Gene
Entrez ID Entrez Gene ID - the GENE ID in NCBI Gene database.
23163
Gene name Gene Name - the full gene name approved by the HGNC.
Golgi associated, gamma adaptin ear containing, ARF binding protein 3
Gene symbol Gene Symbol - the official gene symbol approved by the HGNC.
GGA3
Synonyms (NCBI Gene) Gene synonyms aliases
-
Chromosome Chromosome number
17
Chromosome location Chromosomal Location - indicates the cytogenetic location of the gene or region on the chromosome.
17q25.1
Summary Summary of gene provided in NCBI Entrez Gene.
This gene encodes a member of the Golgi-localized, gamma adaptin ear-containing, ARF-binding (GGA) family. This family includes ubiquitous coat proteins that regulate the trafficking of proteins between the trans-Golgi network and the lysosome. These prot
miRNA miRNA information provided by mirtarbase database.
miRTarBase ID miRNA Experiments Reference
MIRT026056 hsa-miR-196a-5p Sequencing 20371350
MIRT027133 hsa-miR-103a-3p Sequencing 20371350
MIRT029653 hsa-miR-26b-5p Sequencing 20371350
MIRT050447 hsa-miR-23a-3p CLASH 23622248
MIRT040417 hsa-miR-615-3p CLASH 23622248
Gene ontology (GO) Gene ontology information of associated ontologies with gene provided by GO database.
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 11387475, 12505986, 14638859, 15039775, 16977309, 23143332, 24056087, 26053850, 26446845, 26811329
GO:0005764 Component Lysosome IDA 17116753
GO:0005794 Component Golgi apparatus IDA
GO:0005802 Component Trans-Golgi network IDA 10749927
GO:0006622 Process Protein targeting to lysosome IPI 17116753
Other IDs Other ids provides unique ids of gene in databases such as OMIM, HGNC, ENSEMBLE.
MIM HGNC e!Ensembl
606006 17079 ENSG00000125447
Protein
UniProt ID Q9NZ52
Protein name ADP-ribosylation factor-binding protein GGA3 (Golgi-localized, gamma ear-containing, ARF-binding protein 3)
Protein function Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic aci
PDB 1JPL , 1JUQ , 1LF8 , 1P4U , 1WR6 , 1YD8
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00790 VHS 3 142 VHS domain Domain
PF18308 GGA_N-GAT 169 207 GGA N-GAT domain Domain
PF03127 GAT 222 299 GAT domain Domain
PF02883 Alpha_adaptinC2 597 715 Adaptin C-terminal domain Domain
Tissue specificity TISSUE SPECIFICITY: Ubiquitously expressed.
Sequence
MAEAEGESLESWLNKATNPSNRQEDWEYIIGFCDQINKELEGPQIAVRLLAHKIQSPQEW
EALQALTVLEACMKNCGRRFHNEVGKFRFLNELIKVVSPKYLGDRVSEKVKTKVIELLYS
WTMALPEEAKIKDAYHMLKRQG
IVQSDPPIPVDRTLIPSPPPRPKNPVFDDEEKSKLLAK
LLKSKNPDDLQEANKLIKSMVKEDEAR
IQKVTKRLHTLEEVNNNVRLLSEMLLHYSQEDS
SDGDRELMKELFDQCENKRRTLFKLASETEDNDNSLGDILQASDNLSRVINSYKTIIEG
Q
VINGEVATLTLPDSEGNSQCSNQGTLIDLAELDTTNSLSSVLAPAPTPPSSGIPILPPPP
QASGPPRSRSSSQAEATLGPSSTSNALSWLDEELLCLGLADPAPNVPPKESAGNSQWHLL
QREQSDLDFFSPRPGTAACGASDAPLLQPSAPSSSSSQAPLPPPFPAPVVPASVPAPSAG
SSLFSTGVAPALAPKVEPAVPGHHGLALGNSALHHLDALDQLLEEAKVTSGLVKPTTSPL
IPTTTPARPLLPFSTGPGSPLFQPLSFQSQGSPPKGPELSLASIHVPLESIKPSSALPVT
AYDKNGFRILFHFAKECPPGRPDVLVVVVSMLNTAPLPVKSIVLQAAVPKSMKVKLQPPS
GTELSPFSPIQPPAAITQVMLLANPLKEKVRLRYKLTFALGEQLSTEVGEVDQFP
PVEQW
GNL
Sequence length 723
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG   Reactome
  Lysosome   TBC/RABGAPs
MET receptor recycling
Amyloid fiber formation
Associated diseases Disease information provided by ClinVar, GenCC, and GWAS databases.
Causal
Disease term Disease name dbSNP ID References
Breast cancer Malignant neoplasm of breast rs587776547, rs1137887, rs137853007, rs587776650, rs80359351, rs80359714, rs121917783, rs104886456, rs121964878, rs80359874, rs80357868, rs80357508, rs387906843, rs80357569, rs80358158
View all (309 more)
Associations from Text Mining
Disease Name Relationship Type References
Bovine Respiratory Disease Complex Associate 31402603
Breast Neoplasms Inhibit 26474971
Diabetes Mellitus Type 2 Associate 29273463, 31402603
Dyslipidemias Associate 31402603
Hypertension Associate 31402603
Hyperuricemia Associate 31402603
Neoplasms Inhibit 26474971
Obesity Associate 31402603