Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
23185
Gene name Gene Name - the full gene name approved by the HGNC.
La ribonucleoprotein 4B
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
LARP4B
Synonyms (NCBI Gene) Gene synonyms aliases
KIAA0217, LARP5
Chromosome Chromosome number
10
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
10p15.3
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of an evolutionarily conserved protein family implicated in RNA metabolism and translation. Members of this family are characterized by the presence of an La motif, which is often located adjacent to one or more RNA recognition
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT027047 hsa-miR-103a-3p Sequencing 20371350
MIRT028584 hsa-miR-30a-5p Proteomics 18668040
MIRT032113 hsa-let-7d-5p Sequencing 20371350
MIRT611360 hsa-miR-6776-3p HITS-CLIP 23824327
MIRT611358 hsa-miR-191-3p HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0003723 Function RNA binding HDA 22658674, 22681889
GO:0003730 Function MRNA 3'-UTR binding IDA 26001795
GO:0005515 Function Protein binding IPI 21988832, 25416956, 28514442, 32296183, 32814053
GO:0005730 Component Nucleolus IDA
GO:0005829 Component Cytosol IDA 20573744
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
616513 28987 ENSG00000107929
Protein
UniProt ID Q92615
Protein name La-related protein 4B (La ribonucleoprotein domain family member 4B) (La ribonucleoprotein domain family member 5) (La-related protein 5)
Protein function Stimulates mRNA translation.
PDB 3PTH
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF05383 La 160 216 La domain Domain
Sequence
MTSDQDAKVVAEPQTQRVQEGKDSAHLMNGPISQTTSQTSSIPPLSQVPATKVSELNPNA
EVWGAPVLHLEASSAADGVSAAWEEVAGHHADRGPQGSDANGDGDQGHENAALPDPQESD
PADMNALALGPSEYDSLPENSETGGNESQPDSQEDPREVLKKTLEFCLSRENLASDMYLI
SQMDSDQYVPITTVANLDHIKKLSTDVDLIVEVLRS
LPLVQVDEKGEKVRPNQNRCIVIL
REISESTPVEEVEALFKGDNLPKFINCEFAYNDNWFITFETEADAQQAYKYLREEVKTFQ
GKPIKARIKAKAIAINTFLPKNGFRPLDVSLYAQQRYATSFYFPPMYSPQQQFPLYSLIT
PQTWSATHSYLDPPLVTPFPNTGFINGFTSPAFKPAASPLTSLRQYPPRSRNPSKSHLRH
AIPSAERGPGLLESPSIFNFTADRLINGVRSPQTRQAGQTRTRIQNPSAYAKREAGPGRV
EPGSLESSPGLGRGRKNSFGYRKKREEKFTSSQTQSPTPPKPPSPSFELGLSSFPPLPGA
AGNLKTEDLFENRLSSLIIGPSKERTLSADASVNTLPVVVSREPSVPASCAVSATYERSP
SPAHLPDDPKVAEKQRETHSVDRLPSALTATACKSVQVNGAATELRKPSYAEICQRTSKE
PPSSPLQPQKEQKPNTVGCGKEEKKLAEPAERYREPPALKSTPGAPRDQRRPAGGRPSPS
AMGKRLSREQSTPPKSPQ
Sequence length 738
Interactions View interactions
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Prostate cancer Prostate carcinoma, Prostate cancer, familial rs121909139, rs121909140, rs121909141, rs121909142, rs121909143, rs606231169, rs606231170, rs137852584, rs137852578, rs137852580, rs137852581, rs137852582 29892016
Prostate cancer, hereditary PROSTATE CANCER, HEREDITARY, 1 rs387906327, rs193929331, rs74315365, rs397516896, rs794729219, rs121913349, rs587782641, rs1114167673, rs1597371666, rs2073394466 29892016
Unknown
Disease term Disease name Evidence References Source
Kidney Disease Kidney Disease GWAS
Hypertension Hypertension GWAS
Associations from Text Mining
Disease Name Relationship Type References
Carcinogenesis Associate 37356415
Carcinoma Hepatocellular Associate 31772683
Glioma Associate 34482648, 36552760
Neoplasms Associate 31772683
Neoplasms Inhibit 37356415
Prostatic Neoplasms Associate 31173237
Stomach Neoplasms Associate 28649990