GSE1 (Gse1 coiled-coil protein)

Gene

• Entrez ID: 23199
• Gene name: Gse1 coiled-coil protein
• Gene symbol: GSE1
• Synonyms (NCBI Gene): CRHSP24, KIAA0182
• Chromosome: 16
• Chromosome location: 16q24.1
• Summary: This gene encodes a proline-rich protein with coiled coil domains that may be a subunit of a BRAF35-HDAC (BHC) histone deacetylase complex. This gene may function as an oncogene in breast cancer and enhanced expression of the encoded protein has been obse

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018548	hsa-miR-335-5p	Microarray	18185580
MIRT043553	hsa-miR-331-3p	CLASH	23622248
MIRT039190	hsa-miR-769-5p	CLASH	23622248
MIRT476037	hsa-miR-27a-3p	PAR-CLIP	24398324
MIRT476036	hsa-miR-27b-3p	PAR-CLIP	24398324
MIRT386575	hsa-miR-548av-3p	PAR-CLIP	24398324
MIRT476035	hsa-miR-548g-3p	PAR-CLIP	24398324
MIRT476034	hsa-miR-4773	PAR-CLIP	24398324
MIRT386574	hsa-miR-5586-3p	PAR-CLIP	24398324
MIRT386572	hsa-miR-759	PAR-CLIP	24398324
MIRT386570	hsa-miR-361-3p	PAR-CLIP	24398324
MIRT386573	hsa-miR-1913	PAR-CLIP	24398324
MIRT386571	hsa-miR-324-3p	PAR-CLIP	24398324
MIRT476033	hsa-miR-29c-5p	PAR-CLIP	24398324
MIRT476032	hsa-miR-1236-5p	PAR-CLIP	24398324
MIRT476031	hsa-miR-4313	PAR-CLIP	24398324
MIRT476030	hsa-miR-4775	PAR-CLIP	24398324
MIRT476029	hsa-miR-5687	PAR-CLIP	24398324
MIRT476028	hsa-miR-513a-5p	PAR-CLIP	24398324
MIRT476037	hsa-miR-27a-3p	PAR-CLIP	23592263
MIRT476036	hsa-miR-27b-3p	PAR-CLIP	23592263
MIRT386575	hsa-miR-548av-3p	PAR-CLIP	23592263
MIRT476035	hsa-miR-548g-3p	PAR-CLIP	23592263
MIRT476034	hsa-miR-4773	PAR-CLIP	23592263
MIRT386574	hsa-miR-5586-3p	PAR-CLIP	23592263
MIRT386572	hsa-miR-759	PAR-CLIP	23592263
MIRT386570	hsa-miR-361-3p	PAR-CLIP	23592263
MIRT386573	hsa-miR-1913	PAR-CLIP	23592263
MIRT386571	hsa-miR-324-3p	PAR-CLIP	23592263
MIRT476033	hsa-miR-29c-5p	PAR-CLIP	23592263
MIRT476032	hsa-miR-1236-5p	PAR-CLIP	23592263
MIRT476031	hsa-miR-4313	PAR-CLIP	23592263
MIRT476030	hsa-miR-4775	PAR-CLIP	23592263
MIRT476029	hsa-miR-5687	PAR-CLIP	23592263
MIRT476028	hsa-miR-513a-5p	PAR-CLIP	23592263
MIRT731266	hsa-miR-489-3p	Luciferase reporter assay	26828271
MIRT731266	hsa-miR-489-3p	Luciferase reporter assay	26828271
MIRT476032	hsa-miR-1236-5p	PAR-CLIP	26701625
MIRT386573	hsa-miR-1913	PAR-CLIP	26701625
MIRT476037	hsa-miR-27a-3p	PAR-CLIP	26701625
MIRT476036	hsa-miR-27b-3p	PAR-CLIP	26701625
MIRT476033	hsa-miR-29c-5p	PAR-CLIP	26701625
MIRT386571	hsa-miR-324-3p	PAR-CLIP	26701625
MIRT386570	hsa-miR-361-3p	PAR-CLIP	26701625
MIRT476031	hsa-miR-4313	PAR-CLIP	26701625
MIRT476034	hsa-miR-4773	PAR-CLIP	26701625
MIRT476030	hsa-miR-4775	PAR-CLIP	26701625
MIRT476028	hsa-miR-513a-5p	PAR-CLIP	26701625
MIRT386575	hsa-miR-548av-3p	PAR-CLIP	26701625
MIRT476035	hsa-miR-548g-3p	PAR-CLIP	26701625
MIRT386574	hsa-miR-5586-3p	PAR-CLIP	26701625
MIRT476029	hsa-miR-5687	PAR-CLIP	26701625
MIRT386572	hsa-miR-759	PAR-CLIP	26701625
MIRT735939	hsa-miR-4665-3p	Western blotting, Microarray, qRT-PCR	31692505
MIRT476037	hsa-miR-27a-3p	PAR-CLIP	24398324
MIRT476036	hsa-miR-27b-3p	PAR-CLIP	24398324
MIRT386575	hsa-miR-548av-3p	PAR-CLIP	24398324
MIRT476035	hsa-miR-548g-3p	PAR-CLIP	24398324
MIRT476034	hsa-miR-4773	PAR-CLIP	24398324
MIRT386574	hsa-miR-5586-3p	PAR-CLIP	24398324
MIRT386572	hsa-miR-759	PAR-CLIP	24398324
MIRT386570	hsa-miR-361-3p	PAR-CLIP	24398324
MIRT386573	hsa-miR-1913	PAR-CLIP	24398324
MIRT386571	hsa-miR-324-3p	PAR-CLIP	24398324
MIRT476033	hsa-miR-29c-5p	PAR-CLIP	24398324
MIRT476032	hsa-miR-1236-5p	PAR-CLIP	24398324
MIRT476031	hsa-miR-4313	PAR-CLIP	24398324
MIRT476030	hsa-miR-4775	PAR-CLIP	24398324
MIRT476029	hsa-miR-5687	PAR-CLIP	24398324
MIRT476028	hsa-miR-513a-5p	PAR-CLIP	24398324
MIRT476037	hsa-miR-27a-3p	PAR-CLIP	23592263
MIRT476036	hsa-miR-27b-3p	PAR-CLIP	23592263
MIRT386575	hsa-miR-548av-3p	PAR-CLIP	23592263
MIRT476035	hsa-miR-548g-3p	PAR-CLIP	23592263
MIRT476034	hsa-miR-4773	PAR-CLIP	23592263
MIRT386574	hsa-miR-5586-3p	PAR-CLIP	23592263
MIRT386572	hsa-miR-759	PAR-CLIP	23592263
MIRT386570	hsa-miR-361-3p	PAR-CLIP	23592263
MIRT386573	hsa-miR-1913	PAR-CLIP	23592263
MIRT386571	hsa-miR-324-3p	PAR-CLIP	23592263
MIRT476033	hsa-miR-29c-5p	PAR-CLIP	23592263
MIRT476032	hsa-miR-1236-5p	PAR-CLIP	23592263
MIRT476031	hsa-miR-4313	PAR-CLIP	23592263
MIRT476030	hsa-miR-4775	PAR-CLIP	23592263
MIRT476029	hsa-miR-5687	PAR-CLIP	23592263
MIRT476028	hsa-miR-513a-5p	PAR-CLIP	23592263

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16189514, 19060904, 25416956, 29568061, 29892012, 32296183, 32814053

Other IDs

• MIM: 616886
• HGNC: 28979
• e!Ensembl: ENSG00000131149

Protein

• UniProt ID: Q14687
• Protein name: Genetic suppressor element 1
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF12540	DUF3736	71 → 239	Protein of unknown function (DUF3736)	Family
  PF12540	DUF3736	732 → 873	Protein of unknown function (DUF3736)	Family

• Sequence:

  MKGMSHEPKSPSLGMLSTATRTTATVNPLTPSPLNGALVPSGSPATSSALSAQAAPSSSF
  AAALRKLAKQAEEPRGSSLSSESSPVSSPATNHSSPASTPKRVPMGPIIVPPGGHSVPST
  PPVVTIAPTKTVNGVWRSESRQDAGSRSSSGGRERLIVEPPLPQEKAGGPAIPSHLLSTP
  YPFGLSPSSVVQDSRFPPLNLQRPVHHVVPPSTVTEDYLRSFRPYHTTDDLRMSSLPPLG
  LDPATAAAYYHPSYLAPHPFPHPAFRMDDSYCLSALRSPFYPIPTPGSLPPLHPSAMHLH
  LSGVRYPPELSHSSLAALHSERMSGLSAERLQMDEELRREREREREREREREADREREKE
  REREREKEREQEKEREREKERERELERQREQRAREKELLAAKALEPSFLPVAELHGLRGH
  ATEERGKPSEQLTPTRAEKLKDAGLQAPKPVQHPLHPVPTPHHTVPSLISNHGIFSLPSS
  SAATALLIQRTNEEEKWLARQRRLRQEKEDRQSQVSEFRQQVLEQHLDMGRPPVPAEAEH
  RPESTTRPGPNRHEPGGRDPPQHFGGPPPLISPKPQLHAAPTALWNPVSLMDNTLETRRA
  ESHSLHSHPAAFEPSRQAAVPLVKVERVFCPEKAEEGPRKREPAPLDKYQPPPPPPREGG
  SLEHQPFLPGPGPFLAELEKSTQTILGQQRASLPQAATFGELSGPLKPGSPYRPPVPRAP
  DPAYIYDEFLQQRRRLVSKLDLEERRRREAQEKGYYYDLDDSYDESDEEEVRAHLRCVAE
  QPPLKLDTSSEKLEFLQLFGLTTQQQKEELVAQKRRKRRRMLRERSPSPPTIQSKRQTPS
  PRLALSTRYSPDEMNNSPNFEEKKKFLTIFNLTHISAEKRKDKERLVEMLRAMKQKALSA
  AVADSLTNSPRDSPAVSLSEPATQQASLDVEKPVGVAASLSDIPKAAEPGKLEQVRPQEL
  SRVQELAPASGEKARLSEAPGGKKSLSMLHYIRGAAPKDIPVPLSHSTNGKSKPWEPFVA
  EEFAHQFHESVLQSTQKALQKHKGSVAVLSAEQNHKVDTSVHYNIPELQSSSRAPPPQHN
  GQQEPPTARKGPPTQELDRDSEEEEEEDDEDGEDEEEVPKRKWQGIEAVFEAYQEHIEEQ
  NLERQVLQTQCRRLEARHYSLSLTAEQLSHSVAELRSQKQKMVSERERLQAELDHLRKCL
  ALPAMHWPRGYLKGYPR

• Sequence length: 1217

Associated diseases

Causal
Disease term	Disease name	dbSNP ID	References
Colorectal cancer	Colorectal Carcinoma	rs137854568, rs137854573, rs137854575, rs387906234, rs121908380, rs121908702, rs267606674, rs794729661, rs121909055, rs281865417, rs267606884, rs28934575, rs587776769, rs104893815, rs587776800, rs63750198, rs63751109, rs863223312, rs63750710, rs63751615, rs63750206, rs63750781, rs63750899, rs63750691, rs63750217, rs121912965, rs63749939, rs63751194, rs63750693, rs63750540, rs63751221, rs193922370, rs80359596, rs397514632, rs483352909, rs200495564, rs397514684, rs397516436, rs398122386, rs79512956, rs74953290, rs587779001, rs63750677, rs63749837, rs267607816, rs63751715, rs267607819, rs267607815, rs267607822, rs63749906, rs587778883, rs63750472, rs63751012, rs63750715, rs63750580, rs267607706, rs267607709, rs267607710, rs587778894, rs63750749, rs63750483, rs63751015, rs63751153, rs63751094, rs63751118, rs63750316, rs63749981, rs587778906, rs267607821, rs587778908, rs63750020, rs587778909, rs63750713, rs267607825, rs63751592, rs281864936, rs587778913, rs587778914, rs63749795, rs63750855, rs63749916, rs63749923, rs63751472, rs63751689, rs267607832, rs267607837, rs267607836, rs587778923, rs63750028, rs587778928, rs587778929, rs587778930, rs63751277, rs587778933, rs267607842, rs267607843, rs63750192, rs587778934, rs63750193, rs587778937, rs587778938, rs267607845, rs63751244, rs63751393, rs63751460, rs267607849, rs267607853, rs267607856, rs267607850, rs63751657, rs267607854, rs267607852, rs587778942, rs63750309, rs63750587, rs63749863, rs63751486, rs63750016, rs63749868, rs63750375, rs63750035, rs63750604, rs63750386, rs63750150, rs63750486, rs63751428, rs267607866, rs63749986, rs63751594, rs63750152, rs63750850, rs267607867, rs267607868, rs63751632, rs267607871, rs63751892, rs587778956, rs63750469, rs587778958, rs63749792, rs267607875, rs63751255, rs281864938, rs63751202, rs63750726, rs63751310, rs63749900, rs587778964, rs267607879, rs267607878, rs587778966, rs267607883, rs267607887, rs63750061, rs63750663, rs587778968, rs587778971, rs63750809, rs63749867, rs63750864, rs587778972, rs63751275, rs267607718, rs267607722, rs63750769, rs267607717, rs587778973, rs267607716, rs267607720, rs63749995, rs63750859, rs587778975, rs63750114, rs587778976, rs63750603, rs267607889, rs267607723, rs63750561, rs63750499, rs63751642, rs63751022, rs587778981, rs63750971, rs267607898, rs267607906, rs267607903, rs587778989, rs587778992, rs267607894, rs267607901, rs267607892, rs63750437, rs587778997, rs587778998, rs63750005, rs63750641, rs63751421, rs11541859, rs63750266, rs111052004, rs267607726, rs267607727, rs63750453, rs267607734, rs267607735, rs63751665, rs267607736, rs267607732, rs63749816, rs63750539, rs267607739, rs587779006, rs587779008, rs267607745, rs267607742, rs63751595, rs267607743, rs587779010, rs587779012, rs63750057, rs63749818, rs63751124, rs587779014, rs587779015, rs63749820, rs63751302, rs267607750, rs267607751, rs267607749, rs63750891, rs63749959, rs63749804, rs267607765, rs267607760, rs587779021, rs267607759, rs63750515, rs587779023, rs63751021, rs63751480, rs267607772, rs267607773, rs587779024, rs63751653, rs587779027, rs267607767, rs587779029, rs63750706, rs63750385, rs267607774, rs267607778, rs267607780, rs587779034, rs63751711, rs267607784, rs587779035, rs63750823, rs63750822, rs267607787, rs63750303, rs63749839, rs63749827, rs267607789, rs267607790, rs267607791, rs267607786, rs267607771, rs267607795, rs267607794, rs267607788, rs267607799, rs267607801, rs587779045, rs63750034, rs587779047, rs63750216, rs63751707, rs63751598, rs267607803, rs267607777, rs63750144, rs267607805, rs63750547, rs63750489, rs63750993, rs587779054, rs63751259, rs63749926, rs63750796, rs587779058, rs63750745, rs63750582, rs180177084, rs587779866, rs200389141, rs587779950, rs587780104, rs587780183, rs587778536, rs587780683, rs587781554, rs267607712, rs587777627, rs587783057, rs730881734, rs41542214, rs730881273, rs786203456, rs786201990, rs786202767, rs748005072, rs786204317, rs786204318, rs797045117, rs63750549, rs863225383, rs863225384, rs863225373, rs863225376, rs863225377, rs863225378, rs863225379, rs863225380, rs863225381, rs63750059, rs267607823, rs864622457, rs869312767, rs869312753, rs876661059, rs876658915, rs876658923, rs876660860, rs876660822, rs876660458, rs876660214, rs876658657, rs876658247, rs876659226, rs876658821, rs876660589, rs876659068, rs876659681, rs876659608, rs878853794, rs878853778, rs878853780, rs878853785, rs886039423, rs886039424, rs1057517543, rs1057517541, rs756843954, rs1057517617, rs1057517558, rs1057519256, rs1060500689, rs764085979, rs1060500707, rs1060500699, rs1060500706, rs1060500703, rs1064795341, rs1064793607, rs1064794348, rs1064795441, rs1064794373, rs1064793172, rs1064794122, rs1064795515, rs1064794331, rs63750978, rs1114167435, rs1553641362, rs63751448, rs1553648029, rs1553648058, rs587778903, rs1553653237, rs1553664353, rs267607744, rs1553647995, rs1553648047, rs1553653084, rs1553663750, rs1553664436, rs1553488015, rs1553637293, rs63750310, rs63750443, rs63751596, rs1553646681, rs550890395, rs1064796057, rs1553642079, rs1553648023, rs587782087, rs746536721, rs1553653037, rs1248251121, rs1553646602, rs1434898623, rs1553665683, rs1553648068, rs1553645331, rs1553644123, rs1553658246, rs1553651299, rs1553648149, rs1553663159, rs1302248679, rs1553664119, rs1553658009, rs1553665977, rs1416171624, rs1553663834, rs1553664617, rs1553664702, rs1553647969, rs1553648040, rs1437454428, rs1553641273, rs63751101, rs1553646764, rs1553648225, rs1554082118, rs1553648201, rs1553638868, rs1553665866, rs376736188, rs1553642707, rs1553645226, rs1553652883, rs63751435, rs1553653115, rs1553653195, rs63750300, rs1553662622, rs1553658104, rs1553648220, rs1559544064, rs63750584, rs267608083, rs1559551570, rs1559575107, rs1559553501, rs1565986506, rs1559524405, rs1559553492, rs1559554339, rs1559588540, rs1559558071, rs761329565, rs1559521039, rs1559574795, rs1567221417, rs1559578422, rs1481129490, rs1570714352, rs779783209, rs1575376830, rs1575469070, rs1575537843, rs1575620443, rs1575621506, rs587779022, rs1575414904, rs1575449093, rs1575469505, rs1575536254, rs1575537933, rs1575632112, rs1575639851, rs1575441094, rs1575449402, rs267607831, rs2081922847, rs2083403132, rs2085415927, rs2085469647, rs2043913790, rs147542208

Unknown
Disease term	Disease name	Evidence	References	Source
Alopecia Areata	Alopecia Areata			GWAS
Metabolic Syndrome	Metabolic Syndrome			GWAS
Diabetes	Diabetes			GWAS
Schizophrenia	Schizophrenia			GWAS

Associations from Text Mining
Disease Name	Relationship Type	References
Carcinogenesis	Associate	22282400
Colorectal Neoplasms	Stimulate	22282400
Colorectal Neoplasms	Associate	22282400
Endometrial Neoplasms	Associate	30888986
Lymphatic Metastasis	Associate	33623790
Meningioma	Associate	31470906
Stomach Neoplasms	Associate	33623790