RCOR1 (REST corepressor 1)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 23186 |
| Gene name | REST corepressor 1 |
| Gene symbol | RCOR1 |
| Synonyms (NCBI Gene) |
CORESTRCOR
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| Chromosome | 14 |
| Chromosome location | 14q32.31-q32.32 |
| Summary | This gene encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining neural cell differentiation. The encoded protein binds to the C-terminal domain of REST (repressor element-1 silencing transcription factor |
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SNPs
SNP information provided by dbSNP.
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miRNA
miRNA information provided by mirtarbase database.
953
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q9UKL0 | |||||||||||||||
| Protein name | REST corepressor 1 (Protein CoREST) | |||||||||||||||
| Protein function | Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specifi | |||||||||||||||
| PDB | 2IW5 , 2UXN , 2UXX , 2V1D , 2X0L , 2XAF , 2XAG , 2XAH , 2XAJ , 2XAQ , 2XAS , 2Y48 , 3ZMS , 3ZMT , 3ZMU , 3ZMV , 3ZMZ , 3ZN0 , 3ZN1 , 4BAY , 4KUM , 4UV8 , 4UV9 , 4UVA , 4UVB , 4UVC , 4UXN , 4XBF , 5H6Q , 5H6R , 5L3B , 5L3C , 5L3D , 5L3E , 5L3F , 5L3G , 5LBQ , 5LGN , 5LGT , 5LGU , 5LHG , 5LHH , 5LHI , 5X60 , 5YJB , 6K3E , 6KGK , 6KGL , 6KGM , 6KGN , 6S35 | |||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Ubiquitously expressed. {ECO:0000269|PubMed:10449787}. | |||||||||||||||
| Sequence |
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| Sequence length | 485 | |||||||||||||||
| Interactions | View interactions | |||||||||||||||
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Pathways
Pathway information has different metabolic/signaling pathways associated with genes.
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Associated diseases
Disease associations from ClinVar categorized as Causal (Pathogenic/Likely Pathogenic) or Unknown.
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