Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	23198
Gene name	Proteasome activator subunit 4
Gene symbol	PSME4
Synonyms (NCBI Gene)	Blm10PA200hBlm10
Chromosome	2
Chromosome location	2p16.2

319

Show/Hide all (319)

miRTarBase ID	miRNA	Experiments	Reference
MIRT019934	hsa-miR-375	Microarray	20215506
MIRT020902	hsa-miR-155-5p	Proteomics	18668040
MIRT027763	hsa-miR-98-5p	Microarray	19088304
MIRT028604	hsa-miR-30a-5p	Proteomics	18668040
MIRT031835	hsa-miR-16-5p	Proteomics	18668040
MIRT051708	hsa-let-7e-5p	CLASH	23622248
MIRT035894	hsa-miR-1303	CLASH	23622248
MIRT716831	hsa-miR-651-3p	HITS-CLIP	19536157
MIRT716830	hsa-miR-1183	HITS-CLIP	19536157
MIRT716829	hsa-miR-4255	HITS-CLIP	19536157
MIRT716828	hsa-miR-20b-3p	HITS-CLIP	19536157
MIRT716827	hsa-miR-6073	HITS-CLIP	19536157
MIRT716825	hsa-miR-142-3p	HITS-CLIP	19536157
MIRT716826	hsa-miR-4326	HITS-CLIP	19536157
MIRT716825	hsa-miR-142-3p	HITS-CLIP	19536157
MIRT716824	hsa-miR-4477b	HITS-CLIP	19536157
MIRT716823	hsa-miR-7856-5p	HITS-CLIP	19536157
MIRT716831	hsa-miR-651-3p	HITS-CLIP	19536157
MIRT716830	hsa-miR-1183	HITS-CLIP	19536157
MIRT716829	hsa-miR-4255	HITS-CLIP	19536157
MIRT716828	hsa-miR-20b-3p	HITS-CLIP	19536157
MIRT716827	hsa-miR-6073	HITS-CLIP	19536157
MIRT716825	hsa-miR-142-3p	HITS-CLIP	19536157
MIRT716826	hsa-miR-4326	HITS-CLIP	19536157
MIRT716825	hsa-miR-142-3p	HITS-CLIP	19536157
MIRT716824	hsa-miR-4477b	HITS-CLIP	19536157
MIRT716823	hsa-miR-7856-5p	HITS-CLIP	19536157
MIRT439882	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT439882	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT716831	hsa-miR-651-3p	HITS-CLIP	19536157
MIRT716830	hsa-miR-1183	HITS-CLIP	19536157
MIRT716829	hsa-miR-4255	HITS-CLIP	19536157
MIRT716828	hsa-miR-20b-3p	HITS-CLIP	19536157
MIRT716827	hsa-miR-6073	HITS-CLIP	19536157
MIRT716825	hsa-miR-142-3p	HITS-CLIP	19536157
MIRT716826	hsa-miR-4326	HITS-CLIP	19536157
MIRT716825	hsa-miR-142-3p	HITS-CLIP	19536157
MIRT716824	hsa-miR-4477b	HITS-CLIP	19536157
MIRT716823	hsa-miR-7856-5p	HITS-CLIP	19536157
MIRT716831	hsa-miR-651-3p	HITS-CLIP	19536157
MIRT716830	hsa-miR-1183	HITS-CLIP	19536157
MIRT716829	hsa-miR-4255	HITS-CLIP	19536157
MIRT716828	hsa-miR-20b-3p	HITS-CLIP	19536157
MIRT716827	hsa-miR-6073	HITS-CLIP	19536157
MIRT716825	hsa-miR-142-3p	HITS-CLIP	19536157
MIRT716826	hsa-miR-4326	HITS-CLIP	19536157
MIRT716825	hsa-miR-142-3p	HITS-CLIP	19536157
MIRT716824	hsa-miR-4477b	HITS-CLIP	19536157
MIRT716823	hsa-miR-7856-5p	HITS-CLIP	19536157
MIRT1270918	hsa-miR-105	CLIP-seq
MIRT1270919	hsa-miR-1273f	CLIP-seq
MIRT1270920	hsa-miR-140-3p	CLIP-seq
MIRT1270921	hsa-miR-143	CLIP-seq
MIRT1270922	hsa-miR-203	CLIP-seq
MIRT1270923	hsa-miR-2467-3p	CLIP-seq
MIRT1270924	hsa-miR-3136-3p	CLIP-seq
MIRT1270925	hsa-miR-3153	CLIP-seq
MIRT1270926	hsa-miR-3663-5p	CLIP-seq
MIRT1270927	hsa-miR-3672	CLIP-seq
MIRT1270928	hsa-miR-3678-3p	CLIP-seq
MIRT1270929	hsa-miR-377	CLIP-seq
MIRT1270930	hsa-miR-4251	CLIP-seq
MIRT1270931	hsa-miR-4259	CLIP-seq
MIRT1270932	hsa-miR-4303	CLIP-seq
MIRT1270933	hsa-miR-432	CLIP-seq
MIRT1270934	hsa-miR-4329	CLIP-seq
MIRT1270935	hsa-miR-4425	CLIP-seq
MIRT1270936	hsa-miR-4470	CLIP-seq
MIRT1270937	hsa-miR-4522	CLIP-seq
MIRT1270938	hsa-miR-4639-3p	CLIP-seq
MIRT1270939	hsa-miR-4659a-5p	CLIP-seq
MIRT1270940	hsa-miR-4659b-5p	CLIP-seq
MIRT1270941	hsa-miR-4668-3p	CLIP-seq
MIRT1270942	hsa-miR-4668-5p	CLIP-seq
MIRT1270943	hsa-miR-4700-3p	CLIP-seq
MIRT1270944	hsa-miR-4708-5p	CLIP-seq
MIRT1270945	hsa-miR-4742-3p	CLIP-seq
MIRT1270946	hsa-miR-4770	CLIP-seq
MIRT1270947	hsa-miR-492	CLIP-seq
MIRT1270948	hsa-miR-499a-5p	CLIP-seq
MIRT1270949	hsa-miR-519a	CLIP-seq
MIRT1270950	hsa-miR-519b-3p	CLIP-seq
MIRT1270951	hsa-miR-519c-3p	CLIP-seq
MIRT1270952	hsa-miR-520d-5p	CLIP-seq
MIRT1270953	hsa-miR-524-5p	CLIP-seq
MIRT1270954	hsa-miR-548a-3p	CLIP-seq
MIRT1270955	hsa-miR-548e	CLIP-seq
MIRT1270956	hsa-miR-548f	CLIP-seq
MIRT1270957	hsa-miR-556-3p	CLIP-seq
MIRT2079692	hsa-miR-1272	CLIP-seq
MIRT1270920	hsa-miR-140-3p	CLIP-seq
MIRT2079693	hsa-miR-214	CLIP-seq
MIRT1270923	hsa-miR-2467-3p	CLIP-seq
MIRT2079694	hsa-miR-3182	CLIP-seq
MIRT2079695	hsa-miR-338-3p	CLIP-seq
MIRT2079696	hsa-miR-3619-5p	CLIP-seq
MIRT2079697	hsa-miR-3662	CLIP-seq
MIRT1270926	hsa-miR-3663-5p	CLIP-seq
MIRT2079698	hsa-miR-3667-3p	CLIP-seq
MIRT2079699	hsa-miR-3670	CLIP-seq
MIRT1270927	hsa-miR-3672	CLIP-seq
MIRT1270928	hsa-miR-3678-3p	CLIP-seq
MIRT1270929	hsa-miR-377	CLIP-seq
MIRT2079700	hsa-miR-3922-5p	CLIP-seq
MIRT2079701	hsa-miR-3925-3p	CLIP-seq
MIRT2079702	hsa-miR-4291	CLIP-seq
MIRT2079703	hsa-miR-431	CLIP-seq
MIRT1270933	hsa-miR-432	CLIP-seq
MIRT1270937	hsa-miR-4522	CLIP-seq
MIRT2079704	hsa-miR-4530	CLIP-seq
MIRT1270938	hsa-miR-4639-3p	CLIP-seq
MIRT2079705	hsa-miR-4659a-3p	CLIP-seq
MIRT1270939	hsa-miR-4659a-5p	CLIP-seq
MIRT2079706	hsa-miR-4659b-3p	CLIP-seq
MIRT1270940	hsa-miR-4659b-5p	CLIP-seq
MIRT2079707	hsa-miR-4698	CLIP-seq
MIRT2079708	hsa-miR-4711-3p	CLIP-seq
MIRT2079709	hsa-miR-4712-3p	CLIP-seq
MIRT2079710	hsa-miR-4778-5p	CLIP-seq
MIRT2079711	hsa-miR-4789-5p	CLIP-seq
MIRT2079712	hsa-miR-487a	CLIP-seq
MIRT1270948	hsa-miR-499a-5p	CLIP-seq
MIRT2079713	hsa-miR-513c	CLIP-seq
MIRT2079714	hsa-miR-514b-5p	CLIP-seq
MIRT1270954	hsa-miR-548a-3p	CLIP-seq
MIRT1270955	hsa-miR-548e	CLIP-seq
MIRT1270956	hsa-miR-548f	CLIP-seq
MIRT2079715	hsa-miR-555	CLIP-seq
MIRT2079716	hsa-miR-605	CLIP-seq
MIRT2079717	hsa-miR-642a	CLIP-seq
MIRT2079718	hsa-miR-760	CLIP-seq
MIRT2079719	hsa-miR-761	CLIP-seq
MIRT2079720	hsa-miR-766	CLIP-seq
MIRT2079721	hsa-miR-922	CLIP-seq
MIRT2305973	hsa-miR-1184	CLIP-seq
MIRT2305974	hsa-miR-1205	CLIP-seq
MIRT1270920	hsa-miR-140-3p	CLIP-seq
MIRT2305975	hsa-miR-197	CLIP-seq
MIRT1270923	hsa-miR-2467-3p	CLIP-seq
MIRT2305976	hsa-miR-29a	CLIP-seq
MIRT2305977	hsa-miR-29b	CLIP-seq
MIRT2305978	hsa-miR-29c	CLIP-seq
MIRT2305979	hsa-miR-3065-3p	CLIP-seq
MIRT2305980	hsa-miR-3122	CLIP-seq
MIRT2305981	hsa-miR-3158-5p	CLIP-seq
MIRT2079695	hsa-miR-338-3p	CLIP-seq
MIRT2305982	hsa-miR-3675-3p	CLIP-seq
MIRT1270928	hsa-miR-3678-3p	CLIP-seq
MIRT2305983	hsa-miR-3913-5p	CLIP-seq
MIRT2079701	hsa-miR-3925-3p	CLIP-seq
MIRT2305984	hsa-miR-412	CLIP-seq
MIRT2079702	hsa-miR-4291	CLIP-seq
MIRT2079703	hsa-miR-431	CLIP-seq
MIRT2079704	hsa-miR-4530	CLIP-seq
MIRT2305985	hsa-miR-4648	CLIP-seq
MIRT2305986	hsa-miR-4654	CLIP-seq
MIRT2079705	hsa-miR-4659a-3p	CLIP-seq
MIRT2079706	hsa-miR-4659b-3p	CLIP-seq
MIRT2305987	hsa-miR-4729	CLIP-seq
MIRT2305988	hsa-miR-4742-5p	CLIP-seq
MIRT2305989	hsa-miR-4747-5p	CLIP-seq
MIRT2305990	hsa-miR-4769-5p	CLIP-seq
MIRT2079711	hsa-miR-4789-5p	CLIP-seq
MIRT2305991	hsa-miR-508-5p	CLIP-seq
MIRT1270949	hsa-miR-519a	CLIP-seq
MIRT1270950	hsa-miR-519b-3p	CLIP-seq
MIRT1270951	hsa-miR-519c-3p	CLIP-seq
MIRT2305992	hsa-miR-544	CLIP-seq
MIRT1270954	hsa-miR-548a-3p	CLIP-seq
MIRT2305993	hsa-miR-548ae	CLIP-seq
MIRT2305994	hsa-miR-548aj	CLIP-seq
MIRT2305995	hsa-miR-548am	CLIP-seq
MIRT1270955	hsa-miR-548e	CLIP-seq
MIRT1270956	hsa-miR-548f	CLIP-seq
MIRT2305996	hsa-miR-548x	CLIP-seq
MIRT2305997	hsa-miR-622	CLIP-seq
MIRT2079718	hsa-miR-760	CLIP-seq
MIRT1270920	hsa-miR-140-3p	CLIP-seq
MIRT1270923	hsa-miR-2467-3p	CLIP-seq
MIRT1270928	hsa-miR-3678-3p	CLIP-seq
MIRT1270954	hsa-miR-548a-3p	CLIP-seq
MIRT1270955	hsa-miR-548e	CLIP-seq
MIRT1270956	hsa-miR-548f	CLIP-seq
MIRT2079694	hsa-miR-3182	CLIP-seq
MIRT2079703	hsa-miR-431	CLIP-seq
MIRT2079708	hsa-miR-4711-3p	CLIP-seq
MIRT1270948	hsa-miR-499a-5p	CLIP-seq
MIRT2439624	hsa-miR-616	CLIP-seq
MIRT1270948	hsa-miR-499a-5p	CLIP-seq
MIRT1270949	hsa-miR-519a	CLIP-seq
MIRT1270950	hsa-miR-519b-3p	CLIP-seq
MIRT1270951	hsa-miR-519c-3p	CLIP-seq
MIRT2603185	hsa-miR-1245	CLIP-seq
MIRT2603186	hsa-miR-1245b-3p	CLIP-seq
MIRT2603187	hsa-miR-1257	CLIP-seq
MIRT2603188	hsa-miR-1263	CLIP-seq
MIRT2079692	hsa-miR-1272	CLIP-seq
MIRT2603189	hsa-miR-1299	CLIP-seq
MIRT2603190	hsa-miR-1305	CLIP-seq
MIRT2603191	hsa-miR-134	CLIP-seq
MIRT1270920	hsa-miR-140-3p	CLIP-seq
MIRT2603192	hsa-miR-181a	CLIP-seq
MIRT2603193	hsa-miR-181b	CLIP-seq
MIRT2603194	hsa-miR-181c	CLIP-seq
MIRT2603195	hsa-miR-181d	CLIP-seq
MIRT2603196	hsa-miR-1827	CLIP-seq
MIRT2305975	hsa-miR-197	CLIP-seq
MIRT2079693	hsa-miR-214	CLIP-seq
MIRT1270923	hsa-miR-2467-3p	CLIP-seq
MIRT2603197	hsa-miR-2682	CLIP-seq
MIRT2603198	hsa-miR-3118	CLIP-seq
MIRT2603199	hsa-miR-3157-3p	CLIP-seq
MIRT2603200	hsa-miR-3164	CLIP-seq
MIRT2079694	hsa-miR-3182	CLIP-seq
MIRT2603201	hsa-miR-3190	CLIP-seq
MIRT2603202	hsa-miR-3609	CLIP-seq
MIRT2603203	hsa-miR-3611	CLIP-seq
MIRT2603204	hsa-miR-3613-3p	CLIP-seq
MIRT2079696	hsa-miR-3619-5p	CLIP-seq
MIRT2079697	hsa-miR-3662	CLIP-seq
MIRT1270926	hsa-miR-3663-5p	CLIP-seq
MIRT2079698	hsa-miR-3667-3p	CLIP-seq
MIRT2079699	hsa-miR-3670	CLIP-seq
MIRT1270927	hsa-miR-3672	CLIP-seq
MIRT1270928	hsa-miR-3678-3p	CLIP-seq
MIRT2603205	hsa-miR-371b-5p	CLIP-seq
MIRT2603206	hsa-miR-383	CLIP-seq
MIRT2603207	hsa-miR-3911	CLIP-seq
MIRT2079701	hsa-miR-3925-3p	CLIP-seq
MIRT2603208	hsa-miR-4262	CLIP-seq
MIRT2603209	hsa-miR-4290	CLIP-seq
MIRT2079702	hsa-miR-4291	CLIP-seq
MIRT2079703	hsa-miR-431	CLIP-seq
MIRT1270933	hsa-miR-432	CLIP-seq
MIRT2603210	hsa-miR-4328	CLIP-seq
MIRT2603211	hsa-miR-4436a	CLIP-seq
MIRT2603212	hsa-miR-4455	CLIP-seq
MIRT2603213	hsa-miR-449c	CLIP-seq
MIRT1270937	hsa-miR-4522	CLIP-seq
MIRT1270939	hsa-miR-4659a-5p	CLIP-seq
MIRT1270940	hsa-miR-4659b-5p	CLIP-seq
MIRT2079707	hsa-miR-4698	CLIP-seq
MIRT1270943	hsa-miR-4700-3p	CLIP-seq
MIRT2079708	hsa-miR-4711-3p	CLIP-seq
MIRT2079709	hsa-miR-4712-3p	CLIP-seq
MIRT1270945	hsa-miR-4742-3p	CLIP-seq
MIRT2603214	hsa-miR-4772-5p	CLIP-seq
MIRT2079710	hsa-miR-4778-5p	CLIP-seq
MIRT2603215	hsa-miR-4782-5p	CLIP-seq
MIRT2079712	hsa-miR-487a	CLIP-seq
MIRT1270947	hsa-miR-492	CLIP-seq
MIRT1270948	hsa-miR-499a-5p	CLIP-seq
MIRT2603216	hsa-miR-516b	CLIP-seq
MIRT2603217	hsa-miR-544b	CLIP-seq
MIRT1270954	hsa-miR-548a-3p	CLIP-seq
MIRT2603218	hsa-miR-548ah	CLIP-seq
MIRT1270955	hsa-miR-548e	CLIP-seq
MIRT1270956	hsa-miR-548f	CLIP-seq
MIRT2603219	hsa-miR-548t	CLIP-seq
MIRT2079715	hsa-miR-555	CLIP-seq
MIRT2439624	hsa-miR-616	CLIP-seq
MIRT2603220	hsa-miR-630	CLIP-seq
MIRT2079717	hsa-miR-642a	CLIP-seq
MIRT2603221	hsa-miR-758	CLIP-seq
MIRT2079718	hsa-miR-760	CLIP-seq
MIRT2079719	hsa-miR-761	CLIP-seq
MIRT2079720	hsa-miR-766	CLIP-seq
MIRT2603222	hsa-miR-874	CLIP-seq
MIRT2603223	hsa-miR-875-3p	CLIP-seq
MIRT2079721	hsa-miR-922	CLIP-seq
MIRT2603224	hsa-miR-944	CLIP-seq
MIRT2603186	hsa-miR-1245b-3p	CLIP-seq
MIRT2603188	hsa-miR-1263	CLIP-seq
MIRT2079692	hsa-miR-1272	CLIP-seq
MIRT2603191	hsa-miR-134	CLIP-seq
MIRT1270920	hsa-miR-140-3p	CLIP-seq
MIRT2603196	hsa-miR-1827	CLIP-seq
MIRT2079693	hsa-miR-214	CLIP-seq
MIRT1270923	hsa-miR-2467-3p	CLIP-seq
MIRT2603197	hsa-miR-2682	CLIP-seq
MIRT2603198	hsa-miR-3118	CLIP-seq
MIRT2603199	hsa-miR-3157-3p	CLIP-seq
MIRT2603200	hsa-miR-3164	CLIP-seq
MIRT2079694	hsa-miR-3182	CLIP-seq
MIRT2603201	hsa-miR-3190	CLIP-seq
MIRT2603204	hsa-miR-3613-3p	CLIP-seq
MIRT2079696	hsa-miR-3619-5p	CLIP-seq
MIRT2079697	hsa-miR-3662	CLIP-seq
MIRT2079698	hsa-miR-3667-3p	CLIP-seq
MIRT2079699	hsa-miR-3670	CLIP-seq
MIRT1270927	hsa-miR-3672	CLIP-seq
MIRT1270928	hsa-miR-3678-3p	CLIP-seq
MIRT2603205	hsa-miR-371b-5p	CLIP-seq
MIRT2603207	hsa-miR-3911	CLIP-seq
MIRT2079701	hsa-miR-3925-3p	CLIP-seq
MIRT2603209	hsa-miR-4290	CLIP-seq
MIRT2079702	hsa-miR-4291	CLIP-seq
MIRT2079703	hsa-miR-431	CLIP-seq
MIRT2603210	hsa-miR-4328	CLIP-seq
MIRT2603211	hsa-miR-4436a	CLIP-seq
MIRT2603212	hsa-miR-4455	CLIP-seq
MIRT2603213	hsa-miR-449c	CLIP-seq
MIRT2079707	hsa-miR-4698	CLIP-seq
MIRT2079708	hsa-miR-4711-3p	CLIP-seq
MIRT2079709	hsa-miR-4712-3p	CLIP-seq
MIRT1270948	hsa-miR-499a-5p	CLIP-seq
MIRT2603217	hsa-miR-544b	CLIP-seq
MIRT1270954	hsa-miR-548a-3p	CLIP-seq
MIRT1270955	hsa-miR-548e	CLIP-seq
MIRT1270956	hsa-miR-548f	CLIP-seq
MIRT2439624	hsa-miR-616	CLIP-seq
MIRT2603220	hsa-miR-630	CLIP-seq
MIRT2079717	hsa-miR-642a	CLIP-seq
MIRT2603221	hsa-miR-758	CLIP-seq
MIRT2079718	hsa-miR-760	CLIP-seq
MIRT2079719	hsa-miR-761	CLIP-seq
MIRT2079720	hsa-miR-766	CLIP-seq
MIRT2603222	hsa-miR-874	CLIP-seq
MIRT2079721	hsa-miR-922	CLIP-seq

Show/Hide all (32)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000502	Component	Proteasome complex	IEA
GO:0005515	Function	Protein binding	IPI	18845680, 25416956, 35271311
GO:0005634	Component	Nucleus	HDA	21630459
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	ISS
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	ISS
GO:0006281	Process	DNA repair	IEA
GO:0006281	Process	DNA repair	ISS
GO:0006974	Process	DNA damage response	IEA
GO:0006974	Process	DNA damage response	ISS
GO:0007283	Process	Spermatogenesis	IEA
GO:0010499	Process	Proteasomal ubiquitin-independent protein catabolic process	IBA
GO:0010499	Process	Proteasomal ubiquitin-independent protein catabolic process	IEA
GO:0010499	Process	Proteasomal ubiquitin-independent protein catabolic process	ISS
GO:0016504	Function	Peptidase activator activity	IBA
GO:0016504	Function	Peptidase activator activity	IEA
GO:0016504	Function	Peptidase activator activity	ISS
GO:0016607	Component	Nuclear speck	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0035092	Process	Sperm DNA condensation	IEA
GO:0035092	Process	Sperm DNA condensation	ISS
GO:0070628	Function	Proteasome binding	IBA
GO:0070628	Function	Proteasome binding	IEA
GO:0140566	Function	Histone reader activity	IBA
GO:1990111	Component	Spermatoproteasome complex	IBA
GO:1990111	Component	Spermatoproteasome complex	IEA
GO:1990111	Component	Spermatoproteasome complex	ISS

MIM	HGNC	e!Ensembl
607705	20635	ENSG00000068878

Q14997

Protein name

Proteasome activator complex subunit 4 (Proteasome activator PA200) (Protein BLM10 homolog) (Blm10) (hBlm10)

Protein function

Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated hist

PDB

6KWX , 6KWY , 6REY , 7NAQ , 8CVS

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF16507	BLM10_mid	330 → 828	Proteasome-substrate-size regulator, mid region	Family
PF11919	DUF3437	1756 → 1843	Domain of unknown function (DUF3437)	Family

Sequence

MEPAERAGVGEPPEPGGRPEPGPRGFVPQKEIVYNKLLPYAERLDAESDLQLAQIKCNLG
RAVQLQELWPGGLFWTRKLSTYIRLYGRKFSKEDHVLFIKLLYELVSIPKLEISMMQGFA
RLLINLLKKKELLSRADLELPWRPLYDMVERILYSKTEHLGLNWFPNSVENILKTLVKSC
RPYFPADATAEMLEEWRPLMCPFDVTMQKAITYFEIFLPTSLPPELHHKGFKLWFDELIG
LWVSVQNLPQWEGQLVNLFARLATDNIGYIDWDPYVPKIFTRILRSLNLPVGSSQVLVPR
FLTNAYDIGHAVIWITAMMGGPSKLVQKHLAGLFNSITSFYHPSNNGRWLNKLMKLLQRL
PNSVVRRLHRERYKKPSWLTPVPDSHKLTDQDVTDFVQCIIQPVLLAMFSKTGSLEAAQA
LQNLALMRPELVIPPVLERTYPALETLTEPHQLTATLSCVIGVARSLVSGGRWFPEGPTH
MLPLLMRALPGVDPNDFSKCMITFQFIATFSTLVPLVDCSSVLQERNDLTEVERELCSAT
AEFEDFVLQFMDRCFGLIESSTLEQTREETETEKMTHLESLVELGLSSTFSTILTQCSKE
IFMVALQKVFNFSTSHIFETRVAGRMVADMCRAAVKCCPEESLKLFVPHCCSVITQLTMN
DDVLNDEELDKELLWNLQLLSEITRVDGRKLLLYREQLVKILQRTLHLTCKQGYTLSCNL
LHHLLRSTTLIYPTEYCSVPGGFDKPPSEYFPIKDWGKPGDLWNLGIQWHVPSSEEVSFA
FYLLDSFLQPELVKLQHCGDGKLEMSRDDILQSLTIVHNCLIGSGNLLPPLKGEPVTNLV
PSMVSLEETKLYTGLEYDLSRENHREVIATVIRKLLNHILDNSEDDTKSLFLIIKIIGDL
LQFQGSHKHEFDSRWKSFNLVKKSMENRLHGKKQHIRALLIDRVMLQHELRTLTVEGCEY
KKIHQDMIRDLLRLSTSSYSQVRNKAQQTFFAALGAYNFCCRDIIPLVLEFLRPDRQGVT
QQQFKGALYCLLGNHSGVCLANLHDWDCIVQTWPAIVSSGLSQAMSLEKPSIVRLFDDLA
EKIHRQYETIGLDFTIPKSCVEIAELLQQSKNPSINQILLSPEKIKEGIKRQQEKNADAL
RNYENLVDTLLDGVEQRNLPWKFEHIGIGLLSLLLRDDRVLPLRAIRFFVENLNHDAIVV
RKMAISAVAGILKQLKRTHKKLTINPCEISGCPKPTQIIAGDRPDNHWLHYDSKTIPRTK
KEWESSCFVEKTHWGYYTWPKNMVVYAGVEEQPKLGRSREDMTEAEQIIFDHFSDPKFVE
QLITFLSLEDRKGKDKFNPRRFCLFKGIFRNFDDAFLPVLKPHLEHLVADSHESTQRCVA
EIIAGLIRGSKHWTFEKVEKLWELLCPLLRTALSNITVETYNDWGACIATSCESRDPRKL
HWLFELLLESPLSGEGGSFVDACRLYVLQGGLAQQEWRVPELLHRLLKYLEPKLTQVYKN
VRERIGSVLTYIFMIDVSLPNTTPTISPHVPEFTARILEKLKPLMDVDEEIQNHVMEENG
IGEEDERTQGIKLLKTILKWLMASAGRSFSTAVTEQLQLLPLFFKIAPVENDNSYDELKR
DAKLCLSLMSQGLLYPHQVPLVLQVLKQTARSSSWHARYTVLTYLQTMVFYNLFIFLNNE
DAVKDIRWLVISLLEDEQLEVREMAATTLSGLLQCNFLTMDSPMQIHFEQLCKTKLPKKR
KRDPGSVGDTIPSAELVKRHAGVLGLGACVLSSPYDVPTWMPQLLMNLSAHLNDPQPIEM
TVKKTLSNFRRTHHDNWQEHKQQFTDDQLLVLTDLLVSPCYYA

Sequence length

1843

Interactions

View interactions

	KEGG		Reactome
	Proteasome		Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Cross-presentation of soluble exogenous antigens (endosomes) SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G Degradation of beta-catenin by the destruction complex Downstream TCR signaling Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants that don't undergo autocatalytic processing are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases CDT1 association with the CDC6:ORC:origin complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of PTEN stability and activity Neddylation Interleukin-1 signaling Antigen processing: Ubiquitination & Proteasome degradation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (9)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Acute myeloid leukemia	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS, HIP	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS, KNEE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (5)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Abortion Spontaneous	Associate	36139348	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cystitis Interstitial	Associate	39399486	★★★★★ ★☆☆☆☆ Found in Text Mining only
Mitochondrial Diseases	Associate	33562813	★★★★★ ★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Associate	35344764	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Associate	32368861	★★★★★ ★☆☆☆☆ Found in Text Mining only

PSME4 (proteasome activator subunit 4)