Gene Gene information from NCBI Gene database.
Entrez ID 23252
Gene name OTU deubiquitinase 3
Gene symbol OTUD3
Synonyms (NCBI Gene)
DUBA4
Chromosome 1
Chromosome location 1p36.13
miRNA miRNA information provided by mirtarbase database.
682
miRTarBase ID miRNA Experiments Reference
MIRT026967 hsa-miR-192-5p Microarray 19074876
MIRT717221 hsa-miR-4803 HITS-CLIP 19536157
MIRT717220 hsa-miR-216a-5p HITS-CLIP 19536157
MIRT717219 hsa-miR-379-3p HITS-CLIP 19536157
MIRT717218 hsa-miR-411-3p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
37
GO ID Ontology Definition Evidence Reference
GO:0004843 Function Cysteine-type deubiquitinase activity IBA
GO:0004843 Function Cysteine-type deubiquitinase activity IDA 23827681, 26280536, 32011234, 35675826
GO:0004843 Function Cysteine-type deubiquitinase activity IEA
GO:0004843 Function Cysteine-type deubiquitinase activity IMP 26280536
GO:0004843 Function Cysteine-type deubiquitinase activity TAS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
611758 29038 ENSG00000169914
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q5T2D3
Protein name OTU domain-containing protein 3 (EC 3.4.19.12)
Protein function Deubiquitinating enzyme that hydrolyzes 'Lys-6'- and 'Lys-11'-linked polyubiquitin. Also hydrolyzes heterotypic (mixed and branched) and homotypic chains (PubMed:23827681, PubMed:32011234, PubMed:35675826). Important regulator of energy metaboli
PDB 4BOU
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF02338 OTU 71 185 OTU-like cysteine protease Family
Sequence
MSRKQAAKSRPGSGSRKAEAERKRDERAARRALAKERRNRPESGGGGGCEEEFVSFANQL
QALGLKLREVPGDGNCLFRALGDQLEGHSRNHLKHRQETVDYMIKQREDFEPFVEDDIPF
EKHVASLAKPGTFAGNDAIVAFARNHQLNVVIHQLNAPLWQIRGTEKSSVRELHIAYRYG
EHYDS
VRRINDNSEAPAHLQTDFQMLHQDESNKREKIKTKGMDSEDDLRDEVEDAVQKVC
NATGCSDFNLIVQNLEAENYNIESAIIAVLRMNQGKRNNAEENLEPSGRVLKQCGPLWEE
GGSGARIFGNQGLNEGRTENNKAQASPSEENKANKNQLAKVTNKQRREQQWMEKKKRQEE
RHRHKALESRGSHRDNNRSEAEANTQVTLVKTFAALNI
Sequence length 398
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Ovarian tumor domain proteases
Regulation of PTEN stability and activity