BOP1 (BOP1 ribosomal biogenesis factor)

Gene

• Entrez ID: 23246
• Gene name: BOP1 ribosomal biogenesis factor
• Gene symbol: BOP1
• Synonyms (NCBI Gene): -
• Chromosome: 8
• Chromosome location: 8q24.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT043142	hsa-miR-324-5p	CLASH	23622248
MIRT038393	hsa-miR-296-3p	CLASH	23622248
MIRT2182204	hsa-miR-4323	CLIP-seq
MIRT2182205	hsa-miR-4514	CLIP-seq
MIRT2182206	hsa-miR-4645-5p	CLIP-seq
MIRT2182207	hsa-miR-4673	CLIP-seq
MIRT2182208	hsa-miR-4692	CLIP-seq
MIRT2182209	hsa-miR-940	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000027	Process	Ribosomal large subunit assembly	IMP	24120868
GO:0000448	Process	Cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IEA
GO:0000460	Process	Maturation of 5.8S rRNA	IEA
GO:0000463	Process	Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA
GO:0000463	Process	Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IEA
GO:0000463	Process	Maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IMP	17353269
GO:0000466	Process	Maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IEA
GO:0003723	Function	RNA binding	HDA	22658674
GO:0005515	Function	Protein binding	IPI	16043514, 16738141, 17353269, 25825154, 28514442, 33961781, 35271311
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005694	Component	Chromosome	IDA
GO:0005730	Component	Nucleolus	IDA
GO:0005730	Component	Nucleolus	IEA
GO:0006364	Process	RRNA processing	IEA
GO:0006364	Process	RRNA processing	IEA
GO:0008283	Process	Cell population proliferation	IEA
GO:0030687	Component	Preribosome, large subunit precursor	IBA
GO:0030687	Component	Preribosome, large subunit precursor	IEA
GO:0042254	Process	Ribosome biogenesis	IC	17353269
GO:0042254	Process	Ribosome biogenesis	IEA
GO:0042254	Process	Ribosome biogenesis	NAS	16043514
GO:0042273	Process	Ribosomal large subunit biogenesis	IEA
GO:0042273	Process	Ribosomal large subunit biogenesis	IEA
GO:0043021	Function	Ribonucleoprotein complex binding	IBA
GO:0043021	Function	Ribonucleoprotein complex binding	IEA
GO:0051726	Process	Regulation of cell cycle	IMP	16043514
GO:0070545	Component	PeBoW complex	IBA
GO:0070545	Component	PeBoW complex	IDA	16043514, 16738141, 17353269
GO:1901796	Process	Regulation of signal transduction by p53 class mediator	IMP	24120868
GO:1990904	Component	Ribonucleoprotein complex	IDA	18809582

Other IDs

• MIM: 610596
• HGNC: 15519
• e!Ensembl: ENSG00000261236

Protein

• UniProt ID: Q14137
• Protein name: Ribosome biogenesis protein BOP1 (Block of proliferation 1 protein)
• Protein function: Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
• PDB: 8FKP, 8FKQ, 8FKR, 8FKS, 8FKT, 8FKU, 8FKV, 8FKW, 8FKX, 8FKY
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF08145	BOP1NT	144 → 402	BOP1NT (NUC169) domain	Domain
  PF00400	WD40	403 → 441	WD domain, G-beta repeat	Repeat
  PF00400	WD40	653 → 689	WD domain, G-beta repeat	Repeat
  PF00400	WD40	704 → 746	WD domain, G-beta repeat	Repeat

• Sequence:

  MAGSRGAGRTAAPSVRPEKRRSEPELEPEPEPEPPLLCTSPLSHSTGSDSGVSDSEESVF
  SGLEDSGSDSSEDDDEGDEEGEDGALDDEGHSGIKKTTEEQVQASTPCPRTEMASARIGD
  EYAEDSSDEEDIRNTVGNVPLEWYDDFPHVGYDLDGRRIYKPLRTRDELDQFLDKMDDPD
  YWRTVQDPMTGRDLRLTDEQVALVRRLQSGQFGDVGFNPYEPAVDFFSGDVMIHPVTNRP
  ADKRSFIPSLVEKEKVSRMVHAIKMGWIQPRRPRDPTPSFYDLWAQEDPNAVLGRHKMHV
  PAPKLALPGHAESYNPPPEYLLSEEERLAWEQQEPGERKLSFLPRKFPSLRAVPAYGRFI
  QERFERCLDLYLCPRQRKMRVNVDPEDLIPKLPRPRDLQPFPTCQALVYRGHSDLVRCLS
  VSPGGQWLVSGSDDGSLRLWEVATARCVRTVPVGGVVKSVAWNPSPAVCLVAAAVEDSVL
  LLNPALGDRLVAGSTDQLLSAFVPPEEPPLQPARWLEASEEERQVGLRLRICHGKPVTQV
  TWHGRGDYLAVVLATQGHTQVLIHQLSRRRSQSPFRRSHGQVQRVAFHPARPFLLVASQR
  SVRLYHLLRQELTKKLMPNCKWVSSLAVHPAGDNVICGSYDSKLVWFDLDLSTKPYRMLR
  HHKKALRAVAFHPRYPLFASGSDDGSVIVCHGMVYNDLLQNPLLVPVKVLKGHVLTRDLG
  VLDVIFHPTQPWVFSSGADGTVRLFT

• Sequence length: 746

Pathways

Reactome:

Major pathway of rRNA processing in the nucleolus and cytosol