RRS1 (regulator of ribosome synthesis 1)

Gene

• Entrez ID: 23212
• Gene name: Regulator of ribosome synthesis 1
• Gene symbol: RRS1
• Synonyms (NCBI Gene): -
• Chromosome: 8
• Chromosome location: 8q13.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT016031	hsa-miR-374b-5p	Sequencing	20371350
MIRT029717	hsa-miR-26b-5p	Microarray	19088304
MIRT041840	hsa-miR-484	CLASH	23622248
MIRT040785	hsa-miR-18a-3p	CLASH	23622248
MIRT106165	hsa-miR-944	PAR-CLIP	20371350
MIRT106168	hsa-miR-4783-3p	PAR-CLIP	20371350
MIRT106172	hsa-miR-6758-3p	PAR-CLIP	20371350
MIRT571217	hsa-miR-6883-3p	PAR-CLIP	20371350
MIRT571215	hsa-miR-3692-3p	PAR-CLIP	20371350
MIRT571216	hsa-miR-4755-5p	PAR-CLIP	20371350
MIRT571214	hsa-miR-5006-3p	PAR-CLIP	20371350
MIRT571213	hsa-miR-4446-5p	PAR-CLIP	20371350
MIRT563888	hsa-miR-4687-3p	PAR-CLIP	20371350
MIRT106174	hsa-miR-132-3p	PAR-CLIP	21572407
MIRT106173	hsa-miR-212-3p	PAR-CLIP	21572407
MIRT554542	hsa-miR-4272	PAR-CLIP	21572407
MIRT554543	hsa-miR-3614-5p	PAR-CLIP	21572407
MIRT554541	hsa-miR-6500-3p	PAR-CLIP	21572407
MIRT106177	hsa-miR-4704-3p	PAR-CLIP	21572407
MIRT554540	hsa-miR-302b-5p	PAR-CLIP	21572407
MIRT554539	hsa-miR-302d-5p	PAR-CLIP	21572407
MIRT106178	hsa-miR-4774-3p	PAR-CLIP	21572407
MIRT106165	hsa-miR-944	PAR-CLIP	20371350
MIRT106168	hsa-miR-4783-3p	PAR-CLIP	20371350
MIRT106172	hsa-miR-6758-3p	PAR-CLIP	20371350
MIRT571217	hsa-miR-6883-3p	PAR-CLIP	20371350
MIRT571215	hsa-miR-3692-3p	PAR-CLIP	20371350
MIRT571216	hsa-miR-4755-5p	PAR-CLIP	20371350
MIRT571214	hsa-miR-5006-3p	PAR-CLIP	20371350
MIRT571213	hsa-miR-4446-5p	PAR-CLIP	20371350
MIRT563888	hsa-miR-4687-3p	PAR-CLIP	20371350
MIRT106174	hsa-miR-132-3p	PAR-CLIP	21572407
MIRT106173	hsa-miR-212-3p	PAR-CLIP	21572407
MIRT554542	hsa-miR-4272	PAR-CLIP	21572407
MIRT554543	hsa-miR-3614-5p	PAR-CLIP	21572407
MIRT554541	hsa-miR-6500-3p	PAR-CLIP	21572407
MIRT106177	hsa-miR-4704-3p	PAR-CLIP	21572407
MIRT554540	hsa-miR-302b-5p	PAR-CLIP	21572407
MIRT554539	hsa-miR-302d-5p	PAR-CLIP	21572407
MIRT106178	hsa-miR-4774-3p	PAR-CLIP	21572407
MIRT1320770	hsa-miR-1264	CLIP-seq
MIRT1320771	hsa-miR-204	CLIP-seq
MIRT1320772	hsa-miR-211	CLIP-seq
MIRT1320773	hsa-miR-3202	CLIP-seq
MIRT1320774	hsa-miR-3921	CLIP-seq
MIRT1320775	hsa-miR-3926	CLIP-seq
MIRT1320776	hsa-miR-4421	CLIP-seq
MIRT1320777	hsa-miR-4653-5p	CLIP-seq
MIRT1320778	hsa-miR-4766-5p	CLIP-seq
MIRT1320779	hsa-miR-548s	CLIP-seq
MIRT1320780	hsa-miR-593	CLIP-seq
MIRT1320781	hsa-miR-598	CLIP-seq
MIRT1320782	hsa-miR-618	CLIP-seq
MIRT2095237	hsa-miR-2113	CLIP-seq
MIRT2095238	hsa-miR-4775	CLIP-seq
MIRT2319590	hsa-miR-1237	CLIP-seq
MIRT2319591	hsa-miR-1248	CLIP-seq
MIRT2319592	hsa-miR-299-5p	CLIP-seq
MIRT2319593	hsa-miR-3714	CLIP-seq
MIRT2319594	hsa-miR-4303	CLIP-seq
MIRT2319595	hsa-miR-4493	CLIP-seq
MIRT2319596	hsa-miR-885-3p	CLIP-seq
MIRT2458644	hsa-miR-3692	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000027	Process	Ribosomal large subunit assembly	IMP	24120868
GO:0000447	Process	Endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA
GO:0000794	Component	Condensed nuclear chromosome	IDA	19465021
GO:0002244	Process	Hematopoietic progenitor cell differentiation	IEA
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0005515	Function	Protein binding	IPI	16189514, 25416956, 28514442, 30021884, 32296183, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005730	Component	Nucleolus	IBA
GO:0005730	Component	Nucleolus	IDA	19465021
GO:0005730	Component	Nucleolus	IEA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0007080	Process	Mitotic metaphase chromosome alignment	IMP	19465021
GO:0008097	Function	5S rRNA binding	IDA	24120868
GO:0030687	Component	Preribosome, large subunit precursor	IBA
GO:0042254	Process	Ribosome biogenesis	IEA
GO:0042273	Process	Ribosomal large subunit biogenesis	IBA
GO:0042273	Process	Ribosomal large subunit biogenesis	IMP	24120868
GO:1901796	Process	Regulation of signal transduction by p53 class mediator	IMP	24120868
GO:1902570	Process	Protein localization to nucleolus	IMP	24120868

Other IDs

• MIM: 618311
• HGNC: 17083
• e!Ensembl: ENSG00000179041

Protein

• UniProt ID: Q15050
• Protein name: Ribosome biogenesis regulatory protein homolog
• Protein function: Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus.
• PDB: 8FKP, 8FKQ, 8FKR, 8FKS, 8FKT, 8FKU, 8FKV, 8FKW, 8FKX, 8FKY, 8FL0, 8IR1, 8IR3, 8RL2
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF04939	RRS1	31 → 193	Ribosome biogenesis regulatory protein (RRS1)	Family

• Sequence:

  MEGQSVEELLAKAEQDEAEKLQRITVHKELELQFDLGNLLASDRNPPTGLRCAGPTPEAE
  LQALARDNTQLLINQLWQLPTERVEEAIVARLPEPTTRLPREKPLPRPRPLTRWQQFARL
  KGIRPKKKTNLVWDEVSGQWRRRWGYQRARDDTKEWLIEVPGNADPLEDQFAKRIQAKKE
  RVAKNELNRLRNLARAHKMQLPSAAGLHPTGHQSKEELGRAMQVAKVSTASVGRFQERLP
  KEKVPRGSGKKRKFQPLFGDFAAEKKNQLELLRVMNSKKPQLDVTRATNKQMREEDQEEA
  AKRRKMSQKGKRKGGRQGPGGKRKGGPPSQGGKRKGGLGGKMNSGPPGLGGKRKGGQRPG
  GKRRK

• Sequence length: 365