Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
2321
Gene name Gene Name - the full gene name approved by the HGNC.
Fms related receptor tyrosine kinase 1
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
FLT1
Synonyms (NCBI Gene) Gene synonyms aliases
FLT, FLT-1, VEGFR-1, VEGFR1
Chromosome Chromosome number
13
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
13q12.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a tra
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT006441 hsa-miR-200b-3p Luciferase reporter assay, Western blot 21544626
MIRT006441 hsa-miR-200b-3p Luciferase reporter assay, Western blot 21544626
MIRT006441 hsa-miR-200b-3p Luciferase reporter assay, Western blot 21544626
MIRT006850 hsa-miR-100-5p Luciferase reporter assay 22955733
MIRT006850 hsa-miR-100-5p Luciferase reporter assay 22955733
Transcription factors
Transcription factor Regulation Reference
ATF1 Unknown 7499271
CREB1 Unknown 7499271
E2F1 Unknown 20516113
EGR1 Unknown 10828020
EPAS1 Activation 15192019;19616846
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0001525 Process Angiogenesis IEA
GO:0002244 Process Hematopoietic progenitor cell differentiation IBA 21873635
GO:0002548 Process Monocyte chemotaxis IDA 8605350, 18079407
GO:0004714 Function Transmembrane receptor protein tyrosine kinase activity IBA 21873635
GO:0005021 Function Vascular endothelial growth factor-activated receptor activity IDA 1312256, 8605350, 9299537, 15952180
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
165070 3763 ENSG00000102755
Protein
UniProt ID P17948
Protein name Vascular endothelial growth factor receptor 1 (VEGFR-1) (EC 2.7.10.1) (Fms-like tyrosine kinase 1) (FLT-1) (Tyrosine-protein kinase FRT) (Tyrosine-protein kinase receptor FLT) (FLT) (Vascular permeability factor receptor)
Protein function Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, c
PDB 1FLT , 1QSV , 1QSZ , 1QTY , 1RV6 , 2XAC , 3HNG , 4CKV , 4CL7 , 5ABD , 5EX3 , 5T89
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00047 ig 235 326 Immunoglobulin domain Domain
PF07679 I-set 337 426 Immunoglobulin I-set domain Domain
PF13927 Ig_3 560 640 Domain
PF07679 I-set 661 748 Immunoglobulin I-set domain Domain
PF17988 VEGFR-2_TMD 753 787 VEGFR-2 Transmembrane domain Domain
PF07714 PK_Tyr_Ser-Thr 827 1154 Protein tyrosine and serine/threonine kinase Domain
Tissue specificity TISSUE SPECIFICITY: Detected in normal lung, but also in placenta, liver, kidney, heart and brain tissues. Specifically expressed in most of the vascular endothelial cells, and also expressed in peripheral blood monocytes. Isoform 2 is strongly expressed
Sequence
MVSYWDTGVLLCALLSCLLLTGSSSGSKLKDPELSLKGTQHIMQAGQTLHLQCRGEAAHK
WSLPEMVSKESERLSITKSACGRNGKQFCSTLTLNTAQANHTGFYSCKYLAVPTSKKKET
ESAIYIFISDTGRPFVEMYSEIPEIIHMTEGRELVIPCRVTSPNITVTLKKFPLDTLIPD
GKRIIWDSRKGFIISNATYKEIGLLTCEATVNGHLYKTNYLTHRQTNTIIDVQISTPRPV
KLLRGHTLVLNCTATTPLNTRVQMTWSYPDEKNKRASVRRRIDQSNSHANIFYSVLTIDK
MQNKDKGLYTCRVRSGPSFKSVNTSV
HIYDKAFITVKHRKQQVLETVAGKRSYRLSMKVK
AFPSPEVVWLKDGLPATEKSARYLTRGYSLIIKDVTEEDAGNYTILLSIKQSNVFKNLTA
TLIVNV
KPQIYEKAVSSFPDPALYPLGSRQILTCTAYGIPQPTIKWFWHPCNHNHSEARC
DFCSNNEESFILDADSNMGNRIESITQRMAIIEGKNKMASTLVVADSRISGIYICIASNK
VGTVGRNISFYITDVPNGFHVNLEKMPTEGEDLKLSCTVNKFLYRDVTWILLRTVNNRTM
HYSISKQKMAITKEHSITLNLTIMNVSLQDSGTYACRARN
VYTGEEILQKKEITIRDQEA
PYLLRNLSDHTVAISSSTTLDCHANGVPEPQITWFKNNHKIQQEPGIILGPGSSTLFIER
VTEEDEGVYHCKATNQKGSVESSAYLTV
QGTSDKSNLELITLTCTCVAATLFWLLLTLFI
RKMKRSS
SEIKTDYLSIIMDPDEVPLDEQCERLPYDASKWEFARERLKLGKSLGRGAFGK
VVQASAFGIKKSPTCRTVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTK
QGGPLMVIVEYCKYGNLSNYLKSKRDLFFLNKDAALHMEPKKEKMEPGLEQGKKPRLDSV
TSSESFASSGFQEDKSLSDVEEEEDSDGFYKEPITMEDLISYSFQVARGMEFLSSRKCIH
RDLAARNILLSENNVVKICDFGLARDIYKNPDYVRKGDTRLPLKWMAPESIFDKIYSTKS
DVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLREGMRMRAPEYSTPEIYQIMLDCWHRD
PKERPRFAELVEKL
GDLLQANVQQDGKDYIPINAILTGNSGFTYSTPAFSEDFFKESISA
PKFNSGSSDDVRYVNAFKFMSLERIKTFEELLPNATSMFDDYQGDSSTLLASPMLKRFTW
TDSKPKASLKIDLRVTSKSKESGLSDVSRPSFCHSSCGHVSEGKRRFTYDHAELERKIAC
CSPPPDYNSVVLYSTPPI
Sequence length 1338
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
HIF-1 signaling pathway
PI3K-Akt signaling pathway
Focal adhesion
Transcriptional misregulation in cancer
Rheumatoid arthritis
  Neurophilin interactions with VEGF and VEGFR
VEGF binds to VEGFR leading to receptor dimerization
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
23146280, 26124351
Breast carcinoma Breast Carcinoma rs80359671, rs11540652, rs28934575, rs28897672, rs137886232, rs193922376, rs80357783, rs80359306, rs80359405, rs80359507, rs80359598, rs80358429, rs397507683, rs397515636, rs80359451
View all (71 more)
26124351, 23146280
Coronary artery disease Coronary Artery Disease rs137852988, rs121918313, rs121918529, rs121918531, rs137852340, rs1555800701, rs1215189537 29212778, 23202125, 28714975
Diabetes mellitus Diabetes Mellitus, Insulin-Dependent rs587776515, rs61730328, rs606231121, rs606231122, rs79020217, rs77625743, rs78378398, rs606231123, rs1362648752, rs104893649, rs80356624, rs80356616, rs80356625, rs80356611, rs104894237
View all (293 more)
Unknown
Disease term Disease name Evidence References Source
Chromophobe carcinoma Chromophobe Renal Cell Carcinoma 16596207 ClinVar
Coronary heart disease Coronary heart disease 23364394 ClinVar
Hemangiosarcoma Hemangiosarcoma 17569031 ClinVar
Preeclampsia Preeclampsia ClinVar
Associations from Text Mining
Disease Name Relationship Type References
3C syndrome Associate 23704979
AA amyloidosis Stimulate 39752902
Actinic cheilitis Associate 25895461
Adenocarcinoma Associate 21751195, 26525902, 29985074, 35800186
Adenocarcinoma of Lung Associate 20052735
Alzheimer Disease Associate 26082458, 30576228, 32989152, 36905877, 39334869, 39752902
Alzheimer Disease Stimulate 31332262
Amyloidosis Associate 39752902
Anemia Sickle Cell Stimulate 37012663
Angina Stable Associate 36435742