Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
23235
Gene name Gene Name - the full gene name approved by the HGNC.
Salt inducible kinase 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
SIK2
Synonyms (NCBI Gene) Gene synonyms aliases
LOH11CR1I, QIK, SIK-2, SNF1LK2
Chromosome Chromosome number
11
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
11q23.1
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT047302 hsa-miR-181a-5p CLASH 23622248
MIRT045926 hsa-miR-125b-5p CLASH 23622248
MIRT036375 hsa-miR-1229-3p CLASH 23622248
MIRT679370 hsa-miR-4438 HITS-CLIP 23824327
MIRT679369 hsa-miR-4740-3p HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0000287 Function Magnesium ion binding IDA 14976552
GO:0004674 Function Protein serine/threonine kinase activity IBA 21873635
GO:0004674 Function Protein serine/threonine kinase activity IDA 14976552, 18348280
GO:0005515 Function Protein binding IPI 16306228, 20708153, 25416956, 27478041, 32814053
GO:0005524 Function ATP binding IDA 14976552
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
608973 21680 ENSG00000170145
Protein
UniProt ID Q9H0K1
Protein name Serine/threonine-protein kinase SIK2 (EC 2.7.11.1) (Qin-induced kinase) (Salt-inducible kinase 2) (SIK-2) (Serine/threonine-protein kinase SNF1-like kinase 2)
Protein function Serine/threonine-protein kinase that plays a role in many biological processes such as fatty acid oxidation, autophagy, immune response or glucose metabolism (PubMed:23322770, PubMed:26983400). Phosphorylates 'Ser-794' of IRS1 in insulin-stimula
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00069 Pkinase 20 271 Protein kinase domain Domain
Sequence
MVMADGPRHLQRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAVN
LEKIYREVQIMKMLDHPHIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEAR
RKFWQILSAVDYCHGRKIVHRDLKAENLLLDNNMNIKIADFGFGNFFKSGELLATWCGSP
PYAAPEVFEGQQYEGPQLDIWSMGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPYFM
SEDCEHLIRRMLVLDPSKRLTIAQIKEHKWM
LIEVPVQRPVLYPQEQENEPSIGEFNEQV
LRLMHSLGIDQQKTIESLQNKSYNHFAAIYFLLVERLKSHRSSFPVEQRLDGRQRRPSTI
AEQTVAKAQTVGLPVTMHSPNMRLLRSALLPQASNVEAFSFPASGCQAEAAFMEEECVDT
PKVNGCLLDPVPPVLVRKGCQSLPSNMMETSIDEGLETEGEAEEDPAHAFEAFQSTRSGQ
RRHTLSEVTNQLVVMPGAGKIFSMNDSPSLDSVDSEYDMGSVQRDLNFLEDNPSLKDIML
ANQPSPRMTSPFISLRPTNPAMQALSSQKREVHNRSPVSFREGRRASDTSLTQGIVAFRQ
HLQNLARTKGILELNKVQLLYEQIGPEADPNLAPAAPQLQDLASSCPQEEVSQQQESVST
LPASVHPQLSPRQSLETQYLQHRLQKPSLLSKAQNTCQLYCKEPPRSLEQQLQEHRLQQK
RLFLQKQSQLQAYFNQMQIAESSYPQPSQQLPLPRQETPPPSQQAPPFSLTQPLSPVLEP
SSEQMQYSPFLSQYQEMQLQPLPSTSGPRAAPPLPTQLQQQQPPPPPPPPPPRQPGAAPA
PLQFSYQTCELPSAASPAPDYPTPCQYPVDGAQQSDLTGPDCPRSPGLQEAPSSYDPLAL
SELPGLFDCEMLDAVDPQHNGYVLVN
Sequence length 926
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  
  Glucagon signaling pathway  
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Unknown
Disease term Disease name Evidence References Source
Asthma Asthma 31619474 ClinVar, GWAS
Eczema Eczema GWAS
Sclerosing Cholangitis Sclerosing Cholangitis GWAS
Dermatitis Dermatitis GWAS
Associations from Text Mining
Disease Name Relationship Type References
Adenocarcinoma of Lung Associate 22980975
Carcinogenesis Associate 24980480
Colorectal Neoplasms Associate 27236538, 34986532
Colorectal Neoplasms Stimulate 34558647
Drug Hypersensitivity Associate 37966164
Hereditary Breast and Ovarian Cancer Syndrome Associate 35642638
Inflammation Inhibit 37386070
Insulin Resistance Inhibit 37386070
Lymphatic Metastasis Associate 34986532
Neoplasm Metastasis Associate 35278271, 35642638