Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
23177
Gene name Gene Name - the full gene name approved by the HGNC.
Centrosomal protein 68
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
CEP68
Synonyms (NCBI Gene) Gene synonyms aliases
KIAA0582
Chromosome Chromosome number
2
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
2p14
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT020387 hsa-miR-29c-3p Sequencing 20371350
MIRT645117 hsa-miR-3606-3p HITS-CLIP 23824327
MIRT645116 hsa-miR-513a-3p HITS-CLIP 23824327
MIRT645115 hsa-miR-513c-3p HITS-CLIP 23824327
MIRT640721 hsa-miR-548av-5p HITS-CLIP 23824327
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 25416956, 25503564, 32296183, 35709258
GO:0005654 Component Nucleoplasm IDA
GO:0005737 Component Cytoplasm IEA
GO:0005813 Component Centrosome IDA 18042621, 21399614, 31974111
GO:0005813 Component Centrosome IEA
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
616889 29076 ENSG00000011523
Protein
UniProt ID Q76N32
Protein name Centrosomal protein of 68 kDa (Cep68)
Protein function Involved in maintenance of centrosome cohesion, probably as part of a linker structure which prevents centrosome splitting (PubMed:18042621). Required for localization of CDK5RAP2 to the centrosome during interphase (PubMed:24554434, PubMed:2550
Family and domains
Sequence
MALGEEKAEAEASEDTKAQSYGRGSCRERELDIPGPMSGEQPPRLEAEGGLISPVWGAEG
IPAPTCWIGTDPGGPSRAHQPQASDANREPVAERSEPALSGLPPATMGSGDLLLSGESQV
EKTKLSSSEEFPQTLSLPRTTTICSGHDADTEDDPSLADLPQALDLSQQPHSSGLSCLSQ
WKSVLSPGSAAQPSSCSISASSTGSSLQGHQERAEPRGGSLAKVSSSLEPVVPQEPSSVV
GLGPRPQWSPQPVFSGGDASGLGRRRLSFQAEYWACVLPDSLPPSPDRHSPLWNPNKEYE
DLLDYTYPLRPGPQLPKHLDSRVPADPVLQDSGVDLDSFSVSPASTLKSPTNVSPNCPPA
EATALPFSGPREPSLKQWPSRVPQKQGGMGLASWSQLASTPRAPGSRDARWERREPALRG
AKDRLTIGKHLDMGSPQLRTRDRGWPSPRPEREKRTSQSARRPTCTESRWKSEEEVESDD
EYLALPARLTQVSSLVSYLGSISTLVTLPTGDIKGQSPLEVSDSDGPASFPSSSSQSQLP
PGAALQGSGDPEGQNPCFLRSFVRAHDSAGEGSLGSSQALGVSSGLLKTRPSLPARLDRW
PFSDPDVEGQLPRKGGEQGKESLVQCVKTFCCQLEELICWLYNVADVTDHGTAARSNLTS
LKSSLQLYRQFKKDIDEHQSLTESVLQKGEILLQCLLENTPVLEDVLGRIAKQSGELESH
ADRLYDSILASLDMLAGCTLIPDKKPMAAMEHPCEGV
Sequence length 757
Interactions View interactions
<
Associated diseases Disease associations categorized as Causal (pathogenic variants), Unknown (uncertain genetic evidence), or Text Mining (literature-based associations)
Unknown Includes: (1) ClinVar NON-pathogenic variants (Uncertain, Benign, Conflicting, VUS), (2) GenCC associations, (3) GWAS associations, (4) CBGDA evidence-based associations. NOTE: Diseases with pathogenic evidence are excluded to avoid conflicts.
Disease merge term Disease name Evidence References Source
Atrial Fibrillation Atrial fibrillation N/A N/A GWAS
Diabetes Type 2 diabetes, Type 2 diabetes (adjusted for BMI), Type 2 diabetes (PheCode 250.2), Type 2 diabetes with neurological manifestations (PheCode 250.24) N/A N/A GWAS
Hypertension Hypertension, Hypertension (PheCode 401), Essential hypertension (PheCode 401.1), High blood pressure / hypertension N/A N/A GWAS
Associations from Text Mining Disease associations identified through Pubtator
Disease Name Relationship Type References
Angioedema Associate 24618698
Asthma Associate 21072201
Asthma Aspirin Induced Associate 21072201
Atrial Fibrillation Associate 29545482
Hypersensitivity Associate 24618698
Respiratory Tract Diseases Associate 24618698
Retinitis Pigmentosa Associate 15215745
Status Asthmaticus Associate 24618698
Urticaria Associate 24618698