Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	23180
Gene name	Raftlin, lipid raft linker 1
Gene symbol	RFTN1
Synonyms (NCBI Gene)	MIG2PIB10PIG9RAFTLIN
Chromosome	3
Chromosome location	3p24.3

142

Show/Hide all (142)

miRTarBase ID	miRNA	Experiments	Reference
MIRT041930	hsa-miR-484	CLASH	23622248
MIRT1302060	hsa-miR-1179	CLIP-seq
MIRT1302061	hsa-miR-1246	CLIP-seq
MIRT1302062	hsa-miR-1253	CLIP-seq
MIRT1302063	hsa-miR-1290	CLIP-seq
MIRT1302064	hsa-miR-133a	CLIP-seq
MIRT1302065	hsa-miR-133b	CLIP-seq
MIRT1302066	hsa-miR-1915	CLIP-seq
MIRT1302067	hsa-miR-3167	CLIP-seq
MIRT1302068	hsa-miR-3674	CLIP-seq
MIRT1302069	hsa-miR-3938	CLIP-seq
MIRT1302070	hsa-miR-4310	CLIP-seq
MIRT1302071	hsa-miR-4438	CLIP-seq
MIRT1302072	hsa-miR-4648	CLIP-seq
MIRT1302073	hsa-miR-4654	CLIP-seq
MIRT1302074	hsa-miR-4769-5p	CLIP-seq
MIRT1302075	hsa-miR-490-5p	CLIP-seq
MIRT1302076	hsa-miR-515-5p	CLIP-seq
MIRT1302077	hsa-miR-629	CLIP-seq
MIRT1302078	hsa-miR-642a	CLIP-seq
MIRT1302079	hsa-miR-876-5p	CLIP-seq
MIRT2089636	hsa-miR-299-3p	CLIP-seq
MIRT1302071	hsa-miR-4438	CLIP-seq
MIRT1302072	hsa-miR-4648	CLIP-seq
MIRT1302073	hsa-miR-4654	CLIP-seq
MIRT1302074	hsa-miR-4769-5p	CLIP-seq
MIRT1302077	hsa-miR-629	CLIP-seq
MIRT2314595	hsa-miR-3591-3p	CLIP-seq
MIRT1302071	hsa-miR-4438	CLIP-seq
MIRT2314596	hsa-miR-4721	CLIP-seq
MIRT2314597	hsa-miR-4733-3p	CLIP-seq
MIRT2610901	hsa-miR-125a-3p	CLIP-seq
MIRT2610902	hsa-miR-1291	CLIP-seq
MIRT2610903	hsa-miR-141	CLIP-seq
MIRT2610904	hsa-miR-145	CLIP-seq
MIRT2610905	hsa-miR-1825	CLIP-seq
MIRT2610906	hsa-miR-199a-5p	CLIP-seq
MIRT2610907	hsa-miR-199b-5p	CLIP-seq
MIRT2610908	hsa-miR-19a	CLIP-seq
MIRT2610909	hsa-miR-19b	CLIP-seq
MIRT2610910	hsa-miR-200a	CLIP-seq
MIRT2610911	hsa-miR-2276	CLIP-seq
MIRT2610912	hsa-miR-24	CLIP-seq
MIRT2610913	hsa-miR-2467-3p	CLIP-seq
MIRT2610914	hsa-miR-3180-5p	CLIP-seq
MIRT2610915	hsa-miR-3192	CLIP-seq
MIRT2610916	hsa-miR-328	CLIP-seq
MIRT2610917	hsa-miR-3670	CLIP-seq
MIRT2610918	hsa-miR-3678-3p	CLIP-seq
MIRT2610919	hsa-miR-3681	CLIP-seq
MIRT2610920	hsa-miR-3682-5p	CLIP-seq
MIRT2610921	hsa-miR-3689a-3p	CLIP-seq
MIRT2610922	hsa-miR-3689c	CLIP-seq
MIRT2610923	hsa-miR-3691-5p	CLIP-seq
MIRT2610924	hsa-miR-3914	CLIP-seq
MIRT2610925	hsa-miR-3934	CLIP-seq
MIRT2610926	hsa-miR-4292	CLIP-seq
MIRT2610927	hsa-miR-4428	CLIP-seq
MIRT2610928	hsa-miR-4437	CLIP-seq
MIRT2610929	hsa-miR-4457	CLIP-seq
MIRT2314596	hsa-miR-4721	CLIP-seq
MIRT2610930	hsa-miR-4728-5p	CLIP-seq
MIRT2610931	hsa-miR-4764-5p	CLIP-seq
MIRT2610932	hsa-miR-4772-3p	CLIP-seq
MIRT2610933	hsa-miR-4778-3p	CLIP-seq
MIRT2610934	hsa-miR-4792	CLIP-seq
MIRT2610935	hsa-miR-490-3p	CLIP-seq
MIRT2610936	hsa-miR-502-5p	CLIP-seq
MIRT2610937	hsa-miR-513b	CLIP-seq
MIRT2610938	hsa-miR-520a-5p	CLIP-seq
MIRT2610939	hsa-miR-525-5p	CLIP-seq
MIRT2610940	hsa-miR-543	CLIP-seq
MIRT2610941	hsa-miR-544	CLIP-seq
MIRT2610942	hsa-miR-548aa	CLIP-seq
MIRT2610943	hsa-miR-548ac	CLIP-seq
MIRT2610944	hsa-miR-548d-3p	CLIP-seq
MIRT2610945	hsa-miR-548n	CLIP-seq
MIRT2610946	hsa-miR-548z	CLIP-seq
MIRT2610947	hsa-miR-579	CLIP-seq
MIRT2610948	hsa-miR-764	CLIP-seq
MIRT2610949	hsa-miR-873	CLIP-seq
MIRT2610901	hsa-miR-125a-3p	CLIP-seq
MIRT2610902	hsa-miR-1291	CLIP-seq
MIRT2610903	hsa-miR-141	CLIP-seq
MIRT2610904	hsa-miR-145	CLIP-seq
MIRT2610905	hsa-miR-1825	CLIP-seq
MIRT2610906	hsa-miR-199a-5p	CLIP-seq
MIRT2610907	hsa-miR-199b-5p	CLIP-seq
MIRT2610908	hsa-miR-19a	CLIP-seq
MIRT2610909	hsa-miR-19b	CLIP-seq
MIRT2610910	hsa-miR-200a	CLIP-seq
MIRT2610911	hsa-miR-2276	CLIP-seq
MIRT2610912	hsa-miR-24	CLIP-seq
MIRT2610913	hsa-miR-2467-3p	CLIP-seq
MIRT2689693	hsa-miR-3117-3p	CLIP-seq
MIRT2689694	hsa-miR-3169	CLIP-seq
MIRT2610914	hsa-miR-3180-5p	CLIP-seq
MIRT2610915	hsa-miR-3192	CLIP-seq
MIRT2689695	hsa-miR-320a	CLIP-seq
MIRT2689696	hsa-miR-320b	CLIP-seq
MIRT2689697	hsa-miR-320c	CLIP-seq
MIRT2689698	hsa-miR-320d	CLIP-seq
MIRT2689699	hsa-miR-320e	CLIP-seq
MIRT2610916	hsa-miR-328	CLIP-seq
MIRT2610917	hsa-miR-3670	CLIP-seq
MIRT2610918	hsa-miR-3678-3p	CLIP-seq
MIRT2610919	hsa-miR-3681	CLIP-seq
MIRT2610920	hsa-miR-3682-5p	CLIP-seq
MIRT2610921	hsa-miR-3689a-3p	CLIP-seq
MIRT2610922	hsa-miR-3689c	CLIP-seq
MIRT2610923	hsa-miR-3691-5p	CLIP-seq
MIRT2610924	hsa-miR-3914	CLIP-seq
MIRT2610925	hsa-miR-3934	CLIP-seq
MIRT2610926	hsa-miR-4292	CLIP-seq
MIRT2610927	hsa-miR-4428	CLIP-seq
MIRT2689700	hsa-miR-4429	CLIP-seq
MIRT2610928	hsa-miR-4437	CLIP-seq
MIRT2610929	hsa-miR-4457	CLIP-seq
MIRT2314596	hsa-miR-4721	CLIP-seq
MIRT2610930	hsa-miR-4728-5p	CLIP-seq
MIRT2689701	hsa-miR-4759	CLIP-seq
MIRT2610931	hsa-miR-4764-5p	CLIP-seq
MIRT2610932	hsa-miR-4772-3p	CLIP-seq
MIRT2610933	hsa-miR-4778-3p	CLIP-seq
MIRT2610934	hsa-miR-4792	CLIP-seq
MIRT2610935	hsa-miR-490-3p	CLIP-seq
MIRT2610936	hsa-miR-502-5p	CLIP-seq
MIRT2610937	hsa-miR-513b	CLIP-seq
MIRT2610938	hsa-miR-520a-5p	CLIP-seq
MIRT2610939	hsa-miR-525-5p	CLIP-seq
MIRT2689702	hsa-miR-539	CLIP-seq
MIRT2610940	hsa-miR-543	CLIP-seq
MIRT2610941	hsa-miR-544	CLIP-seq
MIRT2610942	hsa-miR-548aa	CLIP-seq
MIRT2610943	hsa-miR-548ac	CLIP-seq
MIRT2610944	hsa-miR-548d-3p	CLIP-seq
MIRT2610945	hsa-miR-548n	CLIP-seq
MIRT2610946	hsa-miR-548z	CLIP-seq
MIRT2610947	hsa-miR-579	CLIP-seq
MIRT2689703	hsa-miR-580	CLIP-seq
MIRT2610948	hsa-miR-764	CLIP-seq
MIRT2610949	hsa-miR-873	CLIP-seq

Show/Hide all (29)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001765	Process	Membrane raft assembly	IMP	12805216
GO:0002457	Process	T cell antigen processing and presentation	IEA
GO:0002457	Process	T cell antigen processing and presentation	ISS
GO:0003725	Function	Double-stranded RNA binding	IDA	21266579
GO:0005737	Component	Cytoplasm	IDA	21266579
GO:0005737	Component	Cytoplasm	IEA
GO:0005768	Component	Endosome	IDA	21266579
GO:0005768	Component	Endosome	IEA
GO:0005769	Component	Early endosome	IEA
GO:0005886	Component	Plasma membrane	IDA	12805216, 21266579
GO:0005886	Component	Plasma membrane	IEA
GO:0016020	Component	Membrane	IEA
GO:0032596	Process	Protein transport into membrane raft	IEA
GO:0032596	Process	Protein transport into membrane raft	ISS
GO:0032740	Process	Positive regulation of interleukin-17 production	IEA
GO:0032740	Process	Positive regulation of interleukin-17 production	ISS
GO:0032991	Component	Protein-containing complex	IDA	21266579
GO:0033227	Process	DsRNA transport	IMP	21266579
GO:0034138	Process	Toll-like receptor 3 signaling pathway	IMP	21266579
GO:0040010	Process	Positive regulation of growth rate	IMP	12805216
GO:0043330	Process	Response to exogenous dsRNA	IMP	21266579
GO:0045121	Component	Membrane raft	IDA	12805216, 21955986
GO:0045121	Component	Membrane raft	IEA
GO:0050852	Process	T cell receptor signaling pathway	IEA
GO:0050852	Process	T cell receptor signaling pathway	ISS
GO:0050853	Process	B cell receptor signaling pathway	IMP	12805216
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:1903044	Process	Protein localization to membrane raft	IEA
GO:1903044	Process	Protein localization to membrane raft	ISS

MIM	HGNC	e!Ensembl
618210	30278	ENSG00000131378

Q14699

Protein name

Raftlin (Cell migration-inducing gene 2 protein) (Raft-linking protein)

Protein function

Involved in protein trafficking via association with clathrin and AP2 complex (PubMed:21266579, PubMed:27022195). Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic cells and macrophages; an

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF15250	Raftlin	1 → 471	Raftlin	Family

Tissue specificity

TISSUE SPECIFICITY: Expressed in B-cells (at protein level) (PubMed:12805216). Expressed in dendritic cells and macrophages (PubMed:21266579, PubMed:27022195). {ECO:0000269|PubMed:12805216, ECO:0000269|PubMed:21266579, ECO:0000269|PubMed:27022195}.

Sequence

MGCGLNKLEKRDEKRPGNIYSTLKRPQVETKIDVSYEYRFLEFTTLSAAELPGSSAVRLA
SLRDLPAQLLELYQQGFSLAALHPFVQPTHEREKTPLEHIFRAILIKKTDRSQKTDLHNE
GYILELDCCSSLDHPTDQKLIPEFIKKIQEAASQGLKFVGVIPQYHSSVNSAGSSAPVST
ANSTEDARDAKNARGDHASLENEKPGTGDVCSAPAGRNQSPEPSSGPRGEVPLAKQPSSP
SGEGDGGELSPQGVSKTLDGPESNPLEVHEEPLSGKMEIFTLFNKPKSHQKCRQYYPVTI
PLHVSKNGQTVSGLDANWLEHMSDHFRKGGMLVNAVFYLGIVNDSLHGLTDGVFIFEAVS
TEDSKTIQGYDAIVVEQWTVLEGVEVQTDYVPLLNSLAAYGWQLTCVLPTPVVKTTSEGS
VSTKQIVFLQRPCLPQKIKKKESKFQWRFSREEMHNRQMRKSKGKLSARDKQQAEENEKN
LEDQSSKAGDMGNCVSGQQQEGGVSEEMKGPVQEDKGEQLSPGGLLCGVGVEGEAVQNGP
ASHSRALVGICTGHSNPGEDARDGDAEEVRELGTVEEN

Sequence length

578

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
FEMALE REPRODUCTIVE SYSTEM DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBESITY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
THORACIC AORTIC ANEURYSM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (11)

Disease Name	Relationship Type	References	Evidence Score
Associations from Text MiningDisease associations identified through Pubtator
Adenocarcinoma of Lung	Associate	33750346, 40224214	★★★★★ ★☆☆☆☆ Found in Text Mining only
Alzheimer Disease	Associate	17387528	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Associate	32544548	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Non Small Cell Lung	Associate	39849531	★★★★★ ★☆☆☆☆ Found in Text Mining only
Chronic Disease	Associate	36139155	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ependymoma	Associate	39679838	★★★★★ ★☆☆☆☆ Found in Text Mining only
Infections	Associate	34506598	★★★★★ ★☆☆☆☆ Found in Text Mining only
Inflammation	Associate	36139155	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Associate	39849531	★★★★★ ★☆☆☆☆ Found in Text Mining only
Nasal Polyps	Stimulate	36139155	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Associate	37041565	★★★★★ ★☆☆☆☆ Found in Text Mining only

RFTN1 (raftlin, lipid raft linker 1)