	CLIP-seq
MIRT1079293	hsa-miR-4529-3p	CLIP-seq
MIRT1079294	hsa-miR-4668-5p	CLIP-seq
MIRT1079295	hsa-miR-4697-5p	CLIP-seq
MIRT1079296	hsa-miR-4716-3p	CLIP-seq
MIRT1079297	hsa-miR-4727-5p	CLIP-seq
MIRT1079298	hsa-miR-4728-5p	CLIP-seq
MIRT1079299	hsa-miR-4733-3p	CLIP-seq
MIRT1079300	hsa-miR-4769-3p	CLIP-seq
MIRT1079301	hsa-miR-4796-3p	CLIP-seq
MIRT1079302	hsa-miR-4797-5p	CLIP-seq
MIRT1079303	hsa-miR-4804-5p	CLIP-seq
MIRT1079304	hsa-miR-483-5p	CLIP-seq
MIRT1079305	hsa-miR-497	CLIP-seq
MIRT1079306	hsa-miR-503	CLIP-seq
MIRT1079307	hsa-miR-519d	CLIP-seq
MIRT1079308	hsa-miR-548ah	CLIP-seq
MIRT1079309	hsa-miR-625	CLIP-seq
MIRT1079310	hsa-miR-635	CLIP-seq
MIRT1079311	hsa-miR-646	CLIP-seq
MIRT1079312	hsa-miR-665	CLIP-seq
MIRT1079313	hsa-miR-759	CLIP-seq
MIRT1079314	hsa-miR-767-3p	CLIP-seq
MIRT1079315	hsa-miR-93	CLIP-seq
MIRT1079316	hsa-miR-943	CLIP-seq
MIRT1079251	hsa-miR-103a	CLIP-seq
MIRT1079254	hsa-miR-107	CLIP-seq
MIRT1079255	hsa-miR-1178	CLIP-seq
MIRT1079257	hsa-miR-1225-5p	CLIP-seq
MIRT1079317	hsa-miR-1252	CLIP-seq
MIRT1079318	hsa-miR-1254	CLIP-seq
MIRT1079319	hsa-miR-1273	CLIP-seq
MIRT1079320	hsa-miR-1293	CLIP-seq
MIRT1079321	hsa-miR-1297	CLIP-seq
MIRT1079322	hsa-miR-1305	CLIP-seq
MIRT1079259	hsa-miR-15a	CLIP-seq
MIRT1079260	hsa-miR-15b	CLIP-seq
MIRT1079261	hsa-miR-16	CLIP-seq
MIRT1079323	hsa-miR-185	CLIP-seq
MIRT1079324	hsa-miR-1909	CLIP-seq
MIRT1079325	hsa-miR-1910	CLIP-seq
MIRT1079264	hsa-miR-194	CLIP-seq
MIRT1079265	hsa-miR-195	CLIP-seq
MIRT1079326	hsa-miR-205	CLIP-seq
MIRT1079327	hsa-miR-26a	CLIP-seq
MIRT1079328	hsa-miR-26b	CLIP-seq
MIRT1079269	hsa-miR-3065-3p	CLIP-seq
MIRT1079329	hsa-miR-3116	CLIP-seq
MIRT1079271	hsa-miR-3132	CLIP-seq
MIRT1079330	hsa-miR-3173-3p	CLIP-seq
MIRT1079331	hsa-miR-3175	CLIP-seq
MIRT1079332	hsa-miR-326	CLIP-seq
MIRT1079333	hsa-miR-330-5p	CLIP-seq
MIRT1079334	hsa-miR-3614-5p	CLIP-seq
MIRT1079335	hsa-miR-3619-3p	CLIP-seq
MIRT1079336	hsa-miR-3676	CLIP-seq
MIRT1079282	hsa-miR-377	CLIP-seq
MIRT1079284	hsa-miR-424	CLIP-seq
MIRT1079337	hsa-miR-4254	CLIP-seq
MIRT1079338	hsa-miR-4257	CLIP-seq
MIRT1079285	hsa-miR-4259	CLIP-seq
MIRT1079339	hsa-miR-4274	CLIP-seq
MIRT1079340	hsa-miR-4275	CLIP-seq
MIRT1079341	hsa-miR-4300	CLIP-seq
MIRT1079342	hsa-miR-4306	CLIP-seq
MIRT1079343	hsa-miR-4419a	CLIP-seq
MIRT1079344	hsa-miR-4428	CLIP-seq
MIRT1079288	hsa-miR-4433	CLIP-seq
MIRT1079289	hsa-miR-4436a	CLIP-seq
MIRT1079345	hsa-miR-4465	CLIP-seq
MIRT1079346	hsa-miR-4483	CLIP-seq
MIRT1079347	hsa-miR-4510	CLIP-seq
MIRT1079291	hsa-miR-4520b-3p	CLIP-seq
MIRT1079292	hsa-miR-4524	CLIP-seq
MIRT1079293	hsa-miR-4529-3p	CLIP-seq
MIRT1079348	hsa-miR-4535	CLIP-seq
MIRT1079349	hsa-miR-4636	CLIP-seq
MIRT1079350	hsa-miR-4644	CLIP-seq
MIRT1079351	hsa-miR-4672	CLIP-seq
MIRT1079352	hsa-miR-4699-3p	CLIP-seq
MIRT1079297	hsa-miR-4727-5p	CLIP-seq
MIRT1079353	hsa-miR-4747-5p	CLIP-seq
MIRT1079300	hsa-miR-4769-3p	CLIP-seq
MIRT1079354	hsa-miR-4776-5p	CLIP-seq
MIRT1079355	hsa-miR-4779	CLIP-seq
MIRT1079302	hsa-miR-4797-5p	CLIP-seq
MIRT1079304	hsa-miR-483-5p	CLIP-seq
MIRT1079305	hsa-miR-497	CLIP-seq
MIRT1079356	hsa-miR-498	CLIP-seq
MIRT1079357	hsa-miR-499-3p	CLIP-seq
MIRT1079358	hsa-miR-499a-3p	CLIP-seq
MIRT1079306	hsa-miR-503	CLIP-seq
MIRT1079359	hsa-miR-5096	CLIP-seq
MIRT1079360	hsa-miR-520d-5p	CLIP-seq
MIRT1079361	hsa-miR-524-5p	CLIP-seq
MIRT1079311	hsa-miR-646	CLIP-seq
MIRT1079312	hsa-miR-665	CLIP-seq
MIRT1079362	hsa-miR-765	CLIP-seq
MIRT1079314	hsa-miR-767-3p	CLIP-seq
MIRT1079363	hsa-miR-920	CLIP-seq
MIRT1079316	hsa-miR-943	CLIP-seq
MIRT738601	hsa-miR-3064-3p	CLIP-seq
MIRT738603	hsa-miR-4317	CLIP-seq
MIRT738602	hsa-miR-4715-3p	CLIP-seq
MIRT738601	hsa-miR-3064-3p	CLIP-seq
MIRT738603	hsa-miR-4317	CLIP-seq
MIRT738602	hsa-miR-4715-3p	CLIP-seq
MIRT2019738	hsa-miR-1202	CLIP-seq
MIRT2019739	hsa-miR-1227	CLIP-seq
MIRT1079268	hsa-miR-2113	CLIP-seq
MIRT2019740	hsa-miR-3194-5p	CLIP-seq
MIRT1079282	hsa-miR-377	CLIP-seq
MIRT2019741	hsa-miR-3972	CLIP-seq
MIRT2019742	hsa-miR-4738-5p	CLIP-seq
MIRT1079302	hsa-miR-4797-5p	CLIP-seq
MIRT1079256	hsa-miR-1182	CLIP-seq
MIRT2251639	hsa-miR-1224-3p	CLIP-seq
MIRT1079319	hsa-miR-1273	CLIP-seq
MIRT1079320	hsa-miR-1293	CLIP-seq
MIRT1079323	hsa-miR-185	CLIP-seq
MIRT1079263	hsa-miR-188-3p	CLIP-seq
MIRT1079324	hsa-miR-1909	CLIP-seq
MIRT1079270	hsa-miR-3126-5p	CLIP-seq
MIRT1079331	hsa-miR-3175	CLIP-seq
MIRT1079275	hsa-miR-3180	CLIP-seq
MIRT1079276	hsa-miR-3180-3p	CLIP-seq
MIRT2251640	hsa-miR-3185	CLIP-seq
MIRT1079277	hsa-miR-3196	CLIP-seq
MIRT1079332	hsa-miR-326	CLIP-seq
MIRT1079333	hsa-miR-330-5p	CLIP-seq
MIRT1079279	hsa-miR-3613-3p	CLIP-seq
MIRT2251641	hsa-miR-3660	CLIP-seq
MIRT1079281	hsa-miR-3663-5p	CLIP-seq
MIRT1079282	hsa-miR-377	CLIP-seq
MIRT1079283	hsa-miR-3913-3p	CLIP-seq
MIRT2251642	hsa-miR-421	CLIP-seq
MIRT1079338	hsa-miR-4257	CLIP-seq
MIRT1079340	hsa-miR-4275	CLIP-seq
MIRT1079286	hsa-miR-4281	CLIP-seq
MIRT1079341	hsa-miR-4300	CLIP-seq
MIRT1079342	hsa-miR-4306	CLIP-seq
MIRT1079287	hsa-miR-4321	CLIP-seq
MIRT1079288	hsa-miR-4433	CLIP-seq
MIRT1079289	hsa-miR-4436a	CLIP-seq
MIRT1079346	hsa-miR-4483	CLIP-seq
MIRT1079291	hsa-miR-4520b-3p	CLIP-seq
MIRT1079292	hsa-miR-4524	CLIP-seq
MIRT2251643	hsa-miR-4526	CLIP-seq
MIRT1079293	hsa-miR-4529-3p	CLIP-seq
MIRT1079349	hsa-miR-4636	CLIP-seq
MIRT1079350	hsa-miR-4644	CLIP-seq
MIRT2251644	hsa-miR-4709-5p	CLIP-seq
MIRT1079297	hsa-miR-4727-5p	CLIP-seq
MIRT1079298	hsa-miR-4728-5p	CLIP-seq
MIRT1079353	hsa-miR-4747-5p	CLIP-seq
MIRT1079300	hsa-miR-4769-3p	CLIP-seq
MIRT1079302	hsa-miR-4797-5p	CLIP-seq
MIRT1079303	hsa-miR-4804-5p	CLIP-seq
MIRT1079304	hsa-miR-483-5p	CLIP-seq
MIRT1079357	hsa-miR-499-3p	CLIP-seq
MIRT1079358	hsa-miR-499a-3p	CLIP-seq
MIRT2251645	hsa-miR-505	CLIP-seq
MIRT1079312	hsa-miR-665	CLIP-seq
MIRT1079363	hsa-miR-920	CLIP-seq
MIRT2389584	hsa-miR-1205	CLIP-seq
MIRT2389585	hsa-miR-1228	CLIP-seq
MIRT2389586	hsa-miR-1321	CLIP-seq
MIRT1079324	hsa-miR-1909	CLIP-seq
MIRT2389587	hsa-miR-3176	CLIP-seq
MIRT1079282	hsa-miR-377	CLIP-seq
MIRT2389588	hsa-miR-3922-3p	CLIP-seq
MIRT2389589	hsa-miR-3928	CLIP-seq
MIRT2389590	hsa-miR-4270	CLIP-seq
MIRT2389591	hsa-miR-4292	CLIP-seq
MIRT2389592	hsa-miR-4441	CLIP-seq
MIRT1079290	hsa-miR-4488	CLIP-seq
MIRT1079295	hsa-miR-4697-5p	CLIP-seq
MIRT1079299	hsa-miR-4733-3p	CLIP-seq
MIRT2389593	hsa-miR-4739	CLIP-seq
MIRT2389594	hsa-miR-4756-5p	CLIP-seq
MIRT2554947	hsa-miR-1538	CLIP-seq
MIRT2554948	hsa-miR-328	CLIP-seq
MIRT2554949	hsa-miR-3922-5p	CLIP-seq
MIRT2554950	hsa-miR-4745-3p	CLIP-seq
MIRT2683196	hsa-miR-3065-5p	CLIP-seq
MIRT1079283	hsa-miR-3913-3p	CLIP-seq
MIRT2683197	hsa-miR-4464	CLIP-seq
MIRT2683198	hsa-miR-4748	CLIP-seq
MIRT1079357	hsa-miR-499-3p	CLIP-seq
MIRT1079358	hsa-miR-499a-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001533	Component	Cornified envelope	IDA	15337775
GO:0005515	Function	Protein binding	IPI	21653829, 25416956, 32296183
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0016607	Component	Nuclear speck	IDA
GO:0030057	Component	Desmosome	IDA	15337775
GO:0030057	Component	Desmosome	IEA
GO:0031424	Process	Keratinization	IEA
GO:0070161	Component	Anchoring junction	IEA

Other IDs

• MIM: 618301
• HGNC: 29173
• e!Ensembl: ENSG00000189337

Protein

• UniProt ID: Q674X7
• Protein name: Kazrin
• Protein function: Component of the cornified envelope of keratinocytes. May be involved in the interplay between adherens junctions and desmosomes. The function in the nucleus is not known.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00536	SAM_1	444 → 509	SAM domain (Sterile alpha motif)	Domain
  PF00536	SAM_1	524 → 585	SAM domain (Sterile alpha motif)	Domain
  PF07647	SAM_2	609 → 672	SAM domain (Sterile alpha motif)	Domain

• Tissue specificity: TISSUE SPECIFICITY: Isoform 2, isoform 3 and isoform 4 are expressed in several cell lines including keratinocytes and bladder and epidermoid carcinoma (at protein level). Isoform 2, isoform 3 and isoform 4 are expressed in hair follicle and interfollicul
• Sequence:

  MMEDNKQLALRIDGAVQSASQEVTNLRAELTATNRRLAELSGGGGPGPGPGAAASASAAG
  DSAATNMENPQLGAQVLLREEVSRLQEEVHLLRQMKEMLAKDLEESQGGKSSEVLSATEL
  RVQLAQKEQELARAKEALQAMKADRKRLKGEKTDLVSQMQQLYATLESREEQLRDFIRNY
  EQHRKESEDAVKALAKEKDLLEREKWELRRQAKEATDHATALRSQLDLKDNRMKELEAEL
  AMAKQSLATLTKDVPKRHSLAMPGETVLNGNQEWVVQADLPLTAAIRQSQQTLYHSHPPH
  PADRQAVRVSPCHSRQPSVISDASAAEGDRSSTPSDINSPRHRTHSLCNGDSPGPVQKNL
  HNPIVQSLEDLEDQKRKKKKEKMGFGSISRVFARGKQRKSLDPGLFDDSDSQCSPTRQSL
  SLSEGEEQMDRLQQVELVRTTPMSHWKAGTVQAWLEVVMAMPMYVKACTENVKSGKVLLS
  LSDEDLQLGLGVCSSLHRRKLRLAIEDYRDAEAGRSLSKAAELDHHWVAKAWLNDIGLSQ
  YSQAFQNHLVDGRMLNSLMKRDLEKHLNVSKKFHQVSILLGIELLYQVNFSREALQERRA
  RCETQNIDPVVWTNQRVLKWVRDIDLKEYADNLTNSGVHGAVLVLEPTFNAEAMATALGI
  PSGKHILRRHLAEEMSAVFHPANSTGIREAERFGTPPGRASSVTRAGKEENSSGLKYKAG
  RLPLGKIGRGFSSKDPDFHDDYGSLQNEDCGDDDPQSRLEQCRLEGYNSLEVTNV

• Sequence length: 775

Pathways

Reactome:

Formation of the cornified envelope