Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.	23228
Gene name Gene Name - the full gene name approved by the HGNC.	Phospholipase C like 2
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.	PLCL2
Synonyms (NCBI Gene) Gene synonyms aliases	PLCE2
Chromosome Chromosome number	3
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.	3p24.3

Show/Hide all(34)

miRTarBase ID	miRNA	Experiments	Reference
MIRT025184	hsa-miR-181a-5p	Microarray	17612493
MIRT2595190	hsa-miR-1910	CLIP-seq
MIRT2595191	hsa-miR-1912	CLIP-seq
MIRT2595192	hsa-miR-25	CLIP-seq
MIRT2595193	hsa-miR-3128	CLIP-seq
MIRT2595194	hsa-miR-3157-5p	CLIP-seq
MIRT2595195	hsa-miR-32	CLIP-seq
MIRT2595196	hsa-miR-363	CLIP-seq
MIRT2595197	hsa-miR-367	CLIP-seq
MIRT2595198	hsa-miR-4270	CLIP-seq
MIRT2595199	hsa-miR-4279	CLIP-seq
MIRT2595200	hsa-miR-4300	CLIP-seq
MIRT2595201	hsa-miR-4304	CLIP-seq
MIRT2595202	hsa-miR-4441	CLIP-seq
MIRT2595203	hsa-miR-4522	CLIP-seq
MIRT2595204	hsa-miR-455-3p	CLIP-seq
MIRT2595205	hsa-miR-4691-3p	CLIP-seq
MIRT2595206	hsa-miR-4715-3p	CLIP-seq
MIRT2595207	hsa-miR-4720-5p	CLIP-seq
MIRT2595208	hsa-miR-4799-3p	CLIP-seq
MIRT2595209	hsa-miR-515-5p	CLIP-seq
MIRT2595210	hsa-miR-760	CLIP-seq
MIRT2595211	hsa-miR-920	CLIP-seq
MIRT2595212	hsa-miR-92a	CLIP-seq
MIRT2595213	hsa-miR-92b	CLIP-seq
MIRT2595190	hsa-miR-1910	CLIP-seq
MIRT2595194	hsa-miR-3157-5p	CLIP-seq
MIRT2595198	hsa-miR-4270	CLIP-seq
MIRT2595200	hsa-miR-4300	CLIP-seq
MIRT2595201	hsa-miR-4304	CLIP-seq
MIRT2595202	hsa-miR-4441	CLIP-seq
MIRT2595204	hsa-miR-455-3p	CLIP-seq
MIRT2595205	hsa-miR-4691-3p	CLIP-seq
MIRT2595211	hsa-miR-920	CLIP-seq

Show/Hide all(15)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002322	Process	B cell proliferation involved in immune response	IEA
GO:0002337	Process	B-1a B cell differentiation	IEA
GO:0004435	Function	Phosphatidylinositol phospholipase C activity	IEA
GO:0005515	Function	Protein binding	IPI	32814053
GO:0005737	Component	Cytoplasm	IEA
GO:0006629	Process	Lipid metabolic process	IEA
GO:0007214	Process	Gamma-aminobutyric acid signaling pathway	IEA
GO:0032228	Process	Regulation of synaptic transmission, GABAergic	IEA
GO:0033135	Process	Regulation of peptidyl-serine phosphorylation	IEA
GO:0048015	Process	Phosphatidylinositol-mediated signaling	IBA	21873635
GO:0050811	Function	GABA receptor binding	IDA	16754670
GO:0050859	Process	Negative regulation of B cell receptor signaling pathway	IEA
GO:0070679	Function	Inositol 1,4,5 trisphosphate binding	IEA
GO:0120163	Process	Negative regulation of cold-induced thermogenesis	ISS	26706316
GO:1900122	Process	Positive regulation of receptor binding	IEA

MIM	HGNC	e!Ensembl
614276	9064	ENSG00000154822

Protein

UniProt ID

Q9UPR0

Protein name

Inactive phospholipase C-like protein 2 (PLC-L(2)) (PLC-L2) (Phospholipase C-L2) (Phospholipase C-epsilon-2) (PLC-epsilon-2)

Protein function

May play an role in the regulation of Ins(1,4,5)P3 around the endoplasmic reticulum.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF16457	PH_12	135 → 251	Pleckstrin homology domain	Domain
PF09279	EF-hand_like	334 → 419	Phosphoinositide-specific phospholipase C, efhand-like	Domain
PF00388	PI-PLC-X	428 → 571	Phosphatidylinositol-specific phospholipase C, X domain	Family
PF00387	PI-PLC-Y	618 → 732	Phosphatidylinositol-specific phospholipase C, Y domain	Family
PF00168	C2	754 → 862	C2 domain	Domain

Sequence

MAECGRGGAAGGALPTSPGPALGAKGALKAGVGEGGGGGGRLGHGRARYDSGGVSNGDCS
LGVSGDEARASPTRGPRGVALAPTPSAVVCTLPRESKPGGLPRRSSIIKDGTKQKRERKK
TVSFSSMPTEKKISSASDCINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKD
SEKAKIDIKSIKEVRTGKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVAN
IWVTGLRYLISYGKHTLDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLN
PGLKTSKIELKFKELHKSKDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDT
KDLMMFLEAEQGVAHINEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPE
HKKVCQDMKQPLSHYFINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDN
EPVIYTGHTMTSQIVFRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLG
DKLYTTSPNVEESYLPSPDVLKGKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQRMGKEN
MEQPNNVPVKRFQLCKELSELVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANEN
PGDFVNYNKRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQ
NGNCGYVLRPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVD
PYVYVEIHGIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDE
FIGQYTIPFECLQTGYRHVPLQSLTGEVLAHASLFVHVAITNRRGGGKPHKRGLSVRKGK
KSREYASLRTLWIKTVDEVFKNAQPPIRDATDLRENMQNAVVSFKELCGLSSVANLMQCM
LAVSPRFLGPDNTPLVVLNLSEQYPTMELQGIVPEVLKKIVTTYDMMIQSLKALIENADA
VYEKIVHCQKAAMEFHEHLHSIGTKEGLKERKLQKAVESFTWNITILKGQADLLKYAKNE
TLENLKQIHFAAVSCGLNKPGTENADVQKPRRSLEVIPEKANDETGE

Sequence length

1127

Interactions

View interactions

Show/Hide Causal Diseases (3)

Disease term	Disease name	dbSNP ID	References
Causal
Psoriasis	Psoriasis	rs281875215, rs587777763, rs281875213, rs281875212	25939698
Rheumatoid arthritis	Rheumatoid Arthritis	rs587776843	24390342, 30423114
Schizophrenia	Schizophrenia	rs13447324, rs387906932, rs387906933, rs863223354, rs863223355, rs776061422, rs863223349, rs748809996, rs759748655, rs863223353, rs863223350, rs863223356, rs781821239, rs863223348, rs863223346 View all (12 more)	21822266, 31374203

Show/Hide Unknown Diseases (15)

Disease term	Disease name	Evidence	References	Source
Unknown
Mental depression	Major Depressive Disorder		29942085	ClinVar
Myocardial infarction	Myocardial Infarction		24916648	ClinVar
Neuroticism	Neuroticism			GWAS
Biliary Cholangitis	Biliary Cholangitis			GWAS
Multiple Sclerosis	Multiple Sclerosis			GWAS
Myocardial Infarction	Myocardial Infarction			GWAS
Breast cancer	Breast cancer	Importantly, breast cancer patients bearing PRC2 LOF mutations displayed significantly worse prognosis compared with PRC2 wild-type patients		GWAS, CBGDA
Anxiety Disorder	Anxiety Disorder			GWAS
Psoriasis vulgaris	Psoriasis vulgaris			GWAS
Dementia	Dementia			GWAS
Asthma	Asthma			GWAS
Otitis media	Otitis media			GWAS
Glioblastoma	Glioblastoma	CRISPR screening of E3 ubiquitin ligases reveals Ring Finger Protein 185 as a novel tumor suppressor in glioblastoma repressed by promoter hypermethylation and miR-587		GWAS, CBGDA
Gastric ulcer	Gastric ulcer			GWAS
Duodenal Ulcer	Duodenal Ulcer			GWAS

Show/Hide Text Mining Associations (9)

Disease Name	Relationship Type	References
Associations from Text Mining
Arthritis Psoriatic	Associate	22328738
Arthritis Rheumatoid	Associate	22328738, 36973646
Atherosclerosis	Associate	24916648
Carcinoma Renal Cell	Associate	24977159
COVID 19	Associate	35927536
Myocardial Infarction	Associate	24916648
Neoplasms	Associate	24977159
Scleroderma Systemic	Associate	25880423
Triple Negative Breast Neoplasms	Associate	36880837

PLCL2 (phospholipase C like 2)