Gene Gene information from NCBI Gene database.
Entrez ID 23243
Gene name Ankyrin repeat domain 28
Gene symbol ANKRD28
Synonyms (NCBI Gene)
CFAP79FAP79PITKPPP1R65
Chromosome 3
Chromosome location 3p25.1
miRNA miRNA information provided by mirtarbase database.
396
miRTarBase ID miRNA Experiments Reference
MIRT021749 hsa-miR-132-3p Microarray 17612493
MIRT030731 hsa-miR-21-5p Microarray 18591254
MIRT046912 hsa-miR-221-3p CLASH 23622248
MIRT624745 hsa-miR-3614-3p HITS-CLIP 23824327
MIRT624744 hsa-miR-3074-3p HITS-CLIP 23824327
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
14
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 18186651, 19118547, 21187329, 23414517, 24255178, 28330616, 32296183, 33961781, 35271311
GO:0005634 Component Nucleus IEA
GO:0005654 Component Nucleoplasm IEA
GO:0005654 Component Nucleoplasm TAS
GO:0005737 Component Cytoplasm IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
611122 29024 ENSG00000206560
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O15084
Protein name Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A (PP6-ARS-A) (Serine/threonine-protein phosphatase 6 regulatory subunit ARS-A) (Ankyrin repeat domain-containing protein 28) (Phosphatase interactor targeting protein hnRNP K) (PITK
Protein function Regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Selectively inhib
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00023 Ank 40 72 Ankyrin repeat Repeat
PF00023 Ank 75 105 Ankyrin repeat Repeat
PF00023 Ank 139 171 Ankyrin repeat Repeat
PF00023 Ank 176 204 Ankyrin repeat Repeat
PF00023 Ank 206 237 Ankyrin repeat Repeat
PF00023 Ank 238 270 Ankyrin repeat Repeat
PF00023 Ank 271 304 Ankyrin repeat Repeat
PF00023 Ank 338 370 Ankyrin repeat Repeat
PF00023 Ank 404 436 Ankyrin repeat Repeat
PF00023 Ank 437 469 Ankyrin repeat Repeat
PF00023 Ank 470 503 Ankyrin repeat Repeat
PF00023 Ank 582 614 Ankyrin repeat Repeat
PF00023 Ank 617 648 Ankyrin repeat Repeat
PF00023 Ank 652 684 Ankyrin repeat Repeat
PF00023 Ank 685 717 Ankyrin repeat Repeat
PF00023 Ank 755 784 Ankyrin repeat Repeat
PF00023 Ank 822 854 Ankyrin repeat Repeat
PF12796 Ank_2 851 920 Ankyrin repeats (3 copies) Repeat
PF12796 Ank_2 885 958 Ankyrin repeats (3 copies) Repeat
Sequence
MAFLKLRDQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELL
ILSGARVNAKDS
KWLTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAV
KCAEALVPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWA
AYMGHIEVVKLLVSHGAEVTCKDK
KSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGN
TPLHVACYNGQDVVVNELIDCGAIVNQKNE
KGFTPLHFAAASTHGALCLELLVGNGADVN
MKSK
DGKTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINTLIT
SGADTAKRGI
HGMFPLHLAALSGFSDCCRKLLSSGFDIDTPDDFGRTCLHAAAAGGNLEC
LNLLLNTGADFNKKDK
FGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCTPLHYAAT
SDTDGKCLEYLLRNDANPGIRDK
QGYNAVHYSAAYGHRLCLQLIASETPLDVLMETSGTD
MLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLDVRNSSGRTPLDLAAFKGHVECVD
VLINQGASILVKDY
ILKRTPIHAAATNGHSECLRLLIGNAEPQNAVDIQDGNGQTPLMLS
VLNGHTDCVYSLLNKGANVDAKDK
WGRTALHRGAVTGHEECVDALLQHGAKCLLRDSRGR
TPIHLSAACGHIGVLGALLQSAASMDANPATADNHGYTALHWACYNGHETCVELLLEQEV
FQKT
EGNAFSPLHCAVINDNEGAAEMLIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQ
LLLSHNAQVN
SVDSTGKTPLMMAAENGQTNTVEMLVSSASAELTLQDNSKNTALHLACSK
GHETSALLILEKITDRNLIN
ATNAALQTPLHVAARNGLTMVVQELLGKGASVLAVDEN
GY
TPALACAPNKDVADCLALILATMMPVSSSSPLSSLTFNAINRYTNTSKTVSFEALPIMRN
EPSSYCSFNNIGGEQEYLYTDVDELNDSDSETY
Sequence length 1053
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    COPII-mediated vesicle transport
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
GOUT GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text MiningDisease associations identified through Pubtator
Disease Name Relationship Type References Evidence Score
Adenocarcinoma Associate 22491060
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Clear Cell Associate 24389164
★☆☆☆☆
Found in Text Mining only
Carcinoma Squamous Cell Associate 22491060
★☆☆☆☆
Found in Text Mining only
Lymphoma Large B Cell Diffuse Associate 33663517
★☆☆☆☆
Found in Text Mining only
Neoplasm Metastasis Associate 22491060
★☆☆☆☆
Found in Text Mining only
Neoplasms Associate 22491060
★☆☆☆☆
Found in Text Mining only